In an effort to strengthen the collaborations between the 5 teams, “scientific clubs” will be created to serve as bridges between the teams. The goal of these informal clubs will be to stimulate reflection and scientific strategies of internal collaborations that should lead to common grant deposit. They will also have a role in proposing seminars either with internal or external orators.

  • Bioinformatics (H. Le Nagard,  O. Tenaillon, C. Charpentier)

    Next generation sequencing methods have massively increased the amount of sequences a laboratory can produce. From whole genome sequence, to RNAseq and polymorphism analysis, all these applications require some computational skill to be analyzed. The aim of this club will be to do a survey of the literature in the field to follow the new sequencing techniques and tools to analyze them and to allow the different members of the unit to share and improve their experience on these data. Some introductory classes in R and perl may also be proposed in the club. The club will be in connexion with the INTEGRASEQ project funded to University Paris Diderot where next-generation sequencing machines and bioinformatics tools are being acquired, Hervé Le Nagard being the responsible for the Medical School.

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  • Clinical Research (A. Lefort, X. Duval)

    Based on a common motivation of the clinical researchers originating from the five teams, the objective will be to develop during the 5 next years an innovative network of epidemio-clinical research integrated in IAME, considering that the patient is simultaneously the source and the aim of this construction. It is expected to sustain a strong and direful interdisciplinary strategy of research associated with training in this field.  The two first steps will be: i) a multidisciplinary monthly meeting dedicated to this thematic, with active participation of both fundamental and clinical researchers to stimulate polymorphic interactions among the different teams, and ii) the common analysis and recognition of the current status of publications and ongoing studies chaired by one of the clinicians of IAME. This step will be the cornerstone for prospective brainstorming, especially to design and perform new common clinical research based-protocols.

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  • Microbiota (J. Tourret, V. de Lastours)
    The digestive microbiota with 1014 bacteria belonging to 500-1000 species is now often considered as an additional human organ despite the fact that it is not a distinct structure. The microbiome, which is all the genes of these bacteria, is estimated to 106 genes whereas the human genome harbours 23,000 genes. Due to the next generation sequencing methods, the exploration of the microbiome is an emerging field, with recent papers linking the microbiota to various human diseases, in addition to its role in the emergence of virulent and resistant bacteria. One of the challenges of microbiota studies is the statistic analysis of the data. Teams 1 and 2 will be involved in projects on microbiota and Team 4 will invest time on the statistical analysis.

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  • Statistics (Lidia Karkas, Thu Thuy Nguyen, Cédric Laouénan)

These club is an introduction to the software R during several half day workshops.

R is rapidly becoming the leading language in data science and statistics. Today, the R programming language is the tool of choice for data scientists in every field.

What you’ll learn:

– R language fundamentals and basic syntax;

– What R is and how it’s used to perform data analysis and graphics.


Workshop Day DD/MM/YYYY Time Place
1 Prise en main de R et statistiques descriptives partie 1 mercredi 16/03/2016 14h-17h S144 (-1 au sous sol)
2 Statistiques descriptives partie 2 et graphiques simples mercredi 06/04/2016 14h-17h S144 (-1 au sous sol)
3 Tests statistiques usuels 1/2 mercredi 25/05/2016 14h-17h S144 (-1 au sous sol)
4 Tests statistiques usuels 2/2 mercredi 22/06/2016 14h-17h S144 (-1 au sous sol)
5 Programmation avancée mercredi 14/09/2016 14h-17h TP 170 (1er étage)
6 Graphiques avancés avec ggplot2 mercredi 09/11/2016 14h-17h TP 170 (1er étage)
7 Statistiques avancées partie 1 mercredi 25/01/2017 14h-17h TP 170 (1er étage)
8 Statistiques avancées partie 2 mercredi 22/02/2017 14h-17h TP 170 (1er étage)
9 Statistiques avancées partie 3 mercredi 15/03/2017 14h-17h TP 170 (1er étage)


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