Members
![]() | First name: Mathilde Last name: Lescat Function: Clinical Microbiologist Position: Associate Professor Email: mathilde.lescat inserm.fr |
Research interest
My research interest is evolution of Escherichia oil in commensal environment.
I'm particularly interested in the implication of nutrition and microbiota on E. coli evolution and diversity in the gut.
Education
Degree
2009: PhD. in Bacteriology, Paris 5 University.
2005: Pharmacy and Medical Biology degrees, Paris 5 University
2005: Pharmacy and Medical Biology degrees, Paris 5 University
Academic positions
Associate Professor in Bacteriology, Medical School, Paris 13 University
List of the main publications
Lescat M, Launay A, Ghalayini M, Magnan M, Glodt J, Pintard C, Dion S, Denamur E, Tenaillon O
Using long-term experimental evolution to uncover the patterns and determinants of molecular evolution of an Escherichia coli natural isolate in the streptomycin-treated mouse gut.
Molecular Ecology 2017, 26, 1802-1817.
Nahon P, Lescat M, Layese R, Bourcier V, Talmat N, Allam S, Marcellin P, Guyader D, Pol S, Larrey D, De Lédinghen V, Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki JP, Zarski JP, Goria O, Calès P, Péron JM, Alric L, Bourlière M, Mathurin P, Blanc JF, Abergel A, Serfaty L, Mallat A, Grangé JD, Attali P, Bacq Y, Wartelle C, Dao T, Benhamou Y, Pilette C, Silvain C, Christidis C, Capron D, Bernard-Chabert B, Hillaire S, Di Martino V, Trinchet JC, Moreau R, Roudot-Thoraval F, ACCaMG
Bacterial infection in compensated viral cirrhosis impairs 5-year survival (ANRS CO12 CirVir prospective cohort).
Gut 2015
Lescat M, Reibel F, Pintard C, Dion S, Glodt J, Gateau C, Launay A, Ledda A, Cruvellier S, Tourret J, Tenaillon O
The Conserved nhaAR Operon Is Drastically Divergent between B2 and Non-B2 Escherichia coli and Is Involved in Extra-Intestinal Virulence.
PloS One 2014, 9, e108738.
Using long-term experimental evolution to uncover the patterns and determinants of molecular evolution of an Escherichia coli natural isolate in the streptomycin-treated mouse gut.
Molecular Ecology 2017, 26, 1802-1817.
Nahon P, Lescat M, Layese R, Bourcier V, Talmat N, Allam S, Marcellin P, Guyader D, Pol S, Larrey D, De Lédinghen V, Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki JP, Zarski JP, Goria O, Calès P, Péron JM, Alric L, Bourlière M, Mathurin P, Blanc JF, Abergel A, Serfaty L, Mallat A, Grangé JD, Attali P, Bacq Y, Wartelle C, Dao T, Benhamou Y, Pilette C, Silvain C, Christidis C, Capron D, Bernard-Chabert B, Hillaire S, Di Martino V, Trinchet JC, Moreau R, Roudot-Thoraval F, ACCaMG
Bacterial infection in compensated viral cirrhosis impairs 5-year survival (ANRS CO12 CirVir prospective cohort).
Gut 2015
Lescat M, Reibel F, Pintard C, Dion S, Glodt J, Gateau C, Launay A, Ledda A, Cruvellier S, Tourret J, Tenaillon O
The Conserved nhaAR Operon Is Drastically Divergent between B2 and Non-B2 Escherichia coli and Is Involved in Extra-Intestinal Virulence.
PloS One 2014, 9, e108738.
Exhaustive list of publications
2021
Ghelfenstein-Ferreira T, Beaumont AL, Dellière S, Peiffer-Smadja N, Pineros N, Carbonnelle E, Greub G, Abbara S, Luong Nguyen LB, Lescat M
An Educational Game Evening for Medical Residents: A Proof of Concept to Evaluate the Impact on Learning of the Use of Games.
Journal of Microbiology & Biology Education 2021, 22, e00119-21.
Lescat M, Magnan M, Kenmoe S, Nordmann P, Poirel L
Co-Lateral Effect of Octenidine, Chlorhexidine and Colistin Selective Pressures on Four Enterobacterial Species: A Comparative Genomic Analysis.
Antibiotics (Basel, Switzerland) 2021, 11, 50.
2020
Saliba R, Zahar JR, El Allaoui F, Carbonnelle E, Lescat M
Impact of freeze/thaw cycles and single freezing at -80 °C on the viability of aerobic bacteria from rectal swabs performed with the ESwabTM system.
Diagnostic Microbiology and Infectious Disease 2020, 96, 114895.
2019
Lescat M, Poirel L, Jayol A, Nordmann P
Performances of the Rapid Polymyxin Acinetobacter and Pseudomonas Tests for Colistin Susceptibility Testing.
Microbial Drug Resistance (Larchmont, N.Y.) 2019, 25, 520-523.
Ghalayini M, Magnan M, Dion S, Zatout O, Bourguignon L, Tenaillon O, Lescat M
Long-term evolution of the natural isolate of Escherichia coli 536 in the mouse gut colonized after maternal transmission reveals convergence in the constitutive expression of the lactose operon.
Molecular Ecology 2019, 28, 4470-4485.
Lescat M, Poirel L, Tinguely C, Nordmann P
A Resazurin Reduction-Based Assay for Rapid Detection of Polymyxin Resistance in Acinetobacter baumannii and Pseudomonas aeruginosa.
Journal of Clinical Microbiology 2019, 57,
2018
Lescat M, Poirel L, Nordmann P
Rapid multiplex polymerase chain reaction for detection of mcr-1 to mcr-5 genes.
Diagnostic Microbiology and Infectious Disease 2018, 92, 267-269.
Ghalayini M, Launay A, Bridier-Nahmias A, Clermont O, Denamur E, Lescat M, Tenaillon O
Evolution of a Dominant Natural Isolate of Escherichia coli in the Human Gut over the Course of a Year Suggests a Neutral Evolution with Reduced Effective Population Size.
Applied and Environmental Microbiology 2018, 84, e02377-17.
2017
Tashk P, Lecronier M, Clermont O, Renvoisé A, Aubry A, Barrou B, Hertig A, Lescat M, Tenaillon O, Denamur E, Tourret J
[Molecular epidemiology and kinetics of early Escherichia coli urinary tract infections in kidney transplant recipients].
Nephrologie & Therapeutique 2017, 13, 236-244.
Lescat M, Launay A, Ghalayini M, Magnan M, Glodt J, Pintard C, Dion S, Denamur E, Tenaillon O
Using long-term experimental evolution to uncover the patterns and determinants of molecular evolution of an Escherichia coli natural isolate in the streptomycin-treated mouse gut.
Molecular Ecology 2017, 26, 1802-1817.
2015
Nahon P, Lescat M, Layese R, Bourcier V, Talmat N, Allam S, Marcellin P, Guyader D, Pol S, Larrey D, De Lédinghen V, Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki JP, Zarski JP, Goria O, Calès P, Péron JM, Alric L, Bourlière M, Mathurin P, Blanc JF, Abergel A, Serfaty L, Mallat A, Grangé JD, Attali P, Bacq Y, Wartelle C, Dao T, Benhamou Y, Pilette C, Silvain C, Christidis C, Capron D, Bernard-Chabert B, Hillaire S, Di Martino V, Trinchet JC, Moreau R, Roudot-Thoraval F, ACCaMG
Bacterial infection in compensated viral cirrhosis impairs 5-year survival (ANRS CO12 CirVir prospective cohort).
Gut 2015
2014
Bonnin RA, Poirel L, van der Reijden TJK, Dijkshoorn L, Lescat M, Nordmann P
Carbapenem resistance in a human clinical isolate identified to be closely related to Acinetobacter indicus.
International Journal of Antimicrobial Agents 2014, 44, 345-350.
Lescat M, Reibel F, Pintard C, Dion S, Glodt J, Gateau C, Launay A, Ledda A, Cruvellier S, Tourret J, Tenaillon O
The Conserved nhaAR Operon Is Drastically Divergent between B2 and Non-B2 Escherichia coli and Is Involved in Extra-Intestinal Virulence.
PloS One 2014, 9, e108738.
2013
Lescat M, Clermont O, Woerther PL, Glodt J, Dion S, Skurnik D, Djossou F, Dupont C, Perroz G, Picard B, Catzeflis F, Andremont A, Denamur E
Commensal Escherichia coli strains in Guiana reveal a high genetic diversity with host-dependant population structure.
Environmental Microbiology Reports 2013, 5, 49-57.
2010
Woerther PL, Angebault C, Lescat M, Ruppé E, Skurnik D, Mniai AE, Clermont O, Jacquier H, Costa AD, Renard M, Bettinger RM, Epelboin L, Dupont C, Guillemot D, Rousset F, Arlet G, Denamur E, Djossou F, Andremont A
Emergence and dissemination of extended-spectrum beta-lactamase-producing Escherichia coli in the community: lessons from the study of a remote and controlled population.
The Journal of Infectious Diseases 2010, 202, 515-523.
2009
Lescat M, Calteau A, Hoede C, Barbe V, Touchon M, Rocha E, Tenaillon O, Médigue C, Johnson JR, Denamur E
A module located at a chromosomal integration hot spot is responsible for the multidrug resistance of a reference strain from Escherichia coli clonal group A.
Antimicrobial Agents and Chemotherapy 2009, 53, 2283-2288.
Lescat M, Hoede C, Clermont O, Garry L, Darlu P, Tuffery P, Denamur E, Picard B
aes, the gene encoding the esterase B in Escherichia coli, is a powerful phylogenetic marker of the species.
BMC microbiology 2009, 9, 273.
2008
Clermont O, Lescat M, O'Brien CL, Gordon DM, Tenaillon O, Denamur E
Evidence for a human-specific Escherichia coli clone.
Environmental Microbiology 2008, 10, 1000-1006.