Members
 | First name: Imane Last name: El Meouche Function: Researcher Position: Chargée de recherche INSERM Email: imane.el-meoucheinserm.fr |
Research interest
My research topics focus on studying bacterial physiology, pathogenesis, and antibiotic response.
Antibiotic resistance is a major health problem. However, even without resistance, many infections are hard to treat and tend to relapse. Even without increase in the minimal inhibitory concentrations, cells can survive longer even in presence of lethal concentrations of bactericidal antibiotics.
In the lab, we use different in vitro and in vivo approaches to understand why bacteria that are sensitive to antibiotic survive. We focus on Escherichia coli, a commensal, opportunistic pathogen and a major cause of urinary tract infections. We are working towards deciphering mechanisms of antibiotic survival in commensal and pathogenic extraintestinal E. coli strains using physiologically relevant conditions.
Education
Degree
2010-2014 Ph.D. in Microbiology, University of Rouen, France
Research training (post doctoral)
2014- May 2019 Postdoctoral scholar, Dunlop laboratory, Boston University, USA
List of the main publications
Romano V, Pasquale V, Lemee L, El Meouche I, Pestel-Caron M, Capuano F, Buono P, Dumontet S
Clostridioides difficile in the environment, food, animals and humans in southern Italy: Occurrence and genetic relatedness.
Comparative Immunology, Microbiology and Infectious Diseases 2018, 59, 41-46.
El Meouche I, Dunlop MJ
Heterogeneity in efflux pump expression predisposes antibiotic-resistant cells to mutation.
Science (New York, N.Y.) 2018, 362, 686-690.
Wydau-Dematteis S, El Meouche I, Courtin P, Hamiot A, Lai-Kuen R, Saubaméa B, Fenaille F, Butel MJ, Pons JL, Dupuy B, Chapot-Chartier MP, Peltier J
Cwp19 Is a Novel Lytic Transglycosylase Involved in Stationary-Phase Autolysis Resulting in Toxin Release in Clostridium difficile.
mBio 2018
El Meouche I, Peltier J
Toxin release mediated by the novel autolysin Cwp19 in Clostridium difficile.
Microbial Cell (Graz, Austria) 2018, 5, 421-423.
Wang T, El Meouche I, Dunlop MJ
Bacterial persistence induced by salicylate via reactive oxygen species.
Scientific Reports 2017, 7, 43839.
Peltier J, Courtin P, El Meouche I, Catel-Ferreira M, Chapot-Chartier MP, Lemée L, Pons JL
Genomic and expression analysis of the vanG-like gene cluster of Clostridium difficile.
Microbiology (Reading, England) 2013, 159, 1510-1520.
El Meouche I, Peltier J, Monot M, Soutourina O, Pestel-Caron M, Dupuy B, Pons JL
Characterization of the SigD regulon of C. difficile and its positive control of toxin production through the regulation of tcdR.
PloS One 2013, 8, e83748.
Peltier J, Courtin P, El Meouche I, Lemée L, Chapot-Chartier MP, Pons JL
Clostridium difficile has an original peptidoglycan structure with a high level of N-acetylglucosamine deacetylation and mainly 3-3 cross-links.
The Journal of Biological Chemistry 2011, 286, 29053-29062.
Clostridioides difficile in the environment, food, animals and humans in southern Italy: Occurrence and genetic relatedness.
Comparative Immunology, Microbiology and Infectious Diseases 2018, 59, 41-46.
El Meouche I, Dunlop MJ
Heterogeneity in efflux pump expression predisposes antibiotic-resistant cells to mutation.
Science (New York, N.Y.) 2018, 362, 686-690.
Wydau-Dematteis S, El Meouche I, Courtin P, Hamiot A, Lai-Kuen R, Saubaméa B, Fenaille F, Butel MJ, Pons JL, Dupuy B, Chapot-Chartier MP, Peltier J
Cwp19 Is a Novel Lytic Transglycosylase Involved in Stationary-Phase Autolysis Resulting in Toxin Release in Clostridium difficile.
mBio 2018
El Meouche I, Peltier J
Toxin release mediated by the novel autolysin Cwp19 in Clostridium difficile.
Microbial Cell (Graz, Austria) 2018, 5, 421-423.
Wang T, El Meouche I, Dunlop MJ
Bacterial persistence induced by salicylate via reactive oxygen species.
Scientific Reports 2017, 7, 43839.
Peltier J, Courtin P, El Meouche I, Catel-Ferreira M, Chapot-Chartier MP, Lemée L, Pons JL
Genomic and expression analysis of the vanG-like gene cluster of Clostridium difficile.
Microbiology (Reading, England) 2013, 159, 1510-1520.
El Meouche I, Peltier J, Monot M, Soutourina O, Pestel-Caron M, Dupuy B, Pons JL
Characterization of the SigD regulon of C. difficile and its positive control of toxin production through the regulation of tcdR.
PloS One 2013, 8, e83748.
Peltier J, Courtin P, El Meouche I, Lemée L, Chapot-Chartier MP, Pons JL
Clostridium difficile has an original peptidoglycan structure with a high level of N-acetylglucosamine deacetylation and mainly 3-3 cross-links.
The Journal of Biological Chemistry 2011, 286, 29053-29062.
Exhaustive list of publications
2022
de Lastours V, El Meouche I, Chau F, Beghain J, Chevret D, Aubert-Frambourg A, Clermont O, Royer G, Bouvet O, Denamur E, Fantin B, CIPHARES Group
Evolution of fluoroquinolone-resistant Escherichia coli in the gut after ciprofloxacin treatment.
International journal of medical microbiology: IJMM 2022, 312, 151548.
Hobson CA, Vigue L, Naimi S, Chassaing B, Magnan M, Bonacorsi S, Gachet B, El Meouche I, Birgy A, Tenaillon O
MiniBioReactor Array (MBRA) in vitro gut model: a reliable system to study microbiota-dependent response to antibiotic treatment.
JAC-antimicrobial resistance 2022, 4, dlac077.
2020
Langevin AM, El Meouche I, Dunlop MJ
Mapping the Role of AcrAB-TolC Efflux Pumps in the Evolution of Antibiotic Resistance Reveals Near-MIC Treatments Facilitate Resistance Acquisition.
mSphere 2020
2019
Rossi NA, El Meouche I, Dunlop MJ
Forecasting cell fate during antibiotic exposure using stochastic gene expression.
Communications Biology 2019, 2, 259.
Rossi NA, El Meouche I, Dunlop MJ
Erratum: Author Correction: Forecasting cell fate during antibiotic exposure using stochastic gene expression..
Communications biology 2019, 2, 330.
2018
Romano V, Pasquale V, Lemee L, El Meouche I, Pestel-Caron M, Capuano F, Buono P, Dumontet S
Clostridioides difficile in the environment, food, animals and humans in southern Italy: Occurrence and genetic relatedness.
Comparative Immunology, Microbiology and Infectious Diseases 2018, 59, 41-46.
El Meouche I, Dunlop MJ
Heterogeneity in efflux pump expression predisposes antibiotic-resistant cells to mutation.
Science (New York, N.Y.) 2018, 362, 686-690.
Wydau-Dematteis S, El Meouche I, Courtin P, Hamiot A, Lai-Kuen R, Saubaméa B, Fenaille F, Butel MJ, Pons JL, Dupuy B, Chapot-Chartier MP, Peltier J
Cwp19 Is a Novel Lytic Transglycosylase Involved in Stationary-Phase Autolysis Resulting in Toxin Release in Clostridium difficile.
mBio 2018
El Meouche I, Peltier J
Toxin release mediated by the novel autolysin Cwp19 in Clostridium difficile.
Microbial Cell (Graz, Austria) 2018, 5, 421-423.
2017
Wang T, El Meouche I, Dunlop MJ
Bacterial persistence induced by salicylate via reactive oxygen species.
Scientific Reports 2017, 7, 43839.
2016
El Meouche I, Siu Y, Dunlop MJ
Stochastic expression of a multiple antibiotic resistance activator confers transient resistance in single cells.
Scientific Reports 2016, 6, 19538.
2013
Peltier J, Courtin P, El Meouche I, Catel-Ferreira M, Chapot-Chartier MP, Lemée L, Pons JL
Genomic and expression analysis of the vanG-like gene cluster of Clostridium difficile.
Microbiology (Reading, England) 2013, 159, 1510-1520.
El Meouche I, Peltier J, Monot M, Soutourina O, Pestel-Caron M, Dupuy B, Pons JL
Characterization of the SigD regulon of C. difficile and its positive control of toxin production through the regulation of tcdR.
PloS One 2013, 8, e83748.
2011
Peltier J, Courtin P, El Meouche I, Lemée L, Chapot-Chartier MP, Pons JL
Clostridium difficile has an original peptidoglycan structure with a high level of N-acetylglucosamine deacetylation and mainly 3-3 cross-links.
The Journal of Biological Chemistry 2011, 286, 29053-29062.
