Members
First name: Jean-Francois Last name: Timsit Function: Head of the medical and infectious diseases ICU APHP Bichat Position: MD PhD Prof Email: jean-francois.timsit aphp.fr |
Research interest
sepsis
septic shock
nosocomial infections and multidrug resistant bacteria
determinants of prognosis
survival models
causal inference
high quality multicenter databases
Education
Degree
MD 1989
PhD 2002 epidemiology and clinical reaserch Nancy I
Research Habilitation 2000 Paris Diderot university
Professor of intensive care medicine 2004 Grenoble 1 university
PhD 2002 epidemiology and clinical reaserch Nancy I
Research Habilitation 2000 Paris Diderot university
Professor of intensive care medicine 2004 Grenoble 1 university
Academic positions
Professor of intensive care medicine Université Paris Cité, Paris France
Research training (post doctoral)
Epidemiology clinical and interventional
List of the main publications
Tabah A, Buetti N, Staiquly Q, Ruckly S, Akova M, Aslan AT, Leone M, Conway Morris A, Bassetti M, Arvaniti K, Lipman J, Ferrer R, Qiu H, Paiva JA, Povoa P, De Bus L, De Waele J, Zand F, Gurjar M, Alsisi A, Abidi K, Bracht H, Hayashi Y, Jeon K, Elhadi M, Barbier F, Timsit JF, EUROBACT-2 Study Group, ESICM, ESCMID ESGCIP and the OUTCOMEREA Network
Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study.
Intensive Care Medicine 2023, 49, 178-190.
Sonneville R, de Montmollin E, Contou D, Ferrer R, Gurjar M, Klouche K, Sarton B, Demeret S, Bailly P, da Silva D, Escudier E, Le Guennec L, Chabanne R, Argaud L, Ben Hadj Salem O, Thyrault M, Frerou A, Louis G, De Pascale G, Horn J, Helbok R, Geri G, Bruneel F, Martin-Loeches I, Taccone FS, De Waele JJ, Ruckly S, Staiquly Q, Citerio G, Timsit JF, EURECA Investigator Study Group
Clinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care (EURECA): an international prospective multicenter cohort study.
Intensive Care Medicine 2023, 49, 517-529.
Buetti N, Ruckly S, Souweine B, Mimoz O, Timsit JF
Risk of infections in intravascular catheters in situ for more than 10 days: a post hoc analysis of randomized controlled trials.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2023, 29, 1200.e1-1200.e5.
Galerneau LM, Bailly S, Terzi N, Ruckly S, Garrouste-Orgeas M, Cohen Y, Hong Tuan Ha V, Gainnier M, Siami S, Dupuis C, Darmon M, Forel JM, Rigault G, Adrie C, Goldgran-Toledano D, Laurent V, de Montmollin E, Argaud L, Reignier J, Pepin JL, Timsit JF, OUTCOMEREA Network
Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease in the ICU: An Observational Study From the OUTCOMEREA Database, 1997-2018.
Critical Care Medicine 2023, 51, 753-764.
Gaillet A, Azoulay E, de Montmollin E, Garrouste-Orgeas M, Cohen Y, Dupuis C, Schwebel C, Reignier J, Siami S, Argaud L, Adrie C, Mourvillier B, Ruckly S, Forel JM, Timsit JF
Outcomes in critically Ill HIV-infected patients between 1997 and 2020: analysis of the OUTCOMEREA multicenter cohort.
Critical Care (London, England) 2023, 27, 108.
Bouadma L, Mekontso-Dessap A, Burdet C, Merdji H, Poissy J, Dupuis C, Guitton C, Schwebel C, Cohen Y, Bruel C, Marzouk M, Geri G, Cerf C, Mégarbane B, Garçon P, Kipnis E, Visseaux B, Beldjoudi N, Chevret S, Timsit JF, COVIDICUS Study Group
High-Dose Dexamethasone and Oxygen Support Strategies in Intensive Care Unit Patients With Severe COVID-19 Acute Hypoxemic Respiratory Failure: The COVIDICUS Randomized Clinical Trial.
JAMA internal medicine 2022, 182, 906-916.
Lavalley-Morelle A, Timsit JF, Mentré F, Mullaert J, OUTCOMEREA network
Joint modeling under competing risks: Application to survival prediction in patients admitted in Intensive Care Unit for sepsis with daily Sequential Organ Failure Assessment score assessments.
CPT: pharmacometrics & systems pharmacology 2022, 11, 1472-1484.
Timsit JF, Paul M, Shields RK, Echols R, Baba T, Yamano Y, Portsmouth S
Cefiderocol for the Treatment of Infections Due To Metallo-Beta-Lactamase-Producing Pathogens in the CREDIBLE-CR And APEKS-NP Phase 3 Randomized Studies.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2022, ciac078.
Buetti N, Tabah A, Loiodice A, Ruckly S, Aslan AT, Montrucchio G, Cortegiani A, Saltoglu N, Kayaaslan B, Aksoy F, Murat A, Akdoğan Ö, Saracoglu KT, Erdogan C, Leone M, Ferrer R, Paiva JA, Hayashi Y, Ramanan M, Conway Morris A, Barbier F, Timsit JF, Eurobact 2 study group
Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study.
Critical Care (London, England) 2022, 26, 319.
Egea A, Dupuis C, de Montmollin E, Wicky PH, Patrier J, Jaquet P, Lefèvre L, Sinnah F, Marzouk M, Sonneville R, Bouadma L, Souweine B, Timsit JF
Augmented renal clearance in the ICU: estimation, incidence, risk factors and consequences-a retrospective observational study.
Annals of Intensive Care 2022, 12, 88.
Voiriot G, Fartoukh M, Durand-Zaleski I, Berard L, Rousseau A, Armand-Lefevre L, Verdet C, Argaud L, Klouche K, Megarbane B, Patrier J, Richard JC, Reignier J, Schwebel C, Souweine B, Tandjaoui-Lambiotte Y, Simon T, Timsit JF, MULTI-CAP study group
Combined use of a broad-panel respiratory multiplex PCR and procalcitonin to reduce duration of antibiotics exposure in patients with severe community-acquired pneumonia (MULTI-CAP): a multicentre, parallel-group, open-label, individual randomised trial conducted in French intensive care units.
BMJ open 2021, 11, e048187.
Timsit JF, Huntington JA, Wunderink RG, Shime N, Kollef MH, Kivistik Ü, Nováček M, Réa-Neto Á, Martin-Loeches I, Yu B, Jensen EH, Butterton JR, Wolf DJ, Rhee EG, Bruno CJ
Ceftolozane/tazobactam versus meropenem in patients with ventilated hospital-acquired bacterial pneumonia: subset analysis of the ASPECT-NP randomized, controlled phase 3 trial.
Critical Care (London, England) 2021, 25, 290.
Meyer A, Buetti N, Houhou-Fidouh N, Patrier J, Abdel-Nabey M, Jaquet P, Presente S, Girard T, Sayagh F, Ruckly S, Wicky PH, de Montmollin E, Bouadma L, Sonneville R, Descamps D, Timsit JF
HSV-1 reactivation is associated with an increased risk of mortality and pneumonia in critically ill COVID-19 patients.
Critical Care (London, England) 2021, 25, 417.
Papin G, Bailly S, Dupuis C, Ruckly S, Gainnier M, Argaud L, Azoulay E, Adrie C, Souweine B, Goldgran-Toledano D, Marcotte G, Gros A, Reignier J, Mourvillier B, Forel JM, Sonneville R, Dumenil AS, Darmon M, Garrouste-Orgeas M, Schwebel C, Timsit JF, OUTCOMEREA study group
Clinical and biological clusters of sepsis patients using hierarchical clustering.
PloS One 2021, 16, e0252793.
Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study.
Intensive Care Medicine 2023, 49, 178-190.
Sonneville R, de Montmollin E, Contou D, Ferrer R, Gurjar M, Klouche K, Sarton B, Demeret S, Bailly P, da Silva D, Escudier E, Le Guennec L, Chabanne R, Argaud L, Ben Hadj Salem O, Thyrault M, Frerou A, Louis G, De Pascale G, Horn J, Helbok R, Geri G, Bruneel F, Martin-Loeches I, Taccone FS, De Waele JJ, Ruckly S, Staiquly Q, Citerio G, Timsit JF, EURECA Investigator Study Group
Clinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care (EURECA): an international prospective multicenter cohort study.
Intensive Care Medicine 2023, 49, 517-529.
Buetti N, Ruckly S, Souweine B, Mimoz O, Timsit JF
Risk of infections in intravascular catheters in situ for more than 10 days: a post hoc analysis of randomized controlled trials.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2023, 29, 1200.e1-1200.e5.
Galerneau LM, Bailly S, Terzi N, Ruckly S, Garrouste-Orgeas M, Cohen Y, Hong Tuan Ha V, Gainnier M, Siami S, Dupuis C, Darmon M, Forel JM, Rigault G, Adrie C, Goldgran-Toledano D, Laurent V, de Montmollin E, Argaud L, Reignier J, Pepin JL, Timsit JF, OUTCOMEREA Network
Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease in the ICU: An Observational Study From the OUTCOMEREA Database, 1997-2018.
Critical Care Medicine 2023, 51, 753-764.
Gaillet A, Azoulay E, de Montmollin E, Garrouste-Orgeas M, Cohen Y, Dupuis C, Schwebel C, Reignier J, Siami S, Argaud L, Adrie C, Mourvillier B, Ruckly S, Forel JM, Timsit JF
Outcomes in critically Ill HIV-infected patients between 1997 and 2020: analysis of the OUTCOMEREA multicenter cohort.
Critical Care (London, England) 2023, 27, 108.
Bouadma L, Mekontso-Dessap A, Burdet C, Merdji H, Poissy J, Dupuis C, Guitton C, Schwebel C, Cohen Y, Bruel C, Marzouk M, Geri G, Cerf C, Mégarbane B, Garçon P, Kipnis E, Visseaux B, Beldjoudi N, Chevret S, Timsit JF, COVIDICUS Study Group
High-Dose Dexamethasone and Oxygen Support Strategies in Intensive Care Unit Patients With Severe COVID-19 Acute Hypoxemic Respiratory Failure: The COVIDICUS Randomized Clinical Trial.
JAMA internal medicine 2022, 182, 906-916.
Lavalley-Morelle A, Timsit JF, Mentré F, Mullaert J, OUTCOMEREA network
Joint modeling under competing risks: Application to survival prediction in patients admitted in Intensive Care Unit for sepsis with daily Sequential Organ Failure Assessment score assessments.
CPT: pharmacometrics & systems pharmacology 2022, 11, 1472-1484.
Timsit JF, Paul M, Shields RK, Echols R, Baba T, Yamano Y, Portsmouth S
Cefiderocol for the Treatment of Infections Due To Metallo-Beta-Lactamase-Producing Pathogens in the CREDIBLE-CR And APEKS-NP Phase 3 Randomized Studies.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2022, ciac078.
Buetti N, Tabah A, Loiodice A, Ruckly S, Aslan AT, Montrucchio G, Cortegiani A, Saltoglu N, Kayaaslan B, Aksoy F, Murat A, Akdoğan Ö, Saracoglu KT, Erdogan C, Leone M, Ferrer R, Paiva JA, Hayashi Y, Ramanan M, Conway Morris A, Barbier F, Timsit JF, Eurobact 2 study group
Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study.
Critical Care (London, England) 2022, 26, 319.
Egea A, Dupuis C, de Montmollin E, Wicky PH, Patrier J, Jaquet P, Lefèvre L, Sinnah F, Marzouk M, Sonneville R, Bouadma L, Souweine B, Timsit JF
Augmented renal clearance in the ICU: estimation, incidence, risk factors and consequences-a retrospective observational study.
Annals of Intensive Care 2022, 12, 88.
Voiriot G, Fartoukh M, Durand-Zaleski I, Berard L, Rousseau A, Armand-Lefevre L, Verdet C, Argaud L, Klouche K, Megarbane B, Patrier J, Richard JC, Reignier J, Schwebel C, Souweine B, Tandjaoui-Lambiotte Y, Simon T, Timsit JF, MULTI-CAP study group
Combined use of a broad-panel respiratory multiplex PCR and procalcitonin to reduce duration of antibiotics exposure in patients with severe community-acquired pneumonia (MULTI-CAP): a multicentre, parallel-group, open-label, individual randomised trial conducted in French intensive care units.
BMJ open 2021, 11, e048187.
Timsit JF, Huntington JA, Wunderink RG, Shime N, Kollef MH, Kivistik Ü, Nováček M, Réa-Neto Á, Martin-Loeches I, Yu B, Jensen EH, Butterton JR, Wolf DJ, Rhee EG, Bruno CJ
Ceftolozane/tazobactam versus meropenem in patients with ventilated hospital-acquired bacterial pneumonia: subset analysis of the ASPECT-NP randomized, controlled phase 3 trial.
Critical Care (London, England) 2021, 25, 290.
Meyer A, Buetti N, Houhou-Fidouh N, Patrier J, Abdel-Nabey M, Jaquet P, Presente S, Girard T, Sayagh F, Ruckly S, Wicky PH, de Montmollin E, Bouadma L, Sonneville R, Descamps D, Timsit JF
HSV-1 reactivation is associated with an increased risk of mortality and pneumonia in critically ill COVID-19 patients.
Critical Care (London, England) 2021, 25, 417.
Papin G, Bailly S, Dupuis C, Ruckly S, Gainnier M, Argaud L, Azoulay E, Adrie C, Souweine B, Goldgran-Toledano D, Marcotte G, Gros A, Reignier J, Mourvillier B, Forel JM, Sonneville R, Dumenil AS, Darmon M, Garrouste-Orgeas M, Schwebel C, Timsit JF, OUTCOMEREA study group
Clinical and biological clusters of sepsis patients using hierarchical clustering.
PloS One 2021, 16, e0252793.
Exhaustive list of publications
2024
Tridon C, Bachelet D, El Baied M, Eloy P, Ortuno S, Para M, Wicky PH, Vellieux G, de Montmollin E, Bouadma L, Manceau H, Timsit JF, Peoc'h K, Sonneville R
Association of Sepsis With Neurologic Outcomes of Adult Patients Treated With Venoarterial Extracorporeal Membrane Oxygnenation.
Critical Care Explorations 2024, 6, e1042.
2023
Labbé V, Contou D, Heming N, Megarbane B, Razazi K, Boissier F, Ait-Oufella H, Turpin M, Carreira S, Robert A, Monchi M, Souweine B, Preau S, Doyen D, Vivier E, Zucman N, Dres M, Fejjal M, Noel-Savina E, Bachir M, Jaffal K, Timsit JF, Picos SA, Mariotte E, Martis N, Juguet W, Melica G, Rondeau P, Audureau E, Mekontso Dessap A, ANTICOVID Investigators
Effects of Standard-Dose Prophylactic, High-Dose Prophylactic, and Therapeutic Anticoagulation in Patients With Hypoxemic COVID-19 Pneumonia: The ANTICOVID Randomized Clinical Trial.
JAMA internal medicine 2023, 183, 520-531.
Tabah A, Buetti N, Staiquly Q, Ruckly S, Akova M, Aslan AT, Leone M, Conway Morris A, Bassetti M, Arvaniti K, Lipman J, Ferrer R, Qiu H, Paiva JA, Povoa P, De Bus L, De Waele J, Zand F, Gurjar M, Alsisi A, Abidi K, Bracht H, Hayashi Y, Jeon K, Elhadi M, Barbier F, Timsit JF, EUROBACT-2 Study Group, ESICM, ESCMID ESGCIP and the OUTCOMEREA Network
Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study.
Intensive Care Medicine 2023, 49, 178-190.
Gaillet A, Bay P, Péju E, Ait-Oufella H, Azoulay E, Benchabane N, Cerf C, Cohen Y, de Prost N, Faguer S, Geri G, Grangé S, Kahn JE, Kreitmann L, Larcher R, Lefèvre G, Mabrouki A, Mekonsto-Dessap A, Panel K, Pène F, Pineton de Chambrun M, Quenot JP, Tandjaoui-Lambiotte Y, Timsit JF, Vieillard-Baron A, Dargent A, Herault A, Groh M
Epidemiology, clinical presentation, and outcomes of 620 patients with eosinophilia in the intensive care unit.
Intensive Care Medicine 2023, 49, 291-301.
Sonneville R, de Montmollin E, Contou D, Ferrer R, Gurjar M, Klouche K, Sarton B, Demeret S, Bailly P, da Silva D, Escudier E, Le Guennec L, Chabanne R, Argaud L, Ben Hadj Salem O, Thyrault M, Frerou A, Louis G, De Pascale G, Horn J, Helbok R, Geri G, Bruneel F, Martin-Loeches I, Taccone FS, De Waele JJ, Ruckly S, Staiquly Q, Citerio G, Timsit JF, EURECA Investigator Study Group
Clinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care (EURECA): an international prospective multicenter cohort study.
Intensive Care Medicine 2023, 49, 517-529.
Sonneville R, de Montmollin E, Gaudemer A, Ruckly S, Timsit JF
Meningoencephalitis requiring intensive care and neuromonitorization. Author's reply.
Intensive Care Medicine 2023, 49, 884-885.
Lefebvre T, Boutten A, Raulet-Bussian C, Raynor A, Manceau H, Puy H, Moulouel B, Schmitt C, Timsit JF, Lefort A, Weiss E, Lescure FX, Ricard JD, Sonneville R, Peoc'h K
Evaluation of iron metabolism in hospitalized COVID-19 patients.
Clinica Chimica Acta; International Journal of Clinical Chemistry 2023, 548, 117509.
Bouzid D, Hingrat QL, Salipante F, Ferré VM, Chevallier T, Tubiana S, Lucet JC, Choquet C, Yazdanpanah Y, Timsit JF, Descamps D, Houhou N, Visseaux B, Loubet P
Agreement of respiratory viruses' detection between nasopharyngeal swab and bronchoalveolar lavage in adults admitted for pneumonia: a retrospective study.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2023, 29, 942.e1-942.e6.
Buetti N, Marschall J, Catho G, Timsit JF, Mermel L
Which trial do we need? Infectious and non-infectious complications of peripherally inserted central venous catheters and midline catheters.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2023, 29, 568-569.
Buetti N, Ruckly S, Souweine B, Mimoz O, Timsit JF
Risk of infections in intravascular catheters in situ for more than 10 days: a post hoc analysis of randomized controlled trials.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2023, 29, 1200.e1-1200.e5.
Blot S, Timsit JF, Zahar JR
Preventing healthcare-acquired infections in cancer patients with febrile neutropenia in intensive care units: The role of granulocyte-colony stimulating factor prophylaxis.
Intensive & Critical Care Nursing 2023, 78, 103466.
Reignier J, Plantefeve G, Mira JP, Argaud L, Asfar P, Aissaoui N, Badie J, Botoc NV, Brisard L, Bui HN, Chatellier D, Chauvelot L, Combes A, Cracco C, Darmon M, Das V, Debarre M, Delbove A, Devaquet J, Dumont LM, Gontier O, Groyer S, Guérin L, Guidet B, Hourmant Y, Jaber S, Lambiotte F, Leroy C, Letocart P, Madeux B, Maizel J, Martinet O, Martino F, Maxime V, Mercier E, Nay MA, Nseir S, Oziel J, Picard W, Piton G, Quenot JP, Reizine F, Renault A, Richecoeur J, Rigaud JP, Schneider F, Silva D, Sirodot M, Souweine B, Tamion F, Terzi N, Thévenin D, Thiery G, Thieulot-Rolin N, Timsit JF, Tinturier F, Tirot P, Vanderlinden T, Vinatier I, Vinsonneau C, Voicu S, Lascarrou JB, Le Gouge A, NUTRIREA-3 Trial Investigators, Clinical Research in Intensive Care, Sepsis (CRICS-TRIGGERSEP)Group
Low versus standard calorie and protein feeding in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3).
The Lancet. Respiratory Medicine 2023, 11, 602-612.
Garrouste-Orgeas M, Marché V, Pujol N, Michel D, Evin A, Fossez-Diaz V, Perruchio S, Vanbésien A, Verlaine C, Copel L, Kaczmarek W, Birkui de Francqueville L, Michonneau-Gandon V, de Larivière E, Poupardin C, Touzet L, Guastella V, Mathias C, Mhalla A, Bouquet G, Richard B, Gracia D, Bienfait F, Verliac V, Ranchou G, Kirsch S, Flahault C, Loiodice A, Bailly S, Ruckly S, Timsit JF
Incidence and risk factors of prolonged grief in relatives of patients with terminal cancer in French palliative care units: The Fami-Life multicenter cohort study.
Palliative & Supportive Care 2023, 1-10.
de Roquetaillade C, Laouenan C, Mira JP, Roy C, Thuong M, Azoulay É, Gruson D, Jacobs F, Chommeloux J, Raffi F, Hocqueloux L, Imbert P, Jeantils V, Delassus JL, Matheron S, Fitting C, Timsit JF, Bruneel F
Cytokine profiles in adults with imported malaria.
Scientific Reports 2023, 13, 10347.
Stern J, Dupuis C, Kpeglo H, Reuter J, Vinclair C, Para M, Nataf P, Pelletier AL, de Montmollin E, Bouadma L, Timsit JF, Sonneville R
Upper gastrointestinal bleeding in adults treated with veno-arterial extracorporeal membrane oxygenation: a cohort study.
European Journal of Cardio-Thoracic Surgery: Official Journal of the European Association for Cardio-Thoracic Surgery 2023, 63, ezad083.
von Cube M, Schumacher M, Timsit JF, Decruyenaere J, Steen J
The population-attributable fraction for time-to-event data.
International Journal of Epidemiology 2023, 52, 837-845.
Aslan AT, Tabah A, Köylü B, Kalem AK, Aksoy F, Erol Ç, Karaali R, Tunay B, Guzeldağ S, Batirel A, Dindar EK, Akdoğan Ö, Bilir Y, Ersöz G, Öztürk B, Selçuk M, Yilmaz M, Akyol A, Akbaş T, Sungurtekin H, Timuroğlu A, Gürbüz Y, Çolak O, Bayindir Y, Eroğlu A, Ferlicolak L, Çeşme U, Dağ O, Buetti N, Barbier F, Ruckly S, Staiquly Q, Timsit JF, Akova M
Epidemiology and risk factors of 28-day mortality of hospital-acquired bloodstream infection in Turkish intensive care units: a prospective observational cohort study.
The Journal of Antimicrobial Chemotherapy 2023, 78, 1757-1768.
Galerneau LM, Bailly S, Terzi N, Ruckly S, Garrouste-Orgeas M, Cohen Y, Hong Tuan Ha V, Gainnier M, Siami S, Dupuis C, Darmon M, Forel JM, Rigault G, Adrie C, Goldgran-Toledano D, Laurent V, de Montmollin E, Argaud L, Reignier J, Pepin JL, Timsit JF, OUTCOMEREA Network
Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease in the ICU: An Observational Study From the OUTCOMEREA Database, 1997-2018.
Critical Care Medicine 2023, 51, 753-764.
Vacheron CH, Friggeri A, Gerbaud-Coulas C, Dagonneau T, Timsit JF, Allaouchiche B, Wallet F, Bohe J, Piriou V, Maucort-Boulch D, Fauvernier M
Improved 30-Day Survival Estimation in ICU Patients: A Comparative Analysis of Different Approaches With Real-World Data.
Critical Care Medicine 2023
Thy M, de Montmollin E, Bouadma L, Timsit JF, Sonneville R
Severe meningoencephalitis: epidemiology and outcomes.
Current Opinion in Critical Care 2023, 29, 415-422.
Barbier F, Woerther PL, Timsit JF
Rapid diagnostics for skin and soft tissue infections: the current landscape and future potential.
Current Opinion in Infectious Diseases 2023, 36, 57-66.
Do Rego H, Timsit JF
Management strategies for severe Pseudomonas aeruginosa infections.
Current Opinion in Infectious Diseases 2023, 36, 585-595.
Presente S, Bonnal C, Normand AC, Gaudonnet Y, Fekkar A, Timsit JF, Kernéis S
Hospital Clonal Outbreak of Fluconazole-Resistant Candida parapsilosis Harboring the Y132F ERG11p Substitution in a French Intensive Care Unit.
Antimicrobial Agents and Chemotherapy 2023, 67, e0113022.
Foucrier A, Roquilly A, Bachelet D, Martin-Loeches I, Bougle A, Timsit JF, Montravers P, Zahar JR, Eloy P, Weiss E, ASPIC study group
Antimicrobial Stewardship for Ventilator Associated Pneumonia in Intensive Care (the ASPIC trial): study protocol for a randomised controlled trial.
BMJ open 2023, 13, e065293.
Sonneville R, Mazighi M, Collet M, Gayat E, Degos V, Duranteau J, Grégoire C, Sharshar T, Naim G, Cortier D, Jost PH, Foucrier A, Bagate F, de Montmollin E, Papin G, Magalhaes E, Guidet B, Ben Hadj Salem O, Benghanem S, le Guennec L, Delpierre E, Legriel S, Megarbane B, Toumert K, Tran M, Geri G, Monchi M, Bodiguel E, Mariotte E, Demoule A, Zarka J, Diehl JL, Roux D, Barré E, Tanaka S, Osman D, Pasquier P, Lamara F, Crassard I, Boursin P, Ruckly S, Staiquly Q, Timsit JF, Woimant F, SPICE Investigators
One-Year Outcomes in Patients With Acute Stroke Requiring Mechanical Ventilation.
Stroke 2023, 54, 2328-2337.
Moreno R, Rhodes A, Piquilloud L, Hernandez G, Takala J, Gershengorn HB, Tavares M, Coopersmith CM, Myatra SN, Singer M, Rezende E, Prescott HC, Soares M, Timsit JF, de Lange DW, Jung C, De Waele JJ, Martin GS, Summers C, Azoulay E, Fujii T, McLean AS, Vincent JL
The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?.
Critical Care (London, England) 2023, 27, 15.
Gaillet A, Azoulay E, de Montmollin E, Garrouste-Orgeas M, Cohen Y, Dupuis C, Schwebel C, Reignier J, Siami S, Argaud L, Adrie C, Mourvillier B, Ruckly S, Forel JM, Timsit JF
Outcomes in critically Ill HIV-infected patients between 1997 and 2020: analysis of the OUTCOMEREA multicenter cohort.
Critical Care (London, England) 2023, 27, 108.
Williams PG, Tabah A, Cotta MO, Sandaradura I, Kanji S, Scheetz MH, Imani S, Elhadi M, Luque-Pardos S, Schellack N, Sanches C, Timsit JF, Xie J, Farkas A, Wilks K, Roberts JA, National Coordinators on behalf of the European Society of Intensive Care Medicine (ESICM) and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Infections in Critically Ill Patients [ESGCIP]
International survey of antibiotic dosing and monitoring in adult intensive care units.
Critical Care (London, England) 2023, 27, 241.
Giacobbe DR, Dettori S, Di Pilato V, Asperges E, Ball L, Berti E, Blennow O, Bruzzone B, Calvet L, Capra Marzani F, Casabella A, Choudaly S, Dartevel A, De Pascale G, Di Meco G, Fallon M, Galerneau LM, Gallego M, Giacomini M, González Sáez A, Hänsel L, Icardi G, Koehler P, Lagrou K, Lahmer T, Lewis White P, Magnasco L, Marchese A, Marelli C, Marín-Arriaza M, Martin-Loeches I, Mekontso-Dessap A, Mikulska M, Mularoni A, Nordlander A, Poissy J, Russelli G, Signori A, Tascini C, Vaconsin LM, Vargas J, Vena A, Wauters J, Pelosi P, Timsit JF, Bassetti M, JIR-ICU investigators (collaborators), Critically Ill Patients Study Group of the European Society of Clinical Microbiology and Infectious Diseases (ESGCIP), and the Fungal Infection Study Group of the European Society of Clinical Microbiology and Infectious Diseases (EFISG)
Pneumocystis jirovecii pneumonia in intensive care units: a multicenter study by ESGCIP and EFISG.
Critical Care (London, England) 2023, 27, 323.
Galerneau LM, Bailly S, Terzi N, Ruckly S, Garrouste-Orgeas M, Oziel J, Hong Tuan Ha V, Gainnier M, Siami S, Dupuis C, Forel JM, Dartevel A, Dessajan J, Adrie C, Goldgran-Toledano D, Laurent V, Argaud L, Reignier J, Pepin JL, Darmon M, Timsit JF, OUTCOME R. E. A. network
Non-ventilator-associated ICU-acquired pneumonia (NV-ICU-AP) in patients with acute exacerbation of COPD: From the French OUTCOMEREA cohort.
Critical Care (London, England) 2023, 27, 359.
Sonneville R, Benghanem S, Jeantin L, de Montmollin E, Doman M, Gaudemer A, Thy M, Timsit JF
The spectrum of sepsis-associated encephalopathy: a clinical perspective.
Critical Care (London, England) 2023, 27, 386.
Martin-Loeches I, Shorr AF, Wunderink RG, Kollef MH, Timsit JF, Yu B, Huntington JA, Jensen E, Bruno CJ
Outcomes in participants with ventilated nosocomial pneumonia and organ failure treated with ceftolozane/tazobactam versus meropenem: a subset analysis of the phase 3, randomized, controlled ASPECT-NP trial.
Annals of Intensive Care 2023, 13, 8.
Iachkine J, Buetti N, de Grooth HJ, Briant AR, Mimoz O, Mégarbane B, Mira JP, Valette X, Daubin C, du Cheyron D, Mermel LA, Timsit JF, Parienti JJ
Development and validation of a multivariable model predicting the required catheter dwell time among mechanically ventilated critically ill patients in three randomized trials.
Annals of Intensive Care 2023, 13, 5.
Jeantin L, Dupuis C, Vellieux G, Jaquet P, de Montmollin E, Timsit JF, Sonneville R, ENCEPHALITICA Study Group
Electroencephalography for prognostication of outcome in adults with severe herpes simplex encephalitis.
Annals of Intensive Care 2023, 13, 10.
Mekontso Dessap A, Papazian L, Schaller M, Nseir S, Megarbane B, Haudebourg L, Timsit JF, Teboul JL, Kuteifan K, Gainnier M, Slama M, Houeto P, Lecourt L, Mercat A, Vieillard-Baron A
Inhaled nitric oxide in patients with acute respiratory distress syndrome caused by COVID-19: treatment modalities, clinical response, and outcomes.
Annals of Intensive Care 2023, 13, 57.
Helms J, Poissy J, Dequin PF, Timsit JF
Treatment of immunothrombosis dysregulation: high-dose corticosteroids is not the good option.
Annals of Intensive Care 2023, 13, 58.
Chevret S, Bouadma L, Dupuis C, Burdet C, Timsit JF, COVIDICUS RCT group
Which severe COVID-19 patients could benefit from high dose dexamethasone? A Bayesian post-hoc reanalysis of the COVIDICUS randomized clinical trial.
Annals of Intensive Care 2023, 13, 75.
Szychowiak P, Boulain T, Timsit JF, Elabaddi A, Argaud L, Ehrmann S, Issa N, Canet E, Martino F, Bruneel F, Quenot JP, Wallet F, Azoulay É, Barbier F
Clinical spectrum and prognostic impact of cancer in critically ill patients with HIV: a multicentre cohort study.
Annals of Intensive Care 2023, 13, 74.
Laurichesse G, Schwebel C, Buetti N, Neuville M, Siami S, Cohen Y, Laurent V, Mourvillier B, Reignier J, Goldgran-Toledano D, Ruckly S, de Montmollin E, Souweine B, Timsit JF, Dupuis C, OUTCOME R. E. A. network
Mortality, incidence, and microbiological documentation of ventilated acquired pneumonia (VAP) in critically ill patients with COVID-19 or influenza.
Annals of Intensive Care 2023, 13, 108.
Reingruber J, Papale A, Ruckly S, Timsit JF, Holcman D
Data-driven multiscale dynamical framework to control a pandemic evolution with non-pharmaceutical interventions.
PloS One 2023, 18, e0278882.
Galerneau LM, Bailly S, Terzi N, Ruckly S, Garrouste-Orgeas M, Cohen Y, Hong Tuan Ha V, Gainnier M, Siami S, Dupuis C, Darmon M, Azoulay E, Forel JM, Sigaud F, Adrie C, Goldgran-Toledano D, Ferré A, de Montmollin E, Argaud L, Reignier J, Pepin JL, Timsit JF, OUTCOMEREA network
Corticosteroids for severe acute exacerbations of chronic obstructive pulmonary disease in intensive care: From the French OUTCOMEREA cohort.
PloS One 2023, 18, e0284591.
Thy M, Timsit JF, de Montmollin E
Aminoglycosides for the Treatment of Severe Infection Due to Resistant Gram-Negative Pathogens.
Antibiotics (Basel, Switzerland) 2023, 12, 860.
Wicky PH, Poiraud J, Alves M, Patrier J, d'Humières C, Lê M, Kramer L, de Montmollin É, Massias L, Armand-Lefèvre L, Timsit JF
Cefiderocol Treatment for Severe Infections due to Difficult-to-Treat-Resistant Non-Fermentative Gram-Negative Bacilli in ICU Patients: A Case Series and Narrative Literature Review.
Antibiotics (Basel, Switzerland) 2023, 12, 991.
Wicky PH, Dupuis C, Cerf C, Siami S, Cohen Y, Laurent V, Mourvillier B, Reignier J, Goldgran-Toledano D, Schwebel C, Ruckly S, de Montmollin E, Buetti N, Timsit JF
Ventilator-Associated Pneumonia in COVID-19 Patients Admitted in Intensive Care Units: Relapse, Therapeutic Failure and Attributable Mortality-A Multicentric Observational Study from the OutcomeRea Network.
Journal of Clinical Medicine 2023, 12, 1298.
Timsit JF
After SARS-CoV-2 Pandemics: New Insights into ICU-Acquired Pneumonia.
Journal of Clinical Medicine 2023, 12, 2160.
Rezzoug I, Visseaux B, Bertine M, Parisey M, Bonnal C, Ruppe E, Descamps D, Timsit JF, Yazdanpanah Y, Armand-Lefevre L, Houze S, Argy N
Faecal Viral Excretion and Gastrointestinal Co-Infection Do Not Explain Digestive Presentation in COVID-19 Patients.
Microorganisms 2023, 11, 1780.
2022
Bouadma L, Mekontso-Dessap A, Burdet C, Merdji H, Poissy J, Dupuis C, Guitton C, Schwebel C, Cohen Y, Bruel C, Marzouk M, Geri G, Cerf C, Mégarbane B, Garçon P, Kipnis E, Visseaux B, Beldjoudi N, Chevret S, Timsit JF, COVIDICUS Study Group
High-Dose Dexamethasone and Oxygen Support Strategies in Intensive Care Unit Patients With Severe COVID-19 Acute Hypoxemic Respiratory Failure: The COVIDICUS Randomized Clinical Trial.
JAMA internal medicine 2022, 182, 906-916.
Lavalley-Morelle A, Timsit JF, Mentré F, Mullaert J, OUTCOMEREA network
Joint modeling under competing risks: Application to survival prediction in patients admitted in Intensive Care Unit for sepsis with daily Sequential Organ Failure Assessment score assessments.
CPT: pharmacometrics & systems pharmacology 2022, 11, 1472-1484.
Buetti N, Rickard CM, Timsit JF
Catheter dressings.
Intensive Care Medicine 2022
Timsit JF, Tabah A, Mimoz O
Update on prevention of intra-vascular accesses complications.
Intensive Care Medicine 2022
Rouzé A, Estella Á, Timsit JF
Is (1,3)-β-D-glucan useless to guide antifungal therapy in ICU?.
Intensive Care Medicine 2022, 48, 930-932.
De Pascale G, Antonelli M, Deschepper M, Arvaniti K, Blot K, Brown BC, de Lange D, De Waele J, Dikmen Y, Dimopoulos G, Eckmann C, Francois G, Girardis M, Koulenti D, Labeau S, Lipman J, Lipovetsky F, Maseda E, Montravers P, Mikstacki A, Paiva JA, Pereyra C, Rello J, Timsit JF, Vogelaers D, Blot S, Abdominal Sepsis Study (AbSeS) group and the Trials Group of the European Society of Intensive Care Medicine
Poor timing and failure of source control are risk factors for mortality in critically ill patients with secondary peritonitis.
Intensive Care Medicine 2022, 48, 1593-1606.
Bassetti M, Vena A, Giacobbe DR, Trucchi C, Ansaldi F, Antonelli M, Adamkova V, Alicino C, Almyroudi MP, Atchade E, Azzini AM, Brugnaro P, Carannante N, Peghin M, Berruti M, Carnelutti A, Castaldo N, Corcione S, Cortegiani A, Dimopoulos G, Dubler S, García-Garmendia JL, Girardis M, Cornely OA, Ianniruberto S, Kullberg BJ, Lagrou K, Lebihan C, Luzzati R, Malbrain M, Merelli M, Marques AJ, Martin-Loeches I, Mesini A, Paiva JA, Raineri SM, Rautemaa-Richardson R, Schouten J, Spapen H, Tasioudis P, Timsit JF, Tisa V, Tumbarello M, Van den Berg CHSB, Veber B, Venditti M, Voiriot G, Wauters J, Zappella N, Montravers P, from the Study Group for Infections in Critically Ill Patients (ESGCIP) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID)
Risk Factors for Intra-Abdominal Candidiasis in Intensive Care Units: Results from EUCANDICU Study.
Infectious Diseases and Therapy 2022, 11, 827-840.
Buetti N, Mermel LA, Timsit JF
Routine catheter-tip cultures for assessing catheter-related bloodstream infections in randomised-controlled trials.
Anaesthesia, Critical Care & Pain Medicine 2022, 41, 101006.
Blot S, Ruppé E, Harbarth S, Asehnoune K, Poulakou G, Luyt CE, Rello J, Klompas M, Depuydt P, Eckmann C, Martin-Loeches I, Povoa P, Bouadma L, Timsit JF, Zahar JR
Healthcare-associated infections in adult intensive care unit patients: Changes in epidemiology, diagnosis, prevention and contributions of new technologies.
Intensive & Critical Care Nursing 2022, 70, 103227.
Arvaniti K, Dimopoulos G, Antonelli M, Blot K, Creagh-Brown B, Deschepper M, de Lange D, De Waele J, Dikmen Y, Eckmann C, Einav S, Francois G, Fjeldsoee-Nielsen H, Girardis M, Jovanovic B, Lindner M, Koulenti D, Labeau S, Lipman J, Lipovestky F, Makikado LDU, Maseda E, Mikstacki A, Montravers P, Paiva JA, Pereyra C, Rello J, Timsit JF, Tomescu D, Vogelaers D, Blot S, Abdominal Sepsis Study (AbSeS) group on behalf of the Trials Group of the European Society of Intensive Care Medicine
Epidemiology and Age-Related Mortality in Critically Ill Patients With Intra-Abdominal Infection or Sepsis: An International Cohort Study.
International Journal of Antimicrobial Agents 2022, 106591.
Ferré VM, Lebourgeois S, Menidjel R, Collin G, Chenane HR, Guindi MO, Yazdanpanah Y, Timsit JF, Charpentier C, Descamps D, Fidouh N, Visseaux B
Decreasing humoral response among healthcare workers up to 4 months after two doses of BNT162b2 vaccine.
The Journal of Infection 2022, 84, 248-288.
Lebourgeois S, Menidjel R, Chenane HR, Ferré VM, Collin G, Damond F, Coppée R, Yazdanpanah Y, Timsit JF, Houhou-Fidouh N, Descamps D, Charpentier C, Visseaux B
Alpha (B.1.1.7) and Delta (B.1.617.2 - AY.40) SARS-CoV-2 variants present strong neutralization decay at M4 post-vaccination and a faster replication rates than D614G (B.1) lineage.
The Journal of Infection 2022, 84, 418-467.
Nasa P, Azoulay E, Chakrabarti A, Divatia JV, Jain R, Rodrigues C, Rosenthal VD, Alhazzani W, Arabi YM, Bakker J, Bassetti M, De Waele J, Dimopoulos G, Du B, Einav S, Evans L, Finfer S, Guérin C, Hammond NE, Jaber S, Kleinpell RM, Koh Y, Kollef M, Levy MM, Machado FR, Mancebo J, Martin-Loeches I, Mer M, Niederman MS, Pelosi P, Perner A, Peter JV, Phua J, Piquilloud L, Pletz MW, Rhodes A, Schultz MJ, Singer M, Timsit JF, Venkatesh B, Vincent JL, Welte T, Myatra SN
Infection control in the intensive care unit: expert consensus statements for SARS-CoV-2 using a Delphi method.
The Lancet. Infectious Diseases 2022, 22, e74-e87.
Gangneux JP, Dannaoui E, Fekkar A, Luyt CE, Botterel F, De Prost N, Tadié JM, Reizine F, Houzé S, Timsit JF, Iriart X, Riu-Poulenc B, Sendid B, Nseir S, Persat F, Wallet F, Le Pape P, Canet E, Novara A, Manai M, Cateau E, Thille AW, Brun S, Cohen Y, Alanio A, Mégarbane B, Cornet M, Terzi N, Lamhaut L, Sabourin E, Desoubeaux G, Ehrmann S, Hennequin C, Voiriot G, Nevez G, Aubron C, Letscher-Bru V, Meziani F, Blaize M, Mayaux J, Monsel A, Boquel F, Robert-Gangneux F, Le Tulzo Y, Seguin P, Guegan H, Autier B, Lesouhaitier M, Pelletier R, Belaz S, Bonnal C, Berry A, Leroy J, François N, Richard JC, Paulus S, Argaud L, Dupont D, Menotti J, Morio F, Soulié M, Schwebel C, Garnaud C, Guitard J, Le Gal S, Quinio D, Morcet J, Laviolle B, Zahar JR, Bougnoux ME
Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study.
The Lancet. Respiratory Medicine 2022, 10, 180-190.
Gangneux JP, Morcet J, Laviolle B, Dannaoui E, Timsit JF, Ruckly S, Zahar JR, Bougnoux ME
Time-dependent bias when analysing COVID-19-associated pulmonary aspergillosis - Authors' reply.
The Lancet. Respiratory Medicine 2022, 10, e27.
de Prost N, Audureau E, Heming N, Gault E, Pham T, Chaghouri A, de Montmollin N, Voiriot G, Morand-Joubert L, Joseph A, Chaix ML, Préau S, Favory R, Guigon A, Luyt CE, Burrel S, Mayaux J, Marot S, Roux D, Descamps D, Meireles S, Pène F, Rozenberg F, Contou D, Henry A, Gaudry S, Brichler S, Timsit JF, Kimmoun A, Hartard C, Jandeaux LM, Fafi-Kremer S, Gabarre P, Emery M, Garcia-Sanchez C, Jochmans S, Pitsch A, Annane D, Azoulay E, Mekontso Dessap A, Rodriguez C, Pawlotsky JM, Fourati S
Clinical phenotypes and outcomes associated with SARS-CoV-2 variant Omicron in critically ill French patients with COVID-19.
Nature Communications 2022, 13, 6025.
Peyneau M, Granger V, Wicky PH, Khelifi-Touhami D, Timsit JF, Lescure FX, Yazdanpanah Y, Tran-Dinh A, Montravers P, Monteiro RC, Chollet-Martin S, Hurtado-Nedelec M, de Chaisemartin L
Innate immune deficiencies are associated with severity and poor prognosis in patients with COVID-19.
Scientific Reports 2022, 12, 638.
Beydon M, Nicaise-Roland P, Mageau A, Farkh C, Daugas E, Descamps V, Dieude P, Dossier A, Goulenok T, Farhi F, Mutuon P, Timsit JF, Papo T, Sacre K
Autoantibodies against IFNα in patients with systemic lupus erythematosus and susceptibility for infection: a retrospective case-control study.
Scientific Reports 2022, 12, 11244.
Wicky PH, Martin-Loeches I, Timsit JF
HAP and VAP after Guidelines.
Seminars in Respiratory and Critical Care Medicine 2022, 43, 248-254.
Rienzo M, Skirecki T, Monneret G, Timsit JF
Immune checkpoint inhibitors for the treatment of sepsis:insights from preclinical and clinical development.
Expert Opinion on Investigational Drugs 2022, 31, 885-894.
Giacobbe DR, Roberts JA, Abdul-Aziz MH, de Montmollin E, Timsit JF, Bassetti M
Treatment of ventilator-associated pneumonia due to carbapenem-resistant Gram-negative bacteria with novel agents: a contemporary, multidisciplinary ESGCIP perspective.
Expert Review of Anti-Infective Therapy 2022, 1-17.
Timsit JF, Paul M, Shields RK, Echols R, Baba T, Yamano Y, Portsmouth S
Cefiderocol for the Treatment of Infections Due To Metallo-Beta-Lactamase-Producing Pathogens in the CREDIBLE-CR And APEKS-NP Phase 3 Randomized Studies.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2022, ciac078.
Martin-Loeches I, Timsit JF, Kollef MH, Wunderink RG, Shime N, Nováček M, Kivistik Ü, Réa-Neto Á, Bruno CJ, Huntington JA, Lin G, Jensen EH, Motyl M, Yu B, Gates D, Butterton JR, Rhee EG
Clinical and microbiological outcomes, by causative pathogen, in the ASPECT-NP randomized, controlled, Phase 3 trial comparing ceftolozane/tazobactam and meropenem for treatment of hospital-acquired/ventilator-associated bacterial pneumonia.
The Journal of Antimicrobial Chemotherapy 2022, 77, 1166-1177.
Abid S, Papin G, Vellieux G, de Montmollin E, Wicky PH, Patrier J, Jaquet P, Bouadma L, Rouvel-Tallec A, Timsit JF, Sonneville R
A Simplified Electroencephalography Montage and Interpretation for Evaluation of Comatose Patients in the ICU.
Critical Care Explorations 2022, 4, e0781.
Vacheron CH, Lepape A, Savey A, Machut A, Timsit JF, Vanhems P, Le QV, Egbeola J, Martin M, Maxime V, Pugliesi PS, Maucort-Boulch D, Friggeri A, REA-REZO Study Group
Increased Incidence of Ventilator-Acquired Pneumonia in Coronavirus Disease 2019 Patients: A Multicentric Cohort Study.
Critical Care Medicine 2022, 50, 449-459.
de Montmollin E, Dupuis C, Jaquet P, Sarton B, Sazio C, Susset V, Conrad M, Argaud L, Demeret S, Tadié JM, Barbier F, Wolff M, Timsit JF, Visseaux B, Sonneville R, ENCEPHALITICA Study Group
Herpes Simplex Virus Encephalitis With Initial Negative Polymerase Chain Reaction in the Cerebrospinal Fluid: Prevalence, Associated Factors, and Clinical Impact.
Critical Care Medicine 2022, 50, e643-e648.
Jaquet P, Legouy C, Le Fevre L, Grinea A, Sinnah F, Franchineau G, Patrier J, Marzouk M, Wicky PH, Alexis Geoffroy P, Arnoult F, Vledouts S, de Montmollin E, Bouadma L, Timsit JF, Sharshar T, Sonneville R
Neurologic Outcomes of Survivors of COVID-19-Associated Acute Respiratory Distress Syndrome Requiring Intubation.
Critical Care Medicine 2022, 50, e674-e682.
Wicky PH, d'Humières C, Timsit JF
How common is ventilator-associated pneumonia after coronavirus disease 2019?.
Current Opinion in Infectious Diseases 2022, 35, 170-175.
Zahar JR, Timsit JF
Risk stratification for selecting empiric antibiotherapy during and after COVID-19.
Current Opinion in Infectious Diseases 2022, 35, 605-613.
Mageau A, Borie R, Crestani B, Timsit JF, Papo T, Sacre K
Epidemiology of interstitial lung disease in systemic lupus erythematosus in France: A nation-wide population-based study over 10 years.
Respirology (Carlton, Vic.) 2022
Mageau A, Papo T, Ruckly S, Strukov A, van Gysel D, Sacre K, Timsit JF
Survival after COVID-19-associated organ failure among inpatients with systemic lupus erythematosus in France: a nationwide study.
Annals of the Rheumatic Diseases 2022, 81, 569-574.
Labbe V, Contou D, Heming N, Megarbane B, Ait-Oufella H, Boissier F, Carreira S, Robert A, Vivier E, Fejjal M, Doyen D, Monchi M, Preau S, Noel-Savina E, Souweine B, Zucman N, Picos SA, Dres M, Juguet W, Mariotte E, Timsit JF, Turpin M, Razazi K, Gendreau S, Baloul S, Voiriot G, Fartoukh M, Audureau E, Mekontso Dessap A
Comparison of standard prophylactic, intermediate prophylactic and therapeutic anticoagulation in patients with severe COVID-19: protocol for the ANTICOVID multicentre, parallel-group, open-label, randomised controlled trial.
BMJ open 2022, 12, e059383.
Vacheron CH, Lepape A, Savey A, Machut A, Timsit JF, Comparot S, Courno G, Vanhems P, Landel V, Lavigne T, Bailly S, Bettega F, Study Group RR, Maucort-Boulch D, Friggeri A
Attributable Mortality of Ventilator-associated Pneumonia Among COVID-19 Patients.
American Journal of Respiratory and Critical Care Medicine 2022
Chevret S, Timsit JF, Biard L
Challenges of using external data in clinical trials- an illustration in patients with COVID-19.
BMC medical research methodology 2022, 22, 321.
Thouy F, Bohé J, Souweine B, Abidi H, Quenot JP, Thiollière F, Dellamonica J, Preiser JC, Timsit JF, Brunot V, Klich A, Sedillot N, Tchenio X, Roudaut JB, Mottard N, Hyvernat H, Wallet F, Danin PE, Badie J, Jospe R, Morel J, Mofredj A, Fatah A, Drai J, Mialon A, Ait Hssain A, Lautrette A, Fontaine E, Vacheron CH, Maucort-Boulch D, Klouche K, Dupuis C
Impact of prolonged requirement for insulin on 90-day mortality in critically ill patients without previous diabetic treatments: a post hoc analysis of the CONTROLING randomized control trial.
Critical Care (London, England) 2022, 26, 138.
Iachkine J, Buetti N, de Grooth HJ, Briant AR, Mimoz O, Mégarbane B, Mira JP, Ruckly S, Souweine B, du Cheyron D, Mermel LA, Timsit JF, Parienti JJ
Development and validation of a multivariable prediction model of central venous catheter-tip colonization in a cohort of five randomized trials.
Critical Care (London, England) 2022, 26, 205.
Patrier J, Villageois-Tran K, Szychowiak P, Ruckly S, Gschwind R, Wicky PH, Gueye S, Armand-Lefevre L, Marzouk M, Sonneville R, Bouadma L, Petitjean M, Lamara F, de Montmollin E, Timsit JF, Ruppé E, French COVID Cohort Study Group
Oropharyngeal and intestinal concentrations of opportunistic pathogens are independently associated with death of SARS-CoV-2 critically ill adults.
Critical Care (London, England) 2022, 26, 300.
Buetti N, Tabah A, Loiodice A, Ruckly S, Aslan AT, Montrucchio G, Cortegiani A, Saltoglu N, Kayaaslan B, Aksoy F, Murat A, Akdoğan Ö, Saracoglu KT, Erdogan C, Leone M, Ferrer R, Paiva JA, Hayashi Y, Ramanan M, Conway Morris A, Barbier F, Timsit JF, Eurobact 2 study group
Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study.
Critical Care (London, England) 2022, 26, 319.
Kollef MH, Timsit JF, Martin-Loeches I, Wunderink RG, Huntington JA, Jensen EH, Yu B, Bruno CJ
Outcomes in participants with failure of initial antibacterial therapy for hospital-acquired/ventilator-associated bacterial pneumonia prior to enrollment in the randomized, controlled phase 3 ASPECT-NP trial of ceftolozane/tazobactam versus meropenem.
Critical Care (London, England) 2022, 26, 373.
Soum E, Timsit JF, Ruckly S, Gruson D, Canet E, Klouche K, Argaud L, Garrouste-Orgeas M, Mariat C, Vincent F, Cayot S, Darmon M, Bohé J, Schwebel C, Bouadma L, Dupuis C, Souweine B, Lautrette A
Predictive factors for severe long-term chronic kidney disease after acute kidney injury requiring renal replacement therapy in critically ill patients: an ancillary study of the ELVIS randomized controlled trial.
Critical Care (London, England) 2022, 26, 367.
Szychowiak P, Villageois-Tran K, Patrier J, Timsit JF, Ruppé É
The role of the microbiota in the management of intensive care patients.
Annals of Intensive Care 2022, 12, 3.
Egea A, Dupuis C, de Montmollin E, Wicky PH, Patrier J, Jaquet P, Lefèvre L, Sinnah F, Marzouk M, Sonneville R, Bouadma L, Souweine B, Timsit JF
Augmented renal clearance in the ICU: estimation, incidence, risk factors and consequences-a retrospective observational study.
Annals of Intensive Care 2022, 12, 88.
Rambaud T, de Montmollin E, Jaquet P, Gaudemer A, Mariotte E, Abid S, Para M, Cimadevilla C, Iung B, Duval X, Wolff M, Bouadma L, Timsit JF, Sonneville R
Cerebrovascular complications and outcomes of critically ill adult patients with infective endocarditis.
Annals of Intensive Care 2022, 12, 119.
Béraud G, Timsit JF, Leleu H
Remdesivir and dexamethasone as tools to relieve hospital care systems stressed by COVID-19: A modelling study on bed resources and budget impact.
PloS One 2022, 17, e0262462.
Flahault C, Vioulac C, Fasse L, Bailly S, Timsit JF, Garrouste-Orgeas M
"A story with gaps": An interpretative phenomenological analysis of ICU survivors' experience.
PloS One 2022, 17, e0264310.
Timsit JF, Wicky PH, de Montmollin E
Treatment of Severe Infections Due to Metallo-Betalactamases Enterobacterales in Critically Ill Patients.
Antibiotics (Basel, Switzerland) 2022, 11, 144.
Tabah A, Lipman J, Barbier F, Buetti N, Timsit JF, On Behalf Of The Escmid Study Group For Infections In Critically Ill Patients-Esgcip n
Use of Antimicrobials for Bloodstream Infections in the Intensive Care Unit, a Clinically Oriented Review.
Antibiotics (Basel, Switzerland) 2022, 11, 362.
de Montmollin E, Peoc'h K, Marzouk M, Ruckly S, Wicky PH, Patrier J, Jaquet P, Sonneville R, Bouadma L, Timsit JF
Mid-Regional Pro-Adrenomedullin as a Prognostic Factor for Severe COVID-19 ARDS.
Antibiotics (Basel, Switzerland) 2022, 11, 1166.
Pajot O, Lakhal K, Lambert J, Gros A, Bruel C, Boulain T, Garot D, Das V, Timsit JF, Cerf C, Souweine B, Chaffaut C, Mentec H, Zahar JR, Mira JP, Jullien V
Empirical Antibiotic Therapy for Gram-Negative Bacilli Ventilator-Associated Pneumonia: Observational Study and Pharmacodynamic Assessment.
Antibiotics (Basel, Switzerland) 2022, 11, 1664.
Delhommeau G, Buetti N, Neuville M, Siami S, Cohen Y, Laurent V, Mourvillier B, Reignier J, Goldgran-Toledano D, Schwebel C, Ruckly S, de Montmollin E, Souweine B, Timsit JF, Dupuis C
Bacterial Pulmonary Co-Infections on ICU Admission: Comparison in Patients with SARS-CoV-2 and Influenza Acute Respiratory Failure: A Multicentre Cohort Study.
Biomedicines 2022, 10, 2646.
2021
Sarton B, Jaquet P, Belkacemi D, de Montmollin E, Bonneville F, Sazio C, Frérou A, Conrad M, Daubin D, Chabanne R, Argaud L, Dailler F, Brulé N, Lerolle N, Maestraggi Q, Marechal J, Bailly P, Razazi K, Mateos F, Guidet B, Levrat A, Susset V, Lautrette A, Mira JP, El Kalioubie A, Robert A, Massri A, Albucher JF, Olivot JM, Conil JM, Boudma L, Timsit JF, Sonneville R, Silva S, ENCEPHALITICA Consortium
Assessment of Magnetic Resonance Imaging Changes and Functional Outcomes Among Adults With Severe Herpes Simplex Encephalitis.
JAMA network open 2021, 4, e2114328.
Buetti N, Souweine B, Mermel L, Mimoz O, Ruckly S, Loiodice A, Mongardon N, Lucet JC, Parienti JJ, Timsit JF
Obesity and risk of catheter-related infections in the ICU. A post hoc analysis of four large randomized controlled trials.
Intensive Care Medicine 2021, 47, 435-443.
Buetti N, Ruckly S, de Montmollin E, Reignier J, Terzi N, Cohen Y, Shiami S, Dupuis C, Timsit JF
COVID-19 increased the risk of ICU-acquired bloodstream infections: a case-cohort study from the multicentric OUTCOMEREA network.
Intensive Care Medicine 2021, 47, 180-187.
Arabi YM, Azoulay E, Al-Dorzi HM, Phua J, Salluh J, Binnie A, Hodgson C, Angus DC, Cecconi M, Du B, Fowler R, Gomersall CD, Horby P, Juffermans NP, Kesecioglu J, Kleinpell RM, Machado FR, Martin GS, Meyfroidt G, Rhodes A, Rowan K, Timsit JF, Vincent JL, Citerio G
How the COVID-19 pandemic will change the future of critical care.
Intensive Care Medicine 2021, 47, 282-291.
Buetti N, Mimoz O, Mongardon N, Parienti JJ, Timsit JF
Ultrasound-guided catheterization and infectious risk in obese ICU patients.
Intensive Care Medicine 2021, 47, 632-634.
Arabi YM, Derde LPG, Timsit JF
How COVID-19 will change the management of other respiratory viral infections.
Intensive Care Medicine 2021
Bohé J, Abidi H, Brunot V, Klich A, Klouche K, Sedillot N, Tchenio X, Quenot JP, Roudaut JB, Mottard N, Thiollière F, Dellamonica J, Wallet F, Souweine B, Lautrette A, Preiser JC, Timsit JF, Vacheron CH, Ait Hssain A, Maucort-Boulch D, CONTROLe INdividualisé de la Glycémie (CONTROLING) Study Group
Individualised versus conventional glucose control in critically-ill patients: the CONTROLING study-a randomized clinical trial.
Intensive Care Medicine 2021, 47, 1271-1283.
Maataoui N, Chemali L, Patrier J, Tran Dinh A, Le Fèvre L, Lortat-Jacob B, Marzouk M, d'Humières C, Rondinaud E, Ruppé E, Montravers P, Timsit JF, Armand-Lefèvre L
Impact of rapid multiplex PCR on management of antibiotic therapy in COVID-19-positive patients hospitalized in intensive care unit.
European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology 2021, 40, 2227-2234.
Maraolo AE, Corcione S, Grossi A, Signori A, Alicino C, Hussein K, Trecarichi EM, Viale P, Timsit JF, Veeraraghavan B, Villegas MV, Rahav G, Daikos GL, Vardakas KZ, Roilides E, Uhlemann AC, Ghafur AK, Mornese Pinna S, Bassetti M, Kohler PP, Giacobbe DR
The Impact of Carbapenem Resistance on Mortality in Patients With Klebsiella Pneumoniae Bloodstream Infection: An Individual Patient Data Meta-Analysis of 1952 Patients.
Infectious Diseases and Therapy 2021
Muff S, Tabah A, Que YA, Timsit JF, Mermel L, Harbarth S, Buetti N
Short-Course Versus Long-Course Systemic Antibiotic Treatment for Uncomplicated Intravascular Catheter-Related Bloodstream Infections due to Gram-Negative Bacteria, Enterococci or Coagulase-Negative Staphylococci: A Systematic Review.
Infectious Diseases and Therapy 2021, 10, 1591-1605.
Boyer A, Timsit JF, Klouche K, Canet E, Phan TN, Bohé J, Rubin S, Orieux A, Lautrette A, Gruson D, Souweine B
Aminoglycosides in Critically Ill Septic Patients With Acute Kidney Injury Receiving Continuous Renal Replacement Therapy: A Multicenter, Observational Study.
Clinical Therapeutics 2021, S0149-2918(21)00206-X.
Boyer A, Timsit JF, Klouche K, Canet E, Phan TN, Bohé J, Rubin S, Orieux A, Lautrette A, Gruson D, Souweine B
Aminoglycosides in Critically Ill Septic Patients With Acute Kidney Injury Receiving Intermittent Hemodialysis: A Multicenter, Observational Study.
Clinical Therapeutics 2021, S0149-2918(21)00210-1.
Buetti N, Marschall J, Timsit JF, Atkinson A, Kronenberg A, Sommerstein R, Swiss Centre for Antibiotic Resistance (ANRESIS)
Distribution of pathogens and antimicrobial resistance in bacteraemia according to hospitalization duration: a nationwide surveillance study in Switzerland.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2021, S1198-743X(21)00212-3.
Castan B, Akrich B, Levy-Bachelot L, Amode A, Berthelot A, Mackosso C, Mathis L, Mootien J, Ruimy R, Ruiz F, Timsit JF, Boutoille D
Real-world evaluation of ceftolozane/tazobactam therapy and clinical outcomes in France.
Infectious Diseases Now 2021, S2666-9919(21)00111-1.
Lévy Y, Wiedemann A, Hejblum BP, Durand M, Lefebvre C, Surénaud M, Lacabaratz C, Perreau M, Foucat E, Déchenaud M, Tisserand P, Blengio F, Hivert B, Gauthier M, Cervantes-Gonzalez M, Bachelet D, Laouénan C, Bouadma L, Timsit JF, Yazdanpanah Y, Pantaleo G, Hocini H, Thiébaut R, French COVID cohort study group
CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death.
iScience 2021, 24, 102711.
Lepape A, Machut A, Gerbier-Colomban S, Kuczewski E, Rasigade JP, Timsit JF, Vanhems P, Wallet F, Savey A, Friggeri A, REA-REZO Group
Automated surveillance in French ICUs: is it feasible? Results from a survey in French ICUs participating in a surveillance network.
The Journal of Hospital Infection 2021, 115, 1-4.
de Montmollin E, Faille D, Andrieu V, Ajzenberg N, Timsit JF
Intensified thromboprophylaxis in COVID-19 critically ill patients: Is it enough?.
The Journal of Infection 2021
Fournier M, Faille D, Dossier A, Mageau A, Nicaise Roland P, Ajzenberg N, Borie R, Bouadma L, Bunel V, Castier Y, Choquet C, Crestani B, Daugas E, Deconinck L, Descamps D, Descamps V, Dieudé P, Ducrocq G, Faucher N, Goulenok T, Guidoux C, Khalil A, Lavallée P, Lescure FX, Lortat-Jacob B, Mal H, Mutuon P, Pellenc Q, Steg PG, Taille C, Timsit JF, Yazdanpanah Y, Papo T, Sacré K
Arterial Thrombotic Events in Adult Inpatients With COVID-19.
Mayo Clinic Proceedings 2021, 96, 295-303.
Wunderink RG, Matsunaga Y, Ariyasu M, Clevenbergh P, Echols R, Kaye KS, Kollef M, Menon A, Pogue JM, Shorr AF, Timsit JF, Zeitlinger M, Nagata TD
Cefiderocol versus high-dose, extended-infusion meropenem for the treatment of Gram-negative nosocomial pneumonia (APEKS-NP): a randomised, double-blind, phase 3, non-inferiority trial.
The Lancet. Infectious Diseases 2021, 21, 213-225.
Flament H, Rouland M, Beaudoin L, Toubal A, Bertrand L, Lebourgeois S, Rousseau C, Soulard P, Gouda Z, Cagninacci L, Monteiro AC, Hurtado-Nedelec M, Luce S, Bailly K, Andrieu M, Saintpierre B, Letourneur F, Jouan Y, Si-Tahar M, Baranek T, Paget C, Boitard C, Vallet-Pichard A, Gautier JF, Ajzenberg N, Terrier B, Pène F, Ghosn J, Lescure X, Yazdanpanah Y, Visseaux B, Descamps D, Timsit JF, Monteiro RC, Lehuen A
Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity.
Nature Immunology 2021, 22, 322-335.
Crawford C, Vanoli E, Decorde B, Lancelot M, Duprat C, Josserand C, Jilesen J, Bouadma L, Timsit JF
Modeling of aerosol transmission of airborne pathogens in ICU rooms of COVID-19 patients with acute respiratory failure.
Scientific Reports 2021, 11, 11778.
de Montmollin E, Timsit JF
How Antibiotics Stewardship Can Be Safely Implemented in Patients with Septic Shock?.
Seminars in Respiratory and Critical Care Medicine 2021, 42, 689-697.
Néant N, Lingas G, Le Hingrat Q, Ghosn J, Engelmann I, Lepiller Q, Gaymard A, Ferré V, Hartard C, Plantier JC, Thibault V, Marlet J, Montes B, Bouiller K, Lescure FX, Timsit JF, Faure E, Poissy J, Chidiac C, Raffi F, Kimmoun A, Etienne M, Richard JC, Tattevin P, Garot D, Le Moing V, Bachelet D, Tardivon C, Duval X, Yazdanpanah Y, Mentré F, Laouénan C, Visseaux B, Guedj J, French COVID Cohort Investigators and French Cohort Study groups
Modeling SARS-CoV-2 viral kinetics and association with mortality in hospitalized patients from the French COVID cohort.
Proceedings of the National Academy of Sciences of the United States of America 2021, 118,
Dupuis C, Timsit JF
Antibiotics in the first hour: is there new evidence?.
Expert Review of Anti-Infective Therapy 2021, 19, 45-54.
Buetti N, Patrier J, Le Hingrat Q, Loiodice A, Bouadma L, Visseaux B, Timsit JF
Risk Factors for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Detection in Blood of Critically Ill Patients.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2021, 72, e690-e691.
Buetti N, Mimoz O, Mermel L, Ruckly S, Mongardon N, Dupuis C, Mira JP, Lucet JC, Mégarbane B, Bailly S, Parienti JJ, Timsit JF
Ultrasound Guidance and Risk for Central Venous Catheter-Related Infections in the Intensive Care Unit: A Post Hoc Analysis of Individual Data of 3 Multicenter Randomized Trials.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2021, 73, e1054-e1061.
Dupuis C, Le Bihan C, Maubon D, Calvet L, Ruckly S, Schwebel C, Bouadma L, Azoulay E, Cornet M, Timsit JF, Empiricus Study Group
Performance of Repeated Measures of (1-3)-β-D-Glucan, Mannan Antigen, and Antimannan Antibodies for the Diagnosis of Invasive Candidiasis in ICU Patients: A Preplanned Ancillary Analysis of the EMPIRICUS Randomized Clinical Trial.
Open Forum Infectious Diseases 2021, 8, ofab080.
Dupuis C, Bouadma L, de Montmollin E, Goldgran-Toledano D, Schwebel C, Reignier J, Neuville M, Ursino M, Siami S, Ruckly S, Alberti C, Mourvillier B, Bailly S, Grapin K, Laurent V, Buetti N, Gainnier M, Souweine B, Timsit JF
Association Between Early Invasive Mechanical Ventilation and Day-60 Mortality in Acute Hypoxemic Respiratory Failure Related to Coronavirus Disease-2019 Pneumonia.
Critical Care Explorations 2021, 3, e0329.
de Montmollin E, Schwebel C, Dupuis C, Garrouste-Orgeas M, da Silva D, Azoulay E, Laurent V, Thiéry G, Grinea A, Marcotte G, Oziel J, Gainnier M, Siami S, Reignier J, Sztrymf B, Adrie C, Ruckly S, Sonneville R, Timsit JF
Life Support Limitations in Mechanically Ventilated Stroke Patients.
Critical Care Explorations 2021, 3, e0341.
Flahault C, Trosdorf M, Sonrier M, Vioulac C, Fasse L, Timsit JF, Bailly S, Garrouste-Orgeas M
ICU Survivors Experience of ICU Diaries: An Ancillary Qualitative Analysis of the ICU Diary Study.
Critical Care Explorations 2021, 3, e0384.
Legouy C, Girard-Stein L, Wanono R, de Montmollin E, Vellieux G, Bouadma L, Dupuis C, Abid S, Vinclair C, Ruckly S, Rouvel-Tallec A, d'Ortho MP, Timsit JF, Sonneville R
Association of Standard Electroencephalography Findings With Mortality and Command Following in Mechanically Ventilated Patients Remaining Unresponsive After Sedation Interruption.
Critical Care Medicine 2021, 49, e423-e432.
Kerneis S, Visseaux B, Armand-Lefevre L, Timsit JF
Molecular diagnostic methods for pneumonia: how can they be applied in practice?.
Current Opinion in Infectious Diseases 2021, 34, 118-125.
Tabah A, Buetti N, Barbier F, Timsit JF
Current opinion in management of septic shock due to Gram-negative bacteria.
Current Opinion in Infectious Diseases 2021, 34, 718-727.
Le Hingrat Q, Bouzid D, Choquet C, Laurent O, Lescure FX, Timsit JF, Houhou-Fidouh N, Casalino E, Lucet JC, Descamps D, Visseaux B
Viral epidemiology and SARS-CoV-2 co-infections with other respiratory viruses during the first COVID-19 wave in Paris, France.
Influenza and Other Respiratory Viruses 2021, 15, 425-428.
Mageau A, Aldebert G, Van Gysel D, Papo T, Timsit JF, Sacre K
SARS-CoV-2 infection among inpatients with systemic lupus erythematosus in France: a nationwide epidemiological study.
Annals of the Rheumatic Diseases 2021
Reignier J, Le Gouge A, Lascarrou JB, Annane D, Argaud L, Hourmant Y, Asfar P, Badie J, Nay MA, Botoc NV, Brisard L, Bui HN, Chatellier D, Chauvelot L, Combes A, Cracco C, Darmon M, Das V, Debarre M, Delbove A, Devaquet J, Voicu S, Aissaoui-Balanant N, Dumont LM, Oziel J, Gontier O, Groyer S, Guidet B, Jaber S, Lambiotte F, Leroy C, Letocart P, Madeux B, Maizel J, Martinet O, Martino F, Mercier E, Mira JP, Nseir S, Picard W, Piton G, Plantefeve G, Quenot JP, Renault A, Guérin L, Richecoeur J, Rigaud JP, Schneider F, Silva D, Sirodot M, Souweine B, Reizine F, Tamion F, Terzi N, Thévenin D, Thiéry G, Thieulot-Rolin N, Timsit JF, Tinturier F, Tirot P, Vanderlinden T, Vinatier I, Vinsonneau C, Maugars D, Giraudeau B
Impact of early low-calorie low-protein versus standard-calorie standard-protein feeding on outcomes of ventilated adults with shock: design and conduct of a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3).
BMJ open 2021, 11, e045041.
Voiriot G, Fartoukh M, Durand-Zaleski I, Berard L, Rousseau A, Armand-Lefevre L, Verdet C, Argaud L, Klouche K, Megarbane B, Patrier J, Richard JC, Reignier J, Schwebel C, Souweine B, Tandjaoui-Lambiotte Y, Simon T, Timsit JF, MULTI-CAP study group
Combined use of a broad-panel respiratory multiplex PCR and procalcitonin to reduce duration of antibiotics exposure in patients with severe community-acquired pneumonia (MULTI-CAP): a multicentre, parallel-group, open-label, individual randomised trial conducted in French intensive care units.
BMJ open 2021, 11, e048187.
Buetti N, Mimoz O, Schwebel C, Ruckly S, Castry M, Dupuis C, Souweine B, Lucet JC, Timsit JF
Insertion Site and Infection Risk among Peripheral Arterial Catheters.
American Journal of Respiratory and Critical Care Medicine 2021, 203, 630-633.
Dumas G, Lemiale V, Rathi N, Cortegiani A, Pène F, Bonny V, Salluh J, Albaiceta GM, Soares M, Soubani AO, Canet E, Hanane T, Kouatchet A, Mokart D, Lebiedz P, Türkoğlu M, Coudroy R, Jeon K, Demoule A, Mehta S, Caruso P, Frat JP, Yang KY, Roca O, Laffey J, Timsit JF, Azoulay E, Darmon M
Survival in Immunocompromised Patients Ultimately Requiring Invasive Mechanical Ventilation: A Pooled Individual Patient Data Analysis.
American Journal of Respiratory and Critical Care Medicine 2021, 204, 187-196.
Tandjaoui-Lambiotte Y, Timsit JF, Alloui C, Zahar JR, Vanoli E
Viral Dispersion in the Intensive Care Unit: The Wind Effect.
American Journal of Respiratory and Critical Care Medicine 2021
von Cube M, Timsit JF, Kammerlander A, Schumacher M
Quantifying and communicating the burden of COVID-19.
BMC medical research methodology 2021, 21, 164.
Blanc E, Chaize G, Fievez S, Féger C, Herquelot E, Vainchtock A, Timsit JF, Gaillat J
The impact of comorbidities and their stacking on short- and long-term prognosis of patients over 50 with community-acquired pneumonia.
BMC infectious diseases 2021, 21, 949.
Gheerbrant H, Timsit JF, Terzi N, Ruckly S, Laramas M, Levra MG, Jacquet E, Falque L, Moro-Sibilot D, Toffart AC
Factors associated with survival of patients with solid Cancer alive after intensive care unit discharge between 2005 and 2013.
BMC cancer 2021, 21, 9.
Dupuis C, Sabra A, Patrier J, Chaize G, Saighi A, Féger C, Vainchtock A, Gaillat J, Timsit JF
Burden of pneumococcal pneumonia requiring ICU admission in France: 1-year prognosis, resources use, and costs.
Critical Care (London, England) 2021, 25, 24.
Buetti N, Ruckly S, Lucet JC, Mimoz O, Souweine B, Timsit JF
Factors influencing local signs at catheter insertion site regardless of catheter-related bloodstream infections.
Critical Care (London, England) 2021, 25, 71.
Wicky PH, Niedermann MS, Timsit JF
Ventilator-associated pneumonia in the era of COVID-19 pandemic: How common and what is the impact?.
Critical Care (London, England) 2021, 25, 153.
Timsit JF, Huntington JA, Wunderink RG, Shime N, Kollef MH, Kivistik Ü, Nováček M, Réa-Neto Á, Martin-Loeches I, Yu B, Jensen EH, Butterton JR, Wolf DJ, Rhee EG, Bruno CJ
Ceftolozane/tazobactam versus meropenem in patients with ventilated hospital-acquired bacterial pneumonia: subset analysis of the ASPECT-NP randomized, controlled phase 3 trial.
Critical Care (London, England) 2021, 25, 290.
Kollef MH, Shorr AF, Bassetti M, Timsit JF, Micek ST, Michelson AP, Garnacho-Montero J
Timing of antibiotic therapy in the ICU.
Critical Care (London, England) 2021, 25, 360.
Meyer A, Buetti N, Houhou-Fidouh N, Patrier J, Abdel-Nabey M, Jaquet P, Presente S, Girard T, Sayagh F, Ruckly S, Wicky PH, de Montmollin E, Bouadma L, Sonneville R, Descamps D, Timsit JF
HSV-1 reactivation is associated with an increased risk of mortality and pneumonia in critically ill COVID-19 patients.
Critical Care (London, England) 2021, 25, 417.
Touchard C, Cartailler J, Vellieux G, de Montmollin E, Jaquet P, Wanono R, Reuter J, Para M, Bouadma L, Timsit JF, d'Ortho MP, Kubis N, Rouvel Tallec A, Sonneville R, DINAMO Study Group
Simplified frontal EEG in adults under veno-arterial extracorporeal membrane oxygenation.
Annals of Intensive Care 2021, 11, 76.
Jung B, Le Bihan C, Portales P, Bourgeois N, Vincent T, Lachaud L, Chanques G, Conseil M, Corne P, Massanet P, Timsit JF, Jaber S
Monocyte human leukocyte antigen-DR but not β-D-glucan may help early diagnosing invasive Candida infection in critically ill patients.
Annals of Intensive Care 2021, 11, 129.
Buetti N, Ruckly S, Lucet JC, Mageau A, Dupuis C, Souweine B, Mimoz O, Timsit JF
Practices and intravascular catheter infection during on- and off-hours in critically ill patients.
Annals of Intensive Care 2021, 11, 153.
d'Humières C, Patrier J, Lortat-Jacob B, Tran-Dinh A, Chemali L, Maataoui N, Rondinaud E, Ruppé E, Burdet C, Ruckly S, Montravers P, Timsit JF, Armand-Lefevre L
Two original observations concerning bacterial infections in COVID-19 patients hospitalized in intensive care units during the first wave of the epidemic in France.
PloS One 2021, 16, e0250728.
Papin G, Bailly S, Dupuis C, Ruckly S, Gainnier M, Argaud L, Azoulay E, Adrie C, Souweine B, Goldgran-Toledano D, Marcotte G, Gros A, Reignier J, Mourvillier B, Forel JM, Sonneville R, Dumenil AS, Darmon M, Garrouste-Orgeas M, Schwebel C, Timsit JF, OUTCOMEREA study group
Clinical and biological clusters of sepsis patients using hierarchical clustering.
PloS One 2021, 16, e0252793.
Dupuis C, de Montmollin E, Buetti N, Goldgran-Toledano D, Reignier J, Schwebel C, Domitile J, Neuville M, Ursino M, Siami S, Ruckly S, Alberti C, Mourvillier B, Bailly S, Laurent V, Gainnier M, Souweine B, Timsit JF, OutcomeReaTM research network
Impact of early corticosteroids on 60-day mortality in critically ill patients with COVID-19: A multicenter cohort study of the OUTCOMEREA network.
PloS One 2021, 16, e0255644.
Evrard D, Jurcisin I, Assadi M, Patrier J, Tafani V, Ullmann N, Timsit JF, Montravers P, Barry B, Weiss E, Rozencwajg S
Tracheostomy in COVID-19 acute respiratory distress syndrome patients and follow-up: A parisian bicentric retrospective cohort.
PloS One 2021, 16, e0261024.
Lebourgeois S, Chenane HR, Houhou-Fidouh N, Menidjel R, Ferré VM, Collin G, Benmalek N, Coppée R, Larrouy L, Yazdanpanah Y, Timsit JF, Charpentier C, Descamps D, Visseaux B
Earlier In Vitro Viral Production With SARS-CoV-2 Alpha Than With Beta, Gamma, B, or A.27 Variants.
Frontiers in Cellular and Infection Microbiology 2021, 11, 792202.
Ursino M, Dupuis C, Buetti N, de Montmollin E, Bouadma L, Golgran-Toledano D, Ruckly S, Neuville M, Cohen Y, Mourvillier B, Souweine B, Gainnier M, Laurent V, Terzi N, Shiami S, Reignier J, Alberti C, Timsit JF, On Behalf Of The Outcomerea Study Group n
Multistate Modeling of COVID-19 Patients Using a Large Multicentric Prospective Cohort of Critically Ill Patients.
Journal of Clinical Medicine 2021, 10,
2020
Vincent JL, Sakr Y, Singer M, Martin-Loeches I, Machado FR, Marshall JC, Finfer S, Pelosi P, Brazzi L, Aditianingsih D, Timsit JF, Du B, Wittebole X, Máca J, Kannan S, Gorordo-Delsol LA, De Waele JJ, Mehta Y, Bonten MJM, Khanna AK, Kollef M, Human M, Angus DC, EPIC III Investigators
Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017.
JAMA 2020, 323, 1478-1487.
Luyt CE, Forel JM, Hajage D, Jaber S, Cayot-Constantin S, Rimmelé T, Coupez E, Lu Q, Diallo MH, Penot-Ragon C, Clavel M, Schwebel C, Timsit JF, Bedos JP, Hauw-Berlemont C, Bourenne J, Mayaux J, Lefrant JY, Mira JP, Combes A, Wolff M, Chastre J, Papazian L, for the Preemptive Treatment for Herpesviridae Study Group, Réseau Européen de recherche en Ventilation Artificielle Network
Acyclovir for Mechanically Ventilated Patients With Herpes Simplex Virus Oropharyngeal Reactivation: A Randomized Clinical Trial.
JAMA Internal Medicine 2020, 180, 263.
von Cube M, Schumacher M, Putter H, Timsit JF, van de Velde C, Wolkewitz M
The population-attributable fraction for time-dependent exposures using dynamic prediction and landmarking.
Biometrical Journal. Biometrische Zeitschrift 2020, 62, 583-597.
Heyard R, Timsit JF, Held L, COMBACTE-MAGNET consortium
Validation of discrete time-to-event prediction models in the presence of competing risks.
Biometrical Journal. Biometrische Zeitschrift 2020, 62, 643-657.
Denny KJ, Kumar A, Timsit JF, Laupland KB
Extra-cardiac endovascular infections in the critically ill.
Intensive Care Medicine 2020, 46, 173-181.
Saied WI, Martin-Loeches I, Timsit JF
What is new in non-ventilated ICU-acquired pneumonia?.
Intensive Care Medicine 2020, 46, 488-491.
Tabah A, Bassetti M, Kollef MH, Zahar JR, Paiva JA, Timsit JF, Roberts JA, Schouten J, Giamarellou H, Rello J, De Waele J, Shorr AF, Leone M, Poulakou G, Depuydt P, Garnacho-Montero J
Antimicrobial de-escalation in critically ill patients: a position statement from a task force of the European Society of Intensive Care Medicine (ESICM) and European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Critically Ill Patients Study Group (ESGCIP).
Intensive Care Medicine 2020, 46, 245-265.
Timsit JF, Ruppé E, Barbier F, Tabah A, Bassetti M
Bloodstream infections in critically ill patients: an expert statement.
Intensive Care Medicine 2020, 46, 266-284.
Timsit JF, Lipman J, Bassetti M
Antimicrobial de-escalation is part of appropriate antibiotic usage in ICU.
Intensive Care Medicine 2020, 46, 1039-1042.
Bouadma L, Lescure FX, Lucet JC, Yazdanpanah Y, Timsit JF
Severe SARS-CoV-2 infections: practical considerations and management strategy for intensivists.
Intensive Care Medicine 2020, 46, 579-582.
Andremont O, Armand-Lefevre L, Dupuis C, de Montmollin E, Ruckly S, Lucet JC, Smonig R, Magalhaes E, Ruppé E, Mourvillier B, Lebut J, Lermuzeaux M, Sonneville R, Bouadma L, Timsit JF, COMBACTE net consortium
Semi-quantitative cultures of throat and rectal swabs are efficient tests to predict ESBL-Enterobacterales ventilator-associated pneumonia in mechanically ventilated ESBL carriers.
Intensive Care Medicine 2020, 46, 1232-1242.
Abdul-Aziz MH, Alffenaar JWC, Bassetti M, Bracht H, Dimopoulos G, Marriott D, Neely MN, Paiva JA, Pea F, Sjovall F, Timsit JF, Udy AA, Wicha SG, Zeitlinger M, De Waele JJ, Roberts JA, Infection Section of European Society of Intensive Care Medicine (ESICM), Pharmacokinetic/pharmacodynamic and Critically Ill Patient Study Groups of European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Group of International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT), Infections in the ICU and Sepsis Working Group of International Society of Antimicrobial Chemotherapy (ISAC)
Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper.
Intensive Care Medicine 2020, 46, 1127-1153.
De Bus L, Depuydt P, Steen J, Dhaese S, De Smet K, Tabah A, Akova M, Cotta MO, De Pascale G, Dimopoulos G, Fujitani S, Garnacho-Montero J, Leone M, Lipman J, Ostermann M, Paiva JA, Schouten J, Sjövall F, Timsit JF, Roberts JA, Zahar JR, Zand F, Zirpe K, De Waele JJ, DIANA study group
Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study.
Intensive Care Medicine 2020, 46, 1404-1417.
Bassetti M, Kollef MH, Timsit JF
Bacterial and fungal superinfections in critically ill patients with COVID-19.
Intensive Care Medicine 2020, 46, 2071-2074.
Kalil AC, Timsit JF
Less is more: critically ill status is not a carte blanche for unlimited antibiotic use.
Intensive Care Medicine 2020, 46, 2075-2078.
Luyt CE, Bouadma L, Morris AC, Dhanani JA, Kollef M, Lipman J, Martin-Loeches I, Nseir S, Ranzani OT, Roquilly A, Schmidt M, Torres A, Timsit JF
Pulmonary infections complicating ARDS.
Intensive Care Medicine 2020, 46, 2168-2183.
Bouadma L, Wiedemann A, Patrier J, Surénaud M, Wicky PH, Foucat E, Diehl JL, Hejblum BP, Sinnah F, de Montmollin E, Lacabaratz C, Thiébaut R, Timsit JF, Lévy Y
Immune Alterations in a Patient with SARS-CoV-2-Related Acute Respiratory Distress Syndrome.
Journal of Clinical Immunology 2020, 40, 1082-1092.
Sonneville R, Mazighi M, Bresson D, Crassard I, Crozier S, de Montmollin E, Degos V, Faugeras F, Gayat E, Josse L, Lamy C, Magalhaes E, Maldjian A, Ruckly S, Servan J, Vassel P, Vigué B, Timsit JF, Woimant F, SPICE investigators
Outcomes of Acute Stroke Patients Requiring Mechanical Ventilation: Study Protocol for the SPICE Multicenter Prospective Observational Study.
Neurocritical Care 2020, 32, 624-629.
Magalhaes E, Reuter J, Wanono R, Bouadma L, Jaquet P, Tanaka S, Sinnah F, Ruckly S, Dupuis C, de Montmollin E, Para M, Braham W, Pisani A, d'Ortho MP, Rouvel-Tallec A, Timsit JF, Sonneville R, DINAMO study group
Early EEG for Prognostication Under Venoarterial Extracorporeal Membrane Oxygenation.
Neurocritical Care 2020, 33, 688-694.
Rello J, Belliato M, Dimopoulos MA, Giamarellos-Bourboulis EJ, Jaksic V, Martin-Loeches I, Mporas I, Pelosi P, Poulakou G, Pournaras S, Tamae-Kakazu M, Timsit JF, Waterer G, Tejada S, Dimopoulos G
Update in COVID-19 in the intensive care unit from the 2020 HELLENIC Athens International symposium.
Anaesthesia, Critical Care & Pain Medicine 2020, 39, 723-730.
Michallet M, Sobh M, Deray G, Gangneux JP, Pigneux A, Larrey D, Ribaud P, Mira JP, Nivoix Y, Yakoub-Agha I, Timsit JF, Alfandari S, Herbrecht R
Antifungal Stewardship in Hematology: Reflection of a Multidisciplinary Group of Experts.
Clinical Lymphoma Myeloma and Leukemia 2020, S2152265020304250.
de Grooth HJ, Timsit JF, Mermel L, Mimoz O, Buetti N, du Cheyron D, Oudemans-van Straaten HM, Parienti JJ, 3SITES, CLEAN and DRESSING groups
Validity of surrogate endpoints assessing central venous catheter-related infection: evidence from individual- and study-level analyses.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2020, 26, 563-571.
Peiffer-Smadja N, Lucet JC, Bendjelloul G, Bouadma L, Gerard S, Choquet C, Jacques S, Khalil A, Maisani P, Casalino E, Descamps D, Timsit JF, Yazdanpanah Y, Lescure FX
Challenges and issues about organising a hospital to respond to the COVID-19 outbreak: experience from a French reference centre.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2020
Buetti N, Souweine B, Mermel L, Mimoz O, Ruckly S, Loiodice A, Mongardon N, Lucet JC, Parienti JJ, Timsit JF
Concurrent systemic antibiotics at catheter insertion and intravascular catheter-related infection in the ICU: a post hoc analysis using individual data from five large RCTs.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2020
Muff S, Hebeisen U, Timsit JF, Mermel L, Harbarth S, Buetti N
Treatment duration of enterococcal intravascular catheter-related infections.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2020
Hingrat QL, Visseaux B, Laouenan C, Tubiana S, Bouadma L, Yazdanpanah Y, Duval X, Burdet C, Ichou H, Damond F, Bertine M, Benmalek N, Choquet C, Timsit JF, Ghosn J, Charpentier C, Descamps D, Houhou-Fidouh N, French COVID cohort management committee, CoV-CONTACT study group, members of the French-COVID cohort study group (by alphabetical order), member of the CoV-CONTACT study group. Principal investigator, Steering Committee, CoV-CONTACT Clinical Centers, Coordination and statistical analyses, Virological Lab, Biological Center, Partners, Sponsor, Genetic
Detection of SARS-CoV-2 N-antigen in blood during acute COVID-19 provides a sensitive new marker and new testing alternatives.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2020, S1198-743X(20)30721-7.
Benchetrit L, Mathy V, Armand-Lefevre L, Bouadma L, Timsit JF
Successful treatment of septic shock due to NDM-1-producing Klebsiella pneumoniae using ceftazidime/avibactam combined with aztreonam in solid organ transplant recipients: report of two cases.
International Journal of Antimicrobial Agents 2020, 55, 105842.
Bailly S, Galerneau LM, Ruckly S, Seiller A, Terzi N, Schwebel C, Dupuis C, Tamisier R, Mourvillier B, Pepin JL, Timsit JF
Impact of obstructive sleep apnea on the obesity paradox in critically ill patients.
Journal of Critical Care 2020, 56, 120-124.
Jolivet S, Lolom I, Bailly S, Bouadma L, Lortat-Jacob B, Montravers P, Armand-Lefevre L, Timsit JF, Lucet JC
Impact of colonization pressure on acquisition of extended-spectrum β-lactamase-producing Enterobacterales and meticillin-resistant Staphylococcus aureus in two intensive care units: a 19-year retrospective surveillance.
The Journal of Hospital Infection 2020, 105, 10-16.
Ibn Saied W, Merceron S, Schwebel C, Le Monnier A, Oziel J, Garrouste-Orgeas M, Marcotte G, Ruckly S, Souweine B, Darmon M, Bouadma L, de Montmollin E, Mourvillier B, Reignier J, Papazian L, Siami S, Azoulay E, Bédos JP, Timsit JF
Ventilator-associated pneumonia due to Stenotrophomonas maltophilia: Risk factors and outcome.
The Journal of Infection 2020, 80, 279-285.
San C, Lê MP, Matheron S, Mourvillier B, Caseris M, Timsit JF, Wolff M, Yazdanpanah Y, Descamps D, Peytavin G
Management of oral antiretroviral administration in patients with swallowing disorders or with an enteral feeding tube.
Medecine Et Maladies Infectieuses 2020, 50, 537-544.
Denis N, Timsit JF, Giaj Levra M, Sakhri L, Duruisseaux M, Schwebel C, Merle P, Pinsolle J, Ferrer L, Moro-Sibilot D, Toffart AC
Impact of systematic advanced care planning in lung cancer patients: A prospective study.
Respiratory Medicine and Research 2020, 77, 11-17.
Lescure FX, Bouadma L, Nguyen D, Parisey M, Wicky PH, Behillil S, Gaymard A, Bouscambert-Duchamp M, Donati F, Le Hingrat Q, Enouf V, Houhou-Fidouh N, Valette M, Mailles A, Lucet JC, Mentre F, Duval X, Descamps D, Malvy D, Timsit JF, Lina B, van-der-Werf S, Yazdanpanah Y
Clinical and virological data of the first cases of COVID-19 in Europe: a case series.
The Lancet. Infectious Diseases 2020, 20, 697-706.
von Cube M, Timsit JF, Schumacher M, Motschall E, Schumacher M
Quantification and interpretation of attributable mortality in core clinical infectious disease journals.
The Lancet. Infectious Diseases 2020, 20, e299-e306.
Lê MP, Jaquet P, Patrier J, Wicky PH, Le Hingrat Q, Veyrier M, Kauv J, Sonneville R, Visseaux B, Laouénan C, Bouadma L, Descamps D, de Montmollin E, Peytavin G, Timsit JF
Pharmacokinetics of lopinavir/ritonavir oral solution to treat COVID-19 in mechanically ventilated ICU patients.
The Journal of Antimicrobial Chemotherapy 2020, 75, 2657-2660.
Reuter J, Peoc'h K, Bouadma L, Ruckly S, Chicha-Cattoir V, Faille D, Bourrienne MC, Dupuis C, Magalhaes E, Tanaka S, Vinclair C, de Montmollin E, Mazighi M, Para M, Braham W, Pisani A, Ajzenberg N, Timsit JF, Sonneville R
Neuron-Specific Enolase Levels in Adults Under Venoarterial Extracorporeal Membrane Oxygenation.
Critical Care Explorations 2020, 2, e0239.
Buetti N, Ruckly S, Lucet JC, Perozziello A, Mimoz O, Souweine B, Timsit JF
The Insertion Site Should Be Considered for the Empirical Therapy of Short-Term Central Venous and Arterial Catheter-Related Infections.
Critical Care Medicine 2020, 48, 739-744.
Baudry G, Sonneville R, Waintraub X, Lebreton G, Deguillard C, Mertens E, Bouadma L, Demondion P, Bréchot N, Luyt CE, Extramiana F, Hékimian G, Dupuis C, Para M, Pisani A, Braham W, Gandjbakhch E, Leenhardt A, Timsit JF, Leprince P, Combes A, Schmidt M
Extracorporeal Membrane Oxygenation to Support Life-Threatening Drug-Refractory Electrical Storm.
Critical Care Medicine 2020, 48, e856-e863.
Buetti N, Tabah A, Timsit JF, Zingg W
What is new in catheter use and catheter infection prevention in the ICU.
Current Opinion in Critical Care 2020, 26, 459-465.
Patrier J, Timsit JF
Carbapenem use in critically ill patients.
Current Opinion in Infectious Diseases 2020, 33, 86-91.
Barbier F, Timsit JF
Risk stratification for multidrug-resistant bacteria in patients with skin and soft tissue infection.
Current Opinion in Infectious Diseases 2020, 33, 137-145.
Le Fevre L, Timsit JF
Duration of antimicrobial therapy for Gram-negative infections.
Current Opinion in Infectious Diseases 2020, 33, 511-516.
Timsit JF, Leverger G, Milpied N, Gachot B
Treatment of invasive fungal infections in intensive care units with micafungin: The MYRIADE study.
Mycoses 2020, 63, 443-451.
Lê MP, Le Hingrat Q, Jaquet P, Wicky PH, Bunel V, Massias L, Visseaux B, Messika J, Descamps D, Mal H, Timsit JF, Peytavin G
Removal of Remdesivir's Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19.
Antimicrobial Agents and Chemotherapy 2020, 64,
Bailly S, Gautier-Veyret E, Lê MP, Bouadma L, Andremont O, Neuville M, Mourvillier B, Sonneville R, Magalhaes E, Lebut J, Radjou A, Smonig R, Wolff M, Massias L, Dupuis C, Timsit JF
Impact of Loading Dose of Caspofungin in Pharmacokinetic-Pharmacodynamic Target Attainment for Severe Candidiasis Infections in Patients in Intensive Care Units: the CASPOLOAD Study.
Antimicrobial Agents and Chemotherapy 2020, 64, e01545-20.
Lê MP, Le Beller C, Le Hingrat Q, Jaquet P, Wicky PH, Bunel V, Massias L, Visseaux B, Messika J, Descamps D, Mal H, Timsit JF, Peytavin G
Reply to Yan and Muller, "Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity".
Antimicrobial Agents and Chemotherapy 2020, 64,
Visseaux B, Le Hingrat Q, Collin G, Bouzid D, Lebourgeois S, Le Pluart D, Deconinck L, Lescure FX, Lucet JC, Bouadma L, Timsit JF, Descamps D, Yazdanpanah Y, Casalino E, Houhou-Fidouh N, McAdam AJ
Evaluation of the QIAstat-Dx Respiratory SARS-CoV-2 Panel, the First Rapid Multiplex PCR Commercial Assay for SARS-CoV-2 Detection.
Journal of Clinical Microbiology 2020, 58, e00630-20, /jcm/58/8/JCM.00630-20.atom.
Peiffer-Smadja N, Bouadma L, Mathy V, Allouche K, Patrier J, Reboul M, Montravers P, Timsit JF, Armand-Lefevre L
Performance and impact of a multiplex PCR in ICU patients with ventilator-associated pneumonia or ventilated hospital-acquired pneumonia.
Critical Care (London, England) 2020, 24, 366.
Buetti N, Ruckly S, Schwebel C, Mimoz O, Souweine B, Lucet JC, Timsit JF
Chlorhexidine-impregnated sponge versus chlorhexidine gel dressing for short-term intravascular catheters: which one is better?.
Critical Care (London, England) 2020, 24, 458.
Buetti N, Wicky PH, Le Hingrat Q, Ruckly S, Mazzuchelli T, Loiodice A, Trimboli P, Forni Ogna V, de Montmollin E, Bernasconi E, Visseaux B, Timsit JF
SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients.
Critical Care (London, England) 2020, 24, 610.
Buetti N, Ruckly S, Lucet JC, Bouadma L, Garrouste-Orgeas M, Schwebel C, Mimoz O, Souweine B, Timsit JF
Local signs at insertion site and catheter-related bloodstream infections: an observational post hoc analysis using individual data of four RCTs.
Critical Care (London, England) 2020, 24, 694.
Vinclair C, De Montmollin E, Sonneville R, Reuter J, Lebut J, Cally R, Mourvillier B, Neuville M, Ruckly S, Timsit JF, Bouadma L
Factors associated with major adverse kidney events in patients who underwent veno-arterial extracorporeal membrane oxygenation.
Annals of Intensive Care 2020, 10, 44.
OUTCOMEREA Study Group, de Montmollin E, Terzi N, Dupuis C, Garrouste-Orgeas M, da Silva D, Darmon M, Laurent V, Thiéry G, Oziel J, Marcotte G, Gainnier M, Siami S, Sztrymf B, Adrie C, Reignier J, Ruckly S, Sonneville R, Timsit JF
One-year survival in acute stroke patients requiring mechanical ventilation: a multicenter cohort study.
Annals of Intensive Care 2020, 10, 53.
Buetti N, Ruckly S, Lucet JC, Bouadma L, Schwebel C, Mimoz O, Timsit JF
Ultrasound guidance and risk for intravascular catheter-related infections among peripheral arterial catheters: a post-hoc analysis of two large randomized-controlled trials.
Annals of Intensive Care 2020, 10, 89.
Timsit JF, Baleine J, Bernard L, Calvino-Gunther S, Darmon M, Dellamonica J, Desruennes E, Leone M, Lepape A, Leroy O, Lucet JC, Merchaoui Z, Mimoz O, Misset B, Parienti JJ, Quenot JP, Roch A, Schmidt M, Slama M, Souweine B, Zahar JR, Zingg W, Bodet-Contentin L, Maxime V
Expert consensus-based clinical practice guidelines management of intravascular catheters in the intensive care unit.
Annals of Intensive Care 2020, 10, 118.
Elabbadi A, Pichon J, Visseaux B, Schnuriger A, Bouadma L, Philippot Q, Patrier J, Labbé V, Ruckly S, Fartoukh M, Timsit JF, Voiriot G
Respiratory virus-associated infections in HIV-infected adults admitted to the intensive care unit for acute respiratory failure: a 6-year bicenter retrospective study (HIV-VIR study).
Annals of Intensive Care 2020, 10, 123.
Dupuis C, Bouadma L, Ruckly S, Perozziello A, Van-Gysel D, Mageau A, Mourvillier B, de Montmollin E, Bailly S, Papin G, Sinnah F, Vinclair C, Abid S, Sonneville R, Timsit JF
Sepsis and septic shock in France: incidences, outcomes and costs of care.
Annals of Intensive Care 2020, 10, 145.
Sonneville R, Smonig R, Dupuis C, Bouadma L, de Montmollin E, Timsit JF
Natural light exposure and delirium in ICU: does the dark side cloud everything?.
Annals of Intensive Care 2020, 10, 25.
Fontaine C, Armand-Lefèvre L, Magnan M, Nazimoudine A, Timsit JF, Ruppé E
Relationship between the composition of the intestinal microbiota and the tracheal and intestinal colonization by opportunistic pathogens in intensive care patients.
PloS One 2020, 15, e0237260.
Bouzid D, Mullaert J, Le Hingrat Q, Laurent O, Duval X, Lescure X, Timsit JF, Descamps D, Montravers P, Choquet C, Lucet JC, Casalino E, Visseaux B, ED influenza study group
Characteristics associated with COVID-19 or other respiratory viruses' infections at a single-center emergency department.
PloS One 2020, 15, e0243261.
Borie R, Savale L, Dossier A, Ghosn J, Taillé C, Visseaux B, Jebreen K, Diallo A, Tesmoingt C, Morer L, Goletto T, Faucher N, Hajouji L, Neukirch C, Phillips M, Stelianides S, Bouadma L, Brosseau S, Ottaviani S, Pluvy J, Le Pluart D, Debray MP, Raynaud-Simon A, Descamps D, Khalil A, Timsit JF, Lescure FX, Descamps V, Papo T, Humbert M, Crestani B, Dieude P, Vicaut E, Zalcman G, Bichat & Kremlin-Bicêtre AP-HP COVID teams
Glucocorticoids with low-dose anti-IL1 anakinra rescue in severe non-ICU COVID-19 infection: A cohort study.
PloS One 2020, 15, e0243961.
Dang E, Sayagh F, Lê MP, Neuville M, Sinnah F, Timsit JF, Peytavin G
Plasma pharmacokinetics of bedaquiline administered by nasogastric tube in an intensive care unit.
The International Journal of Tuberculosis and Lung Disease: The Official Journal of the International Union Against Tuberculosis and Lung Disease 2020, 24, 110-112.
2019
Garrouste-Orgeas M, Bailly S, Timsit JF
Use of an ICU Diary and Patient Posttraumatic Stress Disorder Symptoms—Reply.
JAMA 2019, 322, 2025.
Garrouste-Orgeas M, Flahault C, Vinatier I, Rigaud JP, Thieulot-Rolin N, Mercier E, Rouget A, Grand H, Lesieur O, Tamion F, Hamidfar R, Renault A, Parmentier-Decrucq E, Monseau Y, Argaud L, Bretonnière C, Lautrette A, Badié J, Boulet E, Floccard B, Forceville X, Kipnis E, Soufir L, Valade S, Bige N, Gaffinel A, Hamzaoui O, Simon G, Thirion M, Bouadma L, Large A, Mira JP, Amdjar-Badidi N, Jourdain M, Jost PH, Maxime V, Santoli F, Ruckly S, Vioulac C, Leborgne MA, Bellalou L, Fasse L, Misset B, Bailly S, Timsit JF
Effect of an ICU Diary on Posttraumatic Stress Disorder Symptoms Among Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial.
JAMA 2019, 322, 229-239.
von Cube M, Schumacher M, Bailly S, Timsit JF, Lepape A, Savey A, Machut A, Wolkewitz M
The population-attributable fraction for time-dependent exposures and competing risks-A discussion on estimands.
Statistics in Medicine 2019, 38, 3880-3895.
Timsit JF, Bassetti M, Cremer O, Daikos G, de Waele J, Kallil A, Kipnis E, Kollef M, Laupland K, Paiva JA, Rodríguez-Baño J, Ruppé É, Salluh J, Taccone FS, Weiss E, Barbier F
Rationalizing antimicrobial therapy in the ICU: a narrative review.
Intensive Care Medicine 2019, 45, 172-189.
Timsit JF, Citerio G, Lavilloniere M, Perner A, Ruckly S, Bakker J, Bassetti M, Benoit D, Curtis JR, Doig GS, Herridge M, Jaber S, Papazian L, Peters MJ, Singer P, Smith M, Soares M, Torres A, Vieillard-Baron A, Azoulay E
Determinants of downloads and citations for articles published in Intensive Care Medicine.
Intensive Care Medicine 2019, 45, 1058-1060.
Pons S, Timsit JF, Ruckly S, Schwebel C, Papazian L, Azoulay E, Reignier J, Zafrani L
Impact of macrolide therapy in critically ill patients with acute respiratory failure: a desirability of outcome ranking analysis to investigate the OUTCOMEREA database.
Intensive Care Medicine 2019
Timsit JF, Sonneville R, Kalil AC, Bassetti M, Ferrer R, Jaber S, Lanternier F, Luyt CE, Machado F, Mikulska M, Papazian L, Pène F, Poulakou G, Viscoli C, Wolff M, Zafrani L, Van Delden C
Diagnostic and therapeutic approach to infectious diseases in solid organ transplant recipients.
Intensive Care Medicine 2019, 45, 573-591.
Martin-Loeches I, Antonelli M, Cuenca-Estrella M, Dimopoulos G, Einav S, De Waele JJ, Garnacho-Montero J, Kanj SS, Machado FR, Montravers P, Sakr Y, Sanguinetti M, Timsit JF, Bassetti M
ESICM/ESCMID task force on practical management of invasive candidiasis in critically ill patients.
Intensive Care Medicine 2019, 45, 789-805.
Timsit JF, Schwebel C, Styfalova L, Cornet M, Poirier P, Forrestier C, Ruckly S, Jacob MC, Souweine B
Impact of bronchial colonization with Candida spp. on the risk of bacterial ventilator-associated pneumonia in the ICU: the FUNGIBACT prospective cohort study.
Intensive Care Medicine 2019, 45, 834-843.
Blot S, Poulakou G, Timsit JF
Catheter-associated bloodstream infection rates: how low can you go?.
Intensive Care Medicine 2019, 45, 896-897.
Jaquet P, de Montmollin E, Dupuis C, Sazio C, Conrad M, Susset V, Demeret S, Tadie JM, Argaud L, Barbier F, Sarton B, Chabane R, Daubin D, Brulé N, Lerolle N, Alves M, Da Silva D, Kalioubi AE, Silva S, Bailly P, Wolff M, Bouadma L, Timsit JF, Sonneville R, ENCEPHALITICA study group
Functional outcomes in adult patients with herpes simplex encephalitis admitted to the ICU: a multicenter cohort study.
Intensive Care Medicine 2019, 45, 1103-1111.
Buetti N, Ruckly S, Lucet JC, Mimoz O, Souweine B, Timsit JF
Short-term dialysis catheter versus central venous catheter infections in ICU patients: a post hoc analysis of individual data of 4 multi-centric randomized trials.
Intensive Care Medicine 2019
Blot S, Antonelli M, Arvaniti K, Blot K, Creagh-Brown B, de Lange D, De Waele J, Deschepper M, Dikmen Y, Dimopoulos G, Eckmann C, Francois G, Girardis M, Koulenti D, Labeau S, Lipman J, Lipovestky F, Maseda E, Montravers P, Mikstacki A, Paiva JA, Pereyra C, Rello J, Timsit JF, Vogelaers D, Abdominal Sepsis Study (AbSeS) group on behalf of the Trials Group of the European Society of Intensive Care Medicine
Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM Trials Group Project.
Intensive Care Medicine 2019, 45, 1703-1717.
Mageau A, Timsit JF, Perrozziello A, Ruckly S, Dupuis C, Bouadma L, Papo T, Sacre K
The burden of chronic kidney disease in systemic lupus erythematosus: A nationwide epidemiologic study.
Autoimmunity Reviews 2019, 18, 733-737.
Schweitzer VA, van Werkhoven CH, Rodríguez Baño J, Bielicki J, Harbarth S, Hulscher M, Huttner B, Islam J, Little P, Pulcini C, Savoldi A, Tacconelli E, Timsit JF, van Smeden M, Wolkewitz M, Bonten MJM, Walker AS, Llewelyn MJ, Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) Working Group on Design of Antimicrobial Stewardship Evaluations
Optimizing design of research to evaluate antibiotic stewardship interventions: consensus recommendations of a multinational working group.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2019
Martin-Loeches I, Timsit JF, Leone M, de Waele J, Sartelli M, Kerrigan S, Azevedo LCP, Einav S
Clinical controversies in abdominal sepsis. Insights for critical care settings.
Journal of Critical Care 2019, 53, 53-58.
Mageau A, Sacré K, Perozziello A, Ruckly S, Dupuis C, Bouadma L, Papo T, Timsit JF
Septic shock among patients with systemic lupus erythematosus: short and long-term outcome. Analysis of a French nationwide database.
The Journal of Infection 2019
de Montmollin E, Ruckly S, Schwebel C, Philippart F, Adrie C, Mariotte E, Marcotte G, Cohen Y, Sztrymf B, da Silva D, Bruneel F, Gainnier M, Garrouste-Orgeas M, Sonneville R, Timsit JF, OUTCOMEREA Study Group
Pneumonia in acute ischemic stroke patients requiring invasive ventilation: Impact on short and long-term outcomes.
The Journal of Infection 2019, 79, 220-227.
Lattuca-Truc M, Timsit JF, Levra MG, Ruckly S, Villa J, Dumas I, Pinsolle J, Ferrer L, Guillem P, Moro-Sibilot D, Toffart AC
Trends in response rate and survival in small-cell lung cancer patients between 1997 and 2017.
Lung Cancer 2019, 131, 122-127.
Kollef MH, Nováček M, Kivistik Ü, Réa-Neto Á, Shime N, Martin-Loeches I, Timsit JF, Wunderink RG, Bruno CJ, Huntington JA, Lin G, Yu B, Butterton JR, Rhee EG
Ceftolozane-tazobactam versus meropenem for treatment of nosocomial pneumonia (ASPECT-NP): a randomised, controlled, double-blind, phase 3, non-inferiority trial.
The Lancet. Infectious Diseases 2019
Birgand G, Azevedo C, Rukly S, Pissard-Gibollet R, Toupet G, Timsit JF, Lucet JC, the ARIBO Study Group
Motion-capture system to assess intraoperative staff movements and door openings: Impact on surrogates of the infectious risk in surgery.
Infection Control & Hospital Epidemiology 2019, 40, 566-573.
Buetti N, Timsit JF
Management and Prevention of Central Venous Catheter-Related Infections in the ICU.
Seminars in Respiratory and Critical Care Medicine 2019, 40, 508-523.
Weiss E, Zahar JR, Alder J, Asehnoune K, Bassetti M, Bonten MJM, Chastre J, De Waele J, Dimopoulos G, Eggimann P, Engelhardt M, Ewig S, Kollef M, Lipman J, Luna C, Martin-Loeches I, Pagani L, Palmer LB, Papazian L, Poulakou G, Prokocimer P, Rello J, Rex JH, Shorr AF, Talbot GH, Thamlikitkul V, Torres A, Wunderink RG, Timsit JF
Elaboration of Consensus Clinical Endpoints to Evaluate Antimicrobial Treatment Efficacy in Future Hospital-acquired/Ventilator-associated Bacterial Pneumonia Clinical Trials.
Clinical Infectious Diseases 2019, 69, 1912-1918.
Bertrand PM, Pereira B, Adda M, Timsit JF, Wolff M, Hilbert G, Gruson D, Garrouste-Orgeas M, Argaud L, Constantin JM, Chabanne R, Quenot JP, Bohe J, Guerin C, Papazian L, Jonquet O, Klouche K, Delahaye A, Riu B, Zieleskiewicz L, Darmon M, Azoulay E, Souweine B, Lautrette A
Disagreement Between Clinicians and Score in Decision-Making Capacity of Critically Ill Patients*:.
Critical Care Medicine 2019, 47, 337-344.
Ibn Saied W, Mourvillier B, Cohen Y, Ruckly S, Reignier J, Marcotte G, Siami S, Bouadma L, Darmon M, de Montmollin E, Argaud L, Kallel H, Garrouste-Orgeas M, Soufir L, Schwebel C, Souweine B, Glodgran-Toledano D, Papazian L, Timsit JF
A Comparison of the Mortality Risk Associated With Ventilator-Acquired Bacterial Pneumonia and Nonventilator ICU-Acquired Bacterial Pneumonia*:.
Critical Care Medicine 2019, 47, 345-352.
Leverger G, Timsit JF, Milpied N, Gachot B
Use of Micafungin for the Prevention and Treatment of Invasive Fungal Infections in Everyday Pediatric Care in France: Results of the MYRIADE Study.
The Pediatric Infectious Disease Journal 2019, 38, 716-721.
Garnacho-Montero J, Timsit JF
Managing Acinetobacter baumannii infections:.
Current Opinion in Infectious Diseases 2019, 32, 69-76.
Bassetti M, Scudeller L, Giacobbe DR, Lamoth F, Righi E, Zuccaro V, Grecchi C, Rebuffi C, Akova M, Alastruey-Izquierdo A, Arikan-Akdagli S, Azoulay E, Blot SI, Cornely OA, Lass-Flörl C, Koehler P, Cuenca-Estrella M, de Lange DW, De Rosa FG, De Waele JJ, Dimopoulos G, Garnacho-Montero J, Hoenigl M, Kanj SS, Maertens J, Martin-Loeches I, Muñoz P, Kullberg BJ, Agvald-Ohman C, Poulakou G, Rello J, Sanguinetti M, Taccone FS, Timsit JF, Torres A, Vazquez JA, Calandra T, from the Study Group for Infections in Critically Ill Patients (ESGCIP) and the Fungal Infection Study Group (EFISG) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), European Society of Intensive Care Medicine (ESICM), European Confederation of Medical Mycology (ECMM), Mycoses Study Group Education and Research Consortium (MSGERC)
Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units. Protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project.
Mycoses 2019, 62, 310-319.
Boisson M, Corbi P, Kerforne T, Camilleri L, Debauchez M, Demondion P, Eljezi V, Flecher E, Lepelletier D, Leprince P, Nesseler N, Nizou JY, Roussel JC, Rozec B, Ruckly S, Lucet JC, Timsit JF, Mimoz O
Multicentre, open-label, randomised, controlled clinical trial comparing 2% chlorhexidine-70% isopropanol and 5% povidone iodine-69% ethanol for skin antisepsis in reducing surgical-site infection after cardiac surgery: the CLEAN 2 study protocol.
BMJ open 2019, 9, e026929.
Garrouste-Orgeas M, Flahault C, Poulain E, Evin A, Guirimand F, Fossez-Diaz V, Perruchio S, Verlaine C, Vanbésien A, Kaczmarek W, Birkui de Francqueville L, De Larivière E, Bouquet G, Copel L, Verliac V, Marché V, Mathias C, Gracia D, Mhalla A, Michonneau-Gandon V, Poupardin C, Touzet L, Ranchou G, Guastella V, Richard B, Bienfait F, Sonrier M, Michel D, Ruckly S, Bailly S, Timsit JF
The Fami-life study: protocol of a prospective observational multicenter mixed study of psychological consequences of grieving relatives in French palliative care units on behalf of the family research in palliative care (F.R.I.P.C research network).
BMC Palliative Care 2019, 18, 111.
Bassetti M, Giacobbe DR, Vena A, Trucchi C, Ansaldi F, Antonelli M, Adamkova V, Alicino C, Almyroudi MP, Atchade E, Azzini AM, Carannante N, Carnelutti A, Corcione S, Cortegiani A, Dimopoulos G, Dubler S, García-Garmendia JL, Girardis M, Cornely OA, Ianniruberto S, Kullberg BJ, Lagrou K, Le Bihan C, Luzzati R, Malbrain MLNG, Merelli M, Marques AJ, Martin-Loeches I, Mesini A, Paiva JA, Peghin M, Raineri SM, Rautemaa-Richardson R, Schouten J, Brugnaro P, Spapen H, Tasioudis P, Timsit JF, Tisa V, Tumbarello M, van den Berg CHSB, Veber B, Venditti M, Voiriot G, Wauters J, Montravers P
Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project.
Critical Care 2019, 23,
Morvan AC, Garrouste-Orgeas M, Ruckly S, Forel JM, Argaud L, Rimmelé T, Bedos JP, Azoulay E, Dupuis C, Mourvillier B, Schwebel C, Timsit JF
Impact of species and antibiotic therapy of enterococcal peritonitis on 30-day mortality in critical care—an analysis of the OUTCOMEREA database.
Critical Care 2019, 23, 307.
Bouadma L, Darmon M, Argaud L, Vinclair C, Siami S, Garrouste-Orgeas M, Papazian L, Cohen Y, Marcotte G, Styfalova L, Reignier J, Lautrette A, Schwebel C, Timsit JF
Influence of dyskalemia at admission and early dyskalemia correction on survival and cardiac events of critically ill patients.
Critical Care 2019, 23,
Pons S, Sonneville R, Bouadma L, Styfalova L, Ruckly S, Neuville M, Radjou A, Lebut J, Dilly MP, Mourvillier B, Dorent R, Nataf P, Wolff M, Timsit JF
Infectious complications following heart transplantation in the era of high-priority allocation and extracorporeal membrane oxygenation.
Annals of Intensive Care 2019, 9, 17.
Karpanen TJ, Casey AL, Whitehouse T, Timsit JF, Mimoz O, Palomar M, Elliott TSJ
A clinical evaluation of two central venous catheter stabilization systems.
Annals of Intensive Care 2019, 9, 49.
Smonig R, Magalhaes E, Bouadma L, Andremont O, de Montmollin E, Essardy F, Mourvillier B, Lebut J, Dupuis C, Neuville M, Lermuzeaux M, Timsit JF, Sonneville R
Impact of natural light exposure on delirium burden in adult patients receiving invasive mechanical ventilation in the ICU: a prospective study.
Annals of Intensive Care 2019, 9, 120.
2018
Bluhmki T, Allignol A, Ruckly S, Timsit JF, Wolkewitz M, Beyersmann J
Estimation of adjusted expected excess length-of-stay associated with ventilation-acquired pneumonia in intensive care: A multistate approach accounting for time-dependent mechanical ventilation.
Biometrical Journal. Biometrische Zeitschrift 2018, 60, 1135-1150.
Bailly S, Meyfroidt G, Timsit JF
What's new in ICU in 2050: big data and machine learning.
Intensive Care Medicine 2018, 44, 1524-1527.
De Waele JJ, Akova M, Antonelli M, Canton R, Carlet J, De Backer D, Dimopoulos G, Garnacho-Montero J, Kesecioglu J, Lipman J, Mer M, Paiva JA, Poljak M, Roberts JA, Rodriguez Bano J, Timsit JF, Zahar JR, Bassetti M
Antimicrobial resistance and antibiotic stewardship programs in the ICU: insistence and persistence in the fight against resistance. A position statement from ESICM/ESCMID/WAAAR round table on multi-drug resistance.
Intensive Care Medicine 2018, 44, 189-196.
La Combe B, Bleibtreu A, Messika J, Fernandes R, Clermont O, Branger C, Billard-Pomares T, Barnaud G, Magdoud F, Eveillard M, Kouatchet A, Lasocki S, Asfar P, Corvec S, Lakhal K, Armand-Lefevre L, Wolff M, Timsit JF, Bourdon S, Reignier J, Martin S, Fihman V, de Prost N, Bador J, Charles PE, Goret J, Boyer A, Wallet F, Jaillette E, Nseir S, Landraud L, Ruimy R, Danin PE, Dellamonica J, Cremniter J, Frat JP, Jauréguy F, Clec'h C, Decré D, Maury E, Dreyfuss D, Denamur E, Ricard JD
Decreased susceptibility to chlorhexidine affects a quarter of Escherichia coli isolates responsible for pneumonia in ICU patients.
Intensive Care Medicine 2018, 44, 531-533.
von Cube MK, Timsit JF, Sommer H, Darmon M, Schwebel C, Bailly S, Souweine B, Wolkewitz M
Relative risk and population-attributable fraction of ICU death caused by susceptible and resistant Pseudomonas aeruginosa ventilator-associated pneumonia: a competing risks approach to investigate the OUTCOMEREA database.
Intensive Care Medicine 2018, 44, 1177-1179.
Barbier F, Bailly S, Schwebel C, Papazian L, Azoulay É, Kallel H, Siami S, Argaud L, Marcotte G, Misset B, Reignier J, Darmon M, Zahar JR, Goldgran-Toledano D, de Montmollin É, Souweine B, Mourvillier B, Timsit JF, OUTCOMEREA Study Group
Infection-related ventilator-associated complications in ICU patients colonised with extended-spectrum β-lactamase-producing Enterobacteriaceae.
Intensive Care Medicine 2018
Timsit JF, Bassetti M
Antipathy against SDD is justified: Yes.
Intensive Care Medicine 2018
Azoulay E, Lemiale V, Mourvillier B, Garrouste-Orgeas M, Schwebel C, Ruckly S, Argaud L, Cohen Y, Souweine B, Papazian L, Reignier J, Marcotte G, Siami S, Kallel H, Darmon M, Timsit JF, OUTCOMEREA Study Group
Management and outcomes of acute respiratory distress syndrome patients with and without comorbid conditions.
Intensive Care Medicine 2018
Timsit JF, Rupp M, Bouza E, Chopra V, Kärpänen T, Laupland K, Lisboa T, Mermel L, Mimoz O, Parienti JJ, Poulakou G, Souweine B, Zingg W
A state of the art review on optimal practices to prevent, recognize, and manage complications associated with intravascular devices in the critically ill.
Intensive Care Medicine 2018, 44, 742-759.
Puntillo KA, Max A, Timsit JF, Ruckly S, Chanques G, Robleda G, Roche-Campo F, Mancebo J, Divatia JV, Soares M, Ionescu DC, Grintescu IM, Maggiore SM, Rusinova K, Owczuk R, Egerod I, Papathanassoglou EDE, Kyranou M, Joynt GM, Burghi G, Freebairn RC, Ho KM, Kaarlola A, Gerritsen RT, Kesecioglu J, Sulaj MMS, Norrenberg M, Benoit DD, Seha MSG, Hennein A, Pereira FJ, Benbenishty JS, Abroug F, Aquilina A, Monte JRC, An Y, Azoulay E
Pain distress: the negative emotion associated with procedures in ICU patients.
Intensive Care Medicine 2018, 44, 1493-1501.
Timsit JF, Ruppe E, Ferrer R
Focus on sepsis: new concepts and findings in sepsis care.
Intensive Care Medicine 2018, 44, 1997-1999.
Timsit JF, Aboab J, Parienti JJ
Is research from databases reliable? Yes.
Intensive Care Medicine 2018
Garrouste-Orgeas M, Azoulay E, Ruckly S, Schwebel C, de Montmollin E, Bedos JP, Souweine B, Marcotte G, Adrie C, Goldgran-Toledano D, Dumenil AS, Kallel H, Jamali S, Argaud L, Darmon M, Zahar JR, Timsit JF
Diabetes was the only comorbid condition associated with mortality of invasive pneumococcal infection in ICU patients: a multicenter observational study from the Outcomerea research group.
Infection 2018, 46, 669-677.
Ruppé E, Martin-Loeches I, Rouzé A, Levast B, Ferry T, Timsit JF
What's new in restoring the gut microbiota in ICU patients? Potential role of faecal microbiota transplantation.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2018, 24, 803-805.
Annane D, Renault A, Brun-Buisson C, Megarbane B, Quenot JP, Siami S, Cariou A, Forceville X, Schwebel C, Martin C, Timsit JF, Misset B, Ali Benali M, Colin G, Souweine B, Asehnoune K, Mercier E, Chimot L, Charpentier C, François B, Boulain T, Petitpas F, Constantin JM, Dhonneur G, Baudin F, Combes A, Bohé J, Loriferne JF, Amathieu R, Cook F, Slama M, Leroy O, Capellier G, Dargent A, Hissem T, Maxime V, Bellissant E, CRICS-TRIGGERSEP Network
Hydrocortisone plus Fludrocortisone for Adults with Septic Shock.
The New England Journal of Medicine 2018, 378, 809-818.
de Kraker MEA, Sommer H, de Velde F, Gravestock I, Weiss E, McAleenan A, Nikolakopoulos S, Amit O, Ashton T, Beyersmann J, Held L, Lovering AM, MacGowan AP, Mouton JW, Timsit JF, Wilson D, Wolkewitz M, Bettiol E, Dane A, Harbarth S, COMBACTE-NET Consortium
Optimizing the Design and Analysis of Clinical Trials for Antibacterials Against Multidrug-resistant Organisms: A White Paper From COMBACTE's STAT-Net.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2018, 67, 1922-1931.
Zahar JR, Blot S, Nordmann P, Martischang R, Timsit JF, Harbarth S, Barbier F
Screening for intestinal carriage of ESBL-producing Enterobacteriaceae in critically ill patients: expected benefits and evidence-based controversies.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2018
Dananché C, Vanhems P, Machut A, Aupée M, Bervas C, L'Hériteau F, Lepape A, Lucet JC, Stoeckel V, Timsit JF, Berger-Carbonne A, Savey A, Bénet T, Healthcare-Associated Infections (HAIs) Surveillance Network of ICUs (Réseau REA-Raisin)
Trends of Incidence and Risk Factors of Ventilator-Associated Pneumonia in Elderly Patients Admitted to French ICUs Between 2007 and 2014.
Critical Care Medicine 2018, 46, 869-877.
Sommer H, Timsit JF, von Cube M, Schumacher M, Darmon M, Schwebel C, Ruckly S, Wolkewitz M, COMBACTE-MAGNET Consortium
The Impact of Early Adequate Treatment on Extubation and Discharge Alive of Patients With Pseudomonas aeruginosa-Related Ventilator-Associated Pneumonia.
Critical Care Medicine 2018, 46, 1643-1648.
Gros A, Dupuis C, Ruckly S, Lautrette A, Garrouste-Orgeas M, Gainnier M, Forel JM, Marcotte G, Azoulay E, Cohen Y, Schwebel C, Argaud L, de Montmollin E, Siami S, Goldgran-Toledano D, Darmon M, Timsit JF, OUTCOMEREA Study Group
Association Between Body Weight Variation and Survival and Other Adverse Events in Critically Ill Patients With Shock: A Multicenter Cohort Study of the OUTCOMEREA Network.
Critical Care Medicine 2018, 46, e981-e987.
Cantier M, Morisot A, Guérot E, Megarbane B, Razazi K, Contou D, Mariotte E, Canet E, De Montmollin E, Dubée V, Boulet E, Gaudry S, Voiriot G, Mayaux J, Pène F, Neuville M, Mourvillier B, Ruckly S, Bouadma L, Wolff M, Timsit JF, Sonneville R, ENCEPHALITICA study group
Functional outcomes in adults with tuberculous meningitis admitted to the ICU: a multicenter cohort study.
Critical Care (London, England) 2018, 22, 210.
Truche AS, Ragey SP, Souweine B, Bailly S, Zafrani L, Bouadma L, Clec'h C, Garrouste-Orgeas M, Lacave G, Schwebel C, Guebre-Egziabher F, Adrie C, Dumenil AS, Zaoui P, Argaud L, Jamali S, Goldran Toledano D, Marcotte G, Timsit JF, Darmon M
ICU survival and need of renal replacement therapy with respect to AKI duration in critically ill patients.
Annals of Intensive Care 2018, 8, 127.
Gangneux JP, Cornet M, Bailly S, Fradin C, Féger C, Timsit JF, Leroy O, Sendid B, Bougnoux ME
Clinical Impact of Antifungal Susceptibility, Biofilm Formation and Mannoside Expression of Candida Yeasts on the Outcome of Invasive Candidiasis in ICU: An Ancillary Study on the Prospective AmarCAND2 Cohort.
Frontiers in Microbiology 2018, 9, 2907.
2017
Sonneville R, Gimenez L, Labreuche J, Smonig R, Magalhaes E, Bouadma L, Timsit JF, Mazighi M
What is the prognosis of acute stroke patients requiring ICU admission?.
Intensive Care Medicine 2017, 43, 271-272.
Bassetti M, Garnacho-Montero J, Calandra T, Kullberg B, Dimopoulos G, Azoulay E, Chakrabarti A, Kett D, Leon C, Ostrosky-Zeichner L, Sanguinetti M, Timsit JF, Richardson MD, Shorr A, Cornely OA
Intensive care medicine research agenda on invasive fungal infection in critically ill patients.
Intensive Care Medicine 2017, 43, 1225-1238.
Poulakou G, Matthaiou DK, Bassetti M, Erdem H, Dimopoulos G, Curcio DJ, Carlet J, Lipman J, Timsit JF, Giamarellou H, Arfaras-Melainis A, Rello J, ESGCIP Investigators
"Salvage treatment" for infections by extensively- and pan-drug-resistant pathogens is common and often sub-optimal.
Intensive Care Medicine 2017, 43, 1164-1166.
Timsit JF, de Kraker MEA, Sommer H, Weiss E, Bettiol E, Wolkewitz M, Nikolakopoulos S, Wilson D, Harbarth S, COMBACTE-NET consortium
Appropriate endpoints for evaluation of new antibiotic therapies for severe infections: a perspective from COMBACTE's STAT-Net.
Intensive Care Medicine 2017, 43, 1002-1012.
Sonneville R, de Montmollin E, Poujade J, Garrouste-Orgeas M, Souweine B, Darmon M, Mariotte E, Argaud L, Barbier F, Goldgran-Toledano D, Marcotte G, Dumenil AS, Jamali S, Lacave G, Ruckly S, Mourvillier B, Timsit JF
Potentially modifiable factors contributing to sepsis-associated encephalopathy.
Intensive Care Medicine 2017, 43, 1075-1084.
Perner A, Gordon AC, Angus DC, Lamontagne F, Machado F, Russell JA, Timsit JF, Marshall JC, Myburgh J, Shankar-Hari M, Singer M
The intensive care medicine research agenda on septic shock.
Intensive Care Medicine 2017, 43, 1294-1305.
Laupland KB, Paiva JA, Timsit JF
Focus on severe infections.
Intensive Care Medicine 2017, 43, 1033-1036.
Yamaga S, Shime N, Sonneville R, de Montmollin E, Timsit JF
Risk factors for sepsis-associated encephalopathy.
Intensive Care Medicine 2017, 43, 1548-1549.
Montravers P, Perrigault PF, Timsit JF, Mira JP, Lortholary O, Leroy O, Gangneux JP, Guillemot D, Bensoussan C, Bailly S, Azoulay E, Constantin JM, Dupont H, AmarCAND2 Study Group
Antifungal therapy for patients with proven or suspected Candida peritonitis: Amarcand2, a prospective cohort study in French intensive care units.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2017, 23, 117.e1-117.e8.
Bleibtreu A, Arias P, Vallois D, Debit A, Lermuzeaux M, Rioux C, Cabras O, Lucet JC, Choquet C, Timsit JF, Yazdanpanah Y, Lescure FX
Delayed management of Staphyloccocus aureus infective endocarditis in a Middle East respiratory syndrome coronavirus possible case hospitalized in 2015 in Paris, France.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2017, 23, 416-417.
Zahar JR, Lesprit P, Ruckly S, Eden A, Hikombo H, Bernard L, Harbarth S, Timsit JF, Brun-Buisson C, BacterCom Study Group
Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae.
International Journal of Antimicrobial Agents 2017, 49, 67-73.
Zahar JR, Lesprit P, Ruckly S, Eden A, Hikombo H, Bernard L, Harbarth S, Timsit JF, Brun-Buisson C, BacterCom Study Group
Erratum to 'Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae' [International Journal of Antimicrobial Agents 49/1 67-73].
International Journal of Antimicrobial Agents 2017, 49, 480-481.
Bailly S, Leroy O, Dupont H, Timsit JF
Secondarily documented invasive candidiasis is unpredictable using traditional risk factors in non transplant - non-neutropenic adult ICU patients.
International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases 2017, 54, 31-33.
Loubet P, Voiriot G, Houhou-Fidouh N, Neuville M, Bouadma L, Lescure FX, Descamps D, Timsit JF, Yazdanpanah Y, Visseaux B
Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study.
Journal of Clinical Virology: The Official Publication of the Pan American Society for Clinical Virology 2017, 91, 52-57.
Adrie C, Garrouste-Orgeas M, Ibn Essaied W, Schwebel C, Darmon M, Mourvillier B, Ruckly S, Dumenil AS, Kallel H, Argaud L, Marcotte G, Barbier F, Laurent V, Goldgran-Toledano D, Clec'h C, Azoulay E, Souweine B, Timsit JF, OUTCOMEREA Study Group*
Attributable mortality of ICU-acquired bloodstream infections: Impact of the source, causative micro-organism, resistance profile and antimicrobial therapy.
The Journal of Infection 2017, 74, 131-141.
Bailly S, Leroy O, Azoulay E, Montravers P, Constantin JM, Dupont H, Guillemot D, Lortholary O, Mira JP, Perrigault PF, Gangneux JP, Timsit JF, AmarCAND2 Study Group
Impact of echinocandin on prognosis of proven invasive candidiasis in ICU: A post-hoc causal inference model using the AmarCAND2 study.
The Journal of Infection 2017, 74, 408-417.
Baldesi O, Bailly S, Ruckly S, Lepape A, L'Heriteau F, Aupee M, Boussat S, Bervas C, Machut A, Berger-Carbonne A, Savey A, Timsit JF, REA-RAISIN network
ICU-acquired candidaemia in France: Epidemiology and temporal trends, 2004-2013 - A study from the REA-RAISIN network.
The Journal of Infection 2017, 75, 59-67.
Timsit JF, Pilmis B, Zahar JR
How Should We Treat Hospital-Acquired and Ventilator-Associated Pneumonia Caused by Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae?.
Seminars in Respiratory and Critical Care Medicine 2017, 38, 287-300.
Jullien V, Azoulay E, Schwebel C, Le Saux T, Charles PE, Cornet M, Souweine B, Klouche K, Jaber S, Trouillet JL, Bruneel F, Cour M, Cousson J, Meziani F, Gruson D, Paris A, Darmon M, Garrouste-Orgeas M, Navellou JC, Foucrier A, Allaouchiche B, Das V, Gangneux JP, Ruckly S, Wolff M, Timsit JF, EMPIRICUS Trial Study Group
Population pharmacokinetics of micafungin in ICU patients with sepsis and mechanical ventilation.
The Journal of Antimicrobial Chemotherapy 2017, 72, 181-189.
Jullien V, Azoulay E, Schwebel C, Le Saux T, Charles PE, Cornet M, Souweine B, Klouche K, Jaber S, Trouillet JL, Bruneel F, Cour M, Cousson J, Meziani F, Gruson D, Paris A, Darmon M, Garrouste-Orgeas M, Navellou JC, Foucrier A, Allaouchiche B, Das V, Gangneux JP, Ruckly S, Wolff M, Timsit JF, ETSG
Population pharmacokinetics of micafungin in ICU patients with sepsis and mechanical ventilation.
The Journal of Antimicrobial Chemotherapy 2017, 72, 181-189.
Dupuis C, Garrouste-Orgeas M, Bailly S, Adrie C, Goldgran-Toledano D, Azoulay E, Ruckly S, Marcotte G, Souweine B, Darmon M, Cohen Y, Schwebel C, Lacave G, Bouadma L, Timsit JF, OUTCOMEREA Study Group
Effect of Transfusion on Mortality and Other Adverse Events Among Critically Ill Septic Patients: An Observational Study Using a Marginal Structural Cox Model.
Critical Care Medicine 2017, 45, 1972-1980.
de Montmollin E, Demeret S, Brulé N, Conrad M, Dailler F, Lerolle N, Navellou JC, Schwebel C, Alves M, Cour M, Engrand N, Tonnelier JM, Maury E, Ruckly S, Picard G, Rogemond V, Magalhaes É, Sharshar T, Timsit JF, Honnorat J, Sonneville R, ENCEPHALITICA Study Group ‡
Anti-N-Methyl-d-Aspartate Receptor Encephalitis in Adult Patients Requiring Intensive Care.
American Journal of Respiratory and Critical Care Medicine 2017, 195, 491-499.
Torres A, Niederman MS, Chastre J, Ewig S, Fernandez-Vandellos P, Hanberger H, Kollef M, Li Bassi G, Luna CM, Martin-Loeches I, Paiva JA, Read RC, Rigau D, Timsit JF, Welte T, Wunderink R
International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia: Guidelines for the management of hospital-acquired pneumonia (HAP)/ventilator-associated pneumonia (VAP) of the European Respiratory Society (ERS), European Society of Intensive Care Medicine (ESICM), European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and Asociación Latinoamericana del Tórax (ALAT).
The European Respiratory Journal 2017, 50,
Viglino D, Vesin A, Ruckly S, Morelli X, Slama R, Debaty G, Danel V, Maignan M, Timsit JF
Daily volume of cases in emergency call centers: construction and validation of a predictive model.
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2017, 25, 86.
Weiss E, Essaied W, Adrie C, Zahar JR, Timsit JF
Treatment of severe hospital-acquired and ventilator-associated pneumonia: a systematic review of inclusion and judgment criteria used in randomized controlled trials.
Critical Care (London, England) 2017, 21, 162.
Terzi N, Darmon M, Reignier J, Ruckly S, Garrouste-Orgeas M, Lautrette A, Azoulay E, Mourvillier B, Argaud L, Papazian L, Gainnier M, Goldgran-Toledano D, Jamali S, Dumenil AS, Schwebel C, Timsit JF, OUTCOMEREA study group
Initial nutritional management during noninvasive ventilation and outcomes: a retrospective cohort study.
Critical Care (London, England) 2017, 21, 293.
Garrouste-Orgeas M, Flahault C, Fasse L, Ruckly S, Amdjar-Badidi N, Argaud L, Badie J, Bazire A, Bige N, Boulet E, Bouadma L, Bretonnière C, Floccard B, Gaffinel A, de Forceville X, Grand H, Halidfar R, Hamzaoui O, Jourdain M, Jost PH, Kipnis E, Large A, Lautrette A, Lesieur O, Maxime V, Mercier E, Mira JP, Monseau Y, Parmentier-Decrucq E, Rigaud JP, Rouget A, Santoli F, Simon G, Tamion F, Thieulot-Rolin N, Thirion M, Valade S, Vinatier I, Vioulac C, Bailly S, Timsit JF
The ICU-Diary study: prospective, multicenter comparative study of the impact of an ICU diary on the wellbeing of patients and families in French ICUs.
Trials 2017, 18, 542.
Dupuis C, Sonneville R, Adrie C, Gros A, Darmon M, Bouadma L, Timsit JF
Impact of transfusion on patients with sepsis admitted in intensive care unit: a systematic review and meta-analysis.
Annals of Intensive Care 2017, 7, 5.
Adrie C, Lugosi M, Sonneville R, Souweine B, Ruckly S, Cartier JC, Garrouste-Orgeas M, Schwebel C, Timsit JF, OUTCOMEREA study group
Persistent lymphopenia is a risk factor for ICU-acquired infections and for death in ICU patients with sustained hypotension at admission.
Annals of Intensive Care 2017, 7, 30.
Neuville M, El-Helali N, Magalhaes E, Radjou A, Smonig R, Soubirou JF, Voiriot G, Le Monnier A, Ruckly S, Bouadma L, Sonneville R, Timsit JF, Mourvillier B
Systematic overdosing of oxa- and cloxacillin in severe infections treated in ICU: risk factors and side effects.
Annals of Intensive Care 2017, 7, 34.
Timsit JF, Esaied W, Neuville M, Bouadma L, Mourvllier B
Update on ventilator-associated pneumonia.
F1000Research 2017, 6, 2061.
Azoulay E, Timsit JF, Lautrette A, Legriel S, Max A, Ruckly S, Misset B, Cohen Y, Wolff M
Weekly high-dose liposomal amphotericin B (L-AmB) in critically ill septic patients with multiple Candida colonization: The AmBiDex study.
PloS One 2017, 12, e0177093.
Visseaux B, Burdet C, Voiriot G, Lescure FX, Chougar T, Brugiere O, Crestani B, Casalino E, Charpentier C, Descamps D, Timsit JF, Yazdanpanah Y, Houhou-Fidouh N
Prevalence of respiratory viruses among adults, by season, age, respiratory tract region and type of medical unit in Paris, France, from 2011 to 2016.
PLoS One 2017, 12, e0180888.
Ibn Saied W, Souweine B, Garrouste-Orgeas M, Ruckly S, Darmon M, Bailly S, Cohen Y, Azoulay E, Schwebel C, Radjou A, Kallel H, Adrie C, Dumenil AS, Argaud L, Marcotte G, Jamali S, Papazian L, Goldgran-Toledano D, Bouadma L, Timsit JF, OUTCOMEREA study group
Respective impact of implementation of prevention strategies, colonization with multiresistant bacteria and antimicrobial use on the risk of early- and late-onset VAP: An analysis of the OUTCOMEREA network.
PloS One 2017, 12, e0187791.
Neuville M, Mourvillier B, Bouadma L, Timsit JF
Bundle of care decreased ventilator-associated events-implications for ventilator-associated pneumonia prevention.
Journal of Thoracic Disease 2017, 9, 430-433.
Ara-Somohano C, Bonadona A, Carpentier F, Pavese P, Vesin A, Hamidfar-Roy R, Minet C, Vanzetto G, Schwebel C, Timsit JF
Evaluation of eight biomarkers to predict short-term mortality in patients with acute severe dyspnea.
Minerva Anestesiologica 2017, 83, 824-835.
Sommer H, Timsit JF, Wolkewitz M
Bezlotoxumab and Recurrent Clostridium difficile Infection.
The New England Journal of Medicine 2017, 376, 1594.
2016
Timsit JF, Azoulay E, Schwebel C, Charles PE, Cornet M, Souweine B, Klouche K, Jaber S, Trouillet JL, Bruneel F, Argaud L, Cousson J, Meziani F, Gruson D, Paris A, Darmon M, Garrouste-Orgeas M, Navellou JC, Foucrier A, Allaouchiche B, Das V, Gangneux JP, Ruckly S, Maubon D, Jullien V, Wolff M, EMPIRICUS Trial Group
Empirical Micafungin Treatment and Survival Without Invasive Fungal Infection in Adults With ICU-Acquired Sepsis, Candida Colonization, and Multiple Organ Failure: The EMPIRICUS Randomized Clinical Trial.
JAMA 2016, 316, 1555-1564.
Timsit JF, Azoulay E, Schwebel C, Charles PE, Cornet M, Souweine B, Klouche K, Jaber S, Trouillet JL, Bruneel F, Argaud L, Cousson J, Meziani F, Gruson D, Paris A, Darmon M, Garrouste-Orgeas M, Navellou JC, Foucrier A, Allaouchiche B, Das V, Gangneux JP, Ruckly S, Maubon D, Jullien V, Wolff M, ETG
Empirical Micafungin Treatment and Survival Without Invasive Fungal Infection in Adults With ICU-Acquired Sepsis, Candida Colonization, and Multiple Organ Failure: The EMPIRICUS Randomized Clinical Trial.
JAMA 2016, 316, 1555-1564.
Bailly S, Pirracchio R, Timsit JF
What's new in the quantification of causal effects from longitudinal cohort studies: a brief introduction to marginal structural models for intensivists.
Intensive Care Medicine 2016, 42, 576-579.
Poulakou G, Bassetti M, Timsit JF
Critically ill migrants with infection: diagnostic considerations for intensive care physicians in Europe.
Intensive Care Medicine 2016, 42, 245-248.
Sakr Y, Ferrer R, Reinhart K, Beale R, Rhodes A, Moreno R, Timsit JF, Brochard L, Thompson BT, Rezende E, Chiche JD, IC-GLOSSARI Investigators, ESICM Trials Group
The Intensive Care Global Study on Severe Acute Respiratory Infection (IC-GLOSSARI): a multicenter, multinational, 14-day inception cohort study.
Intensive Care Medicine 2016, 42, 817-828.
Mimoz O, Chopra V, Timsit JF
What's new in catheter-related infection: skin cleansing and skin antisepsis.
Intensive Care Medicine 2016, 42, 1784-1786.
Gélisse E, Neuville M, de Montmollin E, Bouadma L, Mourvillier B, Timsit JF, Sonneville R
Extracorporeal membrane oxygenation (ECMO) does not impact on amikacin pharmacokinetics: a case-control study.
Intensive Care Medicine 2016, 42, 946-948.
Bassetti M, Poulakou G, Timsit JF
Focus on antimicrobial use in the era of increasing antimicrobial resistance in ICU.
Intensive Care Medicine 2016, 42, 955-958.
Truche AS, Darmon M, Bailly S, Clec'h C, Dupuis C, Misset B, Azoulay E, Schwebel C, Bouadma L, Kallel H, Adrie C, Dumenil AS, Argaud L, Marcotte G, Jamali S, Zaoui P, Laurent V, Goldgran-Toledano D, Sonneville R, Souweine B, Timsit JF, OUTCOMEREA Study Group
Continuous renal replacement therapy versus intermittent hemodialysis in intensive care patients: impact on mortality and renal recovery.
Intensive Care Medicine 2016, 42, 1408-1417.
Weiss E, Zahar JR, Garrouste-Orgeas M, Ruckly S, Essaied W, Schwebel C, Timsit JF, OUTCOMEREA Study Group
De-escalation of pivotal beta-lactam in ventilator-associated pneumonia does not impact outcome and marginally affects MDR acquisition.
Intensive Care Medicine 2016, 42, 2098-2100.
Citerio G, Perner A, Timsit JF
The ten wishes and hopes of the deputy editors of Intensive Care Medicine.
Intensive Care Medicine 2016, 42, 1316-1318.
Timsit JF, Paiva JA, Bassetti M
Focus on optimization of early antimicrobial therapy in ICU-acquired infections.
Intensive Care Medicine 2016, 42, 1658-1660.
Truche AS, Darmon M, Timsit JF, OUTCOMEREA Study Group
Renal replacement therapy modalities in the ICU: the continuity is intermittent-response to comments by Schefold.
Intensive Care Medicine 2016, 42, 1840-1841.
Benoit DD, Doig G, Timsit JF
Focus on adequate antimicrobial treatment and de-escalation in the ICU.
Intensive Care Medicine 2016, 42, 1856-1858.
Günther SC, Schwebel C, Hamidfar-Roy R, Bonadona A, Lugosi M, Ara-Somohano C, Minet C, Potton L, Cartier JC, Vésin A, Chautemps M, Styfalova L, Ruckly S, Timsit JF
Complications of intravascular catheters in ICU: definitions, incidence and severity. A randomized controlled trial comparing usual transparent dressings versus new-generation dressings (the ADVANCED study).
Intensive Care Medicine 2016, 42, 1753-1765.
Timsit JF, Perner A
Sepsis: find me, manage me, and stop me!.
Intensive Care Medicine 2016, 42, 1851-1853.
Bailly S, Garnaud C, Cornet M, Pavese P, Hamidfar-Roy R, Foroni L, Boisset S, Timsit JF, Maubon D
Impact of systemic antifungal therapy on the detection of Candida species in blood cultures in clinical cases of candidemia.
European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology 2016, 35, 1023-1032.
Bailly S, Maubon D, Fournier P, Pelloux H, Schwebel C, Chapuis C, Foroni L, Cornet M, Timsit JF
Impact of antifungal prescription on relative distribution and susceptibility of Candida spp. - Trends over 10 years.
The Journal of Infection 2016, 72, 103-111.
Pépin JL, Timsit JF, Tamisier R, Borel JC, Lévy P, Jaber S
Prevention and care of respiratory failure in obese patients.
The Lancet. Respiratory Medicine 2016, 4, 407-418.
Tabah A, Cotta MO, Garnacho-Montero J, Schouten J, Roberts JA, Lipman J, Tacey M, Timsit JF, Leone M, Zahar JR, De Waele JJ, Working Group for Antimicrobial Use in the ICU
A Systematic Review of the Definitions, Determinants, and Clinical Outcomes of Antimicrobial De-escalation in the Intensive Care Unit.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2016, 62, 1009-1017.
Barbier F, Pommier C, Essaied W, Garrouste-Orgeas M, Schwebel C, Ruckly S, Dumenil AS, Lemiale V, Mourvillier B, Clec'h C, Darmon M, Laurent V, Marcotte G, Lucet JC, Souweine B, Zahar JR, Timsit JF, OUTCOMEREA Study Group
Colonization and infection with extended-spectrum β-lactamase-producing Enterobacteriaceae in ICU patients: what impact on outcomes and carbapenem exposure?.
The Journal of Antimicrobial Chemotherapy 2016, 71, 1088-1097.
Bassetti M, Peghin M, Timsit JF
The current treatment landscape: candidiasis.
The Journal of Antimicrobial Chemotherapy 2016, 71, ii13-ii22.
Garrouste-Orgeas M, Max A, Lerin T, Grégoire C, Ruckly S, Kloeckner M, Brochon S, Pichot E, Simons C, El-Mhadri M, Bruel C, Philippart F, Fournier J, Tiercelet K, Timsit JF, Misset B
Impact of Proactive Nurse Participation in ICU Family Conferences: A Mixed-Method Study.
Critical Care Medicine 2016, 44, 1116-1128.
Sonneville R, Mariotte E, Neuville M, Minaud S, Magalhaes E, Ruckly S, Cantier M, Voiriot G, Radjou A, Smonig R, Soubirou JF, Mourvillier B, Bouadma L, Wolff M, Timsit JF
Early-onset status epilepticus in patients with acute encephalitis.
Medicine 2016, 95, e4092.
Mourvillier B, Radjou A, Timsit JF
Subclavian site should be preferred for central venous access.
Evidence-Based Nursing 2016, 19, 126.
Pépin JL, Tamisier R, Baguet JP, Lepaulle B, Arbib F, Arnol N, Timsit JF, Lévy P
Fixed-pressure CPAP versus auto-adjusting CPAP: comparison of efficacy on blood pressure in obstructive sleep apnoea, a randomised clinical trial.
Thorax 2016, 71, 726-733.
Sartelli M, Weber DG, Ruppé E, Bassetti M, Wright BJ, Ansaloni L, Catena F, Coccolini F, Abu-Zidan FM, Coimbra R, Moore EE, Moore FA, Maier RV, De Waele JJ, Kirkpatrick AW, Griffiths EA, Eckmann C, Brink AJ, Mazuski JE, May AK, Sawyer RG, Mertz D, Montravers P, Kumar A, Roberts JA, Vincent JL, Watkins RR, Lowman W, Spellberg B, Abbott IJ, Adesunkanmi AK, Al-Dahir S, Al-Hasan MN, Agresta F, Althani AA, Ansari S, Ansumana R, Augustin G, Bala M, Balogh ZJ, Baraket O, Bhangu A, Beltrán MA, Bernhard M, Biffl WL, Boermeester MA, Brecher SM, Cherry-Bukowiec JR, Buyne OR, Cainzos MA, Cairns KA, Camacho-Ortiz A, Chandy SJ, Che Jusoh A, Chichom-Mefire A, Colijn C, Corcione F, Cui Y, Curcio D, Delibegovic S, Demetrashvili Z, De Simone B, Dhingra S, Diaz JJ, Di Carlo I, Dillip A, Di Saverio S, Doyle MP, Dorj G, Dogjani A, Dupont H, Eachempati SR, Enani MA, Egiev VN, Elmangory MM, Ferrada P, Fitchett JR, Fraga GP, Guessennd N, Giamarellou H, Ghnnam W, Gkiokas G, Goldberg SR, Gomes CA, Gomi H, Guzmán-Blanco M, Haque M, Hansen S, Hecker A, Heizmann WR, Herzog T, Hodonou AM, Hong SK, Kafka-Ritsch R, Kaplan LJ, Kapoor G, Karamarkovic A, Kees MG, Kenig J, Kiguba R, Kim PK, Kluger Y, Khokha V, Koike K, Kok KYY, Kong V, Knox MC, Inaba K, Isik A, Iskandar K, Ivatury RR, Labbate M, Labricciosa FM, Laterre PF, Latifi R, Lee JG, Lee YR, Leone M, Leppaniemi A, Li Y, Liang SY, Loho T, Maegele M, Malama S, Marei HE, Martin-Loeches I, Marwah S, Massele A, McFarlane M, Melo RB, Negoi I, Nicolau DP, Nord CE, Ofori-Asenso R, Omari AH, Ordonez CA, Ouadii M, Pereira Júnior GA, Piazza D, Pupelis G, Rawson TM, Rems M, Rizoli S, Rocha C, Sakakhushev B, Sanchez-Garcia M, Sato N, Segovia Lohse HA, Sganga G, Siribumrungwong B, Shelat VG, Soreide K, Soto R, Talving P, Tilsed JV, Timsit JF, Trueba G, Trung NT, Ulrych J, van Goor H, Vereczkei A, Vohra RS, Wani I, Uhl W, Xiao Y, Yuan KC, Zachariah SK, Zahar JR, Zakrison TL, Corcione A, Melotti RM, Viscoli C, Viale P
Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).
World journal of emergency surgery: WJES 2016, 11,
Paiva JA, Pereira JM, Tabah A, Mikstacki A, de Carvalho FB, Koulenti D, Ruckly S, Çakar N, Misset B, Dimopoulos G, Antonelli M, Rello J, Ma X, Tamowicz B, Timsit JF
Characteristics and risk factors for 28-day mortality of hospital acquired fungemias in ICUs: data from the EUROBACT study.
Critical Care (London, England) 2016, 20,
May F, El-Helali N, Timsit JF, Misset B
Absence of obvious link between supra-therapeutic serum levels of β lactams and clinical toxicity in ICU patients with acute renal failure treated with intermittent hemodialysis.
Critical Care (London, England) 2016, 20, 220.
Coupez E, Timsit JF, Ruckly S, Schwebel C, Gruson D, Canet E, Klouche K, Argaud L, Bohe J, Garrouste-Orgeas M, Mariat C, Vincent F, Cayot S, Cointault O, Lepape A, Darmon M, Boyer A, Azoulay E, Bouadma L, Lautrette A, Souweine B
Guidewire exchange vs new site placement for temporary dialysis catheter insertion in ICU patients: is there a greater risk of colonization or dysfunction?.
Critical Care (London, England) 2016, 20, 230.
Voiriot G, Visseaux B, Cohen J, Nguyen LB, Neuville M, Morbieu C, Burdet C, Radjou A, Lescure FX, Smonig R, Armand-Lefevre L, Mourvillier B, Yazdanpanah Y, Soubirou JF, Ruckly S, Houhou-Fidouh N, Timsit JF
Viral-bacterial coinfection affects the presentation and alters the prognosis of severe community-acquired pneumonia.
Crit Care 2016, 20, 375.
Leroy O, Bailly S, Gangneux JP, Mira JP, Devos P, Dupont H, Montravers P, Perrigault PF, Constantin JM, Guillemot D, Azoulay E, Lortholary O, Bensoussan C, Timsit JF, AmarCAND2 study group
Systemic antifungal therapy for proven or suspected invasive candidiasis: the AmarCAND 2 study.
Annals of Intensive Care 2016, 6, 2.
Garrouste-Orgeas M, Ruckly S, Grégoire C, Dumesnil AS, Pommier C, Jamali S, Golgran-Toledano D, Schwebel C, Clec'h C, Soufir L, Fartoukh M, Marcotte G, Argaud L, Verdière B, Darmon M, Azoulay E, Timsit JF
Treatment intensity and outcome of nonagenarians selected for admission in ICUs: a multicenter study of the Outcomerea Research Group.
Annals of Intensive Care 2016, 6, 31.
Garrouste-Orgeas M, Vinatier I, Tabah A, Misset B, Timsit JF
Reappraisal of visiting policies and procedures of patient's family information in 188 French ICUs: a report of the Outcomerea Research Group.
Annals of Intensive Care 2016, 6, 82.
Bailly S, Destors M, Grillet Y, Richard P, Stach B, Vivodtzev I, Timsit JF, Lévy P, Tamisier R, Pépin JL, scientific council and investigators of the French national sleep apnea registry (OSFP)
Obstructive Sleep Apnea: A Cluster Analysis at Time of Diagnosis.
PloS One 2016, 11, e0157318.
2015
Bakker J, Perner A, Timsit JF
Evaluation of 7.5 years of Surviving Sepsis Campaign Guidelines.
Intensive Care Medicine 2015, 41, 151-153.
Toffart AC, Dhalluin X, Girard N, Chouaid C, Audigier-Valette C, Duruisseaux M, Mennecier B, Parrot A, Fournel P, Moro-Sibilot D, Timsit JF
Patients with advanced lung cancer harboring oncogenic mutations should be admitted to intensive care units.
Intensive Care Medicine [Letter] 2015, 41, 164-165.
Garrouste-Orgeas M, Perrin M, Soufir L, Vesin A, Blot F, Maxime V, Beuret P, Troché G, Klouche K, Argaud L, Azoulay E, Timsit JF
The Iatroref study: medical errors are associated with symptoms of depression in ICU staff but not burnout or safety culture.
Intensive Care Medicine 2015, 41, 273-284.
Reignier J, Darmon M, Sonneville R, Borel AL, Garrouste-Orgeas M, Ruckly S, Souweine B, Dumenil AS, Haouache H, Adrie C, Argaud L, Soufir L, Marcotte G, Laurent V, Goldgran-Toledano D, Clec'h C, Schwebel C, Azoulay E, Timsit JF
Impact of early nutrition and feeding route on outcomes of mechanically ventilated patients with shock: a post hoc marginal structural model study.
Intensive Care Medicine 2015, 41, 875-886.
Timsit JF, Perner A, Bakker J, Bassetti M, Benoit D, Cecconi M, Curtis JR, Doig GS, Herridge M, Jaber S, Joannidis M, Papazian L, Peters MJ, Singer P, Smith M, Soares M, Torres A, Vieillard-Baron A, Citerio G, Azoulay E
Year in review in Intensive Care Medicine 2014: III. Severe infections, septic shock, healthcare-associated infections, highly resistant bacteria, invasive fungal infections, severe viral infections, Ebola virus disease and paediatrics.
Intensive Care Medicine [YEAR IN REVIEW 2014] 2015, 41, 575-588.
Bretonnière C, Leone M, Milési C, Allaouchiche B, Armand-Lefevre L, Baldesi O, Bouadma L, Decré D, Figueiredo S, Gauzit R, Guery B, Joram N, Jung B, Lasocki S, Lepape A, Lesage F, Pajot O, Philippart F, Souweine B, Tattevin P, Timsit JF, Vialet R, Zahar JR, Misset B, Bedos JP
Strategies to reduce curative antibiotic therapy in intensive care units (adult and paediatric).
Intensive Care Medicine 2015, 41, 1181-1196.
Bassetti M, Leon C, Timsit JF
Are prophylactic antifungals in highly colonized patients safe and effective?.
Intensive Care Medicine 2015, 41, 1336-1339.
Lautrette A, Garrouste-Orgeas M, Bertrand PM, Goldgran-Toledano D, Jamali S, Laurent V, Argaud L, Schwebel C, Mourvillier B, Darmon M, Ruckly S, Dumenil AS, Lemiale V, Souweine B, Timsit JF, Outcomerea Study Group
Respective impact of no escalation of treatment, withholding and withdrawal of life-sustaining treatment on ICU patients' prognosis: a multicenter study of the Outcomerea Research Group.
Intensive Care Medicine 2015, 41, 1763-1772.
Bailly S, Leroy O, Montravers P, Constantin JM, Dupont H, Guillemot D, Lortholary O, Mira JP, Perrigault PF, Gangneux JP, Azoulay E, Timsit JF
Antifungal de-escalation was not associated with adverse outcome in critically ill patients treated for invasive candidiasis: post hoc analyses of the AmarCAND2 study data.
Intensive Care Medicine 2015, 41, 1931-1940.
Garnacho-Montero J, Dimopoulos G, Poulakou G, Akova M, Cisneros JM, De Waele J, Petrosillo N, Seifert H, Timsit JF, Vila J, Zahar JR, Bassetti M, European Society of Intensive Care Medicine
Task force on management and prevention of Acinetobacter baumannii infections in the ICU.
Intensive Care Medicine 2015, 41, 2057-2075.
Birgand G, Toupet G, Rukly S, Antoniotti G, Deschamps MN, Lepelletier D, Pornet C, Stern JB, Vandamme YM, van der Mee-Marquet N, Timsit JF, Lucet JC
Air contamination for predicting wound contamination in clean surgery: A large multicenter study.
American Journal of Infection Control 2015, 43, 516-521.
Le Dorze M, Gault N, Foucrier A, Ruppé E, Mourvillier B, Woerther PL, Birgand G, Montravers P, Dilly MP, Tubach F, Andremont A, Timsit JF, Wolff M, Armand-Lefèvre L
Performance and impact of a rapid method combining mass spectrometry and direct antimicrobial susceptibility testing on treatment adequacy of patients with ventilator-associated pneumonia.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2015, 21, 468.e1-6.
Weiss E, Zahar JR, Lesprit P, Ruppe E, Leone M, Chastre J, Lucet JC, Paugam-Burtz C, Brun-Buisson C, Timsit JF, De-escalation Study Group
Elaboration of a consensual definition of de-escalation allowing a ranking of β-lactams.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2015, 21, 649.e1-10.
Shadoud L, Almahmoud I, Jarraud S, Etienne J, Larrat S, Schwebel C, Timsit JF, Schneider D, Maurin M
Hidden Selection of Bacterial Resistance to Fluoroquinolones In Vivo: The Case of Legionella pneumophila and Humans.
EBioMedicine 2015, 2, 1179-1185.
Mimoz O, Lucet JC, Kerforne T, Pascal J, Souweine B, Goudet V, Mercat A, Bouadma L, Lasocki S, Alfandari S, Friggeri A, Wallet F, Allou N, Ruckly S, Balayn D, Lepape A, Timsit JF, CLEAN trial investigators
Skin antisepsis with chlorhexidine-alcohol versus povidone iodine-alcohol, with and without skin scrubbing, for prevention of intravascular-catheter-related infection (CLEAN): an open-label, multicentre, randomised, controlled, two-by-two factorial trial.
Lancet (London, England) 2015, 386, 2069-2077.
Tabah A, De Waele J, Lipman J, Zahar JR, Cotta MO, Barton G, Timsit JF, Roberts JA, Working Group for Antimicrobial Use in the ICU within the Infection Section of the European Society of Intensive Care Medicine (ESICM)
The ADMIN-ICU survey: a survey on antimicrobial dosing and monitoring in ICUs.
The Journal of Antimicrobial Chemotherapy 2015, 70, 2671-2677.
Bouadma L, Sonneville R, Garrouste-Orgeas M, Darmon M, Souweine B, Voiriot G, Kallel H, Schwebel C, Goldgran-Toledano D, Dumenil AS, Argaud L, Ruckly S, Jamali S, Planquette B, Adrie C, Lucet JC, Azoulay E, Timsit JF, OUTCOMEREA Study Group
Ventilator-Associated Events: Prevalence, Outcome, and Relationship With Ventilator-Associated Pneumonia.
Critical Care Medicine 2015, 43, 1798-1806.
Sonneville R, Gault N, de Montmollin E, Klein IF, Mariotte E, Chemam S, Tubach F, Mourvillier B, Timsit JF, Wolff M, Bouadma L
Clinical spectrum and outcomes of patients with encephalitis requiring intensive care.
European Journal of Neurology: The Official Journal of the European Federation of Neurological Societies 2015, 22, 6-16, e1.
Borel JC, Pelletier J, Taleux N, Briault A, Arnol N, Pison C, Tamisier R, Timsit JF, Pepin JL
Parameters recorded by software of non-invasive ventilators predict COPD exacerbation: a proof-of-concept study.
Thorax 2015, 70, 284-285.
Souweine B, Lautrette A, Gruson D, Canet E, Klouche K, Argaud L, Bohe J, Garrouste-Orgeas M, Mariat C, Vincent F, Cayot S, Cointault O, Lepape A, Guelon D, Darmon M, Vesin A, Caillot N, Schwebel C, Boyer A, Azoulay E, Bouadma L, Timsit JF
Ethanol lock and risk of hemodialysis catheter infection in critically ill patients. A randomized controlled trial.
American Journal of Respiratory and Critical Care Medicine 2015, 191, 1024-1032.
Bailly S, Bouadma L, Azoulay E, Orgeas MG, Adrie C, Souweine B, Schwebel C, Maubon D, Hamidfar-Roy R, Darmon M, Wolff M, Cornet M, Timsit JF
Failure of empirical systemic antifungal therapy in mechanically ventilated critically ill patients.
American Journal of Respiratory and Critical Care Medicine 2015, 191, 1139-1146.
Toffart AC, Pizarro CA, Schwebel C, Sakhri L, Minet C, Duruisseaux M, Azoulay E, Moro-Sibilot D, Timsit JF
Selection criteria for intensive care unit referral of lung cancer patients: a pilot study.
European Respiratory Journal 2015, 45, 491-500.
Sartelli M, Malangoni MA, Abu-Zidan FM, Griffiths EA, Di Bella S, McFarland LV, Eltringham I, Shelat VG, Velmahos GC, Kelly CP, Khanna S, Abdelsattar ZM, Alrahmani L, Ansaloni L, Augustin G, Bala M, Barbut F, Ben-Ishay O, Bhangu A, Biffl WL, Brecher SM, Camacho-Ortiz A, Caínzos MA, Canterbury LA, Catena F, Chan S, Cherry-Bukowiec JR, Clanton J, Coccolini F, Cocuz ME, Coimbra R, Cook CH, Cui Y, Czepiel J, Das K, Demetrashvili Z, Di Carlo I, Di Saverio S, Dumitru IM, Eckert C, Eckmann C, Eiland EH, Enani MA, Faro M, Ferrada P, Forrester JD, Fraga GP, Frossard JL, Galeiras R, Ghnnam W, Gomes CA, Gorrepati V, Ahmed MH, Herzog T, Humphrey F, Kim JI, Isik A, Ivatury R, Lee YY, Juang P, Furuya-Kanamori L, Karamarkovic A, Kim PK, Kluger Y, Ko WC, LaBarbera FD, Lee JG, Leppaniemi A, Lohsiriwat V, Marwah S, Mazuski JE, Metan G, Moore EE, Moore FA, Nord CE, Ordoñez CA, Júnior GAP, Petrosillo N, Portela F, Puri BK, Ray A, Raza M, Rems M, Sakakushev BE, Sganga G, Spigaglia P, Stewart DB, Tattevin P, Timsit JF, To KB, Tranà C, Uhl W, Urbánek L, van Goor H, Vassallo A, Zahar JR, Caproli E, Viale P
WSES guidelines for management of Clostridium difficile infection in surgical patients.
World journal of emergency surgery: WJES 2015, 10,
Minet C, Potton L, Bonadona A, Hamidfar-Roy R, Somohano CA, Lugosi M, Cartier JC, Ferretti G, Schwebel C, Timsit JF
Venous thromboembolism in the ICU: main characteristics, diagnosis and thromboprophylaxis.
Critical Care (London, England) 2015, 19,
Timsit JF, Chemam S, Bailly S
Empiric/pre-emptive anti-Candida therapy in non-neutropenic ICU patients.
F1000prime Reports 2015, 7, 21.
Venot M, Weis L, Clec'h C, Darmon M, Allaouchiche B, Goldgran-Tolédano D, Garrouste-Orgeas M, Adrie C, Timsit JF, Azoulay E
Acute Kidney Injury in Severe Sepsis and Septic Shock in Patients with and without Diabetes Mellitus: A Multicenter Study.
PloS One 2015, 10, e0127411.
Maunoury F, Motrunich A, Palka-Santini M, Bernatchez SF, Ruckly S, Timsit JF
Cost-Effectiveness Analysis of a Transparent Antimicrobial Dressing for Managing Central Venous and Arterial Catheters in Intensive Care Units.
PloS One 2015, 10, e0130439.
Philippart F, Bouroche G, Timsit JF, Garrouste-Orgeas M, Azoulay E, Darmon M, Adrie C, Allaouchiche B, Ara-Somohano C, Ruckly S, Dumenil AS, Souweine B, Goldgran-Toledano D, Bouadma L, Misset B, Outcomerea study group
Decreased Risk of Ventilator-Associated Pneumonia in Sepsis Due to Intra-Abdominal Infection.
PloS One 2015, 10, e0137262.
Maignan M, Richard A, Debaty G, Pommier P, Viglino D, Loizzo F, Timsit JF, Hanna J, Carpentier F, Danel V
Intentional Drug Poisoning Care in a Physician-manned Emergency Medical Service.
Prehospital emergency care: official journal of the National Association of EMS Physicians and the National Association of State EMS Directors 2015, 19, 224-231.
Dimopoulos G, Koulenti D, Tabah A, Poulakou G, Vesin A, Arvaniti K, Lathyris D, Matthaiou DK, Armaganidis A, Timsit JF
Bloodstream infections in ICU with increased resistance: epidemiology and outcomes.
Minerva Anestesiologica 2015, 81, 405-418.
2014
van Zanten ARH, Sztark F, Kaisers UX, Zielmann S, Felbinger TW, Sablotzki AR, De Waele JJ, Timsit JF, Honing MLH, Keh D, Vincent JL, Zazzo JF, Fijn HBM, Petit L, Preiser JC, van Horssen PJ, Hofman Z
High-protein enteral nutrition enriched with immune-modulating nutrients vs standard high-protein enteral nutrition and nosocomial infections in the ICU: a randomized clinical trial.
JAMA: the journal of the American Medical Association 2014, 312, 514-524.
Citerio G, Bakker J, Bassetti M, Benoit D, Cecconi M, Curtis JR, Hernandez G, Herridge M, Jaber S, Joannidis M, Papazian L, Peters M, Singer P, Smith M, Soares M, Torres A, Vieillard-Baron A, Timsit JF, Azoulay E
Year in review in Intensive Care Medicine 2013: I. Acute kidney injury, ultrasound, hemodynamics, cardiac arrest, transfusion, neurocritical care, and nutrition.
Intensive Care Medicine 2014, 40, 147-159.
Azoulay E, Citerio G, Bakker J, Bassetti M, Benoit D, Cecconi M, Curtis JR, Hernandez G, Herridge M, Jaber S, Joannidis M, Papazian L, Peters M, Singer P, Smith M, Soares M, Torres A, Vieillard-Baron A, Timsit JF
Year in review in Intensive Care Medicine 2013: II. Sedation, invasive and noninvasive ventilation, airways, ARDS, ECMO, family satisfaction, end-of-life care, organ donation, informed consent, safety, hematological issues in critically ill patients.
Intensive care medicine [YEAR IN REVIEW 2013] 2014, 40, 305-319.
Schnell D, Timsit JF, Darmon M, Vesin A, Goldgran-Toledano D, Dumenil AS, Garrouste-Orgeas M, Adrie C, Bouadma L, Planquette B, Cohen Y, Schwebel C, Soufir L, Jamali S, Souweine B, Azoulay E
Noninvasive mechanical ventilation in acute respiratory failure: trends in use and outcomes.
Intensive Care Medicine 2014, 40, 582-591.
Timsit JF, Citerio G, Bakker J, Bassetti M, Benoit D, Cecconi M, Curtis JR, Hernandez G, Herridge M, Jaber S, Joannidis M, Papazian L, Peters M, Singer P, Smith M, Soares M, Torres A, Vieillard-Baron A, Azoulay E
Year in review in Intensive Care Medicine 2013: III. Sepsis, infections, respiratory diseases, pediatrics.
Intensive care medicine [YEAR IN REVIEW 2013] 2014, 40, 471-483.
Timsit JF, Harbarth S, Carlet J
De-escalation as a potential way of reducing antibiotic use and antimicrobial resistance in ICU.
Intensive Care Medicine 2014, 40, 1580-1582.
Wolff M, Mourvillier B, Sonneville R, Timsit JF
My paper 10 years later: infective endocarditis in the intensive care unit.
Intensive Care Medicine [MY PAPER 20 YEARS LATER] 2014, 40, 1843-1852.
Debaty G, Maignan M, Savary D, Koch FX, Ruckly S, Durand M, Picard J, Escallier C, Chouquer R, Santre C, Minet C, Guergour D, Hammer L, Bouvaist H, Belle L, Adrie C, Payen JF, Carpentier F, Gueugniaud PY, Danel V, Timsit JF
Impact of intra-arrest therapeutic hypothermia in outcomes of prehospital cardiac arrest: a randomized controlled trial.
Intensive Care Medicine 2014, 40, 1832-1842.
Elsen S, Huber P, Bouillot S, Couté Y, Fournier P, Dubois Y, Timsit JF, Maurin M, Attrée I
A type III secretion negative clinical strain of Pseudomonas aeruginosa employs a two-partner secreted exolysin to induce hemorrhagic pneumonia.
Cell Host & Microbe 2014, 15, 164-176.
Elliott T, Timsit JF
epic3: guidelines for preventing infections associated with the use of intravascular access devices.
The Journal of Hospital Infection 2014, 87, 182.
Lugosi M, Alberti C, Zahar JR, Garrouste M, Lemiale V, Descorps-Desclère A, Ricard JD, Goldgran-Tolédano D, Cohen Y, Schwebel C, Vésin A, Timsit JF, Azoulay E
Aspergillus in the lower respiratory tract of immunocompetent critically ill patients.
The Journal of Infection 2014, 69, 284-292.
Zahar JR, Lucet JC, Timsit JF
Antimicrobial resistance in intensive care units.
The Lancet. Infectious Diseases 2014, 14, 3-5.
Soares M, Toffart AC, Timsit JF, Burghi G, Irrazábal C, Pattison N, Tobar E, Almeida BFC, Silva UVA, Azevedo LCP, Rabbat A, Lamer C, Parrot A, Souza-Dantas VC, Wallet F, Blot F, Bourdin G, Piras C, Delemazure J, Durand M, Tejera D, Salluh JIF, Azoulay E, Lung Cancer in Critical Care (LUCCA) Study Investigators
Intensive care in patients with lung cancer: a multinational study.
Annals of Oncology: Official Journal of the European Society for Medical Oncology 2014, 25, 1829-1835.
Mirabel M, Sonneville R, Hajage D, Novy E, Tubach F, Vignon P, Perez P, Lavoue S, Kouatchet A, Pajot O, Mekontso-Dessap A, Tonnelier JM, Bollaert PE, Frat JP, Navellou JC, Hyvernat H, Hssain AA, Timsit JF, Megarbane B, Wolff M, Trouillet JL, for the ENDOREA Study Group
Long-term outcomes and cardiac surgery in critically ill patients with infective endocarditis.
European Heart Journal 2014, 35, 1195-1204.
Chumpitazi BFF, Lebeau B, Faure-Cognet O, Hamidfar-Roy R, Timsit JF, Pavese P, Thiebaut-Bertrand A, Quesada JL, Pelloux H, Pinel C
Characteristic and clinical relevance of Candida mannan test in the diagnosis of probable invasive candidiasis.
Medical Mycology 2014, 52, 462-471.
Garrouste-Orgeas M, Ben-Rehouma M, Darmon M, Ruckly S, Clec'h C, Adrie C, Tabah A, Vesin A, Schwebel C, Misset B, Timsit JF
ICU physician-based determinants of life-sustaining therapy during nights and weekends: French multicenter study from the Outcomerea Research Group.
Critical Care Medicine 2014, 42, 2393-2400.
Darmon M, Pichon M, Schwebel C, Ruckly S, Adrie C, Haouache H, Azoulay E, Bouadma L, Clec'h C, Garrouste-Orgeas M, Souweine B, Goldgran-Toledano D, Khallel H, Argaud L, Dumenil AS, Jamali S, Allaouchiche B, Zeni F, Timsit JF
Influence of early dysnatremia correction on survival of critically ill patients.
Shock (Augusta, Ga.) 2014, 41, 394-399.
Gagneux-Brunon A, Timsit JF, Lepape A, Berthelot P
Vascular catheter-related infection claims to health insurance company: often preventable.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2014, 20, O1084-1087.
Borel JC, Pepin JL, Pison C, Vesin A, Gonzalez-Bermejo J, Court-Fortune I, Timsit JF
Long-term adherence with non-invasive ventilation improves prognosis in obese COPD patients.
Respirology (Carlton, Vic.) 2014, 19, 857-865.
Pépin JL, Timsit JF, Tamisier R, Lévy P
Is CPAP effective in reducing blood pressure in minimally symptomatic obstructive sleep apnoea?.
Thorax [Editorial] 2014, 69, 1068-1070.
Borel JC, Pison C, Timsit JF, Pepin JL
Domiciliary long-term non-invasive ventilation in COPD: should we select subgroups with a better likelihood to respond to NIV in subsequent randomised controlled trials?.
Thorax 2014, 69, 1143.
Puntillo KA, Max A, Timsit JF, Vignoud L, Chanques G, Robleda G, Roche-Campo F, Mancebo J, Divatia JV, Soares M, Ionescu DC, Grintescu I, Vasiliu IL, Maggiore SM, Rusinova K, Owczuk R, Egerod I, Papathanassoglou EDE, Kyranou M, Joynt GM, Burghi G, Freebairn RC, Ho KM, Kaarlola A, Gerritsen RT, Kesecioglu J, Sulaj MMS, Norrenberg M, Benoit DD, Seha MSG, Hennein A, Periera FJ, Benbenishty JS, Abroug F, Aquilina A, Monte JRC, An Y, Azoulay E
Determinants of Procedural Pain Intensity in the Intensive Care Unit The Europain (R) Study.
American Journal of Respiratory and Critical Care Medicine 2014, 189, 39-47.
Weiss E, Timsit JF
Management of invasive candidiasis in nonneutropenic ICU patients.
Therapeutic Advances in Infectious Disease 2014, 2, 105-115.
Timsit JF, Soubirou JF, Voiriot G, Chemam S, Neuville M, Mourvillier B, Sonneville R, Mariotte E, Bouadma L, Wolff M
Treatment of bloodstream infections in ICUs.
BMC infectious diseases 2014, 14, 489.
Toffart AC, Moro-Sibilot D, Couraud S, Merle P, Perol M, Girard N, Souquet PJ, Mastroianni B, Ferretti GR, Romand P, Chatellain P, Vesin A, Brambilla E, Brambilla C, Timsit JF
Evaluation of RECIST in chemotherapy-treated lung cancer: the Pharmacogenoscan Study.
Bmc Cancer 2014, 14, 989.
Tolsma V, Schwebel C, Azoulay E, Darmon M, Souweine B, Vesin A, Goldgran-Toledano D, Lugosi M, Jamali S, Cheval C, Adrie C, Kallel H, Descorps-Declere A, Garrouste-Orgeas M, Bouadma L, Timsit JF
Sepsis severe or septic shock: outcome according to immune status and immunodeficiency profile.
Chest 2014, 146, 1205-1213.
Darmon M, Clec'h C, Adrie C, Argaud L, Allaouchiche B, Azoulay E, Bouadma L, Garrouste-Orgeas M, Haouache H, Schwebel C, Goldgran-Toledano D, Khallel H, Dumenil AS, Jamali S, Souweine B, Zeni F, Cohen Y, Timsit JF
Acute respiratory distress syndrome and risk of AKI among critically ill patients.
Clinical journal of the American Society of Nephrology: CJASN 2014, 9, 1347-1353.
Borel AL, Schwebel C, Planquette B, Vésin A, Garrouste-Orgeas M, Adrie C, Clec'h C, Azoulay E, Souweine B, Allaouchiche B, Goldgran-Toledano D, Jamali S, Darmon M, Timsit JF
Initiation of nutritional support is delayed in critically ill obese patients: a multicenter cohort study.
The American Journal of Clinical Nutrition 2014, 100, 859-866.
2013
Demaret J, Walencik A, Jacob MC, Timsit JF, Venet F, Lepape A, Monneret G
Inter-laboratory assessment of flow cytometric monocyte HLA-DR expression in clinical samples.
Cytometry. Part B, Clinical Cytometry 2013, 84, 59-62.
Antonelli M, Bonten M, Cecconi M, Chastre J, Citerio G, Conti G, Curtis JR, Hedenstierna G, Joannidis M, Macrae D, Maggiore SM, Mancebo J, Mebazaa A, Preiser JC, Rocco P, Timsit JF, Wernerman J, Zhang H
Year in review in Intensive Care Medicine 2012: I. Neurology and neurointensive care, epidemiology and nephrology, biomarkers and inflammation, nutrition, experimentals.
Intensive Care Medicine 2013, 39, 232-246.
Antonelli M, Bonten M, Cecconi M, Chastre J, Citerio G, Conti G, Curtis JR, Hedenstierna G, Joannidis M, Macrae D, Maggiore SM, Mancebo J, Mebazaa A, Preiser JC, Rocco P, Timsit JF, Wernerman J, Zhang H
Year in review in Intensive Care Medicine 2012. II: Pneumonia and infection, sepsis, coagulation, hemodynamics, cardiovascular and microcirculation, critical care organization, imaging, ethics and legal issues.
Intensive Care Medicine 2013, 39, 345-364.
Antonelli M, Bonten M, Cecconi M, Chastre J, Citerio G, Conti G, Curtis JR, Hedenstierna G, Joannidis M, Macrae D, Maggiore SM, Mancebo J, Mebazaa A, Preiser JC, Rocco P, Timsit JF, Wernerman J, Zhang H
Year in review in Intensive Care Medicine 2012: III. Noninvasive ventilation, monitoring and patient-ventilator interactions, acute respiratory distress syndrome, sedation, paediatrics and miscellanea.
Intensive Care Medicine 2013, 39, 543-557.
Potton L, Bonadona A, Minet C, Timsit JF
Pink urine.
Intensive Care Medicine 2013, 39, 389-390.
Vesin A, Azoulay E, Ruckly S, Vignoud L, Rusinovà K, Benoit D, Soares M, Azeivedo-Maia P, Abroug F, Benbenishty J, Timsit JF
Reporting and handling missing values in clinical studies in intensive care units.
Intensive Care Medicine 2013, 39, 1396-1404.
Thiolliere F, Serre-Sapin AF, Reignier J, Benedit M, Constantin JM, Lebert C, Guélon D, Timsit JF, Souweine B
Epidemiology and outcome of thrombocytopenic patients in the intensive care unit: results of a prospective multicenter study.
Intensive Care Medicine 2013, 39, 1460-1468.
Philippart F, Vesin A, Bruel C, Kpodji A, Durand-Gasselin B, Garçon P, Levy-Soussan M, Jagot JL, Calvo-Verjat N, Timsit JF, Misset B, Garrouste-Orgeas M
The ETHICA study (part I): elderly's thoughts about intensive care unit admission for life-sustaining treatments.
Intensive Care Medicine 2013, 39, 1565-1573.
Garrouste-Orgeas M, Tabah A, Vesin A, Philippart F, Kpodji A, Bruel C, Grégoire C, Max A, Timsit JF, Misset B
The ETHICA study (part II): simulation study of determinants and variability of ICU physician decisions in patients aged 80 or over.
Intensive Care Medicine 2013, 39, 1574-1583.
Zahar JR, Garrouste-Orgeas M, Vesin A, Schwebel C, Bonadona A, Philippart F, Ara-Somohano C, Misset B, Timsit JF
Impact of contact isolation for multidrug-resistant organisms on the occurrence of medical errors and adverse events.
Intensive Care Medicine 2013, 39, 2153-2160.
Fagedet D, Thony F, Timsit JF, Rodiere M, Monnin-Bares V, Ferretti GR, Vesin A, Moro-Sibilot D
Endovascular treatment of malignant superior vena cava syndrome: results and predictive factors of clinical efficacy.
Cardiovascular and Interventional Radiology 2013, 36, 140-149.
Stahl JP, Salmon D, Bruneel F, Caumes E, Freymuth F, Bru JP, Morand P, Roblot F, Schmit JL, Strady C, Timsit JF, Rabaud C, Investigators
Adult patients hospitalized for measles in France, in the 21st century.
Medecine Et Maladies Infectieuses 2013, 43, 410-416.
Timsit JF, Laupland KB
Is the burden of severe sepsis and septic shock changing?.
Critical Care Medicine 2013, 41, 1361-1363.
Schwebel C, Clec'h C, Magne S, Minet C, Garrouste-Orgeas M, Bonadona A, Dumenil AS, Jamali S, Kallel H, Goldgran-Toledano D, Marcotte G, Azoulay E, Darmon M, Ruckly S, Souweine B, Timsit JF
Safety of Intrahospital Transport in Ventilated Critically Ill Patients: A Multicenter Cohort Study.
Critical Care Medicine 2013, 41, 1919-1928.
Murat JB, Lebeau B, Chumpitazi B, Cornet M, Maubon D, Faure O, Quesada JL, Thiebaut-Bertrand A, Timsit JF, Pelloux H
Minimum inhibitory concentrations of amphotericin B against Candida krusei isolates from a French teaching hospital laboratory: a retrospective study over 8 years.
Mycoses 2013, 56, 56-60.
Rousseaux S, Debernardi A, Jacquiau B, Vitte AL, Vesin A, Nagy-Mignotte H, Moro-Sibilot D, Brichon PY, Lantuejoul S, Hainaut P, Laffaire J, de Reyniès A, Beer DG, Timsit JF, Brambilla C, Brambilla E, Khochbin S
Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers.
Science Translational Medicine 2013, 5, 186ra66.
Planquette B, Timsit JF, Misset BY, Schwebel C, Azoulay E, Adrie C, Vesin A, Jamali S, Zahar JR, Allaouchiche B, Souweine B, Darmon M, Dumenil AS, Goldgran-Toledano D, Mourvillier BH, Bédos JP, OUTCOMEREA Study Group
Pseudomonas aeruginosa ventilator-associated pneumonia. predictive factors of treatment failure.
American Journal of Respiratory and Critical Care Medicine 2013, 188, 69-76.
Annane D, Timsit JF, Megarbane B, Martin C, Misset B, Mourvillier B, Siami S, Chagnon JL, Constantin JM, Petitpas F, Souweine B, Amathieu R, Forceville X, Charpentier C, Tesnière A, Chastre J, Bohe J, Colin G, Cariou A, Renault A, Brun-Buisson C, Bellissant E, APROCCHSS Trial Investigators
Recombinant human activated protein C for adults with septic shock: a randomized controlled trial.
American Journal of Respiratory and Critical Care Medicine 2013, 187, 1091-1097.
Timsit JF, Bouadma L, Mimoz O, Parienti JJ, Garrouste-Orgeas M, Alfandari S, Plantefeve G, Bronchard R, Troche G, Gauzit R, Antona M, Canet E, Bohe J, Herrault MC, Schwebel C, Ruckly S, Souweine B, Lucet JC
Jugular versus femoral short-term catheterization and risk of infection in intensive care unit patients. Causal analysis of two randomized trials.
American Journal of Respiratory and Critical Care Medicine 2013, 188, 1232-1239.
Goudet V, Timsit JF, Lucet JC, Lepape A, Balayn D, Seguin S, Mimoz O
Comparison of four skin preparation strategies to prevent catheter-related infection in intensive care unit (CLEAN trial): a study protocol for a randomized controlled trial.
Trials 2013, 14, 114.
Timsit JF, Azoulay E, Cornet M, Gangneux JP, Jullien V, Vésin A, Schir E, Wolff M
EMPIRICUS micafungin versus placebo during nosocomial sepsis in Candida multi-colonized ICU patients with multiple organ failures: study protocol for a randomized controlled trial.
Trials 2013, 14, 399.
Darmon M, Diconne E, Souweine B, Ruckly S, Adrie C, Azoulay E, Clec'h C, Garrouste-Orgeas M, Schwebel C, Goldgran-Toledano D, Khallel H, Dumenil AS, Jamali S, Cheval C, Allaouchiche B, Zeni F, Timsit JF
Prognostic consequences of borderline dysnatremia: pay attention to minimal serum sodium change.
Critical Care (London, England) 2013, 17, R12.
Toffart AC, Timsit JF
Is prolonged mechanical ventilation of cancer patients futile?.
Critical Care (London, England) 2013, 17, 189.
Adrie C, Schwebel C, Garrouste-Orgeas M, Vignoud L, Planquette B, Azoulay E, Kallel H, Darmon M, Souweine B, Dinh-Xuan AT, Jamali S, Zahar JR, Timsit JF, Article Was Written on behalf of the Outcomerea Study Group
Initial use of one or two antibiotics for critically ill patients with community-acquired pneumonia: impact on survival and bacterial resistance.
Critical Care (London, England) 2013, 17, R265.
Niven DJ, Laupland KB, Tabah A, Vesin A, Rello J, Koulenti D, Dimopoulos G, de Waele J, Timsit JF, EUROBACT Investigators
Diagnosis and management of temperature abnormality in ICUs: a EUROBACT investigators' survey.
Critical Care (London, England) 2013, 17, R289.
Zahar JR, Timsit JF
Clostridium difficile outcomes difficult to generalize. Authors' response.
Critical Care (London, England) 2013, 17, 415.
2012
Coeurjolly JF, Nguile-Makao M, Timsit JF, Liquet B
Attributable risk estimation for adjusted disability multistate models: application to nosocomial infections.
Biometrical Journal. Biometrische Zeitschrift 2012, 54, 600-616.
Antonelli M, Bonten M, Chastre J, Citerio G, Conti G, Curtis JR, De Backer D, Hedenstierna G, Joannidis M, Macrae D, Mancebo J, Maggiore SM, Mebazaa A, Preiser JC, Rocco P, Timsit JF, Wernerman J, Zhang H
Year in review in Intensive Care Medicine 2011: I. Nephrology, epidemiology, nutrition and therapeutics, neurology, ethical and legal issues, experimentals.
Intensive Care Medicine 2012, 38, 192-209.
Rhodes A, Moreno RP, Azoulay E, Capuzzo M, Chiche JD, Eddleston J, Endacott R, Ferdinande P, Flaatten H, Guidet B, Kuhlen R, León-Gil C, Martin Delgado MC, Metnitz PG, Soares M, Sprung CL, Timsit JF, Valentin A, Task Force on Safety and Quality of European Society of Intensive Care Medicine (ESICM)
Prospectively defined indicators to improve the safety and quality of care for critically ill patients: a report from the Task Force on Safety and Quality of the European Society of Intensive Care Medicine (ESICM).
Intensive Care Medicine 2012, 38, 598-605.
Antonelli M, Bonten M, Chastre J, Citerio G, Conti G, Curtis JR, De Backer D, Hedenstierna G, Joannidis M, Macrae D, Mancebo J, Maggiore SM, Mebazaa A, Preiser JC, Rocco P, Timsit JF, Wernerman J, Zhang H
Year in review in Intensive Care Medicine 2011. II. Cardiovascular, infections, pneumonia and sepsis, critical care organization and outcome, education, ultrasonography, metabolism and coagulation.
Intensive Care Medicine 2012, 38, 345-358.
Antonelli M, Bonten M, Chastre J, Citerio G, Conti G, Curtis JR, De Backer D, Hedenstierna G, Joannidis M, Macrae D, Mancebo J, Maggiore SM, Mebazaa A, Preiser JC, Rocco P, Timsit JF, Wernerman J, Zhang H
Year in review in Intensive Care Medicine 2011: III. ARDS and ECMO, weaning, mechanical ventilation, noninvasive ventilation, pediatrics and miscellanea.
Intensive Care Medicine 2012, 38, 542-556.
Azoulay E, Garrouste M, Goldgran-Toledano D, Adrie C, Max A, Vesin A, Francais A, Zahar JR, Cohen Y, Allaouchiche B, Schlemmer B, Timsit JF
Increased nonbeneficial care in patients spending their birthday in the ICU.
Intensive Care Medicine 2012, 38, 1169-1176.
Timsit JF, L'Hériteau F, Lepape A, Francais A, Ruckly S, Venier AG, Jarno P, Boussat S, Coignard B, Savey A
A multicentre analysis of catheter-related infection based on a hierarchical model.
Intensive Care Medicine 2012, 38, 1662-1672.
Tabah A, Koulenti D, Laupland K, Misset B, Valles J, Bruzzi de Carvalho F, Paiva JA, Cakar N, Ma X, Eggimann P, Antonelli M, Bonten MJM, Csomos A, Krueger WA, Mikstacki A, Lipman J, Depuydt P, Vesin A, Garrouste-Orgeas M, Zahar JR, Blot S, Carlet J, Brun-Buisson C, Martin C, Rello J, Dimopoulos G, Timsit JF
Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study.
Intensive Care Medicine 2012, 38, 1930-1945.
Ouanes I, Schwebel C, Français A, Bruel C, Philippart F, Vesin A, Soufir L, Adrie C, Garrouste-Orgeas M, Timsit JF, Misset B, Outcomerea Study Group
A model to predict short-term death or readmission after intensive care unit discharge.
Journal of Critical Care 2012, 27, 422.e1-9.
Gibert P, Brudieu E, Timsit JF, Foroni L, Thiébaut-Bertrand A, Allenet B, Pelloux H, Brenier Pinchart MP
Invasive aspergillosis: drug-dispensing systems as a source of filamentous fungal contamination in high-risk units?.
The Journal of Hospital Infection 2012, 82, 293-296.
Nagy-Mignotte H, Guillem P, Vignoud L, Coudurier M, Vesin A, Bonneterre V, Toffart AC, Sakhri L, Brambilla C, Brambilla E, Timsit JF, Moro-Sibilot D, Multidisciplinary Thoracic Oncology Group
Outcomes in recurrent small-cell lung cancer after one to four chemotherapy lines: a retrospective study of 300 patients.
Lung Cancer (Amsterdam, Netherlands) 2012, 78, 112-120.
Minet C, Vivodtzev I, Tamisier R, Arbib F, Wuyam B, Timsit JF, Monneret D, Borel JC, Baguet JP, Lévy P, Pépin JL
Reduced six-minute walking distance, high fat-free-mass index and hypercapnia are associated with endothelial dysfunction in COPD.
Respiratory Physiology & Neurobiology 2012, 183, 128-134.
Laupland KB, Zahar JR, Adrie C, Minet C, Vésin A, Goldgran-Toledano D, Azoulay E, Garrouste-Orgeas M, Cohen Y, Schwebel C, Jamali S, Darmon M, Dumenil AS, Kallel H, Souweine B, Timsit JF
Severe hypothermia increases the risk for intensive care unit-acquired infection.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2012, 54, 1064-1070.
Schwebel C, Lucet JC, Vesin A, Arrault X, Calvino-Gunther S, Bouadma L, Timsit JF
Economic evaluation of chlorhexidine-impregnated sponges for preventing catheter-related infections in critically ill adults in the Dressing Study.
Critical Care Medicine 2012, 40, 11-17.
Laupland KB, Zahar JR, Adrie C, Schwebel C, Goldgran-Toledano D, Azoulay E, Garrouste-Orgeas M, Cohen Y, Jamali S, Souweine B, Darmon M, Timsit JF
Determinants of temperature abnormalities and influence on outcome of critical illness.
Critical Care Medicine 2012, 40, 145-151.
Garrouste-Orgeas M, Soufir L, Tabah A, Schwebel C, Vesin A, Adrie C, Thuong M, Timsit JF, Outcomerea Study Group
A multifaceted program for improving quality of care in intensive care units: IATROREF study.
Critical Care Medicine 2012, 40, 468-476.
Azoulay E, Dupont H, Tabah A, Lortholary O, Stahl JP, Francais A, Martin C, Guidet B, Timsit JF
Systemic antifungal therapy in critically ill patients without invasive fungal infection*.
Critical Care Medicine 2012, 40, 813-822.
Parienti JJ, du Cheyron D, Timsit JF, Traoré O, Kalfon P, Mimoz O, Mermel LA
Meta-analysis of subclavian insertion and nontunneled central venous catheter-associated infection risk reduction in critically ill adults.
Critical Care Medicine 2012, 40, 1627-1634.
Timsit JF, Bouadma L, Ruckly S, Schwebel C, Garrouste-Orgeas M, Bronchard R, Calvino-Gunther S, Laupland K, Adrie C, Thuong M, Herault MC, Pease S, Arrault X, Lucet JC
Dressing disruption is a major risk factor for catheter-related infections.
Crit Care Med 2012, 40, 1707-14.
Garrouste-Orgeas M, Coquet I, Périer A, Timsit JF, Pochard F, Lancrin F, Philippart F, Vesin A, Bruel C, Blel Y, Angeli S, Cousin N, Carlet J, Misset B
Impact of an intensive care unit diary on psychological distress in patients and relatives*.
Critical Care Medicine 2012, 40, 2033-2040.
Minet C, Lugosi M, Savoye PY, Menez C, Ruckly S, Bonadona A, Schwebel C, Hamidfar-Roy R, Dumanoir P, Ara-Somohano C, Ferretti GR, Timsit JF
Pulmonary embolism in mechanically ventilated patients requiring computed tomography: Prevalence, risk factors, and outcome.
Critical Care Medicine 2012, 40, 3202-3208.
Timsit JF, Laupland KB
Update on bloodstream infections in ICUs.
Current Opinion in Critical Care 2012, 18, 479-486.
Timsit JF, Mimoz O, Mourvillier B, Souweine B, Garrouste-Orgeas M, Alfandari S, Plantefeve G, Bronchard R, Troche G, Gauzit R, Antona M, Canet E, Bohe J, Lepape A, Vesin A, Arrault X, Schwebel C, Adrie C, Zahar JR, Ruckly S, Tournegros C, Lucet JC
Randomized controlled trial of chlorhexidine dressing and highly adhesive dressing for preventing catheter-related infections in critically ill adults.
American Journal of Respiratory and Critical Care Medicine 2012, 186, 1272-1278.
Scoccianti C, Vesin A, Martel G, Olivier M, Brambilla E, Timsit JF, Tavecchio L, Brambilla C, Field JK, Hainaut P, European Early Lung Cancer Consortium
Prognostic value of TP53, KRAS and EGFR mutations in nonsmall cell lung cancer: the EUELC cohort.
The European Respiratory Journal 2012, 40, 177-184.
Liquet B, Timsit JF, Rondeau V
Investigating hospital heterogeneity with a multi-state frailty model: application to nosocomial pneumonia disease in intensive care units.
BMC medical research methodology 2012, 12, 79.
Mrozek N, Lautrette A, Timsit JF, Souweine B
How to deal with dialysis catheters in the ICU setting.
Annals of Intensive Care 2012, 2, 48.
Zahar JR, Schwebel C, Adrie C, Garrouste-Orgeas M, Français A, Vesin A, Nguile-Makao M, Tabah A, Laupland K, Le-Monnier A, Timsit JF, OUTCOMEREA study group
Outcome of ICU patients with Clostridium difficile infection.
Critical Care (London, England) 2012, 16, R215.
Clec'h C, Darmon M, Lautrette A, Chemouni F, Azoulay E, Schwebel C, Dumenil AS, Garrouste-Orgeas M, Goldgran-Toledano D, Cohen Y, Timsit JF
Efficacy of renal replacement therapy in critically ill patients: a propensity analysis.
Critical Care (London, England) 2012, 16, R236.
Pajares MJ, Agorreta J, Larrayoz M, Vesin A, Ezponda T, Zudaire I, Torre W, Lozano MD, Brambilla E, Brambilla C, Wistuba II, Behrens C, Timsit JF, Pio R, Field JK, Montuenga LM
Expression of tumor-derived vascular endothelial growth factor and its receptors is associated with outcome in early squamous cell carcinoma of the lung.
Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 2012, 30, 1129-1136.
Lupo J, Bernard S, Wintenberger C, Baccard M, Vabret A, Antona D, Timsit JF, Morand P
Fatal measles without rash in immunocompetent adult, France.
Emerging Infectious Diseases 2012, 18, 521-523.
2009
Timsit JF, Schwebel C, Bouadma L, Geffroy A, Garrouste-Orgeas M, Pease S, Herault MC, Haouache H, Calvino-Gunther S, Gestin B, Armand-Lefevre L, Leflon V, Chaplain C, Benali A, Francais A, Adrie C, Zahar JR, Thuong M, Arrault X, Croize J, Lucet JC
Chlorhexidine-impregnated sponges and less frequent dressing changes for prevention of catheter-related infections in critically ill adults: a randomized controlled trial..
JAMA 2009, 301, 1231-1241.
2006
Auburtin M, Wolff M, Charpentier J, Varon E, Le Tulzo Y, Girault C, Mohammedi I, Renard B, Mourvillier B, Bruneel F, Ricard JD, Timsit JF
Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: the PNEUMOREA prospective multicenter study..
Critical care medicine 2006, 34, 2758-2765.
Research domains : Sepsis and antibiotic therapy, Catheter-related infections, Ventilator-associated pneumonia, fungal infections, multidrug resistant infections in ICU;Medication errors and Adverse Events, Improvement of quality of care in intensive care, High quality Database, Prognostic models, mortality, competing risks
Supervision of masters and doctoral thesis : 16 Masters and 5 thesis in the past 7 years in clinical epidemiology.