Members
![]() | First name: Mélanie Last name: Magnan Function: Research Position: Engineer Email: melanie.magnan inserm.fr |
Research interest
Education
Degree
2007 : Licence Professionnelle de Biotechnologies Option Biologie Moléculaire, Mont-de-Marsan
2006 : BTS Bio Analyses et Contrôles, Limoges
2006 : BTS Bio Analyses et Contrôles, Limoges
Academic positions
2014-present : Engineer at INSERM U1137 IAME, QEM, Paris
2010-2013 : Engineer assistant at INSERM U1016, Cochin Institut, Paris
2009-2010 : Senior Technician at CIRAD, Petit-Bourg, Guadeloupe
2007-2008 : Senior Technician at Pasteur Institut, Paris
2010-2013 : Engineer assistant at INSERM U1016, Cochin Institut, Paris
2009-2010 : Senior Technician at CIRAD, Petit-Bourg, Guadeloupe
2007-2008 : Senior Technician at Pasteur Institut, Paris
List of the main publications
Kemble H, Eisenhauer C, Couce A, Chapron A, Magnan M, Gautier G, Le Nagard H, Nghe P, Tenaillon O
Flux, toxicity, and expression costs generate complex genetic interactions in a metabolic pathway.
Science Advances 2020, 6, eabb2236.
Lescat M, Launay A, Ghalayini M, Magnan M, Glodt J, Pintard C, Dion S, Denamur E, Tenaillon O
Using long-term experimental evolution to uncover the patterns and determinants of molecular evolution of an Escherichia coli natural isolate in the streptomycin-treated mouse gut.
Molecular Ecology 2017, 26, 1802-1817.
Flux, toxicity, and expression costs generate complex genetic interactions in a metabolic pathway.
Science Advances 2020, 6, eabb2236.
Lescat M, Launay A, Ghalayini M, Magnan M, Glodt J, Pintard C, Dion S, Denamur E, Tenaillon O
Using long-term experimental evolution to uncover the patterns and determinants of molecular evolution of an Escherichia coli natural isolate in the streptomycin-treated mouse gut.
Molecular Ecology 2017, 26, 1802-1817.
Exhaustive list of publications
2022
Guk J, Bridier-Nahmias A, Magnan M, Grall N, Duval X, Clermont O, Ruppé E, d'Humières C, Tenaillon O, Denamur E, Mentré F, Guedj J, Burdet C, Csg
Modeling the bacterial dynamics in the gut microbiota following an antibiotic-induced perturbation.
CPT: pharmacometrics & systems pharmacology 2022, 11, 906-918.
Caméléna F, Poncin T, Magnan M, Jacquier H, Merimèche M, Berçot B
Detection of Klebsiella pneumoniae isolates coproducing the plasmid-encoded 16S rRNA methyltransferase RmtF and carbapenemase in Paris, France.
International Journal of Antimicrobial Agents 2022, 60, 106634.
Hobson CA, Vigue L, Naimi S, Chassaing B, Magnan M, Bonacorsi S, Gachet B, El Meouche I, Birgy A, Tenaillon O
MiniBioReactor Array (MBRA) in vitro gut model: a reliable system to study microbiota-dependent response to antibiotic treatment.
JAC-antimicrobial resistance 2022, 4, dlac077.
Bizot E, Cointe A, Bidet P, Mariani-Kurkdjian P, Hobson CA, Courroux C, Liguori S, Bridier-Nahmias A, Magnan M, Merimèche M, Caméléna F, Berçot B, Weill FX, Lefèvre S, Bonacorsi S, Birgy A
Azithromycin Resistance in Shiga Toxin-Producing Escherichia coli in France between 2004 and 2020 and Detection of mef(C)-mph(G) Genes.
Antimicrobial Agents and Chemotherapy 2022, 66, e0194921.
Hobson CA, Vigué L, Magnan M, Chassaing B, Naimi S, Gachet B, Claraz P, Storme T, Bonacorsi S, Tenaillon O, Birgy A
A Microbiota-Dependent Response to Anticancer Treatment in an In Vitro Human Microbiota Model: A Pilot Study With Hydroxycarbamide and Daunorubicin.
Frontiers in Cellular and Infection Microbiology 2022, 12, 886447.
Birgy A, Magnan M, Hobson CA, Figliuzzi M, Panigoni K, Codde C, Tenaillon O, Jacquier H
Local and Global Protein Interactions Contribute to Residue Entrenchment in Beta-Lactamase TEM-1.
Antibiotics (Basel, Switzerland) 2022, 11, 652.
2021
Hobson CA, Cointe A, Jacquier H, Choudhury A, Magnan M, Courroux C, Tenaillon O, Bonacorsi S, Birgy A
Cross-resistance to cefiderocol and ceftazidime-avibactam in KPC β-lactamase mutants and the inoculum effect.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2021, 27, 1172.e7-1172.e10.
Bridier-Nahmias A, Launay A, Bleibtreu A, Magnan M, Walewski V, Chatel J, Dion S, Robbe-Saule V, Clermont O, Norel F, Denamur E, Tenaillon O
Escherichia coli Genomic Diversity within Extraintestinal Acute Infections Argues for Adaptive Evolution at Play.
mSphere 2021, 6, e01176-20.
Lescat M, Magnan M, Kenmoe S, Nordmann P, Poirel L
Co-Lateral Effect of Octenidine, Chlorhexidine and Colistin Selective Pressures on Four Enterobacterial Species: A Comparative Genomic Analysis.
Antibiotics (Basel, Switzerland) 2021, 11, 50.
2020
Kemble H, Eisenhauer C, Couce A, Chapron A, Magnan M, Gautier G, Le Nagard H, Nghe P, Tenaillon O
Flux, toxicity, and expression costs generate complex genetic interactions in a metabolic pathway.
Science Advances 2020, 6, eabb2236.
Hobson CA, Bonacorsi S, Jacquier H, Choudhury A, Magnan M, Cointe A, Bercot B, Tenaillon O, Birgy A
KPC Beta-Lactamases Are Permissive to Insertions and Deletions Conferring Substrate Spectrum Modifications and Resistance to Ceftazidime-Avibactam.
Antimicrobial Agents and Chemotherapy 2020, 64, e01175-20.
Fontaine C, Armand-Lefèvre L, Magnan M, Nazimoudine A, Timsit JF, Ruppé E
Relationship between the composition of the intestinal microbiota and the tracheal and intestinal colonization by opportunistic pathogens in intensive care patients.
PloS One 2020, 15, e0237260.
2019
Ghalayini M, Magnan M, Dion S, Zatout O, Bourguignon L, Tenaillon O, Lescat M
Long-term evolution of the natural isolate of Escherichia coli 536 in the mouse gut colonized after maternal transmission reveals convergence in the constitutive expression of the lactose operon.
Molecular Ecology 2019, 28, 4470-4485.
Birgy A, Levy C, Nicolas-Chanoine MH, Cointe A, Hobson CA, Magnan M, Bechet S, Bidet P, Cohen R, Bonacorsi S
Independent Host Factors and Bacterial Genetic Determinants of the Emergence and Dominance of Escherichia coli Sequence Type 131 CTX-M-27 in a Community Pediatric Cohort Study.
Antimicrobial Agents and Chemotherapy 2019, 63,
Mahérault AC, Kemble H, Magnan M, Gachet B, Roche D, Le Nagard H, Tenaillon O, Denamur E, Branger C, Landraud L
Advantage of the F2:A1:B- IncF Pandemic Plasmid over IncC Plasmids in In Vitro Acquisition and Evolution of blaCTX-M Gene-Bearing Plasmids in Escherichia coli.
Antimicrobial Agents and Chemotherapy 2019, 63,
Burdet C, Grall N, Linard M, Bridier-Nahmias A, Benhayoun M, Bourabha K, Magnan M, Clermont O, d'Humières C, Tenaillon O, Denamur E, Massias L, Tubiana S, Alavoine L, Andremont A, Mentré F, Duval X, CG
Ceftriaxone and Cefotaxime Have Similar Effects on the Intestinal Microbiota in Human Volunteers Treated by Standard-Dose Regimens.
Antimicrobial Agents and Chemotherapy 2019, 63, e02244-18.
Geslain G, Birgy A, Adiba S, Magnan M, Courroux C, Levy C, Cohen R, Bidet P, Bonacorsi S
Genome sequencing of strains of the most prevalent clonal group of O1:K1:H7 Escherichia coli that causes neonatal meningitis in France.
BMC microbiology 2019, 19, 17.
2017
Birgy A, Delecourt M, Geslain G, Desselas E, Caseris M, Magnan M, Mariani-Kurkdjian P, Bidet P, Bonacorsi S
A combination of mecillinam and amoxicillin/clavulanate can restore susceptibility of high-level TEM-1-producing Escherichia coli to mecillinam.
The Journal of Antimicrobial Chemotherapy 2017, 72, 1911-1914.
Lescat M, Launay A, Ghalayini M, Magnan M, Glodt J, Pintard C, Dion S, Denamur E, Tenaillon O
Using long-term experimental evolution to uncover the patterns and determinants of molecular evolution of an Escherichia coli natural isolate in the streptomycin-treated mouse gut.
Molecular Ecology 2017, 26, 1802-1817.