Members

  First name: André
  Last name: Birgy
  Position: Maitre Conférence des Universités - Praticien hospitalier
  Email: andre.birgy
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inserm.fr

Research interest


My works focus on resistance to antibiotics, particularly to beta-lactams. I follow the French epidemiology of beta-lactam resistance of enterobacteriaceae and try to understand molecular determinants involved in beta-lactamase evolution.

Education

Degree

2013-2017 : PhD Student
2013: Pharmaceutical degree and DES de Biologie Médicale in Microbiology. Descartes University, Paris, France

Academic positions

2018- : Maitre Conférence des Universités – Praticien hospitalier
Microbiology Department, Robert-Debré Hospital, AP-HP, Paris, France

2015-2017 : Assistant Hospitalo-Universitaire, Microbiology Department, Robert-Debré Hospital, AP-HP, Paris, France
2013-2015 : Poste d’accueil Inserm
2008-2013 : Resident, Assistance Publique-Hôpitaux de Paris

List of the main publications

Birgy A, Levy C, Bidet P, Thollot F, Derkx V, Béchet S, Mariani-Kurkdjian P, Cohen R, Bonacorsi S
ESBL-producing Escherichia coli ST131 versus non-ST131: evolution and risk factors of carriage among French children in the community between 2010 and 2015.
The Journal of Antimicrobial Chemotherapy 2016, 71, 2949-2956.

Bidet P, Basmaci R, Guglielmini J, Doit C, Jost C, Birgy A, Bonacorsi S
Genome Analysis of Kingella kingae Strain KWG1 Reveals How a β-Lactamase Gene Inserted in the Chromosome of This Species.
Antimicrobial Agents and Chemotherapy 2016, 60, 703-708.

Jacquier H, Birgy A, Le Nagard H, Mechulam Y, Schmitt E, Glodt J, Bercot B, Petit E, Poulain J, Barnaud G, Gros PA, Tenaillon O
Capturing the mutational landscape of the beta-lactamase TEM-1.
Proceedings of the National Academy of Sciences of the United States of America 2013, 110, 13067–13072.

Birgy A, Mariani-Kurkdjian P, Bidet P, Doit C, Genel N, Courroux C, Arlet G, Bingen E
Characterization of extended-spectrum-beta-lactamase-producing Escherichia coli strains involved in maternal-fetal colonization: prevalence of E. coli ST131.
Journal of Clinical Microbiology 2013, 51, 1727-1732.

Birgy A, Bidet P, Genel N, Doit C, Decré D, Arlet G, Bingen E
Phenotypic screening of carbapenemases and associated β-lactamases in carbapenem-resistant Enterobacteriaceae.
Journal of Clinical Microbiology 2012, 50, 1295-1302.

Birgy A, Cohen R, Levy C, Bidet P, Courroux C, Benani M, Thollot F, Bingen E
Community faecal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae in French children.
BMC infectious diseases 2012, 12, 315.


Exhaustive list of publications

2022


Mizrahi A, Chat L, Danjean M, Mory C, Nguyen Van JC, de Ponfilly GP, Caméléna F, Le Monnier A, Bercot B, Birgy A, Jacquier H, Pilmis B
Inoculum effect of Enterobacterales co-expressing OXA-48 and CTX-M on the susceptibility to ceftazidime/avibactam and meropenem.
European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology 2022, 41, 853-858.

Hobson CA, Bonacorsi S, Baruchel A, Tenaillon O, Birgy A
The interplay between anticancer challenges and the microbial communities from the gut.
European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology 2022, 41, 691-711.

Moussiegt A, Birgy A, Cointe A, Duval X, Bidet P, Bonacorsi S
Escherichia coli community-acquired meningitis in adults: a case series of 29 patients in France.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2022, 28, 1304-1305.

Danjean M, Hobson CA, Gits-Muselli M, Courroux C, Monjault A, Bonacorsi S, Birgy A
Evaluation of the inoculum effect of new antibiotics against carbapenem-resistant enterobacterales.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2022, 28, 1503.e1-1503.e3.

Bidet P, Birgy A, Brethon B, Dalle JH, Mariani-Kurkdjian P, Courroux C, Monjault A, Gits-Muselli M, Bonacorsi S
Epidemiological investigation of Pseudomonas aeruginosa isolates including multidrug-resistant serogroup O12 isolates, by use of a rapid and simplified multiple-locus variable-number of tandem repeats analysis and whole genome sequencing.
The Journal of Hospital Infection 2022, 130, 56-62.

Bidet P, Birgy A, Ouldali N, Béchet S, Levy C, Madhi F, Sobral E, Cohen R, Bonacorsi S
Comparative genomic analysis of ESBL-producing Escherichia coli from faecal carriage and febrile urinary tract infection in children: a prospective multicentre study.
JAC-antimicrobial resistance 2022, 4, dlac056.

Hobson CA, Vigue L, Naimi S, Chassaing B, Magnan M, Bonacorsi S, Gachet B, El Meouche I, Birgy A, Tenaillon O
MiniBioReactor Array (MBRA) in vitro gut model: a reliable system to study microbiota-dependent response to antibiotic treatment.
JAC-antimicrobial resistance 2022, 4, dlac077.

Hobson CA, Pierrat G, Tenaillon O, Bonacorsi S, Bercot B, Jaouen E, Jacquier H, Birgy A
Klebsiella pneumoniae Carbapenemase Variants Resistant to Ceftazidime-Avibactam: an Evolutionary Overview.
Antimicrobial Agents and Chemotherapy 2022, 66, e0044722.

Bizot E, Cointe A, Bidet P, Mariani-Kurkdjian P, Hobson CA, Courroux C, Liguori S, Bridier-Nahmias A, Magnan M, Merimèche M, Caméléna F, Berçot B, Weill FX, Lefèvre S, Bonacorsi S, Birgy A
Azithromycin Resistance in Shiga Toxin-Producing Escherichia coli in France between 2004 and 2020 and Detection of mef(C)-mph(G) Genes.
Antimicrobial Agents and Chemotherapy 2022, 66, e0194921.

Hobson CA, Vigué L, Magnan M, Chassaing B, Naimi S, Gachet B, Claraz P, Storme T, Bonacorsi S, Tenaillon O, Birgy A
A Microbiota-Dependent Response to Anticancer Treatment in an In Vitro Human Microbiota Model: A Pilot Study With Hydroxycarbamide and Daunorubicin.
Frontiers in Cellular and Infection Microbiology 2022, 12, 886447.

Delafoy M, Goutines J, Fourmont AM, Birgy A, Chomton M, Levy M, Naudin J, Zafrani L, Le Mouel L, Yakouben K, Cointe A, Caseris M, Lafaurie M, Bonacorsi S, Mechinaud F, Pereyre S, Boissel N, Baruchel A
Case Report: Hyperammonemic Encephalopathy Linked to Ureaplasma spp. and/or Mycoplasma hominis Systemic Infection in Patients Treated for Leukemia, an Emergency Not to Be Missed.
Frontiers in Oncology 2022, 12, 912695.

Birgy A, Magnan M, Hobson CA, Figliuzzi M, Panigoni K, Codde C, Tenaillon O, Jacquier H
Local and Global Protein Interactions Contribute to Residue Entrenchment in Beta-Lactamase TEM-1.
Antibiotics (Basel, Switzerland) 2022, 11, 652.

2021


Hobson CA, Cointe A, Jacquier H, Choudhury A, Magnan M, Courroux C, Tenaillon O, Bonacorsi S, Birgy A
Cross-resistance to cefiderocol and ceftazidime-avibactam in KPC β-lactamase mutants and the inoculum effect.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2021, 27, 1172.e7-1172.e10.

Birgy A, Madhi F, Jung C, Levy C, Cointe A, Bidet P, Hobson CA, Bechet S, Sobral E, Vuthien H, Ferroni A, Aberrane S, Cuzon G, Beraud L, Gajdos V, Launay E, Pinquier D, Haas H, Desmarest M, Dommergues MA, Cohen R, Bonacorsi S, GotNOoUtIdtEpEic
Clavulanate combinations with mecillinam, cefixime or cefpodoxime against ESBL-producing Enterobacterales frequently associated with blaOXA-1 in a paediatric population with febrile urinary tract infections.
The Journal of Antimicrobial Chemotherapy 2021, 76, 2839-2846.

Lignieres G, Birgy A, Jung C, Bonacorsi S, Levy C, Angoulvant F, Grimprel E, Dommergues MA, Gillet Y, Craiu I, Rybak A, De Pontual L, Dubos F, Cixous E, Gajdos V, Pinquier D, Andriantahina I, Soussan-Banini V, Georget E, Launay E, Vignaud O, Cohen R, Madhi F
Relay oral therapy in febrile urinary tract infections caused by extended spectrum beta-lactamase-producing Enterobacteriaceae in children: A French multicenter study.
PloS One 2021, 16, e0257217.

Cointe A, Bizot E, Delannoy S, Fach P, Bidet P, Birgy A, Weill FX, Lefèvre S, Mariani-Kurkdjian P, Bonacorsi S
Emergence of New ST301 Shiga Toxin-Producing Escherichia coli Clones Harboring Extra-Intestinal Virulence Traits in Europe.
Toxins 2021, 13, 686.

2020


Cointe A, Birgy A, Pascault A, Louillet F, Dufougeray A, Mariani-Kurkdjian P, Bonacorsi S
Be aware of Shiga-toxin 2f-producing Escherichia coli: case report and false-negative results with certain rapid molecular panels.
Diagnostic Microbiology and Infectious Disease 2020, 98, 115177.

Hobson CA, Bonacorsi S, Hocquet D, Baruchel A, Fahd M, Storme T, Tang R, Doit C, Tenaillon O, Birgy A
Impact of anticancer chemotherapy on the extension of beta-lactamase spectrum: an example with KPC-type carbapenemase activity towards ceftazidime-avibactam.
Scientific Reports 2020, 10, 589.

Hobson CA, Cointe A, Bidet P, Poupon J, Bonacorsi S, Birgy A
Urine zinc concentrations allow proper expression of metallo-β-lactamases in Enterobacteriaceae.
The Journal of Antimicrobial Chemotherapy 2020, 75, 3077-3079.

Birgy A, Madhi F, Jung C, Levy C, Cointe A, Bidet P, Hobson CA, Bechet S, Sobral E, Vuthien H, Ferroni A, Aberrane S, Cuzon G, Beraud L, Gajdos V, Launay E, Pinquier D, Haas H, Desmarest M, Dommergues MA, Cohen R, Bonacorsi S, GotNOoUtIdtEpEic
Diversity and trends in population structure of ESBL-producing Enterobacteriaceae in febrile urinary tract infections in children in France from 2014 to 2017.
The Journal of Antimicrobial Chemotherapy 2020, 75, 96-105.

Cointe A, Birgy A, Bridier-Nahmias A, Mariani-Kurkdjian P, Walewski V, Lévy C, Cohen R, Fach P, Delannoy S, Bidet P, Bonacorsi S
Escherichia coli O80 hybrid pathotype strains producing Shiga toxin and ESBL: molecular characterization and potential therapeutic options.
The Journal of Antimicrobial Chemotherapy 2020, 75, 537-542.

Hobson CA, Bonacorsi S, Jacquier H, Choudhury A, Magnan M, Cointe A, Bercot B, Tenaillon O, Birgy A
KPC Beta-Lactamases Are Permissive to Insertions and Deletions Conferring Substrate Spectrum Modifications and Resistance to Ceftazidime-Avibactam.
Antimicrobial Agents and Chemotherapy 2020, 64, e01175-20.

Petit M, Caméléna F, Cointe A, Poncin T, Merimèche M, Bonacorsi S, Birgy A, Berçot B
Rapid Detection and Characterization of Carbapenemases in Enterobacterales with a New Modified Carbapenem Inactivation Method, mCIMplus.
Journal of Clinical Microbiology 2020, 58, e01370-20.

Dubert M, Visseaux B, Birgy A, Mordant P, Metivier AC, Dauriat G, Fidouh N, Yazdanpanah Y, Grall N, Castier Y, Mal H, Thabut G, Lescure FX
Late viral or bacterial respiratory infections in lung transplanted patients: impact on respiratory function.
BMC infectious diseases 2020, 20, 176.

2019


Birgy A, Levy C, Nicolas-Chanoine MH, Cointe A, Hobson CA, Magnan M, Bechet S, Bidet P, Cohen R, Bonacorsi S
Independent Host Factors and Bacterial Genetic Determinants of the Emergence and Dominance of Escherichia coli Sequence Type 131 CTX-M-27 in a Community Pediatric Cohort Study.
Antimicrobial Agents and Chemotherapy 2019, 63,

Hobson CA, Bonacorsi S, Fahd M, Baruchel A, Cointe A, Poey N, Jacquier H, Doit C, Monjault A, Tenaillon O, Birgy A
Successful Treatment of Bacteremia Due to NDM-1-Producing Morganella morganii with Aztreonam and Ceftazidime-Avibactam Combination in a Pediatric Patient with Hematologic Malignancy.
Antimicrobial Agents and Chemotherapy 2019, 63,

Caméléna F, Birgy A, Smail Y, Courroux C, Mariani-Kurkdjian P, Le Hello S, Bonacorsi S, Bidet P
Rapid and Simple Universal Escherichia coli Genotyping Method Based on Multiple-Locus Variable-Number Tandem-Repeat Analysis Using Single-Tube Multiplex PCR and Standard Gel Electrophoresis.
Applied and Environmental Microbiology 2019, 85,

Geslain G, Birgy A, Adiba S, Magnan M, Courroux C, Levy C, Cohen R, Bidet P, Bonacorsi S
Genome sequencing of strains of the most prevalent clonal group of O1:K1:H7 Escherichia coli that causes neonatal meningitis in France.
BMC microbiology 2019, 19, 17.

Genuini M, Bidet P, Benoist JF, Schlemmer D, Lemaitre C, Birgy A, Bonacorsi S
ShiF acts as an auxiliary factor of aerobactin secretion in meningitis Escherichia coli strain S88.
BMC microbiology 2019, 19, 298.

Cointe A, Walewski V, Hobson CA, Doit C, Bidet P, Dortet L, Bonacorsi S, Birgy A
Rapid Carbapenemase Detection With Xpert Carba-R V2 Directly On Positive Blood Vials.
Infection and Drug Resistance 2019, 12, 3311-3316.

Caméléna F, Birgy A, Smail Y, Courroux C, Mariani-Kurkdjian P, Le Hello S, Bonacorsi S, Bidet P
Rapid and simple universal Escherichia coli genotyping method based on multiple-locus variable-number tandem-repeat analysis using single-tube multiplex PCR and standard gel electrophoresis.
Applied and Environmental Microbiology 2019, 85, e02812–18.

Caméléna F, Birgy A, Smail Y, Courroux C, Mariani-Kurkdjian P, Le Hello S, Bonacorsi S, Bidet P
Rapid and simple universal Escherichia coli genotyping method based on multiple-locus variable-number tandem-repeat analysis using single-tube multiplex PCR and standard gel electrophoresis.
Applied and Environmental Microbiology 2019, 85, e02812–18.

2018


Tran Quang V, Bidet P, Birgy A, Caseris M, Basmaci R, Bonacorsi S
Susceptibility testing of Kingella kingae to cefazolin.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2018, 24, 312-313.

Birgy A, Madhi F, Hogan J, Doit C, Gaschignard J, Caseris M, Bidet P, Cohen R, Bonacorsi S
CTX-M-55-, MCR-1-, and FosA-Producing Multidrug-Resistant Escherichia coli Infection in a Child in France.
Antimicrobial Agents and Chemotherapy 2018, 62,

Cointe A, Bonacorsi S, Truong J, Hobson C, Doit C, Monjault A, Bidet P, Birgy A
Detection of Carbapenemase-Producing Enterobacteriaceae in Positive Blood Culture Using an Immunochromatographic RESIST-4 O.K.N.V. Assay.
Antimicrobial Agents and Chemotherapy 2018, 62,

Caméléna F, Cointe A, Mathy V, Hobson C, Doit C, Bercot B, Decré D, Podglajen I, Dortet L, Monjault A, Bidet P, Bonacorsi S, Birgy A
Within-a-Day Detection and Rapid Characterization of Carbapenemase by Use of a New Carbapenem Inactivation Method-Based Test, CIMplus.
Journal of Clinical Microbiology 2018, 56,

Cointe A, Birgy A, Mariani-Kurkdjian P, Liguori S, Courroux C, Blanco J, Delannoy S, Fach P, Loukiadis E, Bidet P, Bonacorsi S
Emerging Multidrug-Resistant Hybrid Pathotype Shiga Toxin-Producing Escherichia coli O80 and Related Strains of Clonal Complex 165, Europe.
Emerging Infectious Diseases 2018, 24, 2262-2269.

2017


Birgy A, Delecourt M, Geslain G, Desselas E, Caseris M, Magnan M, Mariani-Kurkdjian P, Bidet P, Bonacorsi S
A combination of mecillinam and amoxicillin/clavulanate can restore susceptibility of high-level TEM-1-producing Escherichia coli to mecillinam.
The Journal of Antimicrobial Chemotherapy 2017, 72, 1911-1914.

Bidet P, Tran Quang V, Yagusky P, Birgy A, Bonacorsi S, Basmaci R
Investigation of Kingella kingae Invasive Infection Outbreaks in Day Care Facilities: Assessment of a Rapid Genotyping Tool Targeting the DNA Uptake Sequence.
Journal of Clinical Microbiology 2017, 55, 2422-2430.

Birgy A, Bidet P, Levy C, Sobral E, Cohen R, Bonacorsi S
CTX-M-27-Producing Escherichia coli of Sequence Type 131 and Clade C1-M27, France.
Emerging Infectious Diseases 2017, 23, 885.

2016


Birgy A, Levy C, Bidet P, Thollot F, Derkx V, Béchet S, Mariani-Kurkdjian P, Cohen R, Bonacorsi S
ESBL-producing Escherichia coli ST131 versus non-ST131: evolution and risk factors of carriage among French children in the community between 2010 and 2015.
The Journal of Antimicrobial Chemotherapy 2016, 71, 2949-2956.

Bidet P, Basmaci R, Guglielmini J, Doit C, Jost C, Birgy A, Bonacorsi S
Genome Analysis of Kingella kingae Strain KWG1 Reveals How a β-Lactamase Gene Inserted in the Chromosome of This Species.
Antimicrobial Agents and Chemotherapy 2016, 60, 703-708.

2013


Jacquier H, Birgy A, Le Nagard H, Mechulam Y, Schmitt E, Glodt J, Bercot B, Petit E, Poulain J, Barnaud G, Gros PA, Tenaillon O
Capturing the mutational landscape of the beta-lactamase TEM-1.
Proceedings of the National Academy of Sciences of the United States of America 2013, 110, 13067–13072.

Birgy A, Mariani-Kurkdjian P, Bidet P, Doit C, Genel N, Courroux C, Arlet G, Bingen E
Characterization of extended-spectrum-beta-lactamase-producing Escherichia coli strains involved in maternal-fetal colonization: prevalence of E. coli ST131.
Journal of Clinical Microbiology 2013, 51, 1727-1732.

2012


d'Humières C, Birgy A, Doit C, Bidet P, Arlet G, Bingen E
Use of a new screening medium to detect carbapenem-non-susceptible members of the Enterobacteriaceae.
Journal of Medical Microbiology 2012, 61, 878-880.

Bingen E, Bidet P, Birgy A, Sobral E, Mariani P, Cohen R
In vitro interaction between cefixime and amoxicillin-clavulanate against extended-spectrum-beta-lactamase-producing Escherichia coli causing urinary tract infection.
Journal of Clinical Microbiology 2012, 50, 2540-2541.

Birgy A, Bidet P, Genel N, Doit C, Decré D, Arlet G, Bingen E
Phenotypic screening of carbapenemases and associated β-lactamases in carbapenem-resistant Enterobacteriaceae.
Journal of Clinical Microbiology 2012, 50, 1295-1302.

Birgy A, Cohen R, Levy C, Bidet P, Courroux C, Benani M, Thollot F, Bingen E
Community faecal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae in French children.
BMC infectious diseases 2012, 12, 315.