First name: Vincent
  Last name: Madelain
  Position: PhD student
  Email: vincent.madelain

Research interest

My research interest focuses on pharmacokinetic and viral dynamic modelling, with a PhD subject entitled "Modeling the paradigm of HIV post-treatment controllers using clinical and animal data".



2015: MSc Public Health / Master 2 Santé publique: Méthodes en évaluation thérapeutique (Paris Descartes University)
2006 – 2012: Pharmacist training (Poitiers University)

Exhaustive list of publications


Best K, Guedj J, Madelain V, de Lamballerie X, Lim SY, Osuna CE, Whitney JB, Perelson AS
Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies.
Proceedings of the National Academy of Sciences of the United States of America 2017, 114, 8847-8852.

Madelain V, Le MP, Champenois K, Charpentier C, Landman R, Joly V, Yeni P, Descamps D, Yazdanpanah Y, Peytavin G
Impact of obesity on antiretroviral pharmacokinetics and immuno-virological response in HIV-infected patients: a case-control study.
The Journal of Antimicrobial Chemotherapy 2017, 72, 1137-1146.

Madelain V, Guedj J, Mentré F, Nguyen THT, Jacquot F, Oestereich L, Kadota T, Yamada K, Taburet AM, de Lamballerie X, Raoul H
Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses.
Antimicrobial Agents and Chemotherapy 2017, 61,

Nguyen THT, Guedj J, Anglaret X, Laouénan C, Madelain V, Taburet AM, Baize S, Sissoko D, Pastorino B, Rodallec A, Piorkowski G, Carazo S, Conde MN, Gala JL, Bore JA, Carbonnelle C, Jacquot F, Raoul H, Malvy D, de Lamballerie X, Mentré F, Jsg
Favipiravir pharmacokinetics in Ebola-Infected patients of the JIKI trial reveals concentrations lower than targeted.
PLoS neglected tropical diseases 2017, 11, e0005389.


Madelain V, Nguyen THT, Olivo A, de Lamballerie X, Guedj J, Taburet AM, Mentré F
Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials.
Clinical Pharmacokinetics 2016, 55, 907–923.


Madelain V, Oestereich L, Graw F, Nguyen THT, de Lamballerie X, Mentré F, Günther S, Guedj J
Ebola virus dynamics in mice treated with favipiravir.
Antiviral Research 2015, 123, 70–77.