First name: Agnès
  Last name: Lefort
  Function: Researcher
  Position: Professor (internal medicine and infectious diseases specialist)
  Email: agnes.lefort

Research interest

Antibiotic resistance



2007: Research Director Degree (HDR)
2002: PhD
1996: MD (internal medicine and infectious diseases specialist)

Academic positions

2009-present: PUPH, Internal Medicine Ward, Beaujon Hospital and IAME, Paris-Diderot University
2005-2008: MCU-PH
2000-2004: Assistant

Research training (post doctoral)

2005 – present : Researcher at IAME

List of the main publications

Exhaustive list of publications


Rossi G, Nguyen Y, Lafont E, Rossi B, Canouï E, Roux O, Dokmak S, Bert F, Fantin B, Lefort A
Large retrospective study analysing predictive factors of primary treatment failure, recurrence and death in pyogenic liver abscesses.
Infection 2022, 50, 1205-1215.

Lemaitre M, Galy A, de Lastours V, Thill P, Tattevin P, Lefort A
The intravenous vancomycin prescription practices of French infectious disease specialists: A cross-sectional observational study.
Infectious Diseases Now 2022, 52, 414-417.

Rollin G, Rossi B, Brisse S, Decré D, Leflon-Guibout V, Bert F, Hoffmann I, Decousser JW, Fantin B, Lefort A
Spontaneous and postsurgical/traumatic Klebsiella pneumoniae meningitis: two distinct clinico-microbiological entities.
International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases 2022, 114, 185-191.

Royer G, Clermont O, Condamine B, Mercier-Darty M, Laouénan C, Lefort A, Denamur E, de Lastours V, CaSG
O-Antigen Targeted Vaccines Against Escherichia coli May Be Useful in Reducing Morbidity, Mortality, and Antimicrobial Resistance.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2022, 74, 364-366.

Denamur E, Condamine B, Esposito-Farèse M, Royer G, Clermont O, Laouenan C, Lefort A, de Lastours V, Galardini M, C, Sg
Genome wide association study of Escherichia coli bloodstream infection isolates identifies genetic determinants for the portal of entry but not fatal outcome.
PLoS genetics 2022, 18, e1010112.


Chaussade H, Cazals X, Desoubeaux G, Jouvion G, Bougnoux ME, Lefort A, Rivoisy C, Desnos-Ollivier M, Chretien F, Chouaki T, Gruson B, Bernard L, Lortholary O, Lanternier F, FMsg
Central nervous system candidiasis beyond neonates: Lessons from a nationwide study.
Medical Mycology 2021, 59, 266-277.

Royer G, Darty MM, Clermont O, Condamine B, Laouenan C, Decousser JW, Vallenet D, Lefort A, de Lastours V, Denamur E, CaSg
Phylogroup stability contrasts with high within sequence type complex dynamics of Escherichia coli bloodstream infection isolates over a 12-year period.
Genome Medicine 2021, 13, 77.


Canovas J, Petitjean G, Chau F, Le Monnier A, Fantin B, Lefort A
Expression of CTX-M-15 limits the efficacy of ceftolozane/tazobactam against Escherichia coli in a high-inoculum murine peritonitis model.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2020, 26, 1416.e5-1416.e9.

de Lastours V, Laouénan C, Royer G, Carbonnelle E, Lepeule R, Esposito-Farèse M, Clermont O, Duval X, Fantin B, Mentré F, Decousser JW, Denamur E, Lefort A
Mortality in Escherichia coli bloodstream infections: antibiotic resistance still does not make it.
The Journal of Antimicrobial Chemotherapy 2020, 75, 2334-2343.

Lafont E, Roux O, de Lastours V, Dokmak S, Leflon V, Fantin B, Lefort A
Pyogenic liver abscess in liver transplant recipient: A warning signal for the risk of recurrence and retransplantation.
Transplant Infectious Disease: An Official Journal of the Transplantation Society 2020, 22, e13360.

Tabibzadeh N, Mullaert J, Zafrani L, Balagny P, Frija-Masson J, Marin S, Lefort A, Vidal-Petiot E, Flamant M
Knowledge self-monitoring, efficiency, and determinants of self-confidence statement in multiple choice questions in medical students.
BMC medical education 2020, 20, 445.


Cantier M, Sabben C, Adle-Biassette H, Louedec L, Delbosc S, Desilles JP, Journé C, Diallo D, Ou P, Klein I, Chau F, Lefort A, Iung B, Duval X, Olivot JM, Ho-Tin-Noe B, Michel JB, Sonneville R, Mazighi M
Neurologic Complications of Infective Endocarditis: A Joint Model for a Septic Thromboembolism and Inflammatory Small Vessel Disease.
Critical Care Medicine 2019, 47, e685-e692.

Arangalage D, Abtan J, Gaschignard J, Ceccaldi PF, Remini SA, Etienne I, Ruszniewski P, Plaisance P, De Lastours V, Lefort A, Faye A
Implementation of a large-scale simulation-based cardiovascular clinical examination course for undergraduate medical students - a pilot study.
BMC medical education 2019, 19, 361.


Goulenok T, Chopin D, De Lastours V, Zarrouk V, Lepeule R, Fantin B, Lefort A
[Influenzae and pneumococcal vaccination rate in an internal medicine ward].
La Revue De Medecine Interne 2018, 39, 386-392.

Rossi B, Gasperini ML, Leflon-Guibout V, Gioanni A, de Lastours V, Rossi G, Dokmak S, Ronot M, Roux O, Nicolas-Chanoine MH, Fantin B, Lefort A
Hypervirulent Klebsiella pneumoniae in Cryptogenic Liver Abscesses, Paris, France.
Emerging Infectious Diseases 2018, 24, 221-229.


Parize P, Muth E, Richaud C, Gratigny M, Pilmis B, Lamamy A, Mainardi JL, Cheval J, de Visser L, Jagorel F, Ben Yahia L, Bamba G, Dubois M, Join-Lambert O, Leruez-Ville M, Nassif X, Lefort A, Lanternier F, Suarez F, Lortholary O, Lecuit M, Eloit M
Untargeted next-generation sequencing-based first-line diagnosis of infection in immunocompromised adults: a multicentre, blinded, prospective study.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2017, 23, 574.e1-574.e6.

Rivoisy C, Vena A, Schaeffer L, Charlier C, Fontanet A, Delahaye F, Bouza E, Lortholary O, Munoz P, Lefort A, FMSG&GdAaMdlEe(
Prosthetic valve Candida spp. endocarditis: new insights into long term prognosis - the ESCAPE study.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2017

Richaud C, De Lastours V, Panhard X, Petrover D, Bruno F, Lefort A
Candida vertebral osteomyelitis (CVO) 28 cases from a 10-year retrospective study in France.
Medicine 2017, 96, e7525.

Nguyen Y, Rossi B, Argy N, Baker C, Nickel B, Marti H, Zarrouk V, Houzé S, Fantin B, Lefort A
Autochthonous Case of Eosinophilic Meningitis Caused by Angiostrongylus cantonensis, France, 2016.
Emerging Infectious Diseases 2017, 23, 1045-1046.


Roux D, Meyer G, Cymbalista F, Bouaziz JD, Falgarone G, Tesniere A, Gervais J, Cariou A, Peffault de Latour R, Marat M, Moenaert E, Guebli T, Rodriguez O, Lefort A, Dreyfuss D, Hajage D, Ricard JD
[Computerized ranking test in three French universities: Staff experience and students' feedback].
La Revue De Médecine Interne / Fondée ... Par La Société Nationale Francaise De Médecine Interne 2016, 37, 166-172.

Rossi G, Lafont E, Gasperini L, Dokmak S, Ronot M, Rossi B, Zarrouk V, Fantin B, Lefort A
[Liver abscess].
La Revue De Medecine Interne 2016, 37, 827-833.

Alexandre K, Chau F, Guérin F, Massias L, Lefort A, Cattoir V, Fantin B
Activity of temocillin in a lethal murine model of infection of intra-abdominal origin due to KPC-producing Escherichia coli.
The Journal of Antimicrobial Chemotherapy 2016


Parienti JJ, Lucet JC, Lefort A, Armand-Lefèvre L, Wolff M, Caron F, Cattoir V, Yazdanpanah Y
Empirical therapies among adults hospitalized for community-acquired upper urinary tract infections: A decision-tree analysis of mortality, costs, and resistance.
American Journal of Infection Control 2015, 43, e53-e59.

Rossi B, Soubirou J, Chau F, Massias L, Dion S, Lepeule R, Fantin B, Lefort A
Cefotaxime and Amoxicillin-Clavulanate Synergism against Extended-Spectrum-β-Lactamase-Producing Escherichia coli in a Murine Model of Urinary Tract Infection.
Antimicrobial Agents and Chemotherapy 2015, 32, 1708.


Lefort A, Chau F, Lepeule R, Dubée V, Kitzis MD, Dion S, Fantin B
Activity of fosfomycin alone or combined with cefoxitin in vitro and in vivo in a murine model of urinary tract infection due to Escherichia coli harbouring CTX-M-15-type extended-spectrum β-lactamase.
International Journal of Antimicrobial Agents 2014, 43, 366-369.

Tattevin P, Revest M, Lefort A, Michelet C, Lortholary O
Fungal endocarditis: current challenges.
International Journal of Antimicrobial Agents 2014, 44, 290-294.

Pilmis B, Lefort A, Lecuit M, Join-Lambert O, Nassif X, Lortholary O, Charlier C
Endocarditis due to Neisseria mucosa: case report and review of 21 cases: a rare and severe cause of endocarditis.
The Journal of Infection 2014, 68, 601-604.

Lepeule R, Leflon-Guibout V, Vanjak D, Zahar JR, Lafaurie M, Besson C, Lefort A, GdReIddF(
Clinical spectrum of urine cultures positive for ESBL-producing Escherichia coli in hospitalized patients and impact on antibiotic use.
Medecine Et Maladies Infectieuses 2014, 44, 530-534.

Roubaud Baudron C, Panhard X, Clermont O, Mentré F, Fantin B, Denamur E, Lefort A, CG
Escherichia coli bacteraemia in adults: age-related differences in clinical and bacteriological characteristics, and outcome.
Epidemiology and Infection 2014, 142, 2672-2683.

Burdet C, Clermont O, Bonacorsi S, Laouénan C, Bingen E, Aujard Y, Mentré F, Lefort A, Denamur E, CG
Escherichia coli bacteremia in children: age and portal of entry are the main predictors of severity.
The Pediatric Infectious Disease Journal 2014, 33, 872–879.

Surgers L, Bleibtreu A, Burdet C, Clermont O, Laouénan C, Lefort A, Mentré F, Carbonne B, Bingen E, Meynard JL, Denamur E, CG
Escherichia coli bacteraemia in pregnant women is life-threatening for foetuses.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2014, 20, O1035–1041.

Bourgeois-Nicolaos N, Nguyen TT, Defrance G, Massias L, Alavoine L, Lefort A, Noel V, Senneville E, Doucet-Populaire F, Mentré F, Andremont A, Duval X
The emergence of linezolid resistance among Enterococci in intestinal microbiota of treated patients is unrelated to individual pharmacokinetic characteristics.
Antimicrobial Agents and Chemotherapy 2014, 58, 2681–2687.


Clermont O, Glodt J, Burdet C, Pognard D, Lefort A, Branger C, Denamur E, CGM
Complexity of Escherichia coli bacteremia pathophysiology evidenced by comparison of isolates from blood and portal of entry within single patients.
International journal of medical microbiology: IJMM 2013, 303, 529–532.

Rivière S, Lortholary O, Michon J, Bougnoux ME, Mainardi JL, Sendid B, Bretagne S, Lefort A
Aspergillus endocarditis in the era of new antifungals: major role for antigen detection.
The Journal of Infection 2013, 67, 85-88.

Lefort A
[Why should antibiotic therapy be avoided in case of acute infectious diarrhea?].
Presse Médicale (Paris, France: 1983) 2013, 42, 82-83.


de Montmollin E, Corcos O, Noussair L, Leflon-Guibout V, Belmatoug N, Joly F, Lefort A
Retroperitoneal abscesses due to Nocardia farcinica: report of two cases in patients with malnutrition.
Infection 2012, 40, 93-96.

Froissart A, Gazaignes S, Gellen-Dautremer J, Leflon-Guibout V, Iakovlev G, Zarrouk V, Lefort A, Fantin B
[Intermittent prolonged fever triggered by efforts].
La Revue De Médecine Interne / Fondée ... Par La Société Nationale Francaise De Médecine Interne 2012, 33, 519-521.

Genin A, Desir J, Lambert N, Biervliet M, Van Der Aa N, Pierquin G, Killian A, Tosi M, Urbina M, Lefort A, Libert F, Pirson I, Abramowicz M
Kinetochore KMN network gene CASC5 mutated in primary microcephaly.
Human Molecular Genetics 2012, 21, 5306-5317.

Lefort A, Chartier L, Sendid B, Wolff M, Mainardi JL, Podglajen I, Desnos-Ollivier M, Fontanet A, Bretagne S, Lortholary O, FMSG
Diagnosis, management and outcome of Candida endocarditis.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2012, 18, E99-E109.

Lepeule R, Ruppé E, Le P, Massias L, Chau F, Nucci A, Lefort A, Fantin B
Cefoxitin as an alternative to carbapenems in a murine model of urinary tract infection due to Escherichia coli harboring CTX-M-15-type extended-spectrum β-lactamase.
Antimicrobial Agents and Chemotherapy 2012, 56, 1376-1381.


Lucet JC, Nicolas-Chanoine MH, Lefort A, Roy C, Diamantis S, Papy E, Riveros-Palacios O, Le Grand J, Rioux C, Fantin B, Ravaud P
Do case vignettes accurately reflect antibiotic prescription?.
Infection Control and Hospital Epidemiology 2011, 32, 1003-1009.

Lucet JC, Nicolas-Chanoine MH, Roy C, Riveros-Palacios O, Diamantis S, Le Grand J, Papy E, Rioux C, Fantin B, Lefort A, Ravaud P
Antibiotic use: knowledge and perceptions in two university hospitals.
The Journal of Antimicrobial Chemotherapy 2011, 66, 936-940.

Courpon-Claudinon A, Lefort A, Panhard X, Clermont O, Dornic Q, Fantin B, Mentré F, Wolff M, Denamur E, Branger C, CG
Bacteraemia caused by third-generation cephalosporin-resistant Escherichia coli in France: prevalence, molecular epidemiology and clinical features.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2011, 17, 557-565.

Lefort A, Panhard X, Clermont O, Woerther PL, Branger C, Mentré F, Fantin B, Wolff M, Denamur E, CG
Host factors and portal of entry outweigh bacterial determinants to predict the severity of Escherichia coli bacteremia.
Journal of Clinical Microbiology 2011, 49, 777-783.


Rouzet F, Dominguez Hernandez M, Hervatin F, Sarda-Mantel L, Lefort A, Duval X, Louedec L, Fantin B, Le Guludec D, Michel JB
Technetium 99m-labeled annexin V scintigraphy of platelet activation in vegetations of experimental endocarditis.
Circulation 2008, 117, 781-789.


Lefort A, Arthur M, Depardieu F, Chau F, Pouzet C, Courvalin P, Fantin B
Expression of glycopeptide-resistance gene in response to vancomycin and teicoplanin in the cardiac vegetations of rabbits infected with VanB-type Enterococcus faecalis.
The Journal of Infectious Diseases 2004, 189, 90-97.