Members

  First name: Claire Amaris
  Last name: Hobson
  Function: Assistant professor, Infectious Diseases
  Position: Assistant professor at Université Paris Cité
  Email: claire.hobson
._
_.
aphp.fr

Research interest


Antimicrobial resistance; Ceftazidime-avibactam resistance; Mutagenesis; carbapenemase; Microbiology; Gut microbiota  

Education

Degree

2022: Ph. D in Infectious Disease, ED BioSPC 562


Academic positions

2013-2018: Internship in Pediatrics
2018-2022: PhD in Infectious Diseases, IAME, INSERM U1137
2021-present: Chef de Clinique Assistante, Infectious Disease Department, Bichat University Hospital

Research training (post doctoral)

2017-2018: • Master 2 : Microbiologie MBVP (Paris Chatenay), Pr Tenaillon, Dr Birgy,
INSERM UMR1137, IAME, QEM Team. « Impact of anticander drugs on Echerichia coli and the gut microbiota ». Funding: Fondation ARC, Recherche pour le Cancer. Grant N° : M2R20170505715

2019-2022 : Ph.D Infectious Diseases, École doctorale BioSPC 562. IAME, INSERM U1137, Pr Tenaillon, Dr Birgy.
« In vitro gut model (MBRA) to evaluate the impact of antimicrobials and anticancer drugs on the gut microbiota ». Funding: Fondation ARC, Grant N°DOC20190509066.

List of the main publications

Hobson CA, Bonacorsi S, Baruchel A, Tenaillon O, Birgy A
The interplay between anticancer challenges and the microbial communities from the gut.
European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology 2022, 41, 691-711.

Danjean M, Hobson CA, Gits-Muselli M, Courroux C, Monjault A, Bonacorsi S, Birgy A
Evaluation of the inoculum effect of new antibiotics against carbapenem-resistant enterobacterales.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2022, 28, 1503.e1-1503.e3.

Hobson CA, Vigue L, Naimi S, Chassaing B, Magnan M, Bonacorsi S, Gachet B, El Meouche I, Birgy A, Tenaillon O
MiniBioReactor Array (MBRA) in vitro gut model: a reliable system to study microbiota-dependent response to antibiotic treatment.
JAC-antimicrobial resistance 2022, 4, dlac077.

Hobson CA, Pierrat G, Tenaillon O, Bonacorsi S, Bercot B, Jaouen E, Jacquier H, Birgy A
Klebsiella pneumoniae Carbapenemase Variants Resistant to Ceftazidime-Avibactam: an Evolutionary Overview.
Antimicrobial Agents and Chemotherapy 2022, 66, e0044722.

Bizot E, Cointe A, Bidet P, Mariani-Kurkdjian P, Hobson CA, Courroux C, Liguori S, Bridier-Nahmias A, Magnan M, Merimèche M, Caméléna F, Berçot B, Weill FX, Lefèvre S, Bonacorsi S, Birgy A
Azithromycin Resistance in Shiga Toxin-Producing Escherichia coli in France between 2004 and 2020 and Detection of mef(C)-mph(G) Genes.
Antimicrobial Agents and Chemotherapy 2022, 66, e0194921.

Truong J, Cointe A, Le Roux E, Bidet P, Michel M, Boize J, Mariani-Kurkdjian P, Caseris M, Hobson CA, Desmarest M, Titomanlio L, Faye A, Bonacorsi S
Clinical impact of a gastrointestinal PCR panel in children with infectious diarrhoea.
Archives of Disease in Childhood 2022, 107, 601-605.

Hobson CA, Vigué L, Magnan M, Chassaing B, Naimi S, Gachet B, Claraz P, Storme T, Bonacorsi S, Tenaillon O, Birgy A
A Microbiota-Dependent Response to Anticancer Treatment in an In Vitro Human Microbiota Model: A Pilot Study With Hydroxycarbamide and Daunorubicin.
Frontiers in Cellular and Infection Microbiology 2022, 12, 886447.

Birgy A, Magnan M, Hobson CA, Figliuzzi M, Panigoni K, Codde C, Tenaillon O, Jacquier H
Local and Global Protein Interactions Contribute to Residue Entrenchment in Beta-Lactamase TEM-1.
Antibiotics (Basel, Switzerland) 2022, 11, 652.

Hobson CA, Cointe A, Jacquier H, Choudhury A, Magnan M, Courroux C, Tenaillon O, Bonacorsi S, Birgy A
Cross-resistance to cefiderocol and ceftazidime-avibactam in KPC β-lactamase mutants and the inoculum effect.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2021, 27, 1172.e7-1172.e10.

Birgy A, Madhi F, Jung C, Levy C, Cointe A, Bidet P, Hobson CA, Bechet S, Sobral E, Vuthien H, Ferroni A, Aberrane S, Cuzon G, Beraud L, Gajdos V, Launay E, Pinquier D, Haas H, Desmarest M, Dommergues MA, Cohen R, Bonacorsi S, Group of the National Observatory of Urinary tract Infection due to ESBL-producing Enterobacteriaceae in children
Clavulanate combinations with mecillinam, cefixime or cefpodoxime against ESBL-producing Enterobacterales frequently associated with blaOXA-1 in a paediatric population with febrile urinary tract infections.
The Journal of Antimicrobial Chemotherapy 2021, 76, 2839-2846.

Hobson CA, Bonacorsi S, Hocquet D, Baruchel A, Fahd M, Storme T, Tang R, Doit C, Tenaillon O, Birgy A
Impact of anticancer chemotherapy on the extension of beta-lactamase spectrum: an example with KPC-type carbapenemase activity towards ceftazidime-avibactam.
Scientific Reports 2020, 10, 589.

Hobson CA, Cointe A, Bidet P, Poupon J, Bonacorsi S, Birgy A
Urine zinc concentrations allow proper expression of metallo-β-lactamases in Enterobacteriaceae.
The Journal of Antimicrobial Chemotherapy 2020, 75, 3077-3079.

Birgy A, Madhi F, Jung C, Levy C, Cointe A, Bidet P, Hobson CA, Bechet S, Sobral E, Vuthien H, Ferroni A, Aberrane S, Cuzon G, Beraud L, Gajdos V, Launay E, Pinquier D, Haas H, Desmarest M, Dommergues MA, Cohen R, Bonacorsi S, Group of the National Observatory of Urinary tract Infection due to ESBL-producing Enterobacteriaceae in children
Diversity and trends in population structure of ESBL-producing Enterobacteriaceae in febrile urinary tract infections in children in France from 2014 to 2017.
The Journal of Antimicrobial Chemotherapy 2020, 75, 96-105.

Hobson CA, Bonacorsi S, Jacquier H, Choudhury A, Magnan M, Cointe A, Bercot B, Tenaillon O, Birgy A
KPC Beta-Lactamases Are Permissive to Insertions and Deletions Conferring Substrate Spectrum Modifications and Resistance to Ceftazidime-Avibactam.
Antimicrobial Agents and Chemotherapy 2020, 64, e01175-20.

Birgy A, Levy C, Nicolas-Chanoine MH, Cointe A, Hobson CA, Magnan M, Bechet S, Bidet P, Cohen R, Bonacorsi S
Independent Host Factors and Bacterial Genetic Determinants of the Emergence and Dominance of Escherichia coli Sequence Type 131 CTX-M-27 in a Community Pediatric Cohort Study.
Antimicrobial Agents and Chemotherapy 2019, 63,

Hobson CA, Bonacorsi S, Fahd M, Baruchel A, Cointe A, Poey N, Jacquier H, Doit C, Monjault A, Tenaillon O, Birgy A
Successful Treatment of Bacteremia Due to NDM-1-Producing Morganella morganii with Aztreonam and Ceftazidime-Avibactam Combination in a Pediatric Patient with Hematologic Malignancy.
Antimicrobial Agents and Chemotherapy 2019, 63,

Khoo S, Peytavin G, Burger D, Hill A, Brown K, Moecklinghoff C, La Porte C, Hadacek MB
Pharmacokinetics and Safety of Darunavir/Ritonavir in HIV-Infected Pregnant Women.
AIDS reviews 2017, 19, 16-23.

Koskas P, Henry-Feugeas MC, Feugeas JP, Ou P, Drunat O
Factors Of Rapid Cognitive Decline In Late Onset Alzheimer's Disease.
Current Aging Science 2017

Tourret J, Bagnis CI, Denamur E
[Urinary tract infections in diabetic patients].
La Revue Du Praticien 2014, 64, 980-983.

Bouaud J, Messai N, Laouénan C, Mentré F, Séroussi B
Elicitating patient patterns of physician non-compliance with breast cancer guidelines using formal concept analysis.
Studies in Health Technology and Informatics 2012, 180, 477–481.

Mallet A, Mentre F, Gilles J, Kelman A, Thomson A, Bryson S, Whiting B
Handling covariates in population pharmacokinetics with an application to gentamicin.
Biomedical Measurement Information and Control 1988, 2, 138-146.


Exhaustive list of publications

2024


Moisset H, Rio J, Benhard J, Arnoult F, Deconinck L, Grall N, Iung B, Lescure X, Rouzet F, Suc G, Hoen B, Hobson CA, Duval X
Evaluation of the specificity of the 2023 Duke-International Society of Cardiovascular Infectious Diseases classification for infective endocarditis.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2024, ciae034.

2022


Hobson CA, Bonacorsi S, Baruchel A, Tenaillon O, Birgy A
The interplay between anticancer challenges and the microbial communities from the gut.
European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology 2022, 41, 691-711.

Danjean M, Hobson CA, Gits-Muselli M, Courroux C, Monjault A, Bonacorsi S, Birgy A
Evaluation of the inoculum effect of new antibiotics against carbapenem-resistant enterobacterales.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2022, 28, 1503.e1-1503.e3.

Hobson CA, Vigue L, Naimi S, Chassaing B, Magnan M, Bonacorsi S, Gachet B, El Meouche I, Birgy A, Tenaillon O
MiniBioReactor Array (MBRA) in vitro gut model: a reliable system to study microbiota-dependent response to antibiotic treatment.
JAC-antimicrobial resistance 2022, 4, dlac077.

Hobson CA, Pierrat G, Tenaillon O, Bonacorsi S, Bercot B, Jaouen E, Jacquier H, Birgy A
Klebsiella pneumoniae Carbapenemase Variants Resistant to Ceftazidime-Avibactam: an Evolutionary Overview.
Antimicrobial Agents and Chemotherapy 2022, 66, e0044722.

Bizot E, Cointe A, Bidet P, Mariani-Kurkdjian P, Hobson CA, Courroux C, Liguori S, Bridier-Nahmias A, Magnan M, Merimèche M, Caméléna F, Berçot B, Weill FX, Lefèvre S, Bonacorsi S, Birgy A
Azithromycin Resistance in Shiga Toxin-Producing Escherichia coli in France between 2004 and 2020 and Detection of mef(C)-mph(G) Genes.
Antimicrobial Agents and Chemotherapy 2022, 66, e0194921.

Truong J, Cointe A, Le Roux E, Bidet P, Michel M, Boize J, Mariani-Kurkdjian P, Caseris M, Hobson CA, Desmarest M, Titomanlio L, Faye A, Bonacorsi S
Clinical impact of a gastrointestinal PCR panel in children with infectious diarrhoea.
Archives of Disease in Childhood 2022, 107, 601-605.

Hobson CA, Vigué L, Magnan M, Chassaing B, Naimi S, Gachet B, Claraz P, Storme T, Bonacorsi S, Tenaillon O, Birgy A
A Microbiota-Dependent Response to Anticancer Treatment in an In Vitro Human Microbiota Model: A Pilot Study With Hydroxycarbamide and Daunorubicin.
Frontiers in Cellular and Infection Microbiology 2022, 12, 886447.

Birgy A, Magnan M, Hobson CA, Figliuzzi M, Panigoni K, Codde C, Tenaillon O, Jacquier H
Local and Global Protein Interactions Contribute to Residue Entrenchment in Beta-Lactamase TEM-1.
Antibiotics (Basel, Switzerland) 2022, 11, 652.

2021


Hobson CA, Cointe A, Jacquier H, Choudhury A, Magnan M, Courroux C, Tenaillon O, Bonacorsi S, Birgy A
Cross-resistance to cefiderocol and ceftazidime-avibactam in KPC β-lactamase mutants and the inoculum effect.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2021, 27, 1172.e7-1172.e10.

Birgy A, Madhi F, Jung C, Levy C, Cointe A, Bidet P, Hobson CA, Bechet S, Sobral E, Vuthien H, Ferroni A, Aberrane S, Cuzon G, Beraud L, Gajdos V, Launay E, Pinquier D, Haas H, Desmarest M, Dommergues MA, Cohen R, Bonacorsi S, Group of the National Observatory of Urinary tract Infection due to ESBL-producing Enterobacteriaceae in children
Clavulanate combinations with mecillinam, cefixime or cefpodoxime against ESBL-producing Enterobacterales frequently associated with blaOXA-1 in a paediatric population with febrile urinary tract infections.
The Journal of Antimicrobial Chemotherapy 2021, 76, 2839-2846.

2020


Hobson CA, Bonacorsi S, Hocquet D, Baruchel A, Fahd M, Storme T, Tang R, Doit C, Tenaillon O, Birgy A
Impact of anticancer chemotherapy on the extension of beta-lactamase spectrum: an example with KPC-type carbapenemase activity towards ceftazidime-avibactam.
Scientific Reports 2020, 10, 589.

Hobson CA, Cointe A, Bidet P, Poupon J, Bonacorsi S, Birgy A
Urine zinc concentrations allow proper expression of metallo-β-lactamases in Enterobacteriaceae.
The Journal of Antimicrobial Chemotherapy 2020, 75, 3077-3079.

Birgy A, Madhi F, Jung C, Levy C, Cointe A, Bidet P, Hobson CA, Bechet S, Sobral E, Vuthien H, Ferroni A, Aberrane S, Cuzon G, Beraud L, Gajdos V, Launay E, Pinquier D, Haas H, Desmarest M, Dommergues MA, Cohen R, Bonacorsi S, Group of the National Observatory of Urinary tract Infection due to ESBL-producing Enterobacteriaceae in children
Diversity and trends in population structure of ESBL-producing Enterobacteriaceae in febrile urinary tract infections in children in France from 2014 to 2017.
The Journal of Antimicrobial Chemotherapy 2020, 75, 96-105.

Hobson CA, Bonacorsi S, Jacquier H, Choudhury A, Magnan M, Cointe A, Bercot B, Tenaillon O, Birgy A
KPC Beta-Lactamases Are Permissive to Insertions and Deletions Conferring Substrate Spectrum Modifications and Resistance to Ceftazidime-Avibactam.
Antimicrobial Agents and Chemotherapy 2020, 64, e01175-20.

2019


Birgy A, Levy C, Nicolas-Chanoine MH, Cointe A, Hobson CA, Magnan M, Bechet S, Bidet P, Cohen R, Bonacorsi S
Independent Host Factors and Bacterial Genetic Determinants of the Emergence and Dominance of Escherichia coli Sequence Type 131 CTX-M-27 in a Community Pediatric Cohort Study.
Antimicrobial Agents and Chemotherapy 2019, 63,

Hobson CA, Bonacorsi S, Fahd M, Baruchel A, Cointe A, Poey N, Jacquier H, Doit C, Monjault A, Tenaillon O, Birgy A
Successful Treatment of Bacteremia Due to NDM-1-Producing Morganella morganii with Aztreonam and Ceftazidime-Avibactam Combination in a Pediatric Patient with Hematologic Malignancy.
Antimicrobial Agents and Chemotherapy 2019, 63,

Cointe A, Walewski V, Hobson CA, Doit C, Bidet P, Dortet L, Bonacorsi S, Birgy A
Rapid Carbapenemase Detection With Xpert Carba-R V2 Directly On Positive Blood Vials.
Infection and Drug Resistance 2019, 12, 3311-3316.