Members

  First name: Jean-Ralph
  Last name: Zahar
  Function: Head of the Infection Control Unit
  Position: Professor
  Email: jean-ralph.zahar
._
_.
inserm.fr

Research interest


My main research interest are the ecological consequences of antibiotic therapy, mechanisms of spread and control of mutli drug resistant organisms. Infection control in and out ICU.

Education

Degree

1992, MD school Bichat Claude Bernard University, Paris, France
2012, Models, methods and algorithms in biology, Grenoble University

Academic positions

2016-Head of Infection Control Unit, Bobigny, France
2015-Professor in Infection Control.
2014- Head of Infection Control Unit, Angers, France.
2004-Head of Infection Control and Antimicrobial stewardship Unit Necker Enfants Malades, Paris. Claude-Bernard Hospital, Paris.
2001-2002- Infectious disease practionner, Mantes La Jolie, France.
1998-2001 Chef de Clinique, Intensive Care Unit,
Henri Mondor, University Hospital, Créteil, France.
Institut Gustave Roussy, Hospital, Villejuif, France
Hotel Dieu, Hospital, Paris, France.

1992-1998– Resident/fellow in internal medicine, ICU and infectious
diseases, Paris, France


Exhaustive list of publications

2022


Blot S, Ruppé E, Harbarth S, Asehnoune K, Poulakou G, Luyt CE, Rello J, Klompas M, Depuydt P, Eckmann C, Martin-Loeches I, Povoa P, Bouadma L, Timsit JF, Zahar JR
Healthcare-associated infections in adult intensive care unit patients: Changes in epidemiology, diagnosis, prevention and contributions of new technologies.
Intensive & Critical Care Nursing 2022, 70, 103227.

Saliba R, Lomont A, Eudesson JL, Seytre D, Zahar JR, Pilmis B
Significant variation in the faecal relative abundance of carbapenemase-producing Enterobacteriaceae of colonised patients during hospitalisation: a preliminary study.
International Journal of Antimicrobial Agents 2022, 59, 106479.

Saliba R, Karam-Sarkis D, Zahar JR, Glélé LSA
Adverse events associated with patient isolation: a systematic literature review and meta-analysis.
The Journal of Hospital Infection 2022, 119, 54-63.

Gangneux JP, Dannaoui E, Fekkar A, Luyt CE, Botterel F, De Prost N, Tadié JM, Reizine F, Houzé S, Timsit JF, Iriart X, Riu-Poulenc B, Sendid B, Nseir S, Persat F, Wallet F, Le Pape P, Canet E, Novara A, Manai M, Cateau E, Thille AW, Brun S, Cohen Y, Alanio A, Mégarbane B, Cornet M, Terzi N, Lamhaut L, Sabourin E, Desoubeaux G, Ehrmann S, Hennequin C, Voiriot G, Nevez G, Aubron C, Letscher-Bru V, Meziani F, Blaize M, Mayaux J, Monsel A, Boquel F, Robert-Gangneux F, Le Tulzo Y, Seguin P, Guegan H, Autier B, Lesouhaitier M, Pelletier R, Belaz S, Bonnal C, Berry A, Leroy J, François N, Richard JC, Paulus S, Argaud L, Dupont D, Menotti J, Morio F, Soulié M, Schwebel C, Garnaud C, Guitard J, Le Gal S, Quinio D, Morcet J, Laviolle B, Zahar JR, Bougnoux ME
Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study.
The Lancet. Respiratory Medicine 2022, 10, 180-190.

Smith DRM, Duval A, Zahar JR, EMWGoNSC2M, Opatowski L, Temime L
Rapid antigen testing as a reactive response to surges in nosocomial SARS-CoV-2 outbreak risk.
Nature Communications 2022, 13, 236.

Saliba R, Mizrahi A, Gauthier PdP, Alban LM, Zahar JR, Pilmis B
Antimicrobial Stewardship Program: Reducing Antibiotic's Spectrum of Activity Is not the Solution to Limit the Emergence of Multidrug-Resistant Bacteria.
Antibiotics (Basel, Switzerland) 2022, 11, 70.

Chaïbi K, Péan de Ponfilly G, Dortet L, Zahar JR, Pilmis B
Empiric Treatment in HAP/VAP: "Don't You Want to Take a Leap of Faith?".
Antibiotics (Basel, Switzerland) 2022, 11, 359.

2021


Poline J, Postaire M, Parize P, Pilmis B, Bille E, Zahar JR, Frange P, Cohen JF, Lortholary O, Toubiana J
Stewardship program on carbapenem prescriptions in a tertiary hospital for adults and children in France: a cohort study.
European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology 2021, 40, 1039-1048.

Zahar JR, Allaouchiche B
Even vaccinated against COVID-19, we must continue to wear a mask.
Anaesthesia, Critical Care & Pain Medicine 2021, 40, 100849.

Farfour E, Lomont A, Fihman V, Lecuru M, Hüssler S, Ouzani S, Zahar JR, Dortet L, Gsg
Rapid and accurate eXDR screening: use Xpert Carba-R® with FecalSwab®.
Diagnostic Microbiology and Infectious Disease 2021, 99, 115279.

Pilmis B, de Ponfilly GP, Farfour E, Ranc AG, Fihman V, Bille E, Dortet L, Degand N, Morand P, Potron A, Mizrahi A, Laurent F, Le Brun C, Guillard T, Héry-Arnaud G, Piau C, Barraud O, Ruffier d'Epenoux L, Zahar JR, Le Monnier A, Gsg
Epidemiology and clinical characteristics of Klebsiella spp. meningitis in France.
Infectious Diseases Now 2021, S2666-9919(21)00115-9.

Huriez P, Lourtet-Hascoet J, Zahar JR, Le Monnier A, Pilmis B
Frequency of surface bacterial contamination in family physicians' offices.
Infectious Diseases Now 2021, S2666-9919(21)00117-2.

Pilmis B, Jiang O, Mizrahi A, Nguyen Van JC, Lourtet-Hascoët J, Voisin O, Le Lorc'h E, Hubert S, Ménage E, Azria P, Borie MF, Mahé A, Mourad JJ, Trabattoni E, Ganansia O, Zahar JR, Le Monnier A
No significant difference between ceftriaxone and cefotaxime in the emergence of antibiotic resistance in the gut microbiota of hospitalized patients: A pilot study.
International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases 2021, 104, 617-623.

Saliba R, Ghelfenstein-Ferreira T, Lomont A, Pilmis B, Carbonnelle E, Seytre D, Nasser-Ayoub E, Zahar JR, Karam-Sarkis D
Risk factors for the environmental spread of different multidrug-resistant organisms: a prospective cohort study.
The Journal of Hospital Infection 2021, 111, 155-161.

Pilmis B, Mizrahi A, Péan de Ponfilly G, Philippart F, Bruel C, Zahar JR, Le Monnier A
Relative faecal abundance of extended-spectrum β-lactamase-producing Enterobacterales and its impact on infections among intensive care unit patients: a pilot study.
The Journal of Hospital Infection 2021, 112, 92-95.

de Lafforest S, Magnier A, Vallée M, Bey E, Le Goux C, Saint F, Therby A, Zahar JR, Sotto A, Bruyere F, Grammatico-Guillon L
FUrTIHF: French Urinary Tract Infections in Healthcare Facilities French Urinary Tract Infections in Healthcare Facilities: 5-year historic cohort 2014-2018.
The Journal of Hospital Infection 2021, S0195-6701(21)00225-5.

Grall I, Alloui CA, Tandjaoui-Lambiotte Y, Deslandes A, Seytre D, Chappe J, Carbonnelle E, Brichler S, Jacolot A, Zahar JR, Lomont A
Viral transmission in asymptomatic cases of SARS-CoV-2 infection.
The Journal of Infection 2021, 82, 282-327.

Lachassinne E, de Pontual L, Caseris M, Lorrot M, Guilluy C, Naud A, Dommergues MA, Pinquier D, Wannepain E, Hausherr E, Jung C, Gajdos V, Cohen R, Zahar JR, Brichler S, Basmaci R, Boelle PY, Bloch-Queyrat C, Aupiais C, Cc
SARS-CoV-2 transmission among children and staff in daycare centres during a nationwide lockdown in France: a cross-sectional, multicentre, seroprevalence study.
The Lancet. Child & Adolescent Health 2021, 5, 256-264.

Temime L, Gustin MP, Duval A, Buetti N, Crépey P, Guillemot D, Thiébaut R, Vanhems P, Zahar JR, Smith DRM, Opatowski L
A Conceptual Discussion About the Basic Reproduction Number of Severe Acute Respiratory Syndrome Coronavirus 2 in Healthcare Settings.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2021, 72, 141-143.

Pasquier G, Bounhiol A, Robert Gangneux F, Zahar JR, Gangneux JP, Novara A, Bougnoux ME, Dannaoui E
A review of significance of Aspergillus detection in airways of ICU COVID-19 patients.
Mycoses 2021, 64, 980-988.

Tandjaoui-Lambiotte Y, Timsit JF, Alloui C, Zahar JR, Vanoli E
Viral Dispersion in the Intensive Care Unit: The Wind Effect.
American Journal of Respiratory and Critical Care Medicine 2021

Bonnet N, Martin O, Boubaya M, Levy V, Ebstein N, Karoubi P, Tandjaoui-Lambiotte Y, Van Der Meersch G, Oziel J, Soulie M, Ghalayini M, Winchenne A, Zahar JR, Ahmed P, Gaudry S, Cohen Y
High flow nasal oxygen therapy to avoid invasive mechanical ventilation in SARS-CoV-2 pneumonia: a retrospective study.
Annals of Intensive Care 2021, 11, 37.

Diab-El Schahawi M, Zingg W, Vos M, Humphreys H, Lopez-Cerero L, Fueszl A, Zahar JR, Presterl E, ESGoNI“drwg
Ultraviolet disinfection robots to improve hospital cleaning: Real promise or just a gimmick?.
Antimicrobial Resistance and Infection Control 2021, 10, 33.

Xu E, Pérez-Torres D, Fragkou PC, Zahar JR, Koulenti D
Nosocomial Pneumonia in the Era of Multidrug-Resistance: Updates in Diagnosis and Management.
Microorganisms 2021

2020


Tabah A, Bassetti M, Kollef MH, Zahar JR, Paiva JA, Timsit JF, Roberts JA, Schouten J, Giamarellou H, Rello J, De Waele J, Shorr AF, Leone M, Poulakou G, Depuydt P, Garnacho-Montero J
Antimicrobial de-escalation in critically ill patients: a position statement from a task force of the European Society of Intensive Care Medicine (ESICM) and European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Critically Ill Patients Study Group (ESGCIP).
Intensive Care Medicine 2020, 46, 245-265.

De Bus L, Depuydt P, Steen J, Dhaese S, De Smet K, Tabah A, Akova M, Cotta MO, De Pascale G, Dimopoulos G, Fujitani S, Garnacho-Montero J, Leone M, Lipman J, Ostermann M, Paiva JA, Schouten J, Sjövall F, Timsit JF, Roberts JA, Zahar JR, Zand F, Zirpe K, De Waele JJ, Dsg
Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study.
Intensive Care Medicine 2020, 46, 1404-1417.

Pilmis B, Alby-Laurent F, Fasola ML, Seegers V, Guery R, Guet-Revillet H, Postaire M, Toubiana J, Bille E, Lortholary O, Zahar JR
Pseudomonas aeruginosa bloodstream infections in children: a 9-year retrospective study.
European Journal of Pediatrics 2020, 179, 1247-1254.

Saliba R, Zahar JR, El Allaoui F, Carbonnelle E, Lescat M
Impact of freeze/thaw cycles and single freezing at -80 °C on the viability of aerobic bacteria from rectal swabs performed with the ESwabTM system.
Diagnostic Microbiology and Infectious Disease 2020, 96, 114895.

Mizrahi A, Delerue T, Morel H, Le Monnier A, Carbonnelle E, Pilmis B, Zahar JR, obtSJSG
Infections caused by naturally AmpC-producing Enterobacteriaceae: Can we use third-generation cephalosporins? A narrative review.
International Journal of Antimicrobial Agents 2020, 55, 105834.

Deslandes A, Berti V, Tandjaoui-Lambotte Y, Alloui C, Carbonnelle E, Zahar JR, Brichler S, Cohen Y
SARS-CoV-2 was already spreading in France in late December 2019.
International Journal of Antimicrobial Agents 2020, 55, 106006.

Saliba R, Aho-Glélé LS, Karam-Sarkis D, Zahar JR
Evaluation of polymerase chain reaction assays for direct screening of carbapenemase-producing Enterobacteriaceae from rectal swabs: a diagnostic meta-analysis.
Journal of Hospital Infection 2020, 104, 381-389.

Pilmis B, Billard-Pomares T, Martin M, Clarempuy C, Lemezo C, Saint-Marc C, Bourlon N, Seytre D, Carbonnelle E, Zahar JR
Can environmental contamination be explained by particular traits associated with patients?.
The Journal of Hospital Infection 2020, 104, 293-297.

Hilliquin D, Lomont A, Zahar JR
Cohorting for preventing the nosocomial spread of Carbapenemase-Producing Enterobacterales, in non-epidemic settings: is it mandatory?.
The Journal of Hospital Infection 2020

Deelen JWT, Rottier WC, Giron Ortega JA, Rodriguez-Baño J, Harbarth S, Tacconelli E, Jacobsson G, Zahar JR, van Werkhoven CH, Bonten MJM
An international prospective cohort study to validate two prediction rules for infections caused by 3rd-generation cephalosporin-resistant Enterobacterales.
Clinical Infectious Diseases 2020, ciaa950.

Lomont A, Boubaya M, Khamis W, Deslandes A, Cordel H, Seytre D, Alloui C, Malaure C, Bonnet N, Carbonnelle E, Cohen Y, Nunes H, Bouchaud O, Zahar JR, Tandjaoui-Lambiotte Y
Environmental contamination related to SARS-CoV-2 in ICU patients.
ERJ open research 2020

Clément A, Delage R, Chollier M, Josse L, Gaudry S, Zahar JR, Baubet T, Degos B
Prospective study on a fast-track training in psychiatry for medical students: the psychiatric hat game.
BMC medical education 2020, 20, 373.

Timsit JF, Baleine J, Bernard L, Calvino-Gunther S, Darmon M, Dellamonica J, Desruennes E, Leone M, Lepape A, Leroy O, Lucet JC, Merchaoui Z, Mimoz O, Misset B, Parienti JJ, Quenot JP, Roch A, Schmidt M, Slama M, Souweine B, Zahar JR, Zingg W, Bodet-Contentin L, Maxime V
Expert consensus-based clinical practice guidelines management of intravascular catheters in the intensive care unit.
Annals of Intensive Care 2020, 10, 118.

Kardaś-Słoma L, Yazdanpanah Y, Perozziello A, Zahar JR, Lescure FX, Cousien A, Lucet JC
Hand hygiene improvement or antibiotic restriction to control the household transmission of extended-spectrum β-lactamase-producing Escherichia coli: a mathematical modelling study.
Antimicrobial Resistance and Infection Control 2020, 9, 139.

Pilmis B, Le Monnier A, Zahar JR
Gut Microbiota, Antibiotic Therapy and Antimicrobial Resistance: A Narrative Review.
Microorganisms 2020, 8, 269.

2019


Schnell D, Montlahuc C, Bruneel F, Resche-Rigon M, Kouatchet A, Zahar JR, Darmon M, Pene F, Lemiale V, Rabbat A, Vincent F, Azoulay E, Mokart D
De-escalation of antimicrobial therapy in critically ill hematology patients: a prospective cohort study.
Intensive Care Medicine 2019, 45, 743-745.

Delerue T, Cordel H, Delerue T, Figoni J, Dziri S, Billard-Pomares T, Bouchaud O, Carbonnelle E, Zahar JR
Prediction of methicillin-resistant Staphylococcus aureus bloodstream infection: do we need rapid diagnostic tests?.
European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology 2019, 38, 1319-1326.

Pilmis B, Lourtet-Hascoët J, Barraud O, Piau C, Isnard C, Hery-Arnaud G, Amara M, Merens A, Farfour E, Thomas E, Jacquier H, Zahar JR, Bonnet E, Monnier AL, Cattoir V, Corvec S, Boutoille D, de Ponfilly GP, Reissier S, GSG
Be careful about MICs to amoxicillin for patients with Streptococci-related infective endocarditis.
International Journal of Antimicrobial Agents 2019, 53, 850-854.

Saliba R, Neulier C, Seytre D, Fiacre A, Faibis F, Leduc P, Amara M, Jauréguy F, Carbonnelle E, Zahar JR, Marty L
Can real-time polymerase chain reaction allow a faster recovery of hospital activity in cases of an incidental discovery of carbapenemase-producing Enterobacteriaceae and vancomycin-resistant Enterococci carriers?.
Journal of Hospital Infection 2019, 103, 115-120.

Billard-Pomares T, Bleibtreu A, Walewski V, Dziri S, Barbat A, Zahar JR, Cruaud P, Carbonnelle E
Proposition of a safe Mycobacterium tuberculosis complex denaturation method that does not compromise the integrity of DNA for whole-genome sequencing.
Tuberculosis 2019, 117, 62-64.

Lucet JC, Zahar JR
Simplified control measures for ESBL-producing Enterobacteriacae?.
The Lancet. Infectious Diseases 2019, 19, 1036-1037.

Weiss E, Zahar JR, Alder J, Asehnoune K, Bassetti M, Bonten MJM, Chastre J, De Waele J, Dimopoulos G, Eggimann P, Engelhardt M, Ewig S, Kollef M, Lipman J, Luna C, Martin-Loeches I, Pagani L, Palmer LB, Papazian L, Poulakou G, Prokocimer P, Rello J, Rex JH, Shorr AF, Talbot GH, Thamlikitkul V, Torres A, Wunderink RG, Timsit JF
Elaboration of Consensus Clinical Endpoints to Evaluate Antimicrobial Treatment Efficacy in Future Hospital-acquired/Ventilator-associated Bacterial Pneumonia Clinical Trials.
Clinical Infectious Diseases 2019, 69, 1912-1918.

Prevel R, Boyer A, M’Zali F, Lasheras A, Zahar JR, Rogues AM, Gruson D
Is systematic fecal carriage screening of extended-spectrum beta-lactamase-producing Enterobacteriaceae still useful in intensive care unit: a systematic review.
Critical Care 2019, 23,

Vaillant L, Birgand G, Esposito-Farese M, Astagneau P, Pulcini C, Robert J, Zahar JR, Sales-Wuillemin E, Tubach F, Lucet JC, PSg
Awareness among French healthcare workers of the transmission of multidrug resistant organisms: a large cross-sectional survey.
Antimicrobial Resistance and Infection Control 2019, 8, 173.

Liapis E, Bour M, Triponney P, Jové T, Zahar JR, Valot B, Jeannot K, Plésiat P
Identification of Diverse Integron and Plasmid Structures Carrying a Novel Carbapenemase Among Pseudomonas Species.
Frontiers in Microbiology 2019, 10, 404.

2018


De Waele JJ, Akova M, Antonelli M, Canton R, Carlet J, De Backer D, Dimopoulos G, Garnacho-Montero J, Kesecioglu J, Lipman J, Mer M, Paiva JA, Poljak M, Roberts JA, Rodriguez Bano J, Timsit JF, Zahar JR, Bassetti M
Antimicrobial resistance and antibiotic stewardship programs in the ICU: insistence and persistence in the fight against resistance. A position statement from ESICM/ESCMID/WAAAR round table on multi-drug resistance.
Intensive Care Medicine 2018, 44, 189-196.

Barbier F, Bailly S, Schwebel C, Papazian L, Azoulay É, Kallel H, Siami S, Argaud L, Marcotte G, Misset B, Reignier J, Darmon M, Zahar JR, Goldgran-Toledano D, de Montmollin É, Souweine B, Mourvillier B, Timsit JF, OSG
Infection-related ventilator-associated complications in ICU patients colonised with extended-spectrum β-lactamase-producing Enterobacteriaceae.
Intensive Care Medicine 2018

Garrouste-Orgeas M, Azoulay E, Ruckly S, Schwebel C, de Montmollin E, Bedos JP, Souweine B, Marcotte G, Adrie C, Goldgran-Toledano D, Dumenil AS, Kallel H, Jamali S, Argaud L, Darmon M, Zahar JR, Timsit JF
Diabetes was the only comorbid condition associated with mortality of invasive pneumococcal infection in ICU patients: a multicenter observational study from the Outcomerea research group.
Infection 2018, 46, 669-677.

Leone M, Bouadma L, Bouhemad B, Brissaud O, Dauger S, Gibot S, Hraiech S, Jung B, Kipnis E, Launey Y, Luyt CE, Margetis D, Michel F, Mokart D, Montravers P, Monsel A, Nseir S, Pugin J, Roquilly A, Velly L, Zahar JR, Bruyère R, Chanques G
Hospital-acquired pneumonia in ICU.
Anaesthesia, Critical Care & Pain Medicine 2018, 37, 83-98.

Zahar JR, Blot S
Dilemmas in infection control in the intensive care unit.
Intensive & Critical Care Nursing 2018, 46, 1-3.

Macaux L, Ndoye O, Cordel H, Pomares TB, Seytre D, Bouchaud O, Cohen Y, Zahar JR, Carbonnelle E
Extensively-drug-resistant bacteria carriers among overseas travellers: one-third had not been hospitalized previously.
International Journal of Antimicrobial Agents 2018, 52, 385-389.

Hilliquin D, Le Guern R, Thepot Seegers V, Neulier C, Lomont A, Marie V, Legeay C, Merrer J, Lepelletier D, Rogues AM, Grandbastien B, Lucet JC, Zahar JR
Risk factors for acquisition of OXA-48-producing Klebsiella pneumonia among contact patients: a multicentre study.
The Journal of Hospital Infection 2018, 98, 253-259.

Pilmis B, Cattoir V, Lecointe D, Limelette A, Grall I, Mizrahi A, Marcade G, Poilane I, Guillard T, Bourgeois Nicolaos N, Zahar JR, Le Monnier A
Carriage of ESBL-producing Enterobacteriaceae in French hospitals: the PORTABLSE study.
The Journal of Hospital Infection 2018, 98, 247-252.

Legeay C, Thépot-Seegers V, Pailhoriès H, Hilliquin D, Zahar JR
Is cohorting the only solution to control carbapenemase-producing Enterobacteriaceae outbreaks? A single-centre experience.
The Journal of Hospital Infection 2018, 99, 390-395.

Garinet S, Fihman V, Jacquier H, Corvec S, Le Monnier A, Guillard T, Cattoir V, Zahar JR, Woerther PL, Carbonnelle E, Wargnier A, Kernéis S, Morand PC, G
Elective distribution of resistance to beta-lactams among Enterobacter cloacae genetic clusters.
The Journal of Infection 2018, 77, 178-182.

Birgand G, Zahar JR, Lucet JC
Insight Into the Complex Epidemiology of Multidrug-Resistant Enterobacteriaceae.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2018, 66, 494-496.

Zahar JR, Blot S, Nordmann P, Martischang R, Timsit JF, Harbarth S, Barbier F
Screening for intestinal carriage of ESBL-producing Enterobacteriaceae in critically ill patients: expected benefits and evidence-based controversies.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2018

Bougnoux ME, Brun S, Zahar JR
Healthcare-associated fungal outbreaks: New and uncommon species, New molecular tools for investigation and prevention.
Antimicrobial Resistance and Infection Control 2018, 7, 45.

Pilmis B, Zahar JR
Ventilator-associated pneumonia related to ESBL-producing gram negative bacilli.
Annals of Translational Medicine 2018, 6, 424.

2017


Pilmis B, Thepot-Seegers V, Angebault C, Weiss E, Alaabouche I, Bougnoux ME, Zahar JR
Could we predict airborne Aspergillus contamination during construction work?.
American Journal of Infection Control 2017, 45, 39-41.

Guet-Revillet H, Tomini E, Emirian A, Join-Lambert O, Lécuyer H, Zahar JR, Jullien V
Piperacillin/tazobactam as an alternative antibiotic therapy to carbapenems in the treatment of urinary tract infections due to extended-spectrum β-lactamase-producing Enterobacteriaceae: an in silico pharmacokinetic study.
International Journal of Antimicrobial Agents 2017, 49, 62-66.

Zahar JR, Lesprit P, Ruckly S, Eden A, Hikombo H, Bernard L, Harbarth S, Timsit JF, Brun-Buisson C, BSG
Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae.
International Journal of Antimicrobial Agents 2017, 49, 67-73.

Zahar JR, Lesprit P, Ruckly S, Eden A, Hikombo H, Bernard L, Harbarth S, Timsit JF, Brun-Buisson C, BSG
Erratum to 'Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae' [International Journal of Antimicrobial Agents 49/1 67-73].
International Journal of Antimicrobial Agents 2017, 49, 480-481.

Lequilliec N, Raymond R, Vanjak D, Baghdadi N, Boulestreau H, Zahar JR, Gangneux JP
Practices of infectious control management during neutropenia: A survey from 149 French hospitals.
Journal De Mycologie Medicale 2017, 27, 227-231.

Timsit JF, Pilmis B, Zahar JR
How Should We Treat Hospital-Acquired and Ventilator-Associated Pneumonia Caused by Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae?.
Seminars in Respiratory and Critical Care Medicine 2017, 38, 287-300.

Tschudin-Sutter S, Lucet JC, Mutters NT, Tacconelli E, Zahar JR, Harbarth S
Contact precautions for preventing nosocomial transmission of ESBL-producing Escherichia coli - a point/counterpoint review.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2017, 65, 342-347.

Weiss E, Essaied W, Adrie C, Zahar JR, Timsit JF
Treatment of severe hospital-acquired and ventilator-associated pneumonia: a systematic review of inclusion and judgment criteria used in randomized controlled trials.
Critical Care (London, England) 2017, 21, 162.

Delerue T, de Pontual L, Carbonnelle E, Zahar JR
The potential role of microbiota for controlling the spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) in neonatal population.
F1000Research 2017, 6, 1217.

2016


Weiss E, Zahar JR, Garrouste-Orgeas M, Ruckly S, Essaied W, Schwebel C, Timsit JF, OSG
De-escalation of pivotal beta-lactam in ventilator-associated pneumonia does not impact outcome and marginally affects MDR acquisition.
Intensive Care Medicine 2016, 42, 2098-2100.

Tabah A, Cotta MO, Garnacho-Montero J, Schouten J, Roberts JA, Lipman J, Tacey M, Timsit JF, Leone M, Zahar JR, De Waele JJ, WGfAUitI
A Systematic Review of the Definitions, Determinants, and Clinical Outcomes of Antimicrobial De-escalation in the Intensive Care Unit.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2016, 62, 1009-1017.

Barbier F, Pommier C, Essaied W, Garrouste-Orgeas M, Schwebel C, Ruckly S, Dumenil AS, Lemiale V, Mourvillier B, Clec'h C, Darmon M, Laurent V, Marcotte G, Lucet JC, Souweine B, Zahar JR, Timsit JF, OSG
Colonization and infection with extended-spectrum β-lactamase-producing Enterobacteriaceae in ICU patients: what impact on outcomes and carbapenem exposure?.
The Journal of Antimicrobial Chemotherapy 2016, 71, 1088-1097.

Toubiana J, Timsit S, Ferroni A, Grasseau M, Nassif X, Lortholary O, Zahar JR, Chalumeau M
Community-Onset Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae Invasive Infections in Children in a University Hospital in France.
Medicine 2016, 95, e3163.

Sartelli M, Weber DG, Ruppé E, Bassetti M, Wright BJ, Ansaloni L, Catena F, Coccolini F, Abu-Zidan FM, Coimbra R, Moore EE, Moore FA, Maier RV, De Waele JJ, Kirkpatrick AW, Griffiths EA, Eckmann C, Brink AJ, Mazuski JE, May AK, Sawyer RG, Mertz D, Montravers P, Kumar A, Roberts JA, Vincent JL, Watkins RR, Lowman W, Spellberg B, Abbott IJ, Adesunkanmi AK, Al-Dahir S, Al-Hasan MN, Agresta F, Althani AA, Ansari S, Ansumana R, Augustin G, Bala M, Balogh ZJ, Baraket O, Bhangu A, Beltrán MA, Bernhard M, Biffl WL, Boermeester MA, Brecher SM, Cherry-Bukowiec JR, Buyne OR, Cainzos MA, Cairns KA, Camacho-Ortiz A, Chandy SJ, Che Jusoh A, Chichom-Mefire A, Colijn C, Corcione F, Cui Y, Curcio D, Delibegovic S, Demetrashvili Z, De Simone B, Dhingra S, Diaz JJ, Di Carlo I, Dillip A, Di Saverio S, Doyle MP, Dorj G, Dogjani A, Dupont H, Eachempati SR, Enani MA, Egiev VN, Elmangory MM, Ferrada P, Fitchett JR, Fraga GP, Guessennd N, Giamarellou H, Ghnnam W, Gkiokas G, Goldberg SR, Gomes CA, Gomi H, Guzmán-Blanco M, Haque M, Hansen S, Hecker A, Heizmann WR, Herzog T, Hodonou AM, Hong SK, Kafka-Ritsch R, Kaplan LJ, Kapoor G, Karamarkovic A, Kees MG, Kenig J, Kiguba R, Kim PK, Kluger Y, Khokha V, Koike K, Kok KYY, Kong V, Knox MC, Inaba K, Isik A, Iskandar K, Ivatury RR, Labbate M, Labricciosa FM, Laterre PF, Latifi R, Lee JG, Lee YR, Leone M, Leppaniemi A, Li Y, Liang SY, Loho T, Maegele M, Malama S, Marei HE, Martin-Loeches I, Marwah S, Massele A, McFarlane M, Melo RB, Negoi I, Nicolau DP, Nord CE, Ofori-Asenso R, Omari AH, Ordonez CA, Ouadii M, Pereira Júnior GA, Piazza D, Pupelis G, Rawson TM, Rems M, Rizoli S, Rocha C, Sakakhushev B, Sanchez-Garcia M, Sato N, Segovia Lohse HA, Sganga G, Siribumrungwong B, Shelat VG, Soreide K, Soto R, Talving P, Tilsed JV, Timsit JF, Trueba G, Trung NT, Ulrych J, van Goor H, Vereczkei A, Vohra RS, Wani I, Uhl W, Xiao Y, Yuan KC, Zachariah SK, Zahar JR, Zakrison TL, Corcione A, Melotti RM, Viscoli C, Viale P
Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).
World journal of emergency surgery: WJES 2016, 11,

Schnell D, Azoulay E, Benoit D, Clouzeau B, Demaret P, Ducassou S, Frange P, Lafaurie M, Legrand M, Meert AP, Mokart D, Naudin J, Pene F, Rabbat A, Raffoux E, Ribaud P, Richard JC, Vincent F, Zahar JR, Darmon M
Management of neutropenic patients in the intensive care unit (NEWBORNS EXCLUDED) recommendations from an expert panel from the French Intensive Care Society (SRLF) with the French Group for Pediatric Intensive Care Emergencies (GFRUP), the French Society of Anesthesia and Intensive Care (SFAR), the French Society of Hematology (SFH), the French Society for Hospital Hygiene (SF2H), and the French Infectious Diseases Society (SPILF).
Annals of Intensive Care 2016, 6, 90.

2015


Bretonnière C, Leone M, Milési C, Allaouchiche B, Armand-Lefevre L, Baldesi O, Bouadma L, Decré D, Figueiredo S, Gauzit R, Guery B, Joram N, Jung B, Lasocki S, Lepape A, Lesage F, Pajot O, Philippart F, Souweine B, Tattevin P, Timsit JF, Vialet R, Zahar JR, Misset B, Bedos JP
Strategies to reduce curative antibiotic therapy in intensive care units (adult and paediatric).
Intensive Care Medicine 2015, 41, 1181-1196.

Garnacho-Montero J, Dimopoulos G, Poulakou G, Akova M, Cisneros JM, De Waele J, Petrosillo N, Seifert H, Timsit JF, Vila J, Zahar JR, Bassetti M, ESoICM
Task force on management and prevention of Acinetobacter baumannii infections in the ICU.
Intensive Care Medicine 2015, 41, 2057-2075.

Weiss E, Zahar JR, Lesprit P, Ruppe E, Leone M, Chastre J, Lucet JC, Paugam-Burtz C, Brun-Buisson C, Timsit JF, DeSG
Elaboration of a consensual definition of de-escalation allowing a ranking of β-lactams.
Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2015, 21, 649.e1-10.

Le Monnier A, Duburcq A, Zahar JR, Corvec S, Guillard T, Cattoir V, Woerther PL, Fihman V, Lalande V, Jacquier H, Mizrahi A, Farfour E, Morand P, Marcadé G, Coulomb S, Torreton E, Fagnani F, Barbut F, GSG
Hospital cost of Clostridium difficile infection including the contribution of recurrences in French acute-care hospitals.
The Journal of Hospital Infection 2015, 91, 117-122.

Charlier C, Hourrier S, Leruez-Ville M, Zahar JR, Floret D, Salomon LJ, Toubiana J, Lecuit M, Lapillonne A, Lortholary O, Kermorvant-Duchemin E
Polyvalent immunoglobulins in neonates after perinatal exposure to measles: Benefits and long-term tolerance of immunoglobulins.
The Journal of Infection 2015, 71, 131-134.

Tabah A, De Waele J, Lipman J, Zahar JR, Cotta MO, Barton G, Timsit JF, Roberts JA, WGfAUitIwtISotESoICM(
The ADMIN-ICU survey: a survey on antimicrobial dosing and monitoring in ICUs.
The Journal of Antimicrobial Chemotherapy 2015, 70, 2671-2677.

Sartelli M, Malangoni MA, Abu-Zidan FM, Griffiths EA, Di Bella S, McFarland LV, Eltringham I, Shelat VG, Velmahos GC, Kelly CP, Khanna S, Abdelsattar ZM, Alrahmani L, Ansaloni L, Augustin G, Bala M, Barbut F, Ben-Ishay O, Bhangu A, Biffl WL, Brecher SM, Camacho-Ortiz A, Caínzos MA, Canterbury LA, Catena F, Chan S, Cherry-Bukowiec JR, Clanton J, Coccolini F, Cocuz ME, Coimbra R, Cook CH, Cui Y, Czepiel J, Das K, Demetrashvili Z, Di Carlo I, Di Saverio S, Dumitru IM, Eckert C, Eckmann C, Eiland EH, Enani MA, Faro M, Ferrada P, Forrester JD, Fraga GP, Frossard JL, Galeiras R, Ghnnam W, Gomes CA, Gorrepati V, Ahmed MH, Herzog T, Humphrey F, Kim JI, Isik A, Ivatury R, Lee YY, Juang P, Furuya-Kanamori L, Karamarkovic A, Kim PK, Kluger Y, Ko WC, LaBarbera FD, Lee JG, Leppaniemi A, Lohsiriwat V, Marwah S, Mazuski JE, Metan G, Moore EE, Moore FA, Nord CE, Ordoñez CA, Júnior GAP, Petrosillo N, Portela F, Puri BK, Ray A, Raza M, Rems M, Sakakushev BE, Sganga G, Spigaglia P, Stewart DB, Tattevin P, Timsit JF, To KB, Tranà C, Uhl W, Urbánek L, van Goor H, Vassallo A, Zahar JR, Caproli E, Viale P
WSES guidelines for management of Clostridium difficile infection in surgical patients.
World journal of emergency surgery: WJES 2015, 10,

2014


Lucet JC, Koulenti D, Zahar JR
Persistence of colonisation with MDRO following discharge from the ICU.
Intensive Care Medicine 2014, 40, 603-605.

Lugosi M, Alberti C, Zahar JR, Garrouste M, Lemiale V, Descorps-Desclère A, Ricard JD, Goldgran-Tolédano D, Cohen Y, Schwebel C, Vésin A, Timsit JF, Azoulay E
Aspergillus in the lower respiratory tract of immunocompetent critically ill patients.
The Journal of Infection 2014, 69, 284-292.

Shoai Tehrani M, Hajage D, Fihman V, Tankovic J, Cau S, Day N, Visseaux C, Carbonnelle E, Kouatchet A, Cattoir V, Nhan TX, Corvec S, Jacquier H, Jauréguy F, Le Monnier A, Morand P, Zahar JR, obtGdmc
Gram-negative bacteremia: which empirical antibiotic therapy?.
Médecine Et Maladies Infectieuses 2014, 44, 159-166.

Lepeule R, Leflon-Guibout V, Vanjak D, Zahar JR, Lafaurie M, Besson C, Lefort A, GdReIddF(
Clinical spectrum of urine cultures positive for ESBL-producing Escherichia coli in hospitalized patients and impact on antibiotic use.
Medecine Et Maladies Infectieuses 2014, 44, 530-534.

Zahar JR, Lucet JC, Timsit JF
Antimicrobial resistance in intensive care units.
The Lancet. Infectious Diseases 2014, 14, 3-5.

2013


Zahar JR, Garrouste-Orgeas M, Vesin A, Schwebel C, Bonadona A, Philippart F, Ara-Somohano C, Misset B, Timsit JF
Impact of contact isolation for multidrug-resistant organisms on the occurrence of medical errors and adverse events.
Intensive Care Medicine 2013, 39, 2153-2160.

Prinapori R, Guinaud J, Khalil A, Lecuyer H, Gendrel D, Lortholary O, Nassif X, Viscoli C, Zahar JR
Risk associated with a systematic search of extended-spectrum β-lactamase-producing Enterobacteriaceae.
American Journal of Infection Control 2013, 41, 259-260.

Rivard-Yazigi L, Zahar JR, Le Guillou S, Chalouhi C, Lecuyer H, Bureau C, Nassif X, Gendrel D, Abadie V
Risk factors associated with extended-spectrum β-lactamase-producing Enterobacteriaceae carriage at admission in an infant cohort at a tertiary teaching hospital in France.
American Journal of Infection Control 2013, 41, 844-845.

Goulenok T, Ferroni A, Bille E, Lécuyer H, Join-Lambert O, Descamps P, Nassif X, Zahar JR
Risk factors for developing ESBL E. coli: can clinicians predict infection in patients with prior colonization?.
The Journal of Hospital Infection 2013, 84, 294-299.

Bertrand D, Pallet N, Sartorius A, Zahar JR, Soussan RS, Lortholary O, Legendre C, Mamzer MF
Clinical and microbial impact of screening kidney allograft preservative solution for bacterial contamination with high-sensitivity methods.
Transplant International: Official Journal of the European Society for Organ Transplantation 2013, 26, 795-799.

Planquette B, Timsit JF, Misset BY, Schwebel C, Azoulay E, Adrie C, Vesin A, Jamali S, Zahar JR, Allaouchiche B, Souweine B, Darmon M, Dumenil AS, Goldgran-Toledano D, Mourvillier BH, Bédos JP, OSG
Pseudomonas aeruginosa ventilator-associated pneumonia. predictive factors of treatment failure.
American Journal of Respiratory and Critical Care Medicine 2013, 188, 69-76.

Domenech de Cellès M, Zahar JR, Abadie V, Guillemot D
Limits of patient isolation measures to control extended-spectrum beta-lactamase-producing Enterobacteriaceae: model-based analysis of clinical data in a pediatric ward.
BMC infectious diseases 2013, 13, 187.

Yang ZT, Zahar JR, Méchaï F, Postaire M, Blanot S, Balfagon-Viel S, Nassif X, Lortholary O
Current ciprofloxacin usage in children hospitalized in a referral hospital in Paris.
BMC infectious diseases 2013, 13, 245.

Adrie C, Schwebel C, Garrouste-Orgeas M, Vignoud L, Planquette B, Azoulay E, Kallel H, Darmon M, Souweine B, Dinh-Xuan AT, Jamali S, Zahar JR, Timsit JF, AWWobotOSG
Initial use of one or two antibiotics for critically ill patients with community-acquired pneumonia: impact on survival and bacterial resistance.
Critical Care (London, England) 2013, 17, R265.

Schnell D, Lécuyer H, Geeraerts T, Dumenil AS, Bille E, Mercier FJ, Benhamou D, Zahar JR
Preliminary evaluation of a new clinical algorithm to interpret blood cultures growing coagulase-negative staphylococci.
Scandinavian Journal of Infectious Diseases 2013, 45, 562-566.

Zahar JR, Timsit JF
Clostridium difficile outcomes difficult to generalize. Authors' response.
Critical Care (London, England) 2013, 17, 415.

2012


Azoulay E, Garrouste M, Goldgran-Toledano D, Adrie C, Max A, Vesin A, Francais A, Zahar JR, Cohen Y, Allaouchiche B, Schlemmer B, Timsit JF
Increased nonbeneficial care in patients spending their birthday in the ICU.
Intensive Care Medicine 2012, 38, 1169-1176.

Tabah A, Koulenti D, Laupland K, Misset B, Valles J, Bruzzi de Carvalho F, Paiva JA, Cakar N, Ma X, Eggimann P, Antonelli M, Bonten MJM, Csomos A, Krueger WA, Mikstacki A, Lipman J, Depuydt P, Vesin A, Garrouste-Orgeas M, Zahar JR, Blot S, Carlet J, Brun-Buisson C, Martin C, Rello J, Dimopoulos G, Timsit JF
Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study.
Intensive Care Medicine 2012, 38, 1930-1945.

Guillet M, Zahar JR, Timsit MO, Grandin L, Carbonnelle E, Join-Lambert O, Quesne G, Nassif X, Mejean A, Carbonne A
Horizontal transmission of Streptococcus pneumoniae in the surgical ward: a rare source of nosocomial wound infection.
American Journal of Infection Control 2012, 40, 71-72.

Guet-Revillet H, Le Monnier A, Breton N, Descamps P, Lecuyer H, Alaabouche I, Bureau C, Nassif X, Zahar JR
Environmental contamination with extended-spectrum β-lactamases: is there any difference between Escherichia coli and Klebsiella spp?.
American Journal of Infection Control 2012, 40, 845-848.

Zahar JR, Masse V, Watier L, Lanternier F, Degand N, Postaire M, Descamps P, Nassif X, Lortholary O
Is hand-rub consumption correlated with hand hygiene and rate of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE)-acquired infections?.
The Journal of Hospital Infection 2012, 80, 348-350.

Fihman V, Le Monnier A, Corvec S, Jaureguy F, Tankovic J, Jacquier H, Carbonnelle E, Bille E, Illiaquer M, Cattoir V, Zahar JR
Stenotrophomonas maltophilia--the most worrisome threat among unusual non-fermentative gram-negative bacilli from hospitalized patients: a prospective multicenter study.
The Journal of Infection 2012, 64, 391-398.

Jacquier H, Le Monnier A, Carbonnelle E, Corvec S, Illiaquer M, Bille E, Zahar JR, Jauréguy F, Fihman V, Tankovic J, Cattoir V, GSG
In vitro antimicrobial activity of "last-resort" antibiotics against unusual nonfermenting Gram-negative bacilli clinical isolates.
Microbial Drug Resistance (Larchmont, N.Y.) 2012, 18, 396-401.

Laupland KB, Zahar JR, Adrie C, Minet C, Vésin A, Goldgran-Toledano D, Azoulay E, Garrouste-Orgeas M, Cohen Y, Schwebel C, Jamali S, Darmon M, Dumenil AS, Kallel H, Souweine B, Timsit JF
Severe hypothermia increases the risk for intensive care unit-acquired infection.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2012, 54, 1064-1070.

Rammaert B, Lanternier F, Zahar JR, Dannaoui E, Bougnoux ME, Lecuit M, Lortholary O
Healthcare-associated mucormycosis.
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 2012, 54 Suppl 1, S44-54.

Laupland KB, Zahar JR, Adrie C, Schwebel C, Goldgran-Toledano D, Azoulay E, Garrouste-Orgeas M, Cohen Y, Jamali S, Souweine B, Darmon M, Timsit JF
Determinants of temperature abnormalities and influence on outcome of critical illness.
Critical Care Medicine 2012, 40, 145-151.

Timsit JF, Mimoz O, Mourvillier B, Souweine B, Garrouste-Orgeas M, Alfandari S, Plantefeve G, Bronchard R, Troche G, Gauzit R, Antona M, Canet E, Bohe J, Lepape A, Vesin A, Arrault X, Schwebel C, Adrie C, Zahar JR, Ruckly S, Tournegros C, Lucet JC
Randomized controlled trial of chlorhexidine dressing and highly adhesive dressing for preventing catheter-related infections in critically ill adults.
American Journal of Respiratory and Critical Care Medicine 2012, 186, 1272-1278.

Zahar JR, Schwebel C, Adrie C, Garrouste-Orgeas M, Français A, Vesin A, Nguile-Makao M, Tabah A, Laupland K, Le-Monnier A, Timsit JF, Osg
Outcome of ICU patients with Clostridium difficile infection.
Critical Care (London, England) 2012, 16, R215.

Fournier S, Brossier F, Fortineau N, Gillaizeau F, Akpabie A, Aubry A, Barbut F, Chedhomme FX, Kassis-Chikhani N, Lucet JC, Robert J, Seytre D, Simon I, Vanjak D, Zahar JR, Brun-Buisson C, Jarlier V
Long-term control of vancomycin-resistant Enterococcus faecium at the scale of a large multihospital institution: a seven-year experience.
Euro Surveillance: Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin 2012, 17,