Members
First name: Typhaine Last name: Billard-Pomares Function: Clinical Microbiologist Position: Hospital Practitioner Email: typhaine.billard-pomares aphp.fr |
Research interest
My works focus on epidemiology and genomic comparison of bacterial strains of medical interest.
Initially, in order to better understand the evolutionary success of certain strains of Escherichia coli resistant to antibiotics, genomic comparison was applied to strains of E. coli at the level of the genome and at the scale of the plasmids carried by these strains.
Then, as hospital practitioner in a area where Tuberculosis is of high incidence, my works focus on strains of M. tuberculosis to explore epidemiological and phylogenetic characteristics of these circulating strains.
Education
Degree
2014: Ph. D. in Microbiology, Paris 7 University
2009 : Master in Microbiology, Paris XI University
2008 : Pharmaceutical degree and DES of Medical Biology, Lille II University
2009 : Master in Microbiology, Paris XI University
2008 : Pharmaceutical degree and DES of Medical Biology, Lille II University
Academic positions
2016-present : Hospital Practitioner in Microbiology, AP-HP
2009-2015 : Assistant in Microbiology, AP-HP
2004-2008: Resident in Medical Biology, Lille II University
2009-2015 : Assistant in Microbiology, AP-HP
2004-2008: Resident in Medical Biology, Lille II University
Research training (post doctoral)
2014-present: Member of the team EVRest IAME INSERM UMR 1137
2009-2014: Researcher in the INSERM unit U722 « Ecology and evolution of microorganisms » Paris Diderot.
2009-2014: Researcher in the INSERM unit U722 « Ecology and evolution of microorganisms » Paris Diderot.
List of the main publications
Quagliaro P, Dziri S, Magdoud El Alaoui F, Saint Louis P, de Pontual L, Marin J, Carbonnelle E, Billard-Pomares T
Performances of bioinformatics tools for the analysis of sequencing data of Mycobacterium tuberculosis complex strains.
Tuberculosis (Edinburgh, Scotland) 2023, 139, 102324.
Billard-Pomares T, Marin J, Quagliaro P, Méchaï F, Walewski V, Dziri S, Carbonnelle E
Use of Whole-Genome Sequencing to Explore Mycobacterium tuberculosis Complex Circulating in a Hotspot Department in France.
Microorganisms 2022, 10, 1586.
Billard-Pomares T, Clermont O, Castellanos M, Magdoud F, Royer G, Condamine B, Fouteau S, Barbe V, Roche D, Cruveiller S, Médigue C, Pognard D, Glodt J, Dion S, Rigal O, Picard B, Denamur E, Branger C
The Arginine Deiminase Operon Is Responsible for a Fitness Trade-Off in Extended-Spectrum-β-Lactamase-Producing Strains of Escherichia coli.
Antimicrobial Agents and Chemotherapy 2019, 63,
Billard-Pomares T, Fouteau S, Jacquet ME, Roche D, Barbe V, Castellanos M, Bouet JY, Cruveiller S, Médigue C, Blanco J, Clermont O, Denamur E, Branger C
Characterization of a P1-like bacteriophage encoding an SHV-2 extended-spectrum β-lactamase from an Escherichia coli strain.
Antimicrobial Agents and Chemotherapy 2014
Performances of bioinformatics tools for the analysis of sequencing data of Mycobacterium tuberculosis complex strains.
Tuberculosis (Edinburgh, Scotland) 2023, 139, 102324.
Billard-Pomares T, Marin J, Quagliaro P, Méchaï F, Walewski V, Dziri S, Carbonnelle E
Use of Whole-Genome Sequencing to Explore Mycobacterium tuberculosis Complex Circulating in a Hotspot Department in France.
Microorganisms 2022, 10, 1586.
Billard-Pomares T, Clermont O, Castellanos M, Magdoud F, Royer G, Condamine B, Fouteau S, Barbe V, Roche D, Cruveiller S, Médigue C, Pognard D, Glodt J, Dion S, Rigal O, Picard B, Denamur E, Branger C
The Arginine Deiminase Operon Is Responsible for a Fitness Trade-Off in Extended-Spectrum-β-Lactamase-Producing Strains of Escherichia coli.
Antimicrobial Agents and Chemotherapy 2019, 63,
Billard-Pomares T, Fouteau S, Jacquet ME, Roche D, Barbe V, Castellanos M, Bouet JY, Cruveiller S, Médigue C, Blanco J, Clermont O, Denamur E, Branger C
Characterization of a P1-like bacteriophage encoding an SHV-2 extended-spectrum β-lactamase from an Escherichia coli strain.
Antimicrobial Agents and Chemotherapy 2014
Exhaustive list of publications
2023
Quagliaro P, Dziri S, Magdoud El Alaoui F, Saint Louis P, de Pontual L, Marin J, Carbonnelle E, Billard-Pomares T
Performances of bioinformatics tools for the analysis of sequencing data of Mycobacterium tuberculosis complex strains.
Tuberculosis (Edinburgh, Scotland) 2023, 139, 102324.
Senelle G, Sahal MR, La K, Billard-Pomares T, Marin J, Mougari F, Bridier-Nahmias A, Carbonnelle E, Cambau E, Refrégier G, Guyeux C, Sola C
Towards the reconstruction of a global TB history using a new pipeline "TB-Annotator".
Tuberculosis (Edinburgh, Scotland) 2023, 143S, 102376.
2022
Grall-Zahar I, Rucly S, Billard-Pomares T, Gasnier-Besnardeau K, Al Mouft O, Zahar JR, Zirnhelt I
Prevalence and risk factors for carriage of extended-spectrum β-lactamase-producing enterobacteriaceae in rehabilitation wards in France.
Infectious Diseases Now 2022, 52, 403-407.
Méchaï F, Bachelet D, Han L, Dubert M, Parisey M, Cordel H, Bourgarit A, Bertrac C, Chauveau S, Billard-Pomares T, Carbonnelle E, Bouchaud O, Yazdanpanah Y, Vignier N, Laouénan C
Tuberculosis treatment outcomes among precarious patients in France.
Infectious Diseases Now 2022, 52, 389-395.
Bachir M, Guglielmetti L, Tunesi S, Billard-Pomares T, Chiesi S, Jaffré J, Langris H, Pourcher V, Schramm F, Lemaître N, Robert J, Isoniazid Resistance Group
Molecular detection of isoniazid monoresistance improves tuberculosis treatment: A retrospective cohort in France.
The Journal of Infection 2022, 85, 24-30.
Billard-Pomares T, Marin J, Quagliaro P, Méchaï F, Walewski V, Dziri S, Carbonnelle E
Use of Whole-Genome Sequencing to Explore Mycobacterium tuberculosis Complex Circulating in a Hotspot Department in France.
Microorganisms 2022, 10, 1586.
2021
Farfour E, Si Larbi AG, Cattoir V, Corvec S, Guillard T, Grillon A, Isnard C, Mérens A, Degand N, Billard-Pomares T, Fournier D, Bille E, Le Brun C, Plouzeau C, Flevin E, Yin N, Woerther PL, Lourtet J, Lesprit P, Le Monnier A, GMC study group
Temocillin susceptibility among Enterobacterales strains recovered from blood culture in France.
Diagnostic Microbiology and Infectious Disease 2021, 100, 115368.
Bachir M, Guglielmetti L, Tunesi S, Billard-Pomares T, Chiesi S, Jaffré J, Langris H, Pourcher V, Schramm F, Lemaître N, Robert J, Isoniazid Resistance Group
Isoniazid-monoresistant tuberculosis in France: Risk factors, treatment outcomes and adverse events.
International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases 2021, 107, 86-91.
Gressens SB, Billard-Pomares T, Leboité H, Cruaud P, Bouchaud O, Carbonnelle E, Méchaï F
Pulmonary tuberculosis: Evaluation of current diagnostic strategy.
Infectious Diseases Now 2021, 51, 273-278.
2020
Pilmis B, Billard-Pomares T, Martin M, Clarempuy C, Lemezo C, Saint-Marc C, Bourlon N, Seytre D, Carbonnelle E, Zahar JR
Can environmental contamination be explained by particular traits associated with patients?.
The Journal of Hospital Infection 2020, 104, 293-297.
Onorati I, Guiraudet P, Billard-Pomares T, Martinod E
A recurrent lung abscess caused by delayed diagnosis of unique co-infection with Abiotrophia defectiva.
Interactive Cardiovascular and Thoracic Surgery 2020, 31, 909-911.
Izri A, Aljundi M, Billard-Pomares T, Fofana Y, Marteau A, Ferreira TG, Brun S, Caux F, Akhoundi M
Molecular identification of Actinomadura madurae isolated from a patient originally from Algeria; observations from a case report.
BMC infectious diseases 2020, 20, 829.
2019
Delerue T, Cordel H, Delerue T, Figoni J, Dziri S, Billard-Pomares T, Bouchaud O, Carbonnelle E, Zahar JR
Prediction of methicillin-resistant Staphylococcus aureus bloodstream infection: do we need rapid diagnostic tests?.
European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology 2019, 38, 1319-1326.
Billard-Pomares T, Bleibtreu A, Walewski V, Dziri S, Barbat A, Zahar JR, Cruaud P, Carbonnelle E
Proposition of a safe Mycobacterium tuberculosis complex denaturation method that does not compromise the integrity of DNA for whole-genome sequencing.
Tuberculosis 2019, 117, 62-64.
Branger C, Ledda A, Billard-Pomares T, Doublet B, Barbe V, Roche D, Médigue C, Arlet G, Denamur E
Specialization of small non-conjugative plasmids in Escherichia coli according to their family types.
Microbial Genomics 2019
Billard-Pomares T, Clermont O, Castellanos M, Magdoud F, Royer G, Condamine B, Fouteau S, Barbe V, Roche D, Cruveiller S, Médigue C, Pognard D, Glodt J, Dion S, Rigal O, Picard B, Denamur E, Branger C
The Arginine Deiminase Operon Is Responsible for a Fitness Trade-Off in Extended-Spectrum-β-Lactamase-Producing Strains of Escherichia coli.
Antimicrobial Agents and Chemotherapy 2019, 63,
La Combe B, Clermont O, Messika J, Eveillard M, Kouatchet A, Lasocki S, Corvec S, Lakhal K, Billard-Pomares T, Fernandes R, Armand-Lefevre L, Bourdon S, Reignier J, Fihman V, de Prost N, Bador J, Goret J, Wallet F, Denamur E, Ricard JD, COLOCOLI group, COLOCOLI Group
Pneumonia-Specific Escherichia coli with Distinct Phylogenetic and Virulence Profiles, France, 2012-2014.
Emerging Infectious Diseases 2019, 25, 710-718.
Ternois I, Billard-Pomares T, Carbonelle E, Franchinard L, Duclos C
Using SNOMED-CT to Help the Transition from Microbiological Data to ICD-10 Sepsis Codes..
Studies in health technology and informatics 2019, 264, 1604-1605.
Maillet F, Bonnet N, Billard-Pomares T, El Alaoui Magdoud F, Tandjaoui-Lambiotte Y
Fatal Legionella pneumophila serogroup 1 pleural empyema: A case report..
World journal of critical care medicine 2019, 8, 99-105.
2018
La Combe B, Bleibtreu A, Messika J, Fernandes R, Clermont O, Branger C, Billard-Pomares T, Barnaud G, Magdoud F, Eveillard M, Kouatchet A, Lasocki S, Asfar P, Corvec S, Lakhal K, Armand-Lefevre L, Wolff M, Timsit JF, Bourdon S, Reignier J, Martin S, Fihman V, de Prost N, Bador J, Charles PE, Goret J, Boyer A, Wallet F, Jaillette E, Nseir S, Landraud L, Ruimy R, Danin PE, Dellamonica J, Cremniter J, Frat JP, Jauréguy F, Clec'h C, Decré D, Maury E, Dreyfuss D, Denamur E, Ricard JD
Decreased susceptibility to chlorhexidine affects a quarter of Escherichia coli isolates responsible for pneumonia in ICU patients.
Intensive Care Medicine 2018, 44, 531-533.
Jauréguy F, Mansour H, Bigot J, Walewski V, Billard-Pomares T, Rahajamanana L, Picard B, Carbonnelle E
Use of the Xpert CarbaR assay for direct detection of carbapenemase genes from blood cultures and urine samples.
The Journal of Hospital Infection 2018, 98, 245-246.
La Combe B, Mahérault AC, Messika J, Billard-Pomares T, Branger C, Landraud L, Dreyfuss D, Dib F, Massias L, Ricard JD
Oropharyngeal Bacterial Colonization after Chlorhexidine Mouthwash in Mechanically Ventilated Critically Ill Patients.
Anesthesiology 2018, 129, 1140-1148.
Branger C, Ledda A, Billard-Pomares T, Doublet B, Fouteau S, Barbe V, Roche D, Cruveiller S, Médigue C, Castellanos M, Decré D, Drieux-Rouze L, Clermont O, Glodt J, Tenaillon O, Cloeckaert A, Arlet G, Denamur E
Extended-spectrum β-lactamase-encoding genes are spreading on a wide range of Escherichia coli plasmids existing prior to the use of third-generation cephalosporins.
Microbial Genomics 2018
2017
Billard-Pomares T, Rouyer C, Walewski V, Badell-Ocando E, Dumas M, Zumelzu C, Jaureguy F, Brisse S, Caux F, Bouchaud O, Carbonnelle E
Diagnosis in France of a Non-Toxigenic tox Gene-Bearing Strain of Corynebacterium diphtheriae in a Young Male Back From Senegal.
Open Forum Infectious Diseases 2017, 4, ofw271.
2016
Walewski V, Méchaï F, Billard-Pomares T, Juguet W, Jauréguy F, Picard B, Tandjaoui-Lambiotte Y, Carbonnelle E, Bouchaud O
MALDI-TOF MS contribution to diagnosis of melioidosis in a nonendemic country in three French travellers.
New Microbes and New Infections 2016, 12, 31-34.
Hauser L, Menasie S, Bonacorsi S, Raoult L, AitOubelli N, Belloy M, Avran D, Beyloune A, Simonet M, Billard-Pomares T, Pangon B, Bierling P
Fatal transfusion-transmitted infection due to Citrobacter koseri.
Transfusion 2016, 56, 1311-1313.
2015
Fihman V, Messika J, Hajage D, Tournier V, Gaudry S, Magdoud F, Barnaud G, Billard-Pomares T, Branger C, Dreyfuss D, Ricard JD
Five-year trends for ventilator-associated pneumonia: Correlation between microbiological findings and antimicrobial drug consumption.
International Journal of Antimicrobial Agents 2015, 46, 518-525.
2014
Messika J, Sztrymf B, Bertrand F, Billard-Pomares T, Barnaud G, Branger C, Dreyfuss D, Ricard JD
Risks of nonsteroidal antiinflammatory drugs in undiagnosed intensive care unit pneumococcal pneumonia: Younger and more severely affected patients.
Journal of Critical Care 2014, 29, 733-738.
Billard-Pomares T, Fouteau S, Jacquet ME, Roche D, Barbe V, Castellanos M, Bouet JY, Cruveiller S, Médigue C, Blanco J, Clermont O, Denamur E, Branger C
Characterization of a P1-like bacteriophage encoding an SHV-2 extended-spectrum β-lactamase from an Escherichia coli strain.
Antimicrobial Agents and Chemotherapy 2014
2011
Billard-Pomares T, Herwegh S, Wizla-Derambure N, Turck D, Courcol R, Husson MO
Application of quantitative PCR to the diagnosis and monitoring of Pseudomonas aeruginosa colonization in 5-18-year-old cystic fibrosis patients..
Journal of medical microbiology 2011, 60, 157-161.
Billard-Pomares T, Tenaillon O, Le Nagard H, Rouy Z, Cruveiller S, Médigue C, Arlet G, Denamur E, Branger C
Complete nucleotide sequence of plasmid pTN48, encoding the CTX-M-14 extended-spectrum β-lactamase from an Escherichia coli O102-ST405 strain.
Antimicrobial Agents and Chemotherapy 2011, 55, 1270-1273.