Members

  First name: Olivier
  Last name: Tenaillon
  Function: QEM Director
  Position: Professor
  Email: olivier.tenaillon
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inserm.fr

Research interest


As an evolutionary microbiologist with a theoretical background, my goal is to find some models to characterise the dynamics and diversity of bacterial adaptation. For that purpose, I use genomics coupled to experimental evolution as well as epidemiology.

Education

Degree

2008 HDR at University Paris Diderot
2000: Ph. D. at Université Paris Pierre et Marie Curie (supervised by Miroslav Radman, François Taddei, Ivan Matic and Bernard Godelle)
1997: Master Degree (DEA). Histoire Génétique et Mécanisme de l’Evolution (at Université Paris Pierre et Marie Curie )
1993-96: Ecole Polytechnique

Academic positions

2014-present: Research Director INSERM, Paris Diderot University
2011-present: Assistant Professor, Ecole Polytechinque
2002-2013: Researcher INSERM, Paris Diderot University

Research training (post doctoral)

2014-present: Director of team “Quantitative Evolutionary Mircobiology” in IAME research unit
2009-2011: Visiting Fellow, Department Ecology and Evolutionary Biology, University of California, Irvine (Pr Brandon Gaut, Anthony Long and Albert Bennett)
2002-2013: researcher in the INSERM unit E0339 « Ecology and evolution of microorganisms », then U722 (January 2005), Paris Diderot Medical School, Paris
2001-2002: Visiting Fellow, Department Ecology Behavior and Evolution, University of California, San Diego (Pr Lin Chao)


List of the main publications

Jacquier H, Birgy A, Le Nagard H, Mechulam Y, Schmitt E, Glodt J, Bercot B, Petit E, Poulain J, Barnaud G, Gros PA, Tenaillon O
Capturing the mutational landscape of the beta-lactamase TEM-1.
Proceedings of the National Academy of Sciences of the United States of America 2013, 110, 13067–13072.

Wielgoss S, Barrick JE, Tenaillon O, Wiser MJ, Dittmar WJ, Cruveiller S, Chane-Woon-Ming B, Médigue C, Lenski RE, Schneider D
Mutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load.
Proceedings of the National Academy of Sciences of the United States of America 2013, 110, 222-227.

Gros PA, Tenaillon O
Selection for Chaperone-Like Mediated Genetic Robustness at Low Mutation Rate: Impact of Drift, Epistasis and Complexity.
Genetics 2009, 182, 555-564.

Silander OK, Tenaillon O, Chao L
Understanding the Evolutionary Fate of Finite Populations: The Dynamics of Mutational Effects.
PLoS Biol 2007, 5, e94.

Tenaillon O, Silander OK, Uzan JP, Chao L
Quantifying Organismal Complexity using a Population Genetic Approach.
PLoS ONE 2007, 2, e217.

Bjedov I, Tenaillon O, Gérard B, Souza V, Denamur E, Radman M, Taddei F, Matic I
Stress-induced mutagenesis in bacteria.
Science (New York, N.Y.) 2003, 300, 1404-1409.

Tenaillon O, Toupance B, Le Nagard H, Taddei F, Godelle B
Mutators, population size, adaptive landscape and the adaptation of asexual populations of bacteria.
Genetics 1999, 152, 485-493.


Exhaustive list of publications

2021


Hobson CA, Cointe A, Jacquier H, Choudhury A, Magnan M, Courroux C, Tenaillon O, Bonacorsi S, Birgy A
Cross-resistance to cefiderocol and ceftazidime-avibactam in KPC β-lactamase mutants and the inoculum effect.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2021, S1198-743X(21)00199-3.

Consuegra J, Gaffé J, Lenski RE, Hindré T, Barrick JE, Tenaillon O, Schneider D
Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria.
Nature Communications 2021, 12, 980.

Armand-Lefèvre L, Rondinaud E, Desvillechabrol D, Mullaert J, Clermont O, Petitjean M, Ruppe E, Cokelaer T, Bouchier C, Tenaillon O, Ma L, Nooroya Y, Matheron S, The Voyag-R Study Group n, Andremont A, Denamur E, Kennedy SP
Dynamics of extended-spectrum beta-lactamase-producing Enterobacterales colonization in long-term carriers following travel abroad.
Microbial Genomics 2021

Bridier-Nahmias A, Launay A, Bleibtreu A, Magnan M, Walewski V, Chatel J, Dion S, Robbe-Saule V, Clermont O, Norel F, Denamur E, Tenaillon O
Escherichia coli Genomic Diversity within Extraintestinal Acute Infections Argues for Adaptive Evolution at Play.
mSphere 2021, 6, e01176-20.

Czuppon P, Débarre F, Gonçalves A, Tenaillon O, Perelson AS, Guedj J, Blanquart F
Success of prophylactic antiviral therapy for SARS-CoV-2: Predicted critical efficacies and impact of different drug-specific mechanisms of action.
PLoS computational biology 2021, 17, e1008752.

2020


Tenaillon O, Matic I
The Impact of Neutral Mutations on Genome Evolvability.
Current biology: CB 2020, 30, R527-R534.

Hobson CA, Bonacorsi S, Hocquet D, Baruchel A, Fahd M, Storme T, Tang R, Doit C, Tenaillon O, Birgy A
Impact of anticancer chemotherapy on the extension of beta-lactamase spectrum: an example with KPC-type carbapenemase activity towards ceftazidime-avibactam.
Scientific Reports 2020, 10, 589.

Caméléna F, Morel F, Merimèche M, Decousser JW, Jacquier H, Clermont O, Darty M, Mainardis M, Cambau E, Tenaillon O, Denamur E, Berçot B, IRG
Genomic characterization of 16S rRNA methyltransferase-producing Escherichia coli isolates from the Parisian area, France.
The Journal of Antimicrobial Chemotherapy 2020, 75, 1726-1735.

Kemble H, Eisenhauer C, Couce A, Chapron A, Magnan M, Gautier G, Le Nagard H, Nghe P, Tenaillon O
Flux, toxicity, and expression costs generate complex genetic interactions in a metabolic pathway.
Science Advances 2020, 6, eabb2236.

Hobson CA, Bonacorsi S, Jacquier H, Choudhury A, Magnan M, Cointe A, Bercot B, Tenaillon O, Birgy A
KPC Beta-Lactamases Are Permissive to Insertions and Deletions Conferring Substrate Spectrum Modifications and Resistance to Ceftazidime-Avibactam.
Antimicrobial Agents and Chemotherapy 2020, 64, e01175-20.

Lecronier M, Tashk P, Tamzali Y, Tenaillon O, Denamur E, Barrou B, Aron-Wisnewsky J, Tourret J
Gut microbiota composition alterations are associated with the onset of diabetes in kidney transplant recipients.
PloS One 2020, 15, e0227373.

Choudhury A, Fenster JA, Fankhauser RG, Kaar JL, Tenaillon O, Gill RT
CRISPR/Cas9 recombineering-mediated deep mutational scanning of essential genes in Escherichia coli.
Molecular Systems Biology 2020, 16, e9265.

Escudero JA, Nivina A, Kemble HE, Loot C, Tenaillon O, Mazel D
Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions.
eLife 2020, 9, e58061.

2019


Couce A, Tenaillon O
Mutation bias and GC content shape antimutator invasions.
Nature Communications 2019, 10, 3114.

Kemble H, Nghe P, Tenaillon O
Recent insights into the genotype-phenotype relationship from massively parallel genetic assays.
Evolutionary Applications 2019, 12, 1721-1742.

Ghalayini M, Magnan M, Dion S, Zatout O, Bourguignon L, Tenaillon O, Lescat M
Long-term evolution of the natural isolate of Escherichia coli 536 in the mouse gut colonized after maternal transmission reveals convergence in the constitutive expression of the lactose operon.
Molecular Ecology 2019, 28, 4470-4485.

Mahérault AC, Kemble H, Magnan M, Gachet B, Roche D, Le Nagard H, Tenaillon O, Denamur E, Branger C, Landraud L
Advantage of the F2:A1:B- IncF Pandemic Plasmid over IncC Plasmids in In Vitro Acquisition and Evolution of blaCTX-M Gene-Bearing Plasmids in Escherichia coli.
Antimicrobial Agents and Chemotherapy 2019, 63,

Burdet C, Grall N, Linard M, Bridier-Nahmias A, Benhayoun M, Bourabha K, Magnan M, Clermont O, d'Humières C, Tenaillon O, Denamur E, Massias L, Tubiana S, Alavoine L, Andremont A, Mentré F, Duval X, CG
Ceftriaxone and Cefotaxime Have Similar Effects on the Intestinal Microbiota in Human Volunteers Treated by Standard-Dose Regimens.
Antimicrobial Agents and Chemotherapy 2019, 63, e02244-18.

Hobson CA, Bonacorsi S, Fahd M, Baruchel A, Cointe A, Poey N, Jacquier H, Doit C, Monjault A, Tenaillon O, Birgy A
Successful Treatment of Bacteremia Due to NDM-1-Producing Morganella morganii with Aztreonam and Ceftazidime-Avibactam Combination in a Pediatric Patient with Hematologic Malignancy.
Antimicrobial Agents and Chemotherapy 2019, 63,

2018


Tenaillon O
Experimental evolution heals the scars of genome-scale recoding.
Proceedings of the National Academy of Sciences of the United States of America 2018, 115, 2853-2855.

Branger C, Ledda A, Billard-Pomares T, Doublet B, Fouteau S, Barbe V, Roche D, Cruveiller S, Médigue C, Castellanos M, Decré D, Drieux-Rouze L, Clermont O, Glodt J, Tenaillon O, Cloeckaert A, Arlet G, Denamur E
Extended-spectrum β-lactamase-encoding genes are spreading on a wide range of Escherichia coli plasmids existing prior to the use of third-generation cephalosporins.
Microbial Genomics 2018

Ghalayini M, Launay A, Bridier-Nahmias A, Clermont O, Denamur E, Lescat M, Tenaillon O
Evolution of a Dominant Natural Isolate of Escherichia coli in the Human Gut over the Course of a Year Suggests a Neutral Evolution with Reduced Effective Population Size.
Applied and Environmental Microbiology 2018, 84,

2017


Micaëlo M, Goubard A, La Ruche G, Denamur E, Tenaillon O, Cambau E, Jacquier H, Bercot B
Molecular epidemiology of penicillinase-producing Neisseria gonorrhoeae isolates in France.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2017, 23, 968-973.

Tashk P, Lecronier M, Clermont O, Renvoisé A, Aubry A, Barrou B, Hertig A, Lescat M, Tenaillon O, Denamur E, Tourret J
[Molecular epidemiology and kinetics of early Escherichia coli urinary tract infections in kidney transplant recipients].
Nephrologie & Therapeutique 2017, 13, 236-244.

Couce A, Caudwell LV, Feinauer C, Hindré T, Feugeas JP, Weigt M, Lenski RE, Schneider D, Tenaillon O
Mutator genomes decay, despite sustained fitness gains, in a long-term experiment with bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2017, 114, E9026-E9035.

Lescat M, Launay A, Ghalayini M, Magnan M, Glodt J, Pintard C, Dion S, Denamur E, Tenaillon O
Using long-term experimental evolution to uncover the patterns and determinants of molecular evolution of an Escherichia coli natural isolate in the streptomycin-treated mouse gut.
Molecular Ecology 2017, 26, 1802-1817.

Bosshard L, Dupanloup I, Tenaillon O, Bruggmann R, Ackermann M, Peischl S, Excoffier L
Accumulation of Deleterious Mutations During Bacterial Range Expansions.
Genetics 2017

2016


Tenaillon O, Barrick JE, Ribeck N, Deatherage DE, Blanchard JL, Dasgupta A, Wu GC, Wielgoss S, Cruveiller S, Médigue C, Schneider D, Lenski RE
Tempo and mode of genome evolution in a 50,000-generation experiment.
Nature 2016, 536, 165-170.

Figliuzzi M, Jacquier H, Schug A, Tenaillon O, Weigt M
Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1.
Molecular Biology and Evolution 2016, 33, 268-280.

Rodríguez-Verdugo A, Tenaillon O, Gaut BS
First-Step Mutations during Adaptation Restore the Expression of Hundreds of Genes.
Molecular Biology and Evolution 2016, 33, 25-39.

Skurnik D, Clermont O, Guillard T, Launay A, Danilchanka O, Pons S, Diancourt L, Lebreton F, Kadlec K, Roux D, Jiang D, Dion S, Ashard H, Denamur M, Cywes-Bentley C, Schwarz S, Tenaillon O, Andremont A, Picard B, Mekalanos J, Brisse S, Denamur E
Emergence of Antimicrobial-Resistant Escherichia coli of Animal Origin Spreading in Humans.
Molecular Biology and Evolution 2016, 33, 898.

Feugeas JP, Tourret J, Launay A, Bouvet O, Hoede C, Denamur E, Tenaillon O
Links between Transcription, Environmental Adaptation and Gene Variability in Escherichia coli: Correlations between Gene Expression and Gene Variability Reflect Growth Efficiencies.
Molecular Biology and Evolution 2016

2015


Long A, Liti G, Luptak A, Tenaillon O
Elucidating the molecular architecture of adaptation via evolve and resequence experiments.
Nature Reviews. Genetics 2015, 16, 567-582.

Rodríguez-Beltrán J, Tourret J, Tenaillon O, López E, Bourdelier E, Costas C, Matic I, Denamur E, Blázquez J
High Recombinant Frequency in Extraintestinal Pathogenic Escherichia coli Strains.
Molecular Biology and Evolution 2015, 32, 1708.

Couce A, Tenaillon OA
The rule of declining adaptability in microbial evolution experiments.
Frontiers in Genetics 2015, 6, 99.

2014


Achaz G, Rodriguez-Verdugo A, Gaut BS, Tenaillon O
The reproducibility of adaptation in the light of experimental evolution with whole genome sequencing.
Advances in Experimental Medicine and Biology 2014, 781, 211-231.

Plucain J, Hindré T, Le Gac M, Tenaillon O, Cruveiller S, Médigue C, Leiby N, Harcombe WR, Marx CJ, Lenski RE, Schneider D
Epistasis and allele specificity in the emergence of a stable polymorphism in Escherichia coli.
Science (New York, N.Y.) 2014, 343, 1366-1369.

Raeside C, Gaffé J, Deatherage DE, Tenaillon O, Briska AM, Ptashkin RN, Cruveiller S, Médigue C, Lenski RE, Barrick JE, Schneider D
Large chromosomal rearrangements during a long-term evolution experiment with Escherichia coli.
mBio 2014, 5, e01377-01314.

Lescat M, Reibel F, Pintard C, Dion S, Glodt J, Gateau C, Launay A, Ledda A, Cruvellier S, Tourret J, Tenaillon O
The Conserved nhaAR Operon Is Drastically Divergent between B2 and Non-B2 Escherichia coli and Is Involved in Extra-Intestinal Virulence.
PloS One 2014, 9, e108738.

2013


Jacquier H, Birgy A, Le Nagard H, Mechulam Y, Schmitt E, Glodt J, Bercot B, Petit E, Poulain J, Barnaud G, Gros PA, Tenaillon O
Capturing the mutational landscape of the beta-lactamase TEM-1.
Proceedings of the National Academy of Sciences of the United States of America 2013, 110, 13067–13072.

Wielgoss S, Barrick JE, Tenaillon O, Wiser MJ, Dittmar WJ, Cruveiller S, Chane-Woon-Ming B, Médigue C, Lenski RE, Schneider D
Mutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load.
Proceedings of the National Academy of Sciences of the United States of America 2013, 110, 222-227.

Bleibtreu A, Gros PA, Laouénan C, Clermont O, Le Nagard H, Picard B, Tenaillon O, Denamur E
Fitness, stress resistance, and extraintestinal virulence in Escherichia coli.
Infection and Immunity 2013, 81, 2733–2742.

Díaz-Muñoz SL, Tenaillon O, Goldhill D, Brao K, Turner PE, Chao L
Electrophoretic mobility confirms reassortment bias among geographic isolates of segmented RNA phages.
BMC evolutionary biology 2013, 13, 206.

Rodríguez-Verdugo A, Gaut BS, Tenaillon O
Evolution of Escherichia coli rifampicin resistance in an antibiotic-free environment during thermal stress.
BMC evolutionary biology 2013, 13, 50.

Maharjan RP, Gaffé J, Plucain J, Schliep M, Wang L, Feng L, Tenaillon O, Ferenci T, Schneider D
A case of adaptation through a mutation in a tandem duplication during experimental evolution in Escherichia coli.
BMC genomics 2013, 14, 441.

2011


Tourret J, Aloulou M, Garry L, Tenaillon O, Dion S, Ryffel B, Monteiro RC, Denamur E
The interaction between a non-pathogenic and a pathogenic strain synergistically enhances extra-intestinal virulence in Escherichia coli.
Microbiology (Reading, England) 2011, 157, 774-785.

Billard-Pomares T, Tenaillon O, Le Nagard H, Rouy Z, Cruveiller S, Médigue C, Arlet G, Denamur E, Branger C
Complete nucleotide sequence of plasmid pTN48, encoding the CTX-M-14 extended-spectrum β-lactamase from an Escherichia coli O102-ST405 strain.
Antimicrobial Agents and Chemotherapy 2011, 55, 1270-1273.

2010


Michel A, Clermont O, Denamur E, Tenaillon O
Bacteriophage PhiX174's ecological niche and the flexibility of its Escherichia coli lipopolysaccharide receptor.
Applied and Environmental Microbiology 2010, 76, 7310-7313.

2009


Lescat M, Calteau A, Hoede C, Barbe V, Touchon M, Rocha E, Tenaillon O, Médigue C, Johnson JR, Denamur E
A module located at a chromosomal integration hot spot is responsible for the multidrug resistance of a reference strain from Escherichia coli clonal group A.
Antimicrobial Agents and Chemotherapy 2009, 53, 2283-2288.

Schubert S, Darlu P, Clermont O, Wieser A, Magistro G, Hoffmann C, Weinert K, Tenaillon O, Matic I, Denamur E
Role of intraspecies recombination in the spread of pathogenicity islands within the Escherichia coli species.
PLoS pathogens 2009, 5, e1000257.

Gros PA, Tenaillon O
Selection for Chaperone-Like Mediated Genetic Robustness at Low Mutation Rate: Impact of Drift, Epistasis and Complexity.
Genetics 2009, 182, 555-564.

2008


Clermont O, Lescat M, O'Brien CL, Gordon DM, Tenaillon O, Denamur E
Evidence for a human-specific Escherichia coli clone.
Environmental Microbiology 2008, 10, 1000-1006.

2007


Le Gall T, Clermont O, Gouriou S, Picard B, Nassif X, Denamur E, Tenaillon O
Extraintestinal virulence is a coincidental by-product of commensalism in B2 phylogenetic group Escherichia coli strains.
Molecular Biology and Evolution 2007, 24, 2373-2384.

Silander OK, Tenaillon O, Chao L
Understanding the Evolutionary Fate of Finite Populations: The Dynamics of Mutational Effects.
PLoS Biol 2007, 5, e94.

Tenaillon O, Silander OK, Uzan JP, Chao L
Quantifying Organismal Complexity using a Population Genetic Approach.
PLoS ONE 2007, 2, e217.

2006


Hoede C, Denamur E, Tenaillon O
Selection acts on DNA secondary structures to decrease transcriptional mutagenesis.
PLoS genetics 2006, 2, e176.

2005


Denamur E, Tenaillon O, Deschamps C, Skurnik D, Ronco E, Gaillard JL, Picard B, Branger C, Matic I
Intermediate mutation frequencies favor evolution of multidrug resistance in Escherichia coli.
Genetics 2005, 171, 825-827.

2004


Tenaillon O, Denamur E, Matic I
Evolutionary significance of stress-induced mutagenesis in bacteria.
Trends in Microbiology 2004, 12, 264-270.

2003


Bjedov I, Tenaillon O, Gérard B, Souza V, Denamur E, Radman M, Taddei F, Matic I
Stress-induced mutagenesis in bacteria.
Science (New York, N.Y.) 2003, 300, 1404-1409.

Bjedov I, Lecointre G, Tenaillon O, Vaury C, Radman M, Taddei F, Denamur E, Matic I
Polymorphism of genes encoding SOS polymerases in natural populations of Escherichia coli.
DNA repair 2003, 2, 417-426.

2000


Denamur E, Lecointre G, Darlu P, Tenaillon O, Acquaviva C, Sayada C, Sunjevaric I, Rothstein R, Elion J, Taddei F, Radman M, Matic I
Evolutionary implications of the frequent horizontal transfer of mismatch repair genes.
Cell 2000, 103, 711-721.

1999


Tenaillon O, Toupance B, Le Nagard H, Taddei F, Godelle B
Mutators, population size, adaptive landscape and the adaptation of asexual populations of bacteria.
Genetics 1999, 152, 485-493.