Members

  First name: Laurence
  Last name: Armand-Lefevre
  Email: laurence.armand
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aphp.fr

Research interest


My work is focused on the emergence of bacterial resistance in microbiota in humans. Microbiota are exposed to antibiotics during each and every antibiotic treatments whatever is the reason of their use, appropriate or not, prophylactic or therapeutic. Acquisition and dissemination of resistant clones which result from these exposure lead in turn to both infections in the colonized hosts and dissemination of resistance in the environment. We try to understand better the dynamic of these phenomena by combining specifically designed epidemiological studies and in-depth genetic analysis of the isolates. My work was focused on “bacteria/resistance” associations which cause the current major burden in bacterial infections, first on resistance to methicillin in staphylococci in the nasal flora and now, on resistance to third generation cephalosporin and imipenem in Gram negative bacilli in the gut microbiota. Furthermore, as clinical microbiologist, I am working with collaborators to test new compounds and new rapid diagnosis methods that can help decrease the emergence in commensal flora.


Education

Degree

2009 : Ph. D. in Microbiology, Paris Sud University
1999 : Pharm D. in Clinical Biology, Paris Descartes University
1998 : Master of Sc. in Microbiology, Paris Descartes University
1989-1993 : First and second cycle of Pharmaceutical school, Paris Descartes University


Academic positions

2017- today : Head of Bacteriology laboratory, Bichat Hospital, Paris Diderot University
2016-2017 : Postdoctoral fellow at Pasteur Institute, Pole Biomics (Dr Sean Kennedy)
2015- 2016 : Deputy head of Bacteriology laboratory, Bichat Hospital, Paris Diderot University
2003-2014 : Microbiologist at Bacteriology laboratory, Bichat Hospital, Paris Diderot University
2001-2003 : Assistant Professor in Bacteriology, Paris Diderot University
1999-2001 : Assistant Professor in Bacteriology, Paris Ouest University
1993-1999 : Resident in clinical biology, Paris Descartes University


Research training (post doctoral)

– 2013 – today : Member of research team, IAME, Paris Diderot University.
– 2005-2013 : Member of research team, EA3964, Paris Diderot University.


List of the main publications


Exhaustive list of publications

2020


Benchetrit L, Mathy V, Armand-Lefevre L, Bouadma L, Timsit JF
Successful treatment of septic shock due to NDM-1-producing Klebsiella pneumoniae using ceftazidime/avibactam combined with aztreonam in solid organ transplant recipients: report of two cases.
International Journal of Antimicrobial Agents 2020, 55, 105842.

Jolivet S, Lolom I, Bailly S, Bouadma L, Lortat-Jacob B, Montravers P, Armand-Lefevre L, Timsit JF, Lucet JC
Impact of colonisation pressure on acquisition of extended-spectrum β-lactamase-producing Enterobacteriaceae and meticillin-resistant Staphylococcus aureus in two intensive care units: a 19-year retrospective surveillance.
The Journal of Hospital Infection 2020

2019


Huttner BD, de Lastours V, Wassenberg M, Maharshak N, Mauris A, Galperine T, Zanichelli V, Kapel N, Bellanger A, Olearo F, Duval X, Armand-Lefevre L, Carmeli Y, Bonten M, Fantin B, Harbarth S, RGWsg
A 5-day course of oral antibiotics followed by faecal transplantation to eradicate carriage of multidrug-resistant Enterobacteriaceae: a randomized clinical trial.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2019, 25, 830-838.

Berbescu S, Matt M, Dinh A, Simeon S, Noussair L, Armand-Lefevre L, Davido B
Successful treatment of meningococcal bacteremia using oral doxycycline: a case report.
International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases 2019

La Combe B, Clermont O, Messika J, Eveillard M, Kouatchet A, Lasocki S, Corvec S, Lakhal K, Billard-Pomares T, Fernandes R, Armand-Lefevre L, Bourdon S, Reignier J, Fihman V, de Prost N, Bador J, Goret J, Wallet F, Denamur E, Ricard JD, Cg, CG
Pneumonia-Specific Escherichia coli with Distinct Phylogenetic and Virulence Profiles, France, 2012-2014.
Emerging Infectious Diseases 2019, 25, 710-718.

2018


La Combe B, Bleibtreu A, Messika J, Fernandes R, Clermont O, Branger C, Billard-Pomares T, Barnaud G, Magdoud F, Eveillard M, Kouatchet A, Lasocki S, Asfar P, Corvec S, Lakhal K, Armand-Lefevre L, Wolff M, Timsit JF, Bourdon S, Reignier J, Martin S, Fihman V, de Prost N, Bador J, Charles PE, Goret J, Boyer A, Wallet F, Jaillette E, Nseir S, Landraud L, Ruimy R, Danin PE, Dellamonica J, Cremniter J, Frat JP, Jauréguy F, Clec'h C, Decré D, Maury E, Dreyfuss D, Denamur E, Ricard JD
Decreased susceptibility to chlorhexidine affects a quarter of Escherichia coli isolates responsible for pneumonia in ICU patients.
Intensive Care Medicine 2018, 44, 531-533.

Jolivet S, Lescure FX, Armand-Lefevre L, Raffoul R, Dilly MP, Ghodbane W, Nataf P, Lucet JC
Surgical site infection with extended-spectrum β-lactamase-producing Enterobacteriaceae after cardiac surgery: incidence and risk factors.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2018, 24, 283-288.

Lemaignen A, Armand-Lefevre L, Birgand G, Mabileau G, Lolom I, Ghodbane W, Dilly MP, Nataf P, Lucet JC
Thirteen-year experience with universal Staphylococcus aureus nasal decolonization prior to cardiac surgery: a quasi-experimental study.
The Journal of Hospital Infection 2018, 100, 322-328.

de Gunzburg J, Ghozlane A, Ducher A, Le Chatelier E, Duval X, Ruppé E, Armand-Lefevre L, Sablier-Gallis F, Burdet C, Alavoine L, Chachaty E, Augustin V, Varastet M, Levenez F, Kennedy S, Pons N, Mentré F, Andremont A
Protection of the Human Gut Microbiome From Antibiotics.
The Journal of Infectious Diseases 2018, 217, 628-636.

Lorme F, Maataoui N, Rondinaud E, Esposito-Farèse M, Clermont O, Ruppe E, Arlet G, Genel N, VRsg, Matheron S, Andremont A, Armand-Lefevre L
Acquisition of plasmid-mediated cephalosporinase producing Enterobacteriaceae after a travel to the tropics.
PloS One 2018, 13, e0206909.

2017


Grall N, Lazarevic V, Gaïa N, Couffignal C, Laouénan C, Ilic-Habensus E, Wieder I, Plesiat P, Angebault C, Bougnoux ME, Armand-Lefevre L, Andremont A, Duval X, Schrenzel J
Unexpected persistence of extended-spectrum β-lactamase-producing Enterobacteriaceae in the faecal microbiota of hospitalised patients treated with imipenem.
International Journal of Antimicrobial Agents 2017, 50, 81-87.

Armand-Lefevre L, Ruppé E, Andremont A
ESBL-producing Enterobacteriaceae in travellers: doctors beware.
The Lancet. Infectious Diseases 2017, 17, 8-9.

Sangare SA, Rondinaud E, Maataoui N, Maiga AI, Guindo I, Maiga A, Camara N, Dicko OA, Dao S, Diallo S, Bougoudogo F, Andremont A, Maiga II, Armand-Lefevre L
Very high prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in bacteriemic patients hospitalized in teaching hospitals in Bamako, Mali.
PloS One 2017, 12, e0172652.

2016


Birgand G, Leroy C, Nerome S, Luong Nguyen LB, Lolom I, Armand-Lefevre L, Ciotti C, Lecorre B, Marcade G, Fihman V, Nicolas-Chanoine MH, Pelat C, Perozziello A, Fantin B, Yazdanpanah Y, Ricard JD, Lucet JC
Costs associated with implementation of a strict policy for controlling spread of highly resistant microorganisms in France.
BMJ open 2016, 6, e009029.

Sangare SA, Maiga AI, Guindo I, Maiga A, Camara N, Dicko OA, Diallo S, Bougoudogo F, Armand-Lefevre L, Andremont A, Maiga II
Prevalence of ESBL-producing Enterobacteriaceae isolated from blood cultures in Mali.
Journal of Infection in Developing Countries 2016, 10, 1059-1064.

2015


Bretonnière C, Leone M, Milési C, Allaouchiche B, Armand-Lefevre L, Baldesi O, Bouadma L, Decré D, Figueiredo S, Gauzit R, Guery B, Joram N, Jung B, Lasocki S, Lepape A, Lesage F, Pajot O, Philippart F, Souweine B, Tattevin P, Timsit JF, Vialet R, Zahar JR, Misset B, Bedos JP
Strategies to reduce curative antibiotic therapy in intensive care units (adult and paediatric).
Intensive Care Medicine 2015, 41, 1181-1196.

Lemaignen A, Birgand G, Ghodhbane W, Alkhoder S, Lolom I, Belorgey S, Lescure FX, Armand-Lefevre L, Raffoul R, Dilly MP, Nataf P, Lucet JC
Sternal wound infection after cardiac surgery: incidence and risk factors according to clinical presentation.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2015, 21, 674.e11-18.

Bonnal C, Birgand G, Lolom I, Diamantis S, Dumortier C, L'Heriteau F, Armand-Lefevre L, Lucet JC
Staphylococcus aureus healthcare associated bacteraemia: An indicator of catheter related infections.
Medecine Et Maladies Infectieuses 2015, 45, 84-88.

Sangare SA, Maiga AI, Guindo I, Maiga A, Camara N, Savadogo S, Diallo S, Bougoudogo F, Armand-Lefevre L, Andremont A, Maiga II
Prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae isolated from blood cultures in Africa.
Médecine Et Maladies Infectieuses 2015, 45, 374-382.

Pajot O, Burdet C, Couffignal C, Massias L, Armand-Lefevre L, Foucrier A, Da Silva D, Lasocki S, Laouénan C, Mentec H, Mentré F, Wolff M
Impact of imipenem and amikacin pharmacokinetic/pharmacodynamic parameters on microbiological outcome of Gram-negative bacilli ventilator-associated pneumonia.
The Journal of Antimicrobial Chemotherapy 2015, 70, 1487–1494.

Pajot O, Burdet C, Couffignal C, Massias L, Armand-Lefevre L, Foucrier A, Da Silva D, Lasocki S, Laouénan C, Mentec H, Mentré F, Wolff M
Impact of imipenem and amikacin pharmacokinetic/pharmacodynamic parameters on microbiological outcome of Gram-negative bacilli ventilator-associated pneumonia.
The Journal of Antimicrobial Chemotherapy 2015, 70, 1487-1494.

Loubet P, Lescure FX, Lepage L, Kirsch M, Armand-Lefevre L, Bouadma L, Lariven S, Duval X, Yazdanpanah Y, Joly V
Endocarditis due to gram-negative bacilli at a French teaching hospital over a 6-year period: clinical characteristics and outcome.
Infectious Diseases (London, England) 2015, 47, 889-895.

2014


Amsallem M, Iung B, Bouleti C, Armand-Lefevre L, Eme AL, Touati A, Kirsch M, Duval X, Vahanian A
First reported human case of native mitral infective endocarditis caused by Streptococcus canis.
The Canadian Journal of Cardiology 2014, 30, 1462.e1–2.

Amsallem M, Iung B, Bouleti C, Armand-Lefevre L, Eme AL, Touati A, Kirsch M, Duval X, Vahanian A
First reported human case of native mitral infective endocarditis caused by Streptococcus canis.
The Canadian Journal of Cardiology 2014, 30, 1462.e1-2.

Marc F, Esquirol C, Papy E, Longuet P, Armand-Lefevre L, Rioux C, Diamantis S, Dumortier C, Bourgeois-Nicolaos N, Lucet JC, Wolff M, Arnaud P
A retrospective study of daptomycin use in a Paris teaching-hospital.
Médecine et maladies infectieuses 2014, 44, 25-31.

Birgand G, Schwarzinger M, Perozziello A, Lolom I, Pelat C, Armand-Lefevre L, Buzzi JC, Andremont A, Yazdanpanah Y, Lucet JC
Prolonged hospital stay, an adverse effect of strict national policy for controlling the spread of highly resistant microorganisms.
Infection Control and Hospital Epidemiology 2014, 35, 1427-1429.

Birgand G, Armand-Lefevre L, Lepainteur M, Lolom I, Neulier C, Reibel F, Yazdanpanah Y, Andremont A, Lucet JC
Introduction of highly resistant bacteria into a hospital via patients repatriated or recently hospitalized in a foreign country.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases [RESEARCH NOTE] 2014, 20, O887-890.

Couffignal C, Pajot O, Laouénan C, Burdet C, Foucrier A, Wolff M, Armand-Lefevre L, Mentré F, Massias L
Population pharmacokinetics of imipenem in critically ill patients with suspected ventilator-associated pneumonia and evaluation of dosage regimens.
British Journal of Clinical Pharmacology 2014, 78, 1022–1034.

Couffignal C, Pajot O, Laouénan C, Burdet C, Foucrier A, Wolff M, Armand-Lefevre L, Mentré F, Massias L
Population pharmacokinetics of imipenem in critically ill patients with suspected ventilator-associated pneumonia and evaluation of dosage regimens.
British Journal of Clinical Pharmacology 2014, 78, 1022-1034.

Ruppe E, Armand-Lefevre L, Estellat C, El-Mniai A, Boussadia Y, Consigny P, Girard P, Vittecoq D, Bouchaud O, Pialoux G, Esposito-Farese M, Coignard B, Lucet J, Andremont A, Matheron S
Acquisition of carbapenemase-producing Enterobacteriaceae by healthy travellers to India, France, February 2012 to March 2013.
Euro surveillance: bulletin Européen sur les maladies transmissibles = European communicable disease bulletin 2014, 19,

2013


Birgand G, Armand-Lefevre L, Lolom I, Ruppe E, Andremont A, Lucet JC
Duration of colonization by extended-spectrum β-lactamase-producing Enterobacteriaceae after hospital discharge.
American Journal of Infection Control 2013, 41, 443-447.

Armand-Lefevre L, Angebault C, Barbier F, Hamelet E, Defrance G, Ruppe E, Bronchard R, Lepeule R, Lucet JC, El Mniai A, Wolff M, Montravers P, Plesiat P, Andremont A
Emergence of Imipenem-Resistant Gram-Negative Bacilli in Intestinal Flora of Intensive Care Patients.
Antimicrobial Agents and Chemotherapy 2013, 57, 1488-1495.

Birgand G, Ruimy R, Schwarzinger M, Lolom I, Bendjelloul G, Houhou N, Armand-Lefevre L, Andremont A, Yazdanpanah Y, Lucet JC
Rapid detection of glycopeptide-resistant enterococci: impact on decision-making and costs.
Antimicrobial Resistance and Infection Control 2013, 2, 30.

2012


Roux D, Huy C, Lolom I, Andremont A, Arlet G, Armand-Lefevre L, Lucet JC
Diversity of extended-spectrum β-lactamase-producing Enterobacteriaceae on hospital admission.
Scandinavian Journal of Infectious Diseases 2012, 44, 231-236.

2003


Hanslik T, Hartig C, Jurand C, Armand-Lefevre L, Jubault V, Rouveix E, Dubourg O, Prinseau J, Baglin A, Nicolas-Chanoine MH
Clinical significance of tolerant strains of streptococci in adults with infective endocarditis.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2003, 9, 852-857.

2002


Heym B, Le Moal M, Armand-Lefevre L, Nicolas-Chanoine MH
Multilocus sequence typing (MLST) shows that the 'Iberian' clone of methicillin-resistant Staphylococcus aureus has spread to France and acquired reduced susceptibility to teicoplanin.
The Journal of Antimicrobial Chemotherapy 2002, 50, 323-329.