Members
First name: Guilhem Last name: Royer Position: PhD Student Email: guilhem.royer inserm.fr |
Research interest
I am currently studying strain of Escherichia coli responsible for bacteraemia. Thanks to large-scale NGS analysis I will focus on the link between the severity of infection or a specific portal of entry on one side and with particular bacterial characters or specific metabolic pathway on the other hand. Given the importance of Escherichia coli in human medicin, we hope to find bacterial determinant which may help clinician in estimating bactaeriamia prognostic and/or treatment.
Education
Degree
2016 : Ph D. student – INSERM UMR 1137 (Iame team2 -EVRest)
2016 : Pharm. D., Aix-Marseille University
2015 : Master 2, Montpellier II university
2009 : Second cycle of pharmaceutical studies, Paris XI university
2005 : First cycle of pharmaceutical studies, Paris XI university
2016 : Pharm. D., Aix-Marseille University
2015 : Master 2, Montpellier II university
2009 : Second cycle of pharmaceutical studies, Paris XI university
2005 : First cycle of pharmaceutical studies, Paris XI university
Academic positions
2013-2016 : Resident, CHRU Montpellier
2011-2013 : Resident, AP-HM, Marseille
2011-2013 : Resident, AP-HM, Marseille
Exhaustive list of publications
2024
Sokal A, Royer G, Esposito-Farese M, Clermont O, Condamine B, Laouénan C, Lefort A, Denamur E, de Lastours V, Colibafi, Septicoli and Coliville Groups
Clinical and bacteriological specificities of Escherichia coli bloodstream infections from biliary portal of entries.
The Journal of Infectious Diseases 2024, jiad586.
2023
Royer G, Clermont O, Marin J, Condamine B, Dion S, Blanquart F, Galardini M, Denamur E
Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestinal virulence.
Nature Communications 2023, 14, 3667.
Burgaya J, Marin J, Royer G, Condamine B, Gachet B, Clermont O, Jaureguy F, Burdet C, Lefort A, de Lastours V, Denamur E, Galardini M, Blanquart F, Colibafi/Septicoli & Coliville groups
The bacterial genetic determinants of Escherichia coli capacity to cause bloodstream infections in humans.
PLoS genetics 2023, 19, e1010842.
2022
de Lastours V, El Meouche I, Chau F, Beghain J, Chevret D, Aubert-Frambourg A, Clermont O, Royer G, Bouvet O, Denamur E, Fantin B, CIPHARES Group
Evolution of fluoroquinolone-resistant Escherichia coli in the gut after ciprofloxacin treatment.
International journal of medical microbiology: IJMM 2022, 312, 151548.
Royer G, Clermont O, Condamine B, Mercier-Darty M, Laouénan C, Lefort A, Denamur E, de Lastours V, COLIBAFI and SEPTICOLI Groups
O-Antigen Targeted Vaccines Against Escherichia coli May Be Useful in Reducing Morbidity, Mortality, and Antimicrobial Resistance.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2022, 74, 364-366.
Royer G, Ortiz de la Rosa JM, Vuillemin X, Lacombe B, Chau F, Clermont O, Mercier-Darty M, Decousser JW, Ricard JD, Nordmann P, Denamur E, Poirel L
Reduced Chlorhexidine Susceptibility Is Associated with Tetracycline Resistance tet Genes in Clinical Isolates of Escherichia coli.
Antimicrobial Agents and Chemotherapy 2022, 66, e0197221.
Royer G, Dixit Z, Pédron J, Pierrat G, Demontant V, Berçot B, Rodriguez C, Barny MA, Jacquier H, Woerther PL
Genetic and Phenotypic Study of the Pectobacterium versatile Beta-Lactamase, the Enzyme Most Similar to the Plasmid-Encoded TEM-1.
Applied and Environmental Microbiology 2022, 88, e0022022.
Marin J, Clermont O, Royer G, Mercier-Darty M, Decousser JW, Tenaillon O, Denamur E, Blanquart F
The Population Genomics of Increased Virulence and Antibiotic Resistance in Human Commensal Escherichia coli over 30 Years in France.
Applied and Environmental Microbiology 2022, 88, e0066422.
Denamur E, Condamine B, Esposito-Farèse M, Royer G, Clermont O, Laouenan C, Lefort A, de Lastours V, Galardini M, COLIBAFI, SEPTICOLI groups
Genome wide association study of Escherichia coli bloodstream infection isolates identifies genetic determinants for the portal of entry but not fatal outcome.
PLoS genetics 2022, 18, e1010112.
2021
Pascucci M, Royer G, Adamek J, Asmar MA, Aristizabal D, Blanche L, Bezzarga A, Boniface-Chang G, Brunner A, Curel C, Dulac-Arnold G, Fakhri RM, Malou N, Nordon C, Runge V, Samson F, Sebastian E, Soukieh D, Vert JP, Ambroise C, Madoui MA
AI-based mobile application to fight antibiotic resistance.
Nature Communications 2021, 12, 1173.
Royer G, Roisin L, Demontant V, Lo S, Coutte L, Lim P, Pawlotsky JM, Jacquier H, Lepeule R, Rodriguez C, Woerther PL
Microdiversity of Enterococcus faecalis isolates in cases of infective endocarditis: selection of non-synonymous mutations and large deletions is associated with phenotypic modifications.
Emerging Microbes & Infections 2021, 10, 929-938.
Royer G, Poirel L, La Combe B, Clermont O, Chau F, Mercier-Darty M, Denamur E, Nordmann P, Ricard JD, Decousser JW
Lack of association between colistin resistance and chlorhexidine reduced susceptibility in clinical isolates of Escherichia coli.
The Journal of Antimicrobial Chemotherapy 2021, 76, 2736-2737.
Royer G, Darty MM, Clermont O, Condamine B, Laouenan C, Decousser JW, Vallenet D, Lefort A, de Lastours V, Denamur E, COLIBAFI and SEPTICOLI groups
Phylogroup stability contrasts with high within sequence type complex dynamics of Escherichia coli bloodstream infection isolates over a 12-year period.
Genome Medicine 2021, 13, 77.
2020
Royer G, Fourreau F, Boulanger B, Mercier-Darty M, Ducellier D, Cizeau F, Potron A, Podglajen I, Mongardon N, Decousser JW
Local outbreak of extended-spectrum β-lactamase SHV2a-producing Pseudomonas aeruginosa reveals the emergence of a new specific sub-lineage of the international ST235 high-risk clone.
The Journal of Hospital Infection 2020, 104, 33-39.
Woerther PL, Royer G, Decousser JW, Fihman V, Lepeule R
Emergence of Resistance to Carbapenems Should Not Be Considered the Only Marker of Good Practices in Antibiotic Stewardship.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2020, 71, 2538-2539.
Royer G, Fourreau F, Gomart C, Maurand A, Hacquin B, Ducellier D, Cizeau F, Lo S, Cordonnier-Jourdin C, Mercier-Darty M, Decousser JW
Outbreak of an Uncommon Rifampin-resistant blaNDM-1Citrobacter amalonaticus Strain in a Digestive Rehabilitation Center: The Putative Role of Rifaximin.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2020, 71, 1331-1333.
de Lastours V, Laouénan C, Royer G, Carbonnelle E, Lepeule R, Esposito-Farèse M, Clermont O, Duval X, Fantin B, Mentré F, Decousser JW, Denamur E, Lefort A
Mortality in Escherichia coli bloodstream infections: antibiotic resistance still does not make it.
The Journal of Antimicrobial Chemotherapy 2020, 75, 2334-2343.
Mercier-Darty M, Royer G, Lamy B, Charron C, Lemenand O, Gomart C, Fourreau F, Madec JY, Jumas-Bilak E, Decousser JW
Comparative Whole-Genome Phylogeny of Animal, Environmental, and Human Strains Confirms the Genogroup Organization and Diversity of the Stenotrophomonas maltophilia Complex.
Applied and Environmental Microbiology 2020, 86,
Roisin L, Melloul E, Woerther PL, Royer G, Decousser JW, Guillot J, Dannaoui E, Botterel F
Modulated Response of Aspergillus fumigatus and Stenotrophomonas maltophilia to Antimicrobial Agents in Polymicrobial Biofilm.
Frontiers in Cellular and Infection Microbiology 2020, 10, 574028.
2019
Royer G, Melloul E, Roisin L, Courbin V, Jacquier H, Lepeule R, Coutte L, Darty M, Fihman V, Lim P, Decousser JW, Rodriguez C, Woerther PL
Complete genome sequencing of Enterococcus faecalis strains suggests role of Ebp deletion in infective endocarditis relapse.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2019, 25, 1565-1567.
Bourrel AS, Poirel L, Royer G, Darty M, Vuillemin X, Kieffer N, Clermont O, Denamur E, Nordmann P, Decousser JW, IAME Resistance Group
Colistin resistance in Parisian inpatient faecal Escherichia coli as the result of two distinct evolutionary pathways.
The Journal of Antimicrobial Chemotherapy 2019, 74, 1521-1530.
Billard-Pomares T, Clermont O, Castellanos M, Magdoud F, Royer G, Condamine B, Fouteau S, Barbe V, Roche D, Cruveiller S, Médigue C, Pognard D, Glodt J, Dion S, Rigal O, Picard B, Denamur E, Branger C
The Arginine Deiminase Operon Is Responsible for a Fitness Trade-Off in Extended-Spectrum-β-Lactamase-Producing Strains of Escherichia coli.
Antimicrobial Agents and Chemotherapy 2019, 63,
Kieffer N, Royer G, Decousser JW, Bourrel AS, Palmieri M, Ortiz De La Rosa JM, Jacquier H, Denamur E, Nordmann P, Poirel L
mcr-9, an Inducible Gene Encoding an Acquired Phosphoethanolamine Transferase in Escherichia coli, and Its Origin.
Antimicrobial Agents and Chemotherapy 2019, 63,
Kieffer N, Royer G, Decousser JW, Bourrel AS, Palmieri M, Ortiz De La Rosa JM, Jacquier H, Denamur E, Nordmann P, Poirel L
Erratum for Kieffer et al., "mcr-9, an Inducible Gene Encoding an Acquired Phosphoethanolamine Transferase in Escherichia coli, and Its Origin"..
Antimicrobial agents and chemotherapy 2019, 63,
2018
Royer G, Decousser JW, Branger C, Dubois M, Médigue C, Denamur E, Vallenet D
PlaScope: a targeted approach to assess the plasmidome from genome assemblies at the species level.
Microbial Genomics 2018
Desroches M, Clermont O, Lafeuillade B, Rodriguez C, Darty M, Royer G, Bouvet O, Ounnoughene N, Noizat-Pirenne F, Denamur E, Decousser JW
Genotypic and phenotypic characteristics of Escherichia coli involved in transfusion-transmitted bacterial infections: implications for preventive strategies.
Transfusion 2018, 58, 1940-1950.
Desroches M, Royer G, Roche D, Mercier-Darty M, Vallenet D, Médigue C, Bastard K, Rodriguez C, Clermont O, Denamur E, Decousser JW
The Odyssey of the Ancestral Escherich Strain through Culture Collections: an Example of Allopatric Diversification.
mSphere 2018
2014
Edouard S, Million M, Royer G, Giorgi R, Grisoli D, Raoult D
Reduction in incidence of Q fever endocarditis: 27 years of experience of a national reference center.
The Journal of Infection 2014, 68, 141-148.