Maternal safety and safety indicators in obstetric anesthesia. Analysis of US administrative data Deciphering ethical assumptions about Stepped-Wedge Designs: The case of Ebola vaccine research Ethical concerns about randomizing persons to a no-treatment arm in the context of Ebola epidemic led to consideration of alternative designs. The stepped wedge (SW) design, in which participants or clusters are randomized to receive the experimental intervention at different time points, gained popularity. Common arguments in favor of using this design are when 1) an intervention is likely to do more good than harm, 2) all participants should receive the experimental intervention at some time point during the study, and 3) the design might be preferable for practical reasons. In this talk, I examine these assumptions when considering Ebola vaccine research, and provide an ethical analysis. "Cérémonie pour le renouvellement des 5 structures INSERM du site Bichat (IAME, PHERE de Marina Pretolani, LVTS de Didier Letourneur, CRI de Renato Monteiro, FRIM de François Rouzet)" ‘Nepotistic journals’: a survey of biomedical journals Kinetics of SARS-CoV-2 infection in the human upper and lower respiratory tracts, results from the Discovery trial Current practices of management of maternal Cytomegalovirus infection during first trimester of pregnancy: systematic review SARS-CoV-2 viral dynamics and the importance of Phase II antiviral trials Consommation de médicaments chez la femme enceinte. Étude des données de l'Assurance Maladie par une approche big data. "Dessine-moi un modèle": utilisation de réseaux de neurones pour le développement de simulateurs plus réalistes en analyse causale An Evolutionary Model of Progression to AIDS and Models of Spontaneous HIV Control Using vaccine Immunostimulation/Immunodynamic modelling methods to inform vaccine dose decision-making Multi-response Bayesian non-linear mixed-effects models: application of two recent HIV infection biomarkers Multilevel joint modelling to characterize association between individual lesions kinetics and survival under immunotherapy Individual dynamic predictions and their evaluation in joint analysis with non-linear longitudinal model and parametric competing risk model Remdesivir for the treatment of hospitalized patients with COVID-19 – the DisCoVeRy trial Computation of uncertainty at finite distance in model-based tests of treatment effects on clinical longitudinal data - application to the trial DisCoVeRY Anti-infectious agents prescribed before, during and after pregnancy in France. Study from the French National health database Understanding and controlling the spread of multi-resistant bacteria by analyzing and modeling interindividual interactions networks in hospital settings Using population based Kalman estimator to model COVID-19 epidemics in France: estimating the burden of SARS-Cov-2 and the effects of non-pharmaceutical interventions Conditional Bootstrap for nonlinear mixed effects models Joint Modelling of longitudinal and time-to-event data to earlier estimate the primary endpoint in the oncology Phase III clinical trial ICARIA Analyse et utilisations du papier Morris, 2019, "Using simulation studies to evaluate statistical methods" Evaluation of estimation algorithms in NLMEM with discrete data Clinical Therapeutics - a driver to modernization of tools and methods Mycobacterium tuberculosis bacillary clearance and treatment outcome The mortality, number of cases, sequelaes and treatments of viral haemorrhagic fevers: a systematic review Application of machine learning to estimate immunosuppressant exposure: towards a new way to perform therapeutic drug monitoring? Nested Rhat: assessing convergence of Markov chains Monte Carlo when running many short chains Modeling to assess the impact of variants on viral dynamics and infectiousness Development of a semi-mechanistic model to characterize the long-term dynamic of HBV markers during treatment with lamivudine and Peg-IFN Dynamic predictions of patient and kidney graft survival Evaluation of virological tools to diagnose maternal and congenital CMV infection Evaluating COVID-19 booster vaccination strategies in a partially vaccinated population: a modeling study. Non-Equilibrium Modeling: From Heat Transport to Immunology Bayesian toxicity modeling for dose regimen assessment in early phase oncology trials incorporating pharmacokinetics and pharmacodynamics Systems pharmacology to optimize drug combinations: case study of temozolomide-based chemotherapies Ecological Dynamics and Therapeutic Impacts of Bacteriophage -- a Not-So-Perfect Predator Preterm premature rupture of membranes in women living with HIV. Data from the French Perinatal Cohort ANRS-MIE-EPF CO1/CO11 Statistical methods in Pharmacometrics: present and future? Systems pharmacology to optimize drug combinations: case study of temozolomide-based chemotherapies Decision-making factors in the management of community acquired pneumonia (CAP) in general practice Joint modeling of the evolution of a biomarker by nonlinear mixed-effects models linked to a competing risk survival process: application to patients hospitalized for sepsis or SARS-COV-2 infection Epidemiology & modelling of zoonotic arbo-pathogens Algorithms and multiplex assays for integrated surveillance of malaria, coronaviruses, and neglected tropical diseases Cost-effectiveness of first trimester CMV primary infection screening in France Joint modeling of biomarkers’ kinetics and overall survival on patients infected by SARS-CoV-2 admitted in ICU: RICO cohort Impact of antiviral treatment on household transmission Test Site Variation and Sensitivity Time Trends in Covid Diagnostic Tests Impact of the lockdown on glycemic control in children with type 1 diabetes Bayesian high-dimensional variable selection in non-linear mixed-effects models using the SAEM algorithm In Silico Evaluation of pharmacokinetic optimization for Antimitogram-based clinical trials Multivariate Intrapatient Dose Escalation Algorithm (mIDEA) for targeted cancer therapy Projecting the antiviral efficacy of tecovirimat against mpox in humans Modeling placental transfer of antiviral drugs with ex vivo bolus injections Prevalence and factors associated of antibiotic exposure during pregnancy in a large French population-based study, 2010-2019 Computation of uncertainty at finite distance in model-based tests of treatment effects on clinical longitudinal data - application to the trial Discovery Modeling bacterial dynamics in the digestive tract: inference, adaptive immunity, and evolution. Quasi-experimental designs in community acquired severe pediatric infectious diseases Joint modeling with competing risks using Monolix and R softwares Modeling the long-term dynamics of HBV and HDV viral markers to optimize combination therapy Phylodynamics: using viral phylogenies in epidemiology Decison-making factors in the management of community acquired pneumonia (CAP) in general practice Impact of covariate model selection methods on covariate effects and their uncertainty in population pharmacokinetic analysis Joint modelling of ctDNA, tumour dynamics and progression-free-survival in metastatic colorectal cancer Middle-term impact of non-pharmaceutical interventions in lower respiratory tract infections in children : a time-series analysis. Translational medicine and machine learning in pharmacometrics. Some examples of how preclinical models derived from patients can improve clinical practice in oncology and some of artificial intelligence techniques in pharmacometrics. Influence de la rifampicine sur la pharmacocinétique de la clindamycine dans le traitement des infections osteo-articulaires. Infections périnatales et exposition aux traitements anti-infectieux pendant la grossesse Persistence-colonization trade-off and niche differentiation enable the coexistence of Escherichia coli phylogroups "Using serology and mathematical modeling to understand the risk of infection and pathogen circulation: Application to arbovirus, SARS-CoV-2, and Q fever" Statistical methods to derive robust evidence for longitudinal change and treatment effect in very small clinical trials for multisystemic ataxia Treatment strategies to avoid residents isolation in nursing home: modelling analysis Modeling the antiviral action of a monoclonal antibody on hospitalized patients infected with SARS-CoV-2, a randomized clinical trial: DisCoVeRy Contribution of joint modelling of biomarker dynamics and survival for therapeutic evaluation in oncology Design, methodological, and statistical practices in platform trials: a systematic review M2: Development of a semi-Bayesian algorithm for finite-distance estimation of parameter uncertainty in non-linear mixed-effects models L'analyse de la valeur de l'information en évaluation médico-économique : concept et application pratique Optimize antiviral efficacy of molnupiravir in Sars-COV-2-infected patients: findings from PANORAMIC trial Exposure to macrolides in early pregnancy and risk of major congenital malformations: A French population-based cohort study Pharmacocinétique du méropénème et de la pipéracilline sous épuration extra-rénale chez l'enfant en réanimation Impact of Covid-19 and associated lockdowns and non pharmaceutical interventions on the epidemiology of Childhood Osteomyelitis Unraveling mechanisms underlying control of HIV/SIV infections using mathematical modeling Pr Neumann: "Early prediction of hospitalization and symptomatic status and immune correlates of protection in asymptomatic COVID-19 patients" CORAL research platform: from cohorts to platform trials on Viral Hemorrhagic Fevers Modeling of in vivo bacteriophage dynamics and interactions with immune cells A Bayesian partition model for high-dimensional functional data The use of population pharmacokinetic models in routine clinical practice: description of relevant covariates and implementation of a dosage adjustment tool Données externes et comparaisons indirectes
Pr Dixit: "Predicting the efficacies of COVID-19 vaccines"