Research interest
My research is focused on development and application of methods for nonlinear mixed-effects models in pharmacokinetics and pharmacodynamics for more than 30 years. I am leading the development of the software PFIM for optimal design in pharmacometrics. I wish to extend the application of mixed-effects models for the systematic analysis of longitudinal data in clinical trials and cohorts.
I am also specifically involved in the treatment of (emerging) infectious diseases, where pharmacometrics provides better insight on the variability of response to drugs and the acquisition of resistance.
Education
Degree
- 1993: Habilitation à Diriger des Recherches, University Paris 6
- 1992: Medical Dissertation, University Paris 6
- 1984: PHD in Biomathematics, University Paris 7
- 1980-1984: Student of the Ecole Normale Supérieure in Mathematics
Academic positions
- Since 2000: Professor of Biostatistics, School of Medicine, Université Paris Cité
- 1995-2000: Research Director at INSERM
- 1985-1995: Researcher at INSERM
Research training (post doctoral)
- Since 2025: Director of the research unit IAME/UMR 1137 (Infection - Antimicrobials - Modelling - Evolution) of INSERM, Université Paris Cité and Université Sorbonne Paris Nord
- 2014-2024: Vice Director of research unit UMR 1137 INSERM / University Paris 7: Infection . Antimicrobials. Modelling . Evolution. Co leader of team Biostatistical Modelling, Clinical Investigation and Pharmacometrics in Infection Diseases
- 2003-2013: Director of research unit UMR 738 INSERM / University Paris 7: Models and Methods for the therapeutic assessment of chronic diseases. Head of team Biostatistical Modelling and Pharmacometrics
- 1995-2000: Head of team: Modelling of pharmacological processes; application to the analysis of clinical trial and to therapeutic drug monitoring in INSERM UMR U436 INSERM / University Paris 6 : Mathematical and Statistical Modelling in Biology and Medicine (director Pr A Mallet)