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Clotilde Lepers | IAME
Clotilde Lepers Position: Contract ITA / IR Affiliation: AP-HP
Team: PREVIST

Research interest

After completing a PhD on plant–pollinator interactions and their impact on the evolution of plant reproductive systems (University of Lille), followed by two postdoctoral positions in mathematical modeling applied to evolutionary biology, I am now a research engineer in the team PreViST of IAME laboratory. These experiences allowed me to develop strong skills in modeling complex systems, which I now apply to public health research, particularly in the field of chronic hepatitis B.
My work focuses on the medico-economic evaluation of healthcare strategies. This evaluation has several complementary components: first, modeling the progression of the disease under various treatment scenarios; second, estimating health-related costs; and third, assessing health-related quality of life. Only by combining these elements can we accurately evaluate the cost-effectiveness of treatment strategies and support public health decision-making.
To obtain robust data on disease progression, I am involved in the IP-Cure-B project, which includes a clinical trial assessing the efficacy of innovative therapeutic strategies (https://ipcureb.eu). For cost estimation, I work on a project, analyzing healthcare costs using data from the French National Health Data System (SNDS) and the HEPATHER cohort, which has been linked to SNDS (CACH-B ANRS project). To evaluate health-related quality of life and identify its key determinants in patients living with chronic hepatitis B, I conduct analyses within the HEPATHER cohort.

Education

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