Members
First name: Aurelie Last name: Cointe Function: Clinical Microbiologist Position: Hospital Practitioner Email: aurelie.cointe aphp.fr |
Research interest
Working in a pediatric hospital within a microbiology laboratory belonging to the French National Centre for Escherichia coli, I am interested in E. coli infections in the paediatric population. My main research focuses on E. coli causing hemolytic and uremic syndromes due to Shiga toxin producing-E. coli in order to study the epidemiology and the pathophysiology of these life-threatening infections. My work focuses on an emerging clone with the unusual serotype O80H2, which is a hybrid pathotype harbouring a plasmid containing several extra-intestinal virulence factors involved in invasive infections, exceptional among EHEC strains.
Education
Degree
2023 : Ph. D. in Microbiology – University of Paris – INSERM UMR 1137 (Iame team2 -EVRest)
2016-2017 : Master in Microbiology (Paris XI university)
2008-2018: Pharmaceutical degree and DES of Medical Biology (Paris V University)
2016-2017 : Master in Microbiology (Paris XI university)
2008-2018: Pharmaceutical degree and DES of Medical Biology (Paris V University)
Academic positions
2023 : Hospital Practitioner in Microbiology, AP-HP
2018 – 2022 : Assistant in Microbiology, AP-HP
2013-2018 : Resident in Medical Biology, Assistance Publique-Hôpitaux de Paris
2018 – 2022 : Assistant in Microbiology, AP-HP
2013-2018 : Resident in Medical Biology, Assistance Publique-Hôpitaux de Paris
Research training (post doctoral)
2016 – present : Member of the team EVRest IAME INSERM UMR 1137
List of the main publications
Exhaustive list of publications
2023
Legouge C, Bidet P, Gits-Muselli M, Cointe A, Courroux C, Birgy A, Bonacorsi S
Rapid, simple multi-locus variable number tandem repeat analysis: a reliable tool for Klebsiella pneumoniae outbreak screening.
The Journal of Hospital Infection 2023, 141, 41-48.
Geslain G, Cointe A, Bidet P, Courroux C, Abasse S, Mariani P, Bonacorsi S
Fatal Meningitis from Shiga Toxin-Producing Escherichia coli in 2 Full-Term Neonates, France.
Emerging Infectious Diseases 2023, 29, 1703-1705.
Jones G, Mariani-Kurkdjian P, Cointe A, Bonacorsi S, Lefèvre S, Weill FX, Le Strat Y
Sporadic Shiga Toxin-Producing Escherichia coli-Associated Pediatric Hemolytic Uremic Syndrome, France, 2012-2021.
Emerging Infectious Diseases 2023, 29, 2054-2064.
2022
Moussiegt A, Birgy A, Cointe A, Duval X, Bidet P, Bonacorsi S
Escherichia coli community-acquired meningitis in adults: a case series of 29 patients in France.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2022, 28, 1304-1305.
Bizot E, Cointe A, Bidet P, Mariani-Kurkdjian P, Hobson CA, Courroux C, Liguori S, Bridier-Nahmias A, Magnan M, Merimèche M, Caméléna F, Berçot B, Weill FX, Lefèvre S, Bonacorsi S, Birgy A
Azithromycin Resistance in Shiga Toxin-Producing Escherichia coli in France between 2004 and 2020 and Detection of mef(C)-mph(G) Genes.
Antimicrobial Agents and Chemotherapy 2022, 66, e0194921.
Bizot E, Cointe A, Smadja N, Sergentet D, Lefèvre S, Weill FX, Levy C, Cohen R, Mariani-Kurkdjian P, Bonacorsi S
Improved Molecular Diagnosis and Culture of the Emerging Heteropathotype Enterohemorrhagic Escherichia coli O80:H2 Using Its Non-Melibiose-Fermenting and Antibiotic-Resistance Properties.
Journal of Clinical Microbiology 2022, 60, e0153021.
Truong J, Cointe A, Le Roux E, Bidet P, Michel M, Boize J, Mariani-Kurkdjian P, Caseris M, Hobson CA, Desmarest M, Titomanlio L, Faye A, Bonacorsi S
Clinical impact of a gastrointestinal PCR panel in children with infectious diarrhoea.
Archives of Disease in Childhood 2022, 107, 601-605.
Delafoy M, Goutines J, Fourmont AM, Birgy A, Chomton M, Levy M, Naudin J, Zafrani L, Le Mouel L, Yakouben K, Cointe A, Caseris M, Lafaurie M, Bonacorsi S, Mechinaud F, Pereyre S, Boissel N, Baruchel A
Case Report: Hyperammonemic Encephalopathy Linked to Ureaplasma spp. and/or Mycoplasma hominis Systemic Infection in Patients Treated for Leukemia, an Emergency Not to Be Missed.
Frontiers in Oncology 2022, 12, 912695.
2021
Hobson CA, Cointe A, Jacquier H, Choudhury A, Magnan M, Courroux C, Tenaillon O, Bonacorsi S, Birgy A
Cross-resistance to cefiderocol and ceftazidime-avibactam in KPC β-lactamase mutants and the inoculum effect.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2021, 27, 1172.e7-1172.e10.
Birgy A, Madhi F, Jung C, Levy C, Cointe A, Bidet P, Hobson CA, Bechet S, Sobral E, Vuthien H, Ferroni A, Aberrane S, Cuzon G, Beraud L, Gajdos V, Launay E, Pinquier D, Haas H, Desmarest M, Dommergues MA, Cohen R, Bonacorsi S, Group of the National Observatory of Urinary tract Infection due to ESBL-producing Enterobacteriaceae in children
Clavulanate combinations with mecillinam, cefixime or cefpodoxime against ESBL-producing Enterobacterales frequently associated with blaOXA-1 in a paediatric population with febrile urinary tract infections.
The Journal of Antimicrobial Chemotherapy 2021, 76, 2839-2846.
Cogo H, Caseris M, Lachaume N, Cointe A, Faye A, Pommelet V
Tuberculosis in Children Hospitalized in a Low-burden Country: Description and Risk Factors of Severe Disease.
The Pediatric Infectious Disease Journal 2021, 40, 199-204.
Hogan J, Kwon T, Paye-Jaouen A, Fait C, Cointe A, Baudouin V
Kidney Transplantation in a COVID-19 Positive Pediatric Recipient.
Transplantation 2021
Bizot E, Cointe A, Béchet S, Sobral E, Cohen R, Mariani-Kurkdjian P, Levy C, Bonacorsi S
Shiga toxin-producing Escherichia coli carriage in 959 healthy French infants.
Archives of Disease in Childhood 2021, 106, 1239-1240.
Travert B, Dossier A, Jamme M, Cointe A, Delmas Y, Malot S, Wynckel A, Seguin A, Presne C, Hie M, Benhamou Y, Ribes D, Choukroun G, Grangé S, Hertig A, Le Gall EC, Galicier L, Daugas E, Bouadma L, Weill FX, Azoulay E, Fakhouri F, Veyradier A, Bonacorsi S, Hogan J, Frémeaux-Bacchi V, Rondeau E, Mariani-Kurkdjian P, Coppo P, Centre de Référence des Microangiopathies Thrombotiques2
Shiga Toxin-Associated Hemolytic Uremic Syndrome in Adults, France, 2009-2017.
Emerging Infectious Diseases 2021, 27, 1876-1885.
Charbonnier L, Rouprêt-Serzec J, Caseris M, Danse M, Cointe A, Cohen L, Faye A, Ouldali N, Gaschignard J
Contribution of Serological Rapid Diagnostic Tests to the Strategy of Contact Tracing in Households Following SARS-CoV-2 Infection Diagnosis in Children.
Frontiers in Pediatrics 2021, 9, 638502.
Travert B, Rafat C, Mariani P, Cointe A, Dossier A, Coppo P, Joseph A
Shiga Toxin-Associated Hemolytic Uremic Syndrome: Specificities of Adult Patients and Implications for Critical Care Management.
Toxins 2021, 13,
Cointe A, Bizot E, Delannoy S, Fach P, Bidet P, Birgy A, Weill FX, Lefèvre S, Mariani-Kurkdjian P, Bonacorsi S
Emergence of New ST301 Shiga Toxin-Producing Escherichia coli Clones Harboring Extra-Intestinal Virulence Traits in Europe.
Toxins 2021, 13, 686.
2020
Payen M, Pardos de la Gándara M, Cointe A, Massiot A, Bidet P, Weill FX, Bonacorsi S
Diagnostic challenge of gastrointestinal infection due to lactose-fermenting Salmonella enterica subsp. enterica serovar 4,5:I:.
Diagnostic Microbiology and Infectious Disease 2020, 98, 115105.
Cointe A, Birgy A, Pascault A, Louillet F, Dufougeray A, Mariani-Kurkdjian P, Bonacorsi S
Be aware of Shiga-toxin 2f-producing Escherichia coli: case report and false-negative results with certain rapid molecular panels.
Diagnostic Microbiology and Infectious Disease 2020, 98, 115177.
Hobson CA, Cointe A, Bidet P, Poupon J, Bonacorsi S, Birgy A
Urine zinc concentrations allow proper expression of metallo-β-lactamases in Enterobacteriaceae.
The Journal of Antimicrobial Chemotherapy 2020, 75, 3077-3079.
Birgy A, Madhi F, Jung C, Levy C, Cointe A, Bidet P, Hobson CA, Bechet S, Sobral E, Vuthien H, Ferroni A, Aberrane S, Cuzon G, Beraud L, Gajdos V, Launay E, Pinquier D, Haas H, Desmarest M, Dommergues MA, Cohen R, Bonacorsi S, Group of the National Observatory of Urinary tract Infection due to ESBL-producing Enterobacteriaceae in children
Diversity and trends in population structure of ESBL-producing Enterobacteriaceae in febrile urinary tract infections in children in France from 2014 to 2017.
The Journal of Antimicrobial Chemotherapy 2020, 75, 96-105.
Cointe A, Birgy A, Bridier-Nahmias A, Mariani-Kurkdjian P, Walewski V, Lévy C, Cohen R, Fach P, Delannoy S, Bidet P, Bonacorsi S
Escherichia coli O80 hybrid pathotype strains producing Shiga toxin and ESBL: molecular characterization and potential therapeutic options.
The Journal of Antimicrobial Chemotherapy 2020, 75, 537-542.
Hobson CA, Bonacorsi S, Jacquier H, Choudhury A, Magnan M, Cointe A, Bercot B, Tenaillon O, Birgy A
KPC Beta-Lactamases Are Permissive to Insertions and Deletions Conferring Substrate Spectrum Modifications and Resistance to Ceftazidime-Avibactam.
Antimicrobial Agents and Chemotherapy 2020, 64, e01175-20.
Petit M, Caméléna F, Cointe A, Poncin T, Merimèche M, Bonacorsi S, Birgy A, Berçot B
Rapid Detection and Characterization of Carbapenemases in Enterobacterales with a New Modified Carbapenem Inactivation Method, mCIMplus.
Journal of Clinical Microbiology 2020, 58, e01370-20.
Joseph A, Cointe A, Mariani Kurkdjian P, Rafat C, Hertig A
Shiga Toxin-Associated Hemolytic Uremic Syndrome: A Narrative Review.
Toxins 2020, 12,
2019
Cointe A, de Ponfilly GP, Munier AL, Bachir M, Benmansour H, Crémieux AC, Forien M, Frazier A, Krief E, Cambau E, Jacquier H
Native joint septic arthritis due to Clostridium tarantellae.
Anaerobe 2019, 56, 46-48.
Birgy A, Levy C, Nicolas-Chanoine MH, Cointe A, Hobson CA, Magnan M, Bechet S, Bidet P, Cohen R, Bonacorsi S
Independent Host Factors and Bacterial Genetic Determinants of the Emergence and Dominance of Escherichia coli Sequence Type 131 CTX-M-27 in a Community Pediatric Cohort Study.
Antimicrobial Agents and Chemotherapy 2019, 63,
Hobson CA, Bonacorsi S, Fahd M, Baruchel A, Cointe A, Poey N, Jacquier H, Doit C, Monjault A, Tenaillon O, Birgy A
Successful Treatment of Bacteremia Due to NDM-1-Producing Morganella morganii with Aztreonam and Ceftazidime-Avibactam Combination in a Pediatric Patient with Hematologic Malignancy.
Antimicrobial Agents and Chemotherapy 2019, 63,
Cointe A, Walewski V, Hobson CA, Doit C, Bidet P, Dortet L, Bonacorsi S, Birgy A
Rapid Carbapenemase Detection With Xpert Carba-R V2 Directly On Positive Blood Vials.
Infection and Drug Resistance 2019, 12, 3311-3316.
2018
Cointe A, Bonacorsi S, Truong J, Hobson C, Doit C, Monjault A, Bidet P, Birgy A
Detection of Carbapenemase-Producing Enterobacteriaceae in Positive Blood Culture Using an Immunochromatographic RESIST-4 O.K.N.V. Assay.
Antimicrobial Agents and Chemotherapy 2018, 62,
Caméléna F, Cointe A, Mathy V, Hobson C, Doit C, Bercot B, Decré D, Podglajen I, Dortet L, Monjault A, Bidet P, Bonacorsi S, Birgy A
Within-a-Day Detection and Rapid Characterization of Carbapenemase by Use of a New Carbapenem Inactivation Method-Based Test, CIMplus.
Journal of Clinical Microbiology 2018, 56,
Cointe A, Birgy A, Mariani-Kurkdjian P, Liguori S, Courroux C, Blanco J, Delannoy S, Fach P, Loukiadis E, Bidet P, Bonacorsi S
Emerging Multidrug-Resistant Hybrid Pathotype Shiga Toxin-Producing Escherichia coli O80 and Related Strains of Clonal Complex 165, Europe.
Emerging Infectious Diseases 2018, 24, 2262-2269.