Members

  First name: Drifa
  Last name: Belhadi
  Position: PhD student
  Email: drifa.belhadi
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inserm.fr

Research interest


PhD subject: Bayesian decision analysis to design clinical trials in the context of viral haemorrhagic fevers

Education

Degree

2014: MSc in statistics equivalent (Diplôme d’ingénieur), Ensai, Rennes
Specialization : Data Modelling for Spatial Analysis and Health Economics
2014: MSc in Health economics, Aix-Marseille School of Economics, Marseille

Exhaustive list of publications

2024


Siempos II, Kalil AC, Belhadi D, Veiga VC, Cavalcanti AB, Branch-Elliman W, Papoutsi E, Gkirgkiris K, Xixi NA, Kotanidou A, Hermine O, Porcher R, Mariette X, CORIMUNO-19 Collaborative Group, DisCoVeRy Study Group, ACTT-2 Study Group, ACTT-3 Study Group
Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials.
EClinicalMedicine 2024, 69, 102472.

Hites M, Massonnaud CR, Jamard S, Goehringer F, Danion F, Reignier J, de Castro N, Garot D, Lapique EL, Lacombe K, Tolsma V, Faure E, Malvy D, Staub T, Courjon J, Cazenave-Roblot F, Riise AMD, Leturnier P, Martin-Blondel G, Roger C, Akinosoglou K, Moing VL, Piroth L, Sellier P, Lescure X, Trøseid M, Clevenbergh P, Dalgard O, Gallien S, Gousseff M, Loubet P, Vardon-Bounes F, Visée C, Belkhir L, Botelho-Nevers É, Cabié A, Kotanidou A, Lanternier F, Rouveix-Nordon E, Silva S, Thiery G, Poignard P, Carcelain G, Diallo A, Mercier N, Terzic V, Bouscambert-Duchamp M, Gaymard A, Trabaud MA, Destras G, Josset L, Belhadi D, Billard N, Guedj J, Han THL, Couffin-Cadiergues S, Dechanet A, Delmas C, Esperou H, Fougerou-Leurent C, Mestre SL, Métois A, Noret M, Bally I, Dergan-Dylon S, Tubiana S, Kalif O, Bergaud N, Leveau B, Eustace J, Greil R, Hajdu E, Halanova M, Paiva JA, Piekarska A, Baño JR, Tonby K, Trojánek M, Tsiodras S, Unal S, Burdet C, Costagliola D, Yazdanpanah Y, Peiffer-Smadja N, Mentré F, Ader F, DisCoVeRy study group
Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): a phase 3, randomized, double-blind, placebo-controlled trial.
The Journal of Infection 2024, 106120.

2023


Mercier N, Belhadi D, DeChanet A, Delmas C, Saillard J, Dumousseaux M, Le Mestre S, Fougerou-Leurent C, Ferrane A, Burdet C, Espérou H, Ader F, Hites M, Peiffer-Smadja N, Poissy J, Andrejak C, Paiva JA, Tacconelli E, Staub T, Greil R, Costagliola D, Mentre F, Yazdanpanah Y, Diallo A, DisCoVeRy Safety Working group
Management of pharmacovigilance during the COVID-19 pandemic crisis by the safety department of an academic sponsor: Lessons learnt and challenges from the EU DisCoVeRy clinical trial.
Pharmacology Research & Perspectives 2023, 11, e01072.

Néant N, Lingas G, Gaymard A, Belhadi D, Hites M, Staub T, Greil R, Paiva JA, Poissy J, Peiffer-Smadja N, Costagliola D, Yazdanpanah Y, Bouscambert-Duchamp M, Gagneux-Brunon A, Ader F, Mentré F, Wallet F, Burdet C, Guedj J, DisCoVeRy study group
Association between SARS-CoV-2 viral kinetics and clinical score evolution in hospitalized patients.
CPT: pharmacometrics & systems pharmacology 2023, 12, 2027-2037.

Fougerou-Leurent C, Delmas C, Saillard J, Dumousseaux M, Ferrane A, Mercier N, Terzic V, Le Mestre S, Dechanet A, Belhadi D, Metois A, Burdet C, Mentré F, Noret M, Diallo A, Petrov-Sanchez V, Couffin-Cadiergues S, Hites M, Ader F, Esperou H
Ensuring quality control in a COVID-19 clinical trial during the pandemic: The experience of the Inserm C20-15 DisCoVeRy study.
Contemporary Clinical Trials 2023, 131, 107267.

Amstutz A, Speich B, Mentré F, Rueegg CS, Belhadi D, Assoumou L, Burdet C, Murthy S, Dodd LE, Wang Y, Tikkinen KAO, Ader F, Hites M, Bouscambert M, Trabaud MA, Fralick M, Lee TC, Pinto R, Barratt-Due A, Lund-Johansen F, Müller F, Nevalainen OPO, Cao B, Bonnett T, Griessbach A, Taji Heravi A, Schönenberger C, Janiaud P, Werlen L, Aghlmandi S, Schandelmaier S, Yazdanpanah Y, Costagliola D, Olsen IC, Briel M
Effects of remdesivir in patients hospitalised with COVID-19: a systematic review and individual patient data meta-analysis of randomised controlled trials.
The Lancet. Respiratory Medicine 2023, 11, 453-464.

2022


Ader F, Bouscambert-Duchamp M, Hites M, Peiffer-Smadja N, Poissy J, Belhadi D, Diallo A, Lê MP, Peytavin G, Staub T, Greil R, Guedj J, Paiva JA, Costagliola D, Yazdanpanah Y, Burdet C, Mentré F, DisCoVeRy Study Group
Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial.
The Lancet. Infectious Diseases 2022, 22, 209-221.

Lingas G, Néant N, Gaymard A, Belhadi D, Peytavin G, Hites M, Staub T, Greil R, Paiva JA, Poissy J, Peiffer-Smadja N, Costagliola D, Yazdanpanah Y, Wallet F, Gagneux-Brunon A, Mentré F, Ader F, Burdet C, Guedj J, Bouscambert-Duchamp M
Effect of remdesivir on viral dynamics in COVID-19 hospitalized patients: a modelling analysis of the randomized, controlled, open-label DisCoVeRy trial.
The Journal of Antimicrobial Chemotherapy 2022, 77, 1404-1412.

David C, Duployez N, Eloy P, Belhadi D, Chezel J, Guern VL, Laouénan C, Fenwarth L, Rouzaud D, Mathian A, de Almeida Chaves S, Duhaut P, Fain O, Galicier L, Ghillani-Dalbin P, Kahn JE, Morel N, Perard L, Pha M, Sarrot-Reynauld F, Aumaitre O, Chasset F, Limal N, Desmurs-Clavel H, Ackermann F, Amoura Z, Papo T, Preudhomme C, Costedoat-Chalumeau N, Sacre K
Clonal haematopoiesis of indeterminate potential and cardiovascular events in systemic lupus erythematosus (HEMATOPLUS study).
Rheumatology (Oxford, England) 2022, 61, 4355-4363.

David C, Costedoat-Chalumeau N, Belhadi D, Laouénan C, Boutten A, Chezel J, Rouzaud D, Dehoux M, Guern VL, Mathian A, Chaves SdA, Duhaut P, Fain O, Galicier L, Ghillani-Dalbin P, Kahn JE, Morel N, Perard L, Pha M, Sarrot-Reynauld F, Aumaitre O, Chasset F, Limal N, Desmurs-Clavel H, Ackermann F, Amoura Z, Papo T, Sacre K
Soluble CD163 and incident cardiovascular events in patients with systemic lupus erythematosus: An observational cohort study.
Journal of Internal Medicine 2022, 292, 536-539.

Dauriat G, Reynaud-Gaubert M, Cottin V, Lamia B, Montani D, Belhadi D, Humbert M, Laouenan C, Mal H, French group of investigators on severe PH-COPD
Severe pulmonary hypertension associated with COPD: long-term results of a prospective French multicentre cohort.
The European Respiratory Journal 2022, 60, 2102897.

Belhadi D, El Baied M, Mulier G, Malvy D, Mentré F, Laouénan C
The number of cases, mortality and treatments of viral hemorrhagic fevers: A systematic review.
PLoS neglected tropical diseases 2022, 16, e0010889.

2021


Beauplet B, Soulie O, Niemier JY, Pons-Peyneau C, Belhadi D, Couffignal C, Fossey-Diaz V
Dealing with the lack of evidence to treat depression in older patients with cancer: French Societies of Geriatric Oncology (SOFOG) and PsychoOncology (SFFPO) position paper based on a systematic review.
Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer 2021, 29, 563-571.

Ader F, Peiffer-Smadja N, Poissy J, Bouscambert-Duchamp M, Belhadi D, Diallo A, Delmas C, Saillard J, Dechanet A, Mercier N, Dupont A, Alfaiate T, Lescure FX, Raffi F, Goehringer F, Kimmoun A, Jaureguiberry S, Reignier J, Nseir S, Danion F, Clere-Jehl R, Bouiller K, Navellou JC, Tolsma V, Cabié A, Dubost C, Courjon J, Leroy S, Mootien J, Gaci R, Mourvillier B, Faure E, Pourcher V, Gallien S, Launay O, Lacombe K, Lanoix JP, Makinson A, Martin-Blondel G, Bouadma L, Botelho-Nevers E, Gagneux-Brunon A, Epaulard O, Piroth L, Wallet F, Richard JC, Reuter J, Staub T, Lina B, Noret M, Andrejak C, Lê MP, Peytavin G, Hites M, Costagliola D, Yazdanpanah Y, Burdet C, Mentré F, DisCoVeRy study group
An open-label randomized controlled trial of the effect of lopinavir/ritonavir, lopinavir/ritonavir plus IFN-β-1a and hydroxychloroquine in hospitalized patients with COVID-19.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2021, 27, 1826-1837.

Dauriat G, Reynaud-Gaubert M, Cottin V, Lamia B, Montani D, Canuet M, Boissin C, Tromeur C, Chaouat A, Degano B, Bergot E, Sanchez O, Prevot G, Sitbon O, Thabut G, Belhadi D, de Beauregard YC, Bencherif A, Humbert M, Simonneau G, Laouenan C, Mal H
Severe pulmonary hypertension associated with chronic obstructive pulmonary disease: A prospective French multicenter cohort.
The Journal of Heart and Lung Transplantation: The Official Publication of the International Society for Heart Transplantation 2021, 40, 1009-1018.

Sallard E, Belhadi D, Lescure FX, Yazdanpanah Y, Peiffer-Smadja N
Clinical trial protocols of repurposed prophylaxis for COVID-19: A review.
Infectious Diseases Now 2021, 51, 7-13.

Chezel J, Costedoat-Chalumeau N, Laouénan C, Rouzaud D, Chenevier-Gobeaux C, Le Guern V, Mathian A, Belhadi D, de Almeida Chaves S, Duhaut P, Fain O, Galicier L, Ghillani-Dalbin P, Kahn JE, Morel N, Perard L, Pha M, Saidoune F, Sarrot-Reynauld F, Aumaitre O, Chasset F, Limal N, Desmurs-Clavel H, Ackermann F, Amoura Z, Papo T, Sacre K
Highly sensitive serum cardiac troponin T and cardiovascular events in patients with systemic lupus erythematosus (TROPOPLUS study).
Rheumatology (Oxford, England) 2021, 60, 1210-1215.

Manchon P, Belhadi D, Mentré F, Laouénan C
Evaluation by simulation of clinical trial designs for evaluation of treatment during a viral haemorrhagic fever outbreak.
BMC medical research methodology 2021, 21, 98.

Périllaud-Dubois C, Belhadi D, Laouénan C, Mandelbrot L, Picone O, Vauloup-Fellous C
Current practices of management of maternal and congenital Cytomegalovirus infection during pregnancy after a maternal primary infection occurring in first trimester of pregnancy: Systematic review.
PloS One 2021, 16, e0261011.

2020


Fragkou PC, Belhadi D, Peiffer-Smadja N, Moschopoulos CD, Lescure FX, Janocha H, Karofylakis E, Yazdanpanah Y, Mentré F, Skevaki C, Laouénan C, Tsiodras S, ESCMID Study Group for Respiratory Viruses
Review of trials currently testing treatment and prevention of COVID-19.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2020, 26, 988-998.

Dupin C, Belhadi D, Guilleminault L, Gamez AS, Berger P, De Blay F, Bonniaud P, Leroyer C, Mahay G, Girodet PO, Raherison C, Fry S, Le Bourdellès G, Proust A, Rosencher L, Garcia G, Bourdin A, Chenivesse C, Didier A, Couffignal C, Taillé C
Effectiveness and safety of dupilumab for the treatment of severe asthma in a real-life French multi-centre adult cohort.
Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 2020, 50, 789-798.

Dodd LE, Follmann D, Wang J, Koenig F, Korn LL, Schoergenhofer C, Proschan M, Hunsberger S, Bonnett T, Makowski M, Belhadi D, Wang Y, Cao B, Mentre F, Jaki T
Endpoints for randomized controlled clinical trials for COVID-19 treatments.
Clinical Trials (London, England) 2020, 17, 472-482.

Goulas A, Belhadi D, Descamps A, Andremont A, Benoit P, Courtois S, Dagot C, Grall N, Makowski D, Nazaret S, Nelieu S, Patureau D, Petit F, Roose-Amsaleg C, Vittecoq M, Livoreil B, Laouenan C
How effective are strategies to control the dissemination of antibiotic resistance in the environment? A systematic review.
Environmental Evidence 2020, 9, 4.

Estrella Porter J, Camacho M, Viteri MI, Aguilar K, Belhadi D, Bettoli V, Buestán ADR, Dréno B, Endara P, Layton A, Machado N, Mateus R, Tan J, Terán E, Yépez P, Guillemot J
Pilot study for the evaluation and adaptation of a Four Item-Acne-Scar Risk Assessment Tool (4-ASRAT): a resource to estimate the risk of acne-induced scars.
F1000Research 2020, 9, 651.

2019


Sanai FM, Alghamdi H, Alswat KA, Babatin MA, Ismail MH, Alhamoudi WK, Alalwan AM, Dahlan Y, Alghamdi AS, Alfaleh FZ, Aljumah AA, Altraif IH, Albeladi K, Batwa F, Alshumrani W, Belhadi D, Genestier V, Abdo AA
Greater prevalence of comorbidities with increasing age: Cross-sectional analysis of chronic hepatitis B patients in Saudi Arabia.
Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association 2019, 25, 194-200.

2018


Limosin F, Belhadi D, Comet D, Pacou M, Bouju S, Van Impe K, Guillon P
Comparison of Paliperidone Palmitate and Risperidone Long-Acting Injection in Schizophrenic Patients: Results From a Multicenter Retrospective Cohort Study in France.
Journal of Clinical Psychopharmacology 2018, 38, 19-26.