Members

  First name: Luce
  Last name: Landraud
  Function: associate professor (MCU-PH)
  Position: MD PhD, Louis Mourier Hospital
  Email: landraud.luce
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aphp.fr

Research interest


microbiology, antibiotic resistance, virulence. My work is on multidrug-resistant plasmids in Enterobacterales. I investigate the response of recipient bacteria to the acquisition of these plasmids, and the impact on the spread of antibiotic resistance and bacterial virulence in E. coli.

Education

Degree

2004 : PhD in Bacteriology, Nice Sophia Antipolis


Academic positions

1998-2002: assistant in microbiology, U452 INSERM; 2004-2015: Associate professor in C3M INSERM UMR 1065; 2015-present: Associate professor in IAME INSERM 1137

List of the main publications

Diabate M, Munro P, Garcia E, Jacquel A, Michel G, Obba S, Goncalves D, Luci C, Marchetti S, Demon D, Degos C, Bechah Y, Mege JL, Lamkanfi M, Auberger P, Gorvel JP, Stuart LM, Landraud L, Lemichez E, Boyer L
Escherichia coli α-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia.
PLoS pathogens 2015, 11, e1004732.

Gupta SK, Padmanabhan BR, Diene SM, Lopez-Rojas R, Kempf M, Landraud L, Rolain JM
ARG-ANNOT, a new bioinformatic tool to discover antibiotic resistance genes in bacterial genomes.
Antimicrobial Agents and Chemotherapy 2014, 58, 212-220.

Landraud L, Jauréguy F, Frapy E, Guigon G, Gouriou S, Carbonnelle E, Clermont O, Denamur E, Picard B, Lemichez E, Brisse S, Nassif X
Severity of Escherichia coli bacteraemia is independent of the intrinsic virulence of the strains assessed in a mouse model.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2013, 19, 85-90.

Berrazeg M, Diene SM, Drissi M, Kempf M, Richet H, Landraud L, Rolain JM
Biotyping of multidrug-resistant Klebsiella pneumoniae clinical isolates from France and Algeria using MALDI-TOF MS.
PloS One 2013, 8, e61428.

Sotto A, Richard JL, Messad N, Molinari N, Jourdan N, Schuldiner S, Sultan A, Carrière C, Canivet B, Landraud L, Lina G, Lavigne JP, French Study Group on the Diabetic Foot
Distinguishing colonization from infection with Staphylococcus aureus in diabetic foot ulcers with miniaturized oligonucleotide arrays: a French multicenter study.
Diabetes Care 2012, 35, 617-623.


Exhaustive list of publications

2023


Abraham S, Piarroux R, Zhou Y, Tesic V, Abeleda A, Houhou-Fidouh N, Nicaise-Rolland P, Landraud L, McLeod R, Houzé S
Performances of ICT Toxoplasma IgG-IgM test in comparison with Vidas® toxo competition to determine the immune status against Toxoplasma gondii.
European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology 2023, 42, 1327-1335.

Poisson M, Sibiude J, Mosnino E, Koual M, Landraud L, Fidouh N, Mandelbrot L, Vauloup-Fellous C, Luton D, Benachi A, Vivanti AJ, Picone O
Impact of variants of SARS-CoV-2 on obstetrical and neonatal outcomes.
Journal of Gynecology Obstetrics and Human Reproduction 2023, 52, 102566.

Vivanti AJ, Vauloup-Fellous C, Khalil A, Badr DA, Raimondi F, Salome S, Prasad S, Portella G, Fiorenza M, Jani JC, Landraud L, Picone O, Pezza L, Bourgeois-Nicolaos N, Cordier AG, Vedovelli L, De Luca D
Nasopharyngeal SARS-CoV-2 load and perinatal outcomes after maternal infection diagnosed close to delivery.
Journal of Gynecology Obstetrics and Human Reproduction 2023, 52, 102569.

Allain M, Mahérault AC, Gachet B, Martinez C, Condamine B, Magnan M, Kempf I, Denamur E, Landraud L
Dissemination of IncI plasmid encoding bla CTX-M-1 is not hampered by its fitness cost in the pig's gut.
Antimicrobial Agents and Chemotherapy 2023, 67, e0011123.

Farrugia MA, Le Corvec M, Renou C, Nousbaum JB, Ouizeman DJ, Sire O, Loréal O, Tariel H, Bernard J, Piche T, Tran A, Ait-Oufella H, Landraud L, Gual P, Anty R, The Cytokine Ascites Group n
Mid-Infrared Spectroscopy as a New Tool for Ruling Out Spontaneous Bacterial Peritonitis: A Proof-of-Concept Study.
Biomedicines 2023, 11, 838.

2022


Tsoumtsa Meda LL, Landraud L, Petracchini S, Descorps-Declere S, Perthame E, Nahori MA, Ramirez Finn L, Ingersoll MA, Patiño-Navarrete R, Glaser P, Bonnet R, Dussurget O, Denamur E, Mettouchi A, Lemichez E
The cnf1 gene is associated with an expanding Escherichia coli ST131 H30Rx/C2 subclade and confers a competitive advantage for gut colonization.
Gut Microbes 2022, 14, 2121577.

Rybak A, Aupiais C, Cotillon M, Basmaci R, de Pontual L, Bonacorsi S, Mariani P, Landraud L, Brichler S, Poilane I, Ouldali N, Titomanlio L
Reassessing the Performance of the "Step-By-Step" Approach to Febrile Infants 90 Days of Age and Younger in the Context of the COVID-19 Pandemic: A Multicentric Retrospective Study.
The Pediatric Infectious Disease Journal 2022, 41, e365-e368.

Fourati S, Audureau E, Arrestier R, Marot S, Dubois C, Voiriot G, Luyt CE, Urbina T, Mayaux J, Roque-Afonso AM, Pham T, Landraud L, Visseaux B, Roux D, Bellaiche R, L'honneur AS, Ait Hamou Z, Brichler S, Gaudry S, Salmona M, Clere-Jehl R, Azoulay E, Morand-Joubert L, Marcelin AG, Chaix ML, Descamps D, Mekontso Dessap A, Rodriguez C, Pawlotsky JM, de Prost N
SARS-CoV-2 Genomic Characteristics and Clinical Impact of SARS-CoV-2 Viral Diversity in Critically Ill COVID-19 Patients: A Prospective Multicenter Cohort Study.
Viruses 2022, 14, 1529.

2021


Ben M'Barek I, Landraud L, Desfrere L, Sallah K, Couffignal C, Schneider M, Mandelbrot L
Contribution of vaginal culture to predict early onset neonatal infection in preterm prelabor rupture of membranes.
European Journal of Obstetrics, Gynecology, and Reproductive Biology 2021, 261, 78-84.

2019


Mahérault AC, Kemble H, Magnan M, Gachet B, Roche D, Le Nagard H, Tenaillon O, Denamur E, Branger C, Landraud L
Advantage of the F2:A1:B- IncF Pandemic Plasmid over IncC Plasmids in In Vitro Acquisition and Evolution of blaCTX-M Gene-Bearing Plasmids in Escherichia coli.
Antimicrobial Agents and Chemotherapy 2019, 63,

2018


La Combe B, Bleibtreu A, Messika J, Fernandes R, Clermont O, Branger C, Billard-Pomares T, Barnaud G, Magdoud F, Eveillard M, Kouatchet A, Lasocki S, Asfar P, Corvec S, Lakhal K, Armand-Lefevre L, Wolff M, Timsit JF, Bourdon S, Reignier J, Martin S, Fihman V, de Prost N, Bador J, Charles PE, Goret J, Boyer A, Wallet F, Jaillette E, Nseir S, Landraud L, Ruimy R, Danin PE, Dellamonica J, Cremniter J, Frat JP, Jauréguy F, Clec'h C, Decré D, Maury E, Dreyfuss D, Denamur E, Ricard JD
Decreased susceptibility to chlorhexidine affects a quarter of Escherichia coli isolates responsible for pneumonia in ICU patients.
Intensive Care Medicine 2018, 44, 531-533.

Mondain V, Lieutier F, Pulcini C, Degand N, Landraud L, Ruimy R, Fosse T, Roger PM
Improved quality of care for patients infected or colonised with ESBL-producing Enterobacteriaceae in a French teaching hospital: impact of an interventional prospective study and development of specific tools.
European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology 2018, 37, 977-981.

La Combe B, Mahérault AC, Messika J, Billard-Pomares T, Branger C, Landraud L, Dreyfuss D, Dib F, Massias L, Ricard JD
Oropharyngeal Bacterial Colonization after Chlorhexidine Mouthwash in Mechanically Ventilated Critically Ill Patients.
Anesthesiology 2018, 129, 1140-1148.

2017


Messika J, Clermont O, Landraud L, Schmidt M, Aubry A, Sougakoff W, Fernandes R, Combes A, Denamur E, Ricard JD
Extra-corporeal membrane oxygenation-associated infections: implication of extra-intestinal pathogenic Escherichia coli clones.
Journal of Medical Microbiology 2017, 66, 1189-1195.

Lotte R, Hérissé AL, Berrouane Y, Lotte L, Casagrande F, Landraud L, Herbin S, Ramarao N, Boyer L, Ruimy R
Virulence Analysis of Bacillus cereus Isolated after Death of Preterm Neonates, Nice, France, 2013.
Emerging Infectious Diseases 2017, 23, 845-848.

2016


Ichou L, Carbonell N, Rautou PE, Laurans L, Bourcier S, Pichereau C, Baudel JL, Nousbaum JB, Renou C, Anty R, Tankovic J, Maury E, Guidet B, Landraud L, Ait-Oufella H
Ascitic fluid TREM-1 for the diagnosis of spontaneous bacterial peritonitis.
Gut 2016, 65, 536-538.

2015


Diabate M, Munro P, Garcia E, Jacquel A, Michel G, Obba S, Goncalves D, Luci C, Marchetti S, Demon D, Degos C, Bechah Y, Mege JL, Lamkanfi M, Auberger P, Gorvel JP, Stuart LM, Landraud L, Lemichez E, Boyer L
Escherichia coli α-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia.
PLoS pathogens 2015, 11, e1004732.

2014


Gupta SK, Padmanabhan BR, Diene SM, Lopez-Rojas R, Kempf M, Landraud L, Rolain JM
ARG-ANNOT, a new bioinformatic tool to discover antibiotic resistance genes in bacterial genomes.
Antimicrobial Agents and Chemotherapy 2014, 58, 212-220.

2013


Messad N, Landraud L, Canivet B, Lina G, Richard JL, Sotto A, Lavigne JP, Lemichez E, French Study Group on the Diabetic Foot
Distribution of edin in Staphylococcus aureus isolated from diabetic foot ulcers.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2013, 19, 875-880.

Landraud L, Jauréguy F, Frapy E, Guigon G, Gouriou S, Carbonnelle E, Clermont O, Denamur E, Picard B, Lemichez E, Brisse S, Nassif X
Severity of Escherichia coli bacteraemia is independent of the intrinsic virulence of the strains assessed in a mouse model.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2013, 19, 85-90.

Berrazeg M, Diene SM, Drissi M, Kempf M, Richet H, Landraud L, Rolain JM
Biotyping of multidrug-resistant Klebsiella pneumoniae clinical isolates from France and Algeria using MALDI-TOF MS.
PloS One 2013, 8, e61428.

2012


Sotto A, Richard JL, Messad N, Molinari N, Jourdan N, Schuldiner S, Sultan A, Carrière C, Canivet B, Landraud L, Lina G, Lavigne JP, French Study Group on the Diabetic Foot
Distinguishing colonization from infection with Staphylococcus aureus in diabetic foot ulcers with miniaturized oligonucleotide arrays: a French multicenter study.
Diabetes Care 2012, 35, 617-623.

2010


Munro P, Benchetrit M, Nahori MA, Stefani C, Clément R, Michiels JF, Landraud L, Dussurget O, Lemichez E
The Staphylococcus aureus epidermal cell differentiation inhibitor toxin promotes formation of infection foci in a mouse model of bacteremia..
Infection and immunity 2010, 78, 3404-3411.

2008


Jaureguy F, Landraud L, Passet V, Diancourt L, Frapy E, Guigon G, Carbonnelle E, Lortholary O, Clermont O, Denamur E, Picard B, Nassif X, Brisse S
Phylogenetic and genomic diversity of human bacteremic Escherichia coli strains.
BMC genomics 2008, 9, 560.

2007


Real JM, Munro P, Buisson-Touati C, Lemichez E, Boquet P, Landraud L
Specificity of immunomodulator secretion in urinary samples in response to infection by alpha-hemolysin and CNF1 bearing uropathogenic Escherichia coli..
Cytokine 2007, 37, 22-25.

Landraud L, Lemichez E
[EDIN of S. aureus induces the formation of large transcellular tunnels in endothelial cells and increases vascular permeability]..
Medecine sciences : M/S 2007, 23, 459-460.

Lemonnier M, Landraud L, Lemichez E
Rho GTPase-activating bacterial toxins: from bacterial virulence regulation to eukaryotic cell biology..
FEMS microbiology reviews 2007, 31, 515-534.

2006


Gauthier NC, Ricci V, Landraud L, Boquet P
Helicobacter pylori VacA toxin: a tool to study novel early endosomes..
Trends in microbiology 2006, 14, 292-294.

Boyer L, Doye A, Rolando M, Flatau G, Munro P, Gounon P, Clément R, Pulcini C, Popoff MR, Mettouchi A, Landraud L, Dussurget O, Lemichez E
Induction of transient macroapertures in endothelial cells through RhoA inhibition by Staphylococcus aureus factors..
The Journal of cell biology 2006, 173, 809-819.

2005


Oregioni O, Delaunay P, Bruna P, Gaudart A, Lemichez E, Boquet P, Landraud L
Urinary interleukin-8 is elevated in urinary tract infections independently of the causative germs..
Cytokine 2005, 31, 415-418.

2004


Munro P, Flatau G, Doye A, Boyer L, Oregioni O, Mege JL, Landraud L, Lemichez E
Activation and proteasomal degradation of rho GTPases by cytotoxic necrotizing factor-1 elicit a controlled inflammatory response..
The Journal of biological chemistry 2004, 279, 35849-35857.

Landraud L, Pulcini C, Gounon P, Flatau G, Boquet P, Lemichez E
E. coli CNF1 toxin: a two-in-one system for host-cell invasion..
International journal of medical microbiology : IJMM 2004, 293, 513-518.

2003


Landraud L, Gibert M, Popoff MR, Boquet P, Gauthier M
Expression of cnf1 by Escherichia coli J96 involves a large upstream DNA region including the hlyCABD operon, and is regulated by the RfaH protein..
Molecular microbiology 2003, 47, 1653-1667.

Landraud L, Doye A, Buisson-Touati C, Boquet P, Lemichez E
[Action of cytotoxic necrotizing factor from E. coli]..
Medecine sciences : M/S 2003, 19, 403-405.

Hofman V, Selva E, Landraud L, Sicard D, Vénissac N, Castillo L, Kermarec A, Mouroux J, Dellamonica P, Hofman P
[Value of PCR amplification from formalin-fixed paraffin-embedded tissues in the diagnosis of Mycobacterium tuberculosis infection]..
Annales de pathologie 2003, 23, 206-215.