Members

  First name: Nathalie
  Last name: Grall
  Function: Hospital practitioner
  Position: MD, PhD
  Email: nathalie.grall
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inserm.fr

Research interest


Antibiotic resistance, microbiota, clinical microbiology

Education

Degree

2015: PhD in infectious diseases, Paris Diderot University
2010: Medical Doctor (MD), Paris Descartes University
2008: Master of Sciences (MSc) in Microbiology, Paris Descartes University

Academic positions

2013-current : Hospital practitioner at Bacteriology unit, Bichat Hospital, AP-HP Nord Paris Cité University, Paris
2011-2013: Assistant professor in Microbiology, Medical school, Paris Diderot University

List of the main publications

Sandot A, Grall N, Rodier T, Bunel V, Godet C, Weisenburger G, Tran-Dinh A, Montravers P, Mordant P, Castier Y, Eloy P, Armand-Lefevre L, Mal H, Messika J
Risk of Bronchial Complications After Lung Transplantation With Respiratory Corynebacteria. Results From a Monocenter Retrospective Cohort Study.
Transplant International: Official Journal of the European Society for Organ Transplantation 2023, 36, 10942.

Tran-Dinh A, Slassi L, De Tymowski C, Assadi M, Tanaka S, Zappella N, Lortat Jacob B, Jean-Baptiste S, Atchade E, Castier Y, Mal H, Mordant P, Armand-Lefèvre L, Messika J, Grall N, Montravers P
Secondary Prophylaxis With Inhaled Colistin to Prevent Recurrence of Pseudomonas aeruginosa and Extended-spectrum β-lactamase-producing Enterobacterales Pneumonia in ICU After Lung Transplantation: A Before-and-after Retrospective Cohort Analysis.
Transplantation 2022, 106, 2232-2240.

Burdet C, Grall N, Linard M, Bridier-Nahmias A, Benhayoun M, Bourabha K, Magnan M, Clermont O, d'Humières C, Tenaillon O, Denamur E, Massias L, Tubiana S, Alavoine L, Andremont A, Mentré F, Duval X, CEREMI Group
Ceftriaxone and Cefotaxime Have Similar Effects on the Intestinal Microbiota in Human Volunteers Treated by Standard-Dose Regimens.
Antimicrobial Agents and Chemotherapy 2019, 63, e02244-18.

Grall N, Lazarevic V, Gaia N, Couffignal C, Laouenan C, Ilic-Habensus E, Wieder I, Plesiat P, Angebault C, Bougnoux ME, Armand-Lefevre L, Andremont A, Duval X, Schrenzel J
Unexpected persistence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in the faecal microbiota of hospitalised patients treated with imipenem.
Int J Antimicrob Agents 2017, 50, 81-87.

Grall N, Barraud O, Wieder I, Hua A, Perrier M, Babosan A, Gaschet M, Clermont O, Denamur E, Catzeflis F, Decré D, Ploy MC, Andremont A
Lack of dissemination of acquired resistance to β-lactam in small wild mammals around an isolated village in the Amazonian forest.
Environmental Microbiology Reports 2015

Grall N, Massias L, Nguyen TT, Sayah-Jeanne S, Ducrot N, Chachaty E, de Gunzburg J, Andremont A
Oral DAV131, a charcoal-based adsorbent, inhibits intestinal colonization by β-lactam-resistant Klebsiella pneumoniae in cefotaxime-treated mice.
Antimicrobial Agents and Chemotherapy 2013, 57, 5423–5425.


Exhaustive list of publications

2024


Moisset H, Rio J, Benhard J, Arnoult F, Deconinck L, Grall N, Iung B, Lescure X, Rouzet F, Suc G, Hoen B, Hobson CA, Duval X
Evaluation of the specificity of the 2023 Duke-International Society of Cardiovascular Infectious Diseases classification for infective endocarditis.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2024, ciae034.

2023


Goulenok T, Seurat J, Selle AdL, Jullien V, Leflon-Guibout V, Grall N, Lescure FX, Lepeule R, Bertrand J, Fantin B, Burdet C, Lefort A
Pharmacokinetic interaction between rifampicin and clindamycin in staphylococcal osteoarticular infections.
International Journal of Antimicrobial Agents 2023, 62, 106885.

Lafaurie M, Chevret S, Fontaine JP, Mongiat-Artus P, de Lastours V, Escaut L, Jaureguiberry S, Bernard L, Bruyere F, Gatey C, Abgrall S, Ferreyra M, Aumaitre H, Aparicio C, Garrait V, Meyssonnier V, Bourgarit-Durand A, Chabrol A, Piet E, Talarmin JP, Morrier M, Canoui E, Charlier C, Etienne M, Pacanowski J, Grall N, Desseaux K, Empana-Barat F, Madeleine I, Bercot B, Molina JM, Lefort A, PROSTASHORT Study Group
Antimicrobial for 7 or 14 Days for Febrile Urinary Tract Infection in Men: A Multicenter Noninferiority Double-Blind, Placebo-Controlled, Randomized Clinical Trial.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2023, 76, 2154-2162.

Tran-Dinh A, Tir I, Tanaka S, Atchade E, Lortat-Jacob B, Jean-Baptiste S, Zappella N, Boudinet S, Castier Y, Mal H, Mordant P, Ben Abdallah I, Bunel V, Messika J, Armand-Lefèvre L, Grall N, Montravers P
Impact of Culture-Positive Preservation Fluid on Early Morbidity and Mortality After Lung Transplantation.
Transplant International: Official Journal of the European Society for Organ Transplantation 2023, 36, 10826.

Sandot A, Grall N, Rodier T, Bunel V, Godet C, Weisenburger G, Tran-Dinh A, Montravers P, Mordant P, Castier Y, Eloy P, Armand-Lefevre L, Mal H, Messika J
Risk of Bronchial Complications After Lung Transplantation With Respiratory Corynebacteria. Results From a Monocenter Retrospective Cohort Study.
Transplant International: Official Journal of the European Society for Organ Transplantation 2023, 36, 10942.

de Tymowski C, Sahnoun T, Provenchere S, Para M, Derre N, Mutuon P, Duval X, Grall N, Iung B, Kernéis S, Lucet JC, Montravers P
Impact of Antibiotic Prophylaxis on Surgical Site Infections in Cardiac Surgery.
Antibiotics (Basel, Switzerland) 2023, 12, 85.

2022


Guk J, Bridier-Nahmias A, Magnan M, Grall N, Duval X, Clermont O, Ruppé E, d'Humières C, Tenaillon O, Denamur E, Mentré F, Guedj J, Burdet C, CEREMI study group
Modeling the bacterial dynamics in the gut microbiota following an antibiotic-induced perturbation.
CPT: pharmacometrics & systems pharmacology 2022, 11, 906-918.

Tanaka S, Thy M, Tashk P, Ribeiro L, Lortat-Jacob B, Hermieu JF, Zappella N, Rozencwajg S, Snauwaert A, Atchade E, Grall N, Assadi M, Tran-Dinh A, Montravers P
Impact of prior antibiotic therapy on severe necrotizing soft-tissue infections in ICU patients: results from a French retrospective and observational study.
European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology 2022, 41, 109-117.

De Castro N, Mechaï F, Bachelet D, Canestri A, Joly V, Vandenhende M, Boutoille D, Kerjouan M, Veziris N, Molina JM, Grall N, Tattevin P, Laouénan C, Yazdanpanah Y, FAST TB Study Group
Treatment With a Three-Drug Regimen for Pulmonary Tuberculosis Based on Rapid Molecular Detection of Isoniazid Resistance: A Noninferiority Randomized Trial (FAST-TB).
Open Forum Infectious Diseases 2022, 9, ofac353.

Tran-Dinh A, Slassi L, De Tymowski C, Assadi M, Tanaka S, Zappella N, Lortat Jacob B, Jean-Baptiste S, Atchade E, Castier Y, Mal H, Mordant P, Armand-Lefèvre L, Messika J, Grall N, Montravers P
Secondary Prophylaxis With Inhaled Colistin to Prevent Recurrence of Pseudomonas aeruginosa and Extended-spectrum β-lactamase-producing Enterobacterales Pneumonia in ICU After Lung Transplantation: A Before-and-after Retrospective Cohort Analysis.
Transplantation 2022, 106, 2232-2240.

Delavy M, Burdet C, Sertour N, Devente S, Docquier JD, Grall N, Volant S, Ghozlane A, Duval X, Mentré F, d'Enfert C, Bougnoux ME, PrediRes Study Group
A Clinical Study Provides the First Direct Evidence That Interindividual Variations in Fecal β-Lactamase Activity Affect the Gut Mycobiota Dynamics in Response to β-Lactam Antibiotics.
mBio 2022, 13, e0288022.

Tran-Dinh A, Guiot M, Tanaka S, Lortat-Jacob B, Atchade E, Zappella N, Mordant P, Castier Y, Mal H, Weisenburger G, Messika J, Grall N, Montravers P
Bacteraemia Is Associated with Increased ICU Mortality in the Postoperative Course of Lung Transplantation.
Antibiotics (Basel, Switzerland) 2022, 11, 1405.

2021


Boussion K, Zappella N, Grall N, Ribeiro-Parenti L, Papin G, Montravers P
Epidemiology, clinical relevance and prognosis of staphylococci in hospital-acquired postoperative intra-abdominal infections: an observational study in intensive care unit.
Scientific Reports 2021, 11, 5884.

Montravers P, Esposito-Farèse M, Lasocki S, Grall N, Veber B, Eloy P, Seguin P, Weiss E, Dupont H
Risk factors for therapeutic failure in the management of post-operative peritonitis: a post hoc analysis of the DURAPOP trial.
The Journal of Antimicrobial Chemotherapy 2021, dkab307.

Féron F, de Ponfilly GP, Potier L, Gauthier DC, Salle L, Laloi-Michelin M, Munier AL, Jacquier H, Vidal-Trécan T, Julla JB, Carlier A, Abouleka Y, Venteclef N, Grall N, Mercier F, Riveline JP, Senneville É, Gautier JF, Roussel R, Kevorkian JP
Reliability and Safety of Bedside Blind Bone Biopsy Performed by a Diabetologist for the Diagnosis and Treatment of Diabetic Foot Osteomyelitis.
Diabetes Care 2021, 44, 2480-2486.

Bleibtreu A, Dortet L, Bonnin RA, Wyplosz B, Sacleux SC, Mihaila L, Dupont H, Junot H, Bunel V, Grall N, Razazi K, Duran C, Tattevin P, Dinh A, The Cefiderocol French Study Group OBO
Susceptibility Testing Is Key for the Success of Cefiderocol Treatment: A Retrospective Cohort Study.
Microorganisms 2021

2020


Augustin P, Tran-Dinh A, Desmard M, Tanaka S, Grall N, Ben-Rehouma M, Arapis K, Ribeiro-Parenti L, Montravers P
Usefulness of Gram stain examination of peritoneal fluid in postoperative peritonitis to guide empirical antibiotherapy.
European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society 2020, 46, 1335-1340.

Augustin P, Tanaka S, Tran-Dinh A, Parenti Ribeiro L, Arapis K, Grall N, Al Qarni A, Montravers P
Outcome and Adequacy of Empirical Antibiotherapy in Post-Operative Peritonitis: A Retrospective Study.
Surgical Infections 2020, 21, 284-292.

Dubert M, Visseaux B, Birgy A, Mordant P, Metivier AC, Dauriat G, Fidouh N, Yazdanpanah Y, Grall N, Castier Y, Mal H, Thabut G, Lescure FX
Late viral or bacterial respiratory infections in lung transplanted patients: impact on respiratory function.
BMC infectious diseases 2020, 20, 176.

Logre E, Enser M, Tanaka S, Dubert M, Claudinon A, Grall N, Mentec H, Montravers P, Pajot O
Amikacin pharmacokinetic/pharmacodynamic in intensive care unit: a prospective database.
Annals of Intensive Care 2020, 10, 75.

Goulas A, Belhadi D, Descamps A, Andremont A, Benoit P, Courtois S, Dagot C, Grall N, Makowski D, Nazaret S, Nelieu S, Patureau D, Petit F, Roose-Amsaleg C, Vittecoq M, Livoreil B, Laouenan C
How effective are strategies to control the dissemination of antibiotic resistance in the environment? A systematic review.
Environmental Evidence 2020, 9, 4.

Thy M, Tanaka S, Tran-Dinh A, Ribeiro L, Lortat-Jacob B, Donadio J, Zappella N, Ben-Rehouma M, Tashk P, Snauwaert A, Atchade E, Grall N, Montravers P
Dynamic Changes in Microbial Composition During Necrotizing Soft-Tissue Infections in ICU Patients.
Frontiers in Medicine 2020, 7, 609497.

Pierre-Audigier C, Talla C, Alame-Emane AK, Audigier B, Grall N, Ruimy R, Andremont A, Cadet-Daniel V, Sola C, Takiff H, Gicquel B, Vray M, Armand-Lefevre L
Tuberculosis trends in a hot-spot region in Paris, France.
The International Journal of Tuberculosis and Lung Disease: The Official Journal of the International Union Against Tuberculosis and Lung Disease 2020, 24, 428-435.

Roux P, Josselin LB, Grall N, Dumonceau O, Leport C
[Recurrent urinary tract infections in men: how to avoid antibiotics].
La Revue Du Praticien 2020, 70, 1053-1057.

2019


Dinh A, Hallouin-Bernard MC, Davido B, Lemaignen A, Bouchand F, Duran C, Even A, Denys P, Perrouin-Verbe B, Sotto A, Lavigne JP, Bruyère F, Grall N, Tavernier E, Bernard L
Weekly sequential antibioprophylaxis for recurrent UTI among patients with neurogenic bladder: a randomized controlled trial.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2019

Burdet C, Grall N, Linard M, Bridier-Nahmias A, Benhayoun M, Bourabha K, Magnan M, Clermont O, d'Humières C, Tenaillon O, Denamur E, Massias L, Tubiana S, Alavoine L, Andremont A, Mentré F, Duval X, CEREMI Group
Ceftriaxone and Cefotaxime Have Similar Effects on the Intestinal Microbiota in Human Volunteers Treated by Standard-Dose Regimens.
Antimicrobial Agents and Chemotherapy 2019, 63, e02244-18.

Calais J, Touati A, Grall N, Laouénan C, Benali K, Mahida B, Vigne J, Hyafil F, Iung B, Duval X, Lepage L, Le Guludec D, Rouzet F
Diagnostic Impact of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and White Blood Cell SPECT/Computed Tomography in Patients With Suspected Cardiac Implantable Electronic Device Chronic Infection.
Circulation. Cardiovascular Imaging 2019, 12, e007188.

Perrineau S, Lachâtre M, Lê MP, Rioux C, Loubet P, Fréchet-Jachym M, Gonzales MC, Grall N, Bouvet E, Veziris N, Yazdanpanah Y, Peytavin G
Long-term plasma pharmacokinetics of bedaquiline for multidrug- and extensively drug-resistant tuberculosis.
The International Journal of Tuberculosis and Lung Disease 2019, 23, 99-104.

2018


Loubet P, Burdet C, Vindrios W, Grall N, Wolff M, Yazdanpanah Y, Andremont A, Duval X, Lescure FX
Cefazolin versus anti-staphylococcal penicillins for treatment of methicillin-susceptible Staphylococcus aureus bacteraemia: a narrative review.
Clin Microbiol Infect 2018, 24, 125-132.

Ruppe E, Burdet C, Grall N, de Lastours V, Lescure FX, Andremont A, Armand-Lefevre L
Impact of antibiotics on the intestinal microbiota needs to be re-defined to optimize antibiotic usage.
Clin Microbiol Infect 2018, 24, 3-5.

Bleibtreu A, Grall N, Laissy JP, Rioux C, Strukov A, Lariven S, Yeni P, Yazdanpanah Y, Joly V
Contribution of brain imaging to the diagnosis of intracranial tuberculoma and other brain lesions in patients presenting with miliary tuberculosis.
Medecine Et Maladies Infectieuses 2018, 48, 533-539.

Gras J, De Castro N, Montlahuc C, Champion L, Scemla A, Matignon M, Lachâtre M, Raskine L, Grall N, Peraldi MN, Molina JM
Clinical characteristics, risk factors, and outcome of tuberculosis in kidney transplant recipients: A multicentric case-control study in a low-endemic area.
Transplant Infectious Disease: An Official Journal of the Transplantation Society 2018, 20, e12943.

Burdet C, Loubet P, Le Moing V, Vindrios W, Esposito-Farèse M, Linard M, Ferry T, Massias L, Tattevin P, Wolff M, Vandenesch F, Grall N, Quintin C, Mentré F, Duval X, Lescure FX, CloCeBa study group
Efficacy of cloxacillin versus cefazolin for methicillin-susceptible Staphylococcus aureus bacteraemia (CloCeBa): study protocol for a randomised, controlled, non-inferiority trial.
BMJ open 2018, 8, e023151.

Tanaka S, Geneve C, Tebano G, Grall N, Piednoir P, Bronchard R, Godement M, Atchade E, Augustin P, Mal H, Castier Y, Montravers P, Desmard M
Morbidity and mortality related to pneumonia and TRACHEOBRONCHITIS in ICU after lung transplantation.
BMC pulmonary medicine 2018, 18, 43.

Alqarni A, Kantor E, Grall N, Tanaka S, Zappella N, Godement M, Ribeiro-Parenti L, Tran-Dinh A, Montravers P
Clinical characteristics and prognosis of bacteraemia during postoperative intra-abdominal infections.
Critical Care (London, England) 2018, 22, 175.

Goulas A, Livoreil B, Grall N, Benoit P, Couderc-Obert C, Dagot C, Patureau D, Petit F, Laouénan C, Andremont A
What are the effective solutions to control the dissemination of antibiotic resistance in the environment? A systematic review protocol.
Environmental Evidence 2018, 7, 3.

2017


Grall N, Lazarevic V, Gaia N, Couffignal C, Laouenan C, Ilic-Habensus E, Wieder I, Plesiat P, Angebault C, Bougnoux ME, Armand-Lefevre L, Andremont A, Duval X, Schrenzel J
Unexpected persistence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in the faecal microbiota of hospitalised patients treated with imipenem.
Int J Antimicrob Agents 2017, 50, 81-87.

Delory T, Ferrand H, Grall N, Casalino E, Lafarge M, Melot B, Hajage D, Charpentier C, Aubier M, Tubach F, Bouvet E, Gault N, Yazdanpanah Y
Score for pulmonary tuberculosis in patients with clinical presumption of tuberculosis in a low-prevalence area.
Int J Tuberc Lung Dis 2017, 21, 1272-1279.

2016


Poirier C, Dinh A, Salomon J, Grall N, Andremont A, Bernard L
Prevention of urinary tract infections by antibiotic cycling in spinal cord injury patients and low emergence of multidrug resistant bacteria.
Médecine Et Maladies Infectieuses 2016, 46, 294-299.

Collarino R, Vergeylen U, Emeraud C, Latournèrie G, Grall N, Mammeri H, Messika-Zeitoun D, Vallois D, Yazdanpanah Y, Lescure FX, Bleibtreu A
Mitral endocarditis due to Rothia aeria with cerebral haemorrhage and femoral mycotic aneurysms, first French description.
New Microbes and New Infections 2016, 13, 40-42.

Montravers P, Augustin P, Grall N, Desmard M, Allou N, Marmuse JP, Guglielminotti J
Characteristics and outcomes of anti-infective de-escalation during health care-associated intra-abdominal infections.
Critical Care (London, England) 2016, 20, 83.

2015


Poirier C, Dinh A, Salomon J, Grall N, Andremont A, Bernard L
Antibiotic cycling prevents urinary tract infections in spinal cord injury patients and limits the emergence of multidrug resistant organism.
The Journal of Infection 2015

Grall N, Barraud O, Wieder I, Hua A, Perrier M, Babosan A, Gaschet M, Clermont O, Denamur E, Catzeflis F, Decré D, Ploy MC, Andremont A
Lack of dissemination of acquired resistance to β-lactam in small wild mammals around an isolated village in the Amazonian forest.
Environmental Microbiology Reports 2015

Tebano G, Geneve C, Tanaka S, Grall N, Atchade E, Augustin P, Thabut G, Castier Y, Montravers P, Desmard M
Epidemiology and risk factors of multidrug-resistant bacteria in respiratory samples after lung transplantation.
Transplant Infectious Disease: An Official Journal of the Transplantation Society 2015

2014


Hurmic O, Grall N, Al Nakib M, Poyart C, Grondin S, Ploy MC, Varon E, Raymond J, The ORP Ile de France-Ouest Network
Evidence of a clonal expansion of Streptococcus pneumoniae serotype 19A in adults as in children assessed by the DiversiLab® system.
European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology 2014

2013


Gravey F, Galopin S, Grall N, Auzou M, Andremont A, Leclercq R, Cattoir V
Lincosamide resistance mediated by lnu(C) (L phenotype) in a Streptococcus anginosus clinical isolate.
The Journal of Antimicrobial Chemotherapy 2013, 68, 2464-2467.

Grall N, Massias L, Nguyen TT, Sayah-Jeanne S, Ducrot N, Chachaty E, de Gunzburg J, Andremont A
Oral DAV131, a charcoal-based adsorbent, inhibits intestinal colonization by β-lactam-resistant Klebsiella pneumoniae in cefotaxime-treated mice.
Antimicrobial Agents and Chemotherapy 2013, 57, 5423–5425.

2012


Bille E, Dauphin B, Leto J, Bougnoux ME, Beretti JL, Lotz A, Suarez S, Meyer J, Join-Lambert O, Descamps P, Grall N, Mory F, Dubreuil L, Berche P, Nassif X, Ferroni A
MALDI-TOF MS Andromas strategy for the routine identification of bacteria, mycobacteria, yeasts, Aspergillus spp. and positive blood cultures.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2012, 18, 1117-1125.

2009


Grall N, Livny J, Waldor M, Barel M, Charbit A, Meibom KL
Pivotal role of the Francisella tularensis heat-shock sigma factor RpoH..
Microbiology (Reading, England) 2009, 155, 2560-2572.